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v3.25.3

Segment Reporting - Summary of Segment Profit or Loss, Including Significant Expenses (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Jun. 30, 2025 | Mar. 31, 2025 | Sep. 30, 2024 | Jun. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |
Collaboration revenue | $ 20,750 |  |  |  |  |  | $ 50,146 |
Research and development expense | 67,908 |  |  | $ 41,705 |  |  | 186,666 | $ 117,700
Share-based compensation expense | 10,965 |  |  | 8,324 |  |  | 25,756 | 25,266
Total operating expenses | 100,747 |  |  | 59,884 |  |  | 267,509 | 170,740
Other income (expenses): |  |  |  |  |  |  |  |
Interest and other income | 6,274 |  |  | 5,892 |  |  | 21,088 | 17,190
Income tax expense |  |  |  |  |  |  | (226) |
Net Loss | (74,116) | $ (66,122) | $ (57,429) | (54,404) | $ (50,837) | $ (49,525) | (197,667) | (154,766)
Operating Segments |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |
Collaboration revenue | 20,750 |  |  |  |  |  | 50,146 |
Research and development expense | 13,695 |  |  | 11,474 |  |  | 41,790 | 32,611
Share-based compensation expense | 10,965 |  |  | 8,324 |  |  | 25,756 | 25,266
Other segment expenses | 25,086 |  |  | 13,425 |  |  | 64,340 | 38,992
Total operating expenses | 100,747 |  |  | 59,884 |  |  | 267,509 | 170,740
Other income (expenses): |  |  |  |  |  |  |  |
Interest and other income | 6,274 |  |  | 5,892 |  |  | 21,088 | 17,190
Interest expense | (393) |  |  | (412) |  |  | (1,166) | (1,216)
Income tax expense |  |  |  |  |  |  | (226) |
Net Loss | (74,116) |  |  | (54,404) |  |  | (197,667) | (154,766)
Operating Segments | Ziftomenib |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |
Research and development expense | 40,320 |  |  | 18,993 |  |  | 107,851 | 52,335
Operating Segments | Darlifarnib |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |
Research and development expense | 8,494 |  |  | 5,178 |  |  | 19,871 | 13,026
Operating Segments | Tipifarnib |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |
Research and development expense | 443 |  |  | 721 |  |  | 2,578 | 3,560
Operating Segments | Discovery Stage Program |  |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |  |
Research and development expense | $ 1,744 |  |  | $ 1,769 |  |  | $ 5,323 | $ 4,950

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