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Significant Agreements (Details) $ in Thousands | 3 Months Ended |  |  |  |
--- | --- | --- | --- | --- | ---
Mar. 31, 2026 USD ($) | Mar. 31, 2025 USD ($) | Dec. 31, 2025 USD ($) | Dec. 18, 2024 USD ($) | Dec. 31, 2022 USD ($) | Jun. 30, 2021 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Other commitment, liability, refundable deposit, amount | $ 1,900 |  | $ 1,900 |  |  |
Total operating expenses | 60,242 | $ 41,788 |  |  |  |
IQVIA RDS Inc | Master Clinical Contract Services Agreement |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Initial payment amount |  |  |  | $ 12,800 |  | $ 1,800
Total operating expenses | 9,900 | 14,200 |  |  |  |
Amount paid | 7,700 | $ 12,300 |  |  |  |
Accounts payable | 1,100 |  | 400 |  |  |
Accrued expenses and other current liabilities | $ 9,800 |  | $ 8,600 |  |  |
IQVIA RDS Inc | Master Clinical Contract Services Agreement, Refundable Deposit |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Initial payment amount |  |  |  |  |  | 1,000
IQVIA RDS Inc | Master Clinical Services Agreement, Investigator Grant Payment |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Initial payment amount |  |  |  | 7,300 |  | $ 800
IQVIA RDS Inc | Master Clinical Contract Services Agreement, Additional Refundable Deposit |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Initial payment amount |  |  |  |  | $ 900 |
IQVIA RDS Inc | Master Clinical Contract Services Agreement Deposits For Services |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Initial payment amount |  |  |  | 4,500 |  |
IQVIA RDS Inc | Master Clinical Contract Services Agreement Deposit For Pass Through Costs |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Initial payment amount |  |  |  | $ 1,000 |  |
IQVIA RDS Inc | Master Clinical Contract Services Agreement Incremental Return |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Other commitment percentage |  |  |  | 0.75 |  |

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