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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Pay vs Performance Disclosure          
Pay vs Performance Disclosure, Table
Value of Initial
Fixed
$100
Investment Based
On:
Fiscal
Year
(a)
Summary
Compensa
tion
Table
(“SCT”)
for Mr.
Hanna
(PEO 1)
(b)(1)
CAP to
Mr. Hanna
(PEO 1)
(c)(2)
Summary
Compensa
tion
Table
(“SCT”)
for Mr.
Johnson
(PEO 2)
(d)(1)
CAP to
Mr.
Johnson
(PEO 2)
(e)(2)
SCT for
Dr. Seeto
(PEO 3)
(f)(1)
CAP to
Dr. Seeto
(PEO 3)
(g)(2)
SCT for
Dr. Maag
(PEO 4)
(h)(1)
CAP to
Dr. Maag
(PEO 4)
(i)(2)
Average
SCT
for Non-
PEO NEOs
(j)(3)
Average
CAP
to Non-
PEO
NEOs
(k)(2)
Net
Income
(in
thousands
)
(n)
Revenue
(in
thousand
s)
(o)(5)
TSR
(l)(4)
Peer
Group
TSR
(m)(4)
2024
$9,424,329
$24,178,001
$2,937,571
$7,443,241
—
—
—
—
$2,986,074
$3,772,296
$99.26
$118.20
$52,549
$333,785
2023
—
—
$3,097,438
$1,923,573
$10,551,753
$6,665,898
—
—
$4,617,844
$4,412,835
$55.63
$118.87
($190,284)
$280,324
2022
—
—
—
—
$12,786,270
($648,097)
—
—
$3,784,612
$118,224
$52.90
$113.65
($76,613)
$321,793
2021
—
—
—
—
$7,090,121
($50,411)
—
—
$2,605,699
$140,603
$210.85
$126.45
($30,662)
$296,397
2020
—
—
—
—
$5,618,698
$17,196,016
$6,400,015
$32,731,502
$1,979,508
$7,956,557
$335.88
$126.42
($18,714)
$192,194
        
Company Selected Measure Name Revenue        
Named Executive Officers, Footnote The dollar amounts reported in columns (b), (d), and (f) are the amounts of total compensation reported for Mr. Johnson (our Principal
Executive Officer since November 1, 2023), Dr. Seeto (Chief Executive Officer and Principal Executive Officer from November 1, 2020
to November 1, 2023) and Dr. Maag (Chief Executive Officer until November 1, 2020) for each corresponding year in the “Total”
column of the Summary Compensation Table. Refer to the “Summary Compensation Table” on page 62 for additional information.
2024
2023
2022
2021
2020
Abhishek Jain
Abhishek Jain
Abhishek Jain
Ankur Dhingra
Michael Bell
Keith Kennedy
Abraham Ronai
Alexander Johnson
Alexander Johnson
Sasha King
Jessica Meng
Abraham Ronai
Sasha King
Marcel Konrad
Jeffrey Novack
Ankur Dhingra
Peter Maag, Ph. D.
Sasha King
Marcel Konrad
        
Peer Group Issuers, Footnote TSR is determined based on the value of an initial fixed investment of $100. The TSR peer group consists of the Nasdaq Biotech Index
companies. TSR is calculated by dividing (i) the difference between the stock price at the end of each measurement period shown and
the beginning of the measurement period by (ii) the stock price at the beginning of the measurement period.
        
Adjustment To PEO Compensation, Footnote
Fiscal
Year
Executives
SCT
(a)
Grant Date
Value of
New
Awards
(b)
Year End
Value of
New
Awards
(i)
Change in
Value of
Outstandin
g
Awards
Granted in
Prior Fiscal
Year
(ii)
Change in
Value of
Vested
Awards
Granted
in
Prior
Fiscal
Years
(iii)
Fair Value
of Vested
Awards
Granted
and
Vested in
Current
Fiscal
Year
(iv)
Fair
Value at
Start of
Fiscal
Year of
Awards
that
Failed to
Meet
Vesting
Condition
s
(v)
Value of
Dividend
s
Paid on
Equity
Awards
not
Reflecte
d
in Fair
Value
(vi)
Total
Equity
CAP
(c)=(i)+(ii)+
(iii)+(iv)
CAP
(d)=
(a)-(b)+(c)
2024
PEO 1
$9,424,329
($8,001,024)
$22,754,696
$—
$—
—
—
—
$22,754,696
$24,178,001
PEO 2
$2,937,571
($1,549,738)
$2,802,355
$2,262,180
$185,168
805,705
—
—
$6,055,408
$7,443,241
Non-PEO
NEO Avg
$2,986,074
($2,340,879)
$2,220,533
$577,907
$50,217
278,444
—
—
$3,127,101
$3,772,296
        
Non-PEO NEO Average Total Compensation Amount $ 2,986,074 $ 4,617,844 $ 3,784,612 $ 2,605,699 $ 1,979,508
Non-PEO NEO Average Compensation Actually Paid Amount $ 3,772,296 4,412,835 118,224 140,603 7,956,557
Adjustment to Non-PEO NEO Compensation Footnote
Fiscal
Year
Executives
SCT
(a)
Grant Date
Value of
New
Awards
(b)
Year End
Value of
New
Awards
(i)
Change in
Value of
Outstandin
g
Awards
Granted in
Prior Fiscal
Year
(ii)
Change in
Value of
Vested
Awards
Granted
in
Prior
Fiscal
Years
(iii)
Fair Value
of Vested
Awards
Granted
and
Vested in
Current
Fiscal
Year
(iv)
Fair
Value at
Start of
Fiscal
Year of
Awards
that
Failed to
Meet
Vesting
Condition
s
(v)
Value of
Dividend
s
Paid on
Equity
Awards
not
Reflecte
d
in Fair
Value
(vi)
Total
Equity
CAP
(c)=(i)+(ii)+
(iii)+(iv)
CAP
(d)=
(a)-(b)+(c)
2024
PEO 1
$9,424,329
($8,001,024)
$22,754,696
$—
$—
—
—
—
$22,754,696
$24,178,001
PEO 2
$2,937,571
($1,549,738)
$2,802,355
$2,262,180
$185,168
805,705
—
—
$6,055,408
$7,443,241
Non-PEO
NEO Avg
$2,986,074
($2,340,879)
$2,220,533
$577,907
$50,217
278,444
—
—
$3,127,101
$3,772,296
        
Equity Valuation Assumption Difference, Footnote The recalculated value of equity awards for each applicable year includes the addition (or subtraction, as applicable) of the following:
(d)the year-end fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the
applicable year;
(e)the amount of change as of the end of the applicable year (from the end of the prior fiscal year) in fair value of any awards granted in
prior years that are outstanding and unvested as of the end of the applicable year;
(f)for awards that vest in the applicable year, the change in the fair value as of the vesting date from the beginning of the applicable year;
(g)for awards that failed to meet vesting conditions in the applicable year, the fair value from the end of prior fiscal year.
(h)for awards that failed to meet vesting conditions in the applicable year, the fair value from the end of prior fiscal year;
(i)value of dividend not otherwise captured in the calculation of each Fair Value used to calculate CAP
        
Compensation Actually Paid vs. Net Income Chart 2
CAP vs Net Income Graph.jpg
        
Compensation Actually Paid vs. Company Selected Measure Chart 3
CAP vs Revenue.jpg
        
Total Shareholder Return Vs Peer Group Chart 1
CAP vs TSR Graph.jpg
        
Tabular List, Table
2024 Most Important Performance Measures
The Compensation and Human Capital Committee uses a mix of
performance measures throughout our annual and long-term
incentive programs to align executive pay with Company
performance. As required by SEC rules, the performance measures
identified as the most important for all of our NEOs’ 2024
compensation decisions are listed in the table to the right. The
measures in this table are not ranked.
Most Important Performance Measures
Revenue
Adjusted EBITDA
Pipeline
        
Total Shareholder Return Amount $ 99.26 55.63 52.90 210.85 335.88
Peer Group Total Shareholder Return Amount 118.20 118.87 113.65 126.45 126.42
Net Income (Loss) $ 52,549,000 $ (190,284,000) $ (76,613,000) $ (30,662,000) $ (18,714,000)
Company Selected Measure Amount 333,785,000 280,324,000 321,793,000 296,397,000 192,194,000
PEO Name   Mr. Johnson Dr. Seeto Dr. Seeto Dr. Maag
Additional 402(v) Disclosure The dollar amounts reported in columns (c), (e), (g), (i), and (k) represent the amount of the CAP, as computed in accordance with
SEC rules. The CAP does not necessarily represent cash and/or equity value transferred to the applicable NEO without restriction, but
rather is a value calculated under applicable SEC rules. These amounts reflect the total amount of compensation for our NEOs
reported in the Summary Compensation Table with certain adjustments as described in the table below for the most recent fiscal year.
We do not have a defined benefit plan so no adjustment for pension benefits is included. The valuation assumptions and processes
used to recalculate fair values did not materially differ from those disclosed at the time of grant.
The dollar amounts reported in the Summary Compensation Table for the applicable year.
(b)The grant date fair value of equity awards represents the total of the amounts reported in the “Stock Awards” and “Option Awards”
columns of the Summary Compensation Table for the applicable year.
The CAP does not necessarily represent cash and/or equity value transferred to the applicable NEO without restriction, but rather is a
value calculated under applicable SEC rules.
The dollar amounts reported in column (j) are the average amounts of total compensation reported for the Non-PEO NEOs for each
corresponding year in the “Total” column of the Summary Compensation Table. Refer to our “Summary Compensation Table” on page
62 for additional information. For each of fiscal years in the table, the Non-PEO NEOs were:
We determined Revenue to be the most important financial performance measure used to link Company performance to the CAP to
our PEOs and Non-PEO NEOs in 2024, consistent with the Total Sales targets used for our short-term incentives (annual bonuses)
and long-term incentives (PRSUs). See page 50 of our CD&A for additional information.
Relationship Between the CAP and Performance Measures
We believe the table above shows the alignment between the CAP to the NEOs and the Company’s performance,
consistent with our compensation philosophy as described in our CD&A beginning on page 50. The charts below
show the relationship between the CAP to our PEOs and Non-PEO NEOs and (i) our TSR and the Peer Group TSR;
(ii) our net income and (iii) our Company-Selected Measure, Revenue, during the five most recently completed fiscal
years. 		       
Measure:: 1          
Pay vs Performance Disclosure          
Name Revenue        
Measure:: 2          
Pay vs Performance Disclosure          
Name Adjusted EBITDA        
Measure:: 3          
Pay vs Performance Disclosure          
Name Pipeline        
Mr. John W. Hanna [Member]          
Pay vs Performance Disclosure          
PEO Total Compensation Amount $ 9,424,329        
PEO Actually Paid Compensation Amount 24,178,001        
Mr. Johnson [Member]          
Pay vs Performance Disclosure          
PEO Total Compensation Amount 2,937,571 $ 3,097,438      
PEO Actually Paid Compensation Amount 7,443,241 1,923,573      
Dr. Seeto [Member]          
Pay vs Performance Disclosure          
PEO Total Compensation Amount   10,551,753 $ 12,786,270 $ 7,090,121 $ 5,618,698
PEO Actually Paid Compensation Amount   $ 6,665,898 $ (648,097) $ (50,411) 17,196,016
Dr. Maag [Member]          
Pay vs Performance Disclosure          
PEO Total Compensation Amount         6,400,015
PEO Actually Paid Compensation Amount         $ 32,731,502
PEO | Mr. John W. Hanna [Member] | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (8,001,024)        
PEO | Mr. John W. Hanna [Member] | Equity Awards Adjustments, Excluding Value Reported in Compensation Table          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 22,754,696        
PEO | Mr. John W. Hanna [Member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 22,754,696        
PEO | Mr. John W. Hanna [Member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Mr. John W. Hanna [Member] | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Mr. John W. Hanna [Member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Mr. John W. Hanna [Member] | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Mr. John W. Hanna [Member] | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Mr. Johnson [Member] | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (1,549,738)        
PEO | Mr. Johnson [Member] | Equity Awards Adjustments, Excluding Value Reported in Compensation Table          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 6,055,408        
PEO | Mr. Johnson [Member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 2,802,355        
PEO | Mr. Johnson [Member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 2,262,180        
PEO | Mr. Johnson [Member] | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 805,705        
PEO | Mr. Johnson [Member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 185,168        
PEO | Mr. Johnson [Member] | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Mr. Johnson [Member] | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (2,340,879)        
Non-PEO NEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 3,127,101        
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 2,220,533        
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 577,907        
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 278,444        
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 50,217        
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
Non-PEO NEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount $ 0