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Condensed Statements of Stockholders' Equity (Unaudited) - USD ($) shares in Thousands, $ in Thousands | Total | Common Stock | Additional Paid- In Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2023 | $ 397,273 | $ 7 | $ 1,119,976 | $ (1,271) | $ (721,439)
Beginning balance (in shares) at Dec. 31, 2023 |  | 74,350 |  |  |
Issuance of pre-funded warrants to purchase common stock, net of offering costs | 122,726 |  | 122,726 |  |
Issuance of common stock, net of offering costs | 23,088 | $ 1 | 23,087 |  |
Issuance of common stock, net of offering costs, (in shares) |  | 1,377 |  |  |
Share-based compensation expense | 8,512 |  | 8,512 |  |
Issuance of common stock under equity plans | 2,555 |  | 2,555 |  |
Issuance of common stock under equity plans (in shares) |  | 454 |  |  |
Other comprehensive income (loss) | 455 |  |  | 455 |
Net loss | (49,525) |  |  |  | (49,525)
Ending balance at Mar. 31, 2024 | 505,084 | $ 8 | 1,276,856 | (816) | (770,964)
Ending balance (in shares) at Mar. 31, 2024 |  | 76,181 |  |  |
Beginning balance at Dec. 31, 2023 | 397,273 | $ 7 | 1,119,976 | (1,271) | (721,439)
Beginning balance (in shares) at Dec. 31, 2023 |  | 74,350 |  |  |
Net loss | (154,766) |  |  |  |
Ending balance at Sep. 30, 2024 | 423,771 | $ 8 | 1,298,852 | 1,116 | (876,205)
Ending balance (in shares) at Sep. 30, 2024 |  | 77,749 |  |  |
Beginning balance at Mar. 31, 2024 | 505,084 | $ 8 | 1,276,856 | (816) | (770,964)
Beginning balance (in shares) at Mar. 31, 2024 |  | 76,181 |  |  |
Share-based compensation expense | 8,430 |  | 8,430 |  |
Issuance of common stock under equity plans | 3,040 |  | 3,040 |  |
Issuance of common stock under equity plans (in shares) |  | 241 |  |  |
Other comprehensive income (loss) | 353 |  |  | 353 |
Net loss | (50,837) |  |  |  | (50,837)
Ending balance at Jun. 30, 2024 | 466,070 | $ 8 | 1,288,326 | (463) | (821,801)
Ending balance (in shares) at Jun. 30, 2024 |  | 76,422 |  |  |
Share-based compensation expense | 8,324 |  | 8,324 |  |
Issuance of common stock under equity plans | 2,202 |  | 2,202 |  |
Issuance of common stock under equity plans (in shares) |  | 327 |  |  |
Exercise of pre-funded warrants (in shares) |  | 1,000 |  |  |
Other comprehensive income (loss) | 1,579 |  |  | 1,579 |
Net loss | (54,404) |  |  |  | (54,404)
Ending balance at Sep. 30, 2024 | 423,771 | $ 8 | 1,298,852 | 1,116 | (876,205)
Ending balance (in shares) at Sep. 30, 2024 |  | 77,749 |  |  |
Beginning balance at Dec. 31, 2024 | 413,640 | $ 8 | 1,308,290 | 764 | (895,422)
Beginning balance (in shares) at Dec. 31, 2024 |  | 78,229 |  |  |
Share-based compensation expense | 7,842 |  | 7,842 |  |
Issuance of common stock under equity plans | 143 |  | 143 |  |
Issuance of common stock under equity plans (in shares) |  | 375 |  |  |
Exercise of pre-funded warrants (in shares) |  | 2,174 |  |  |
Other comprehensive income (loss) | 210 |  |  | 210 |
Net loss | (57,429) |  |  |  | (57,429)
Ending balance at Mar. 31, 2025 | 364,406 | $ 8 | 1,316,275 | 974 | (952,851)
Ending balance (in shares) at Mar. 31, 2025 |  | 80,778 |  |  |
Beginning balance at Dec. 31, 2024 | 413,640 | $ 8 | 1,308,290 | 764 | (895,422)
Beginning balance (in shares) at Dec. 31, 2024 |  | 78,229 |  |  |
Net loss | (197,667) |  |  |  |
Ending balance at Sep. 30, 2025 | 242,542 | $ 9 | 1,334,704 | 918 | (1,093,089)
Ending balance (in shares) at Sep. 30, 2025 |  | 87,016 |  |  |
Beginning balance at Mar. 31, 2025 | 364,406 | $ 8 | 1,316,275 | 974 | (952,851)
Beginning balance (in shares) at Mar. 31, 2025 |  | 80,778 |  |  |
Share-based compensation expense | 6,949 |  | 6,949 |  |
Issuance of common stock under equity plans | 515 |  | 515 |  |
Issuance of common stock under equity plans (in shares) |  | 101 |  |  |
Exercise of pre-funded warrants | 1 | $ 1 |  |  |
Exercise of pre-funded warrants (in shares) |  | 5,918 |  |  |
Other comprehensive income (loss) | (263) |  |  | (263) |
Net loss | (66,122) |  |  |  | (66,122)
Ending balance at Jun. 30, 2025 | 305,486 | $ 9 | 1,323,739 | 711 | (1,018,973)
Ending balance (in shares) at Jun. 30, 2025 |  | 86,797 |  |  |
Share-based compensation expense | 10,965 |  | 10,965 |  |
Issuance of common stock under equity plans (in shares) |  | 219 |  |  |
Other comprehensive income (loss) | 207 |  |  | 207 |
Net loss | (74,116) |  |  |  | (74,116)
Ending balance at Sep. 30, 2025 | $ 242,542 | $ 9 | $ 1,334,704 | $ 918 | $ (1,093,089)
Ending balance (in shares) at Sep. 30, 2025 |  | 87,016 |  |  |

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