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Collaboration Agreements - Additional Information (Details) | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |  |
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Aug. 31, 2020 USD ($) Program | Oct. 31, 2018 Program | Mar. 31, 2023 USD ($) | Mar. 31, 2022 USD ($) | Sep. 30, 2020 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2022 USD ($) | Sep. 30, 2021 USD ($) | Dec. 31, 2020 USD ($)
2018 Gilead Agreement [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Research term |  | 3 years |  |  |  |  |  |  |
Number of licensed product | Program |  | 5 |  |  |  |  |  |  |
Non-refundable upfront payment received |  |  | $ 50,000,000.0 |  |  | $ 50,000,000.0 |  |  |
Amended Gilead Agreement [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Research term | 7 years |  |  |  |  |  |  |  |
Number of licensed product | Program | 15 |  |  |  |  |  |  |  |
Non-refundable upfront payment received |  |  | $ 125,000,000.0 |  |  |  |  |  |
Milestone payments receivable | $ 410,000,000.0 |  |  |  |  |  |  |  |
Temporary equity, par value | 125,000,000.0 |  |  |  |  |  |  |  |
Revenue recognized, cumulative catch-up adjustment |  |  |  |  | $ (11,300,000) |  |  |  |
Research extension fee |  |  |  |  |  |  |  | $ 12,000,000.0 | $ 12,000,000.0
Amended Gilead Agreement [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Ownership percentage in common stock |  |  | 10.00% |  |  |  |  |  |
Amended Gilead Agreement [Member] | Series B-1 Preferred Stock [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Temporary equity, par value | $ 20,000,000.0 |  |  |  |  |  |  |  |
Gilead Agreement [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Transaction price allocated to performance obligation |  |  | $ 199,000,000.0 |  |  |  |  |  |
Cummulative research extension fee |  |  | 24,000,000.0 |  |  |  |  |  |
Short-term deferred revenue |  |  | 34,000,000.0 |  |  |  | $ 31,800,000 |  |
Long-term deferred revenue |  |  | 84,100,000 |  |  |  | $ 92,100,000 |  |
Collaboration Revenue [Member] | Gilead Agreement [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Contract with customer liability, revenue recognized |  |  | $ 5,800,000 | $ 5,800,000 |  |  |  |  |

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