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Segment Reporting | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Segment Reporting | 10. Segment Reporting Our CODM manages our operations on an integrated basis for the purpose of allocating resources. When evaluating our financial performance, the CODM regularly reviews total revenues, total expenses, and research and development expenses by project and the CODM makes decisions using this information. The table below is a summary of the segment profit or loss, including significant expenses, in thousands:
| Three Months Ended September 30, |  | Nine Months Ended September 30, |
| 2025 |  |  | 2024 |  | 2025 |  |  | 2024 |
Collaboration revenue | $ | 20,750 |  |  | $ | — |  | $ | 50,146 |  |  | $ | — |
Less: |  |  |  |  |  |  |  |  |  |
Ziftomenib-related costs |  | 40,320 |  |  |  | 18,993 |  |  | 107,851 |  |  |  | 52,335 |
Darlifarnib (KO-2806)-related costs |  | 8,494 |  |  |  | 5,178 |  |  | 19,871 |  |  |  | 13,026 |
Tipifarnib-related costs |  | 443 |  |  |  | 721 |  |  | 2,578 |  |  |  | 3,560 |
Discovery stage program-related costs |  | 1,744 |  |  |  | 1,769 |  |  | 5,323 |  |  |  | 4,950 |
Research and development personnel costs and other expenses |  | 13,695 |  |  |  | 11,474 |  |  | 41,790 |  |  |  | 32,611 |
Share-based compensation expense |  | 10,965 |  |  |  | 8,324 |  |  | 25,756 |  |  |  | 25,266 |
Other segment expenses(1) |  | 25,086 |  |  |  | 13,425 |  |  | 64,340 |  |  |  | 38,992 |
Total operating expenses |  | 100,747 |  |  |  | 59,884 |  |  | 267,509 |  |  |  | 170,740 |
Other income (expenses) |  |  |  |  |  |  |  |  |  |
Interest and other income |  | 6,274 |  |  |  | 5,892 |  |  | 21,088 |  |  |  | 17,190 |
Interest expense |  | (393 | ) |  |  | (412 | ) |  | (1,166 | ) |  |  | (1,216 | )
Income tax expense |  | — |  |  |  | — |  |  | (226 | ) |  |  | — |
Segment and net loss | $ | (74,116 | ) |  | $ | (54,404 | ) | $ | (197,667 | ) |  | $ | (154,766 | )
(1) Other segment expenses are comprised of general and administrative expenses, excluding share-based compensation expense, which is shown separately.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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