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Share-Based Compensation | 9 Months Ended
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Sep. 30, 2025
Share-Based Payment Arrangement [Abstract] |
Share-Based Compensation | 9. Share-Based Compensation The following table summarizes share-based compensation expense for all share-based compensation arrangements, in thousands:
| Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
| 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Research and development | $ | 3,212 |  |  | $ | 3,570 |  |  | $ | 9,253 |  |  | $ | 11,218 |
General and administrative |  | 7,753 |  |  |  | 4,754 |  |  |  | 16,503 |  |  |  | 14,048 |
Total share-based compensation expense | $ | 10,965 |  |  | $ | 8,324 |  |  | $ | 25,756 |  |  | $ | 25,266 |
As of September 30, 2025, unrecognized estimated compensation expense related to stock options, RSUs and PSUs was approximate ly $41.0 million, $12.4 million, and $0.8 million, resp ectively, which is expected to be recognized over a weighted average period of approxim ately 2.7 years, 2.7 years, and 1.0 years, respectively. As of September 30, 2025, 969,417 PSUs were outstan ding and the vesting of 775,534 PSUs were determined to not be probable and have not been included in share-based compen sation expense or unrecognized estimated compensation expense.

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