<SEC-DOCUMENT>0001062993-14-003710.txt : 20140821
<SEC-HEADER>0001062993-14-003710.hdr.sgml : 20140821
<ACCEPTANCE-DATETIME>20140613170911
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0001062993-14-003710
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20140613

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ANAVEX LIFE SCIENCES CORP.
		CENTRAL INDEX KEY:			0001314052
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				208365999
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		51 W 52ND STREET,
		STREET 2:		7TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019-6163
		BUSINESS PHONE:		800-689-3939

	MAIL ADDRESS:	
		STREET 1:		51 W 52ND STREET,
		STREET 2:		7TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019-6163

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Thrifty Printing Inc.
		DATE OF NAME CHANGE:	20050111
</SEC-HEADER>
<DOCUMENT>
<TYPE>CORRESP
<SEQUENCE>1
<FILENAME>filename1.htm
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   <TITLE> Anavex Life Sciences Corp. : Correspondence - Filed by newsfilecorp.com</TITLE>
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  <TR vAlign=top>
    <TD align=center><B>ANAVEX LIFE SCIENCES CORP.</B> </TD></TR>
  <TR vAlign=bottom>
    <TD align=center><B>51 West 52</B><B><SUP>nd </SUP></B><B>Street,
      7</B><B><SUP>th </SUP></B><B>Floor</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center><B>New York, New York 10019-6163</B> </TD></TR></TABLE>
<P align=center>June 13, 2014 </P>
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  <TR vAlign=top>
    <TD align=left><B><U>VIA EDGAR</U></B> </TD></TR>
  <TR>
    <TD>&nbsp; </TD></TR>
  <TR vAlign=top>
    <TD align=left>Jeffrey P. Riedler, Assistant Director </TD></TR>
  <TR vAlign=top>
    <TD align=left>United States Securities and Exchange Commission </TD></TR>
  <TR vAlign=top>
    <TD align=left>Division of Corporate Finance </TD></TR>
  <TR vAlign=top>
    <TD align=left>100 F Street, N.E. </TD></TR>
  <TR vAlign=top>
    <TD align=left>Washington, D.C. 20549 </TD></TR>
  <TR vAlign=top>
    <TD align=left>Tel: (202) 551-3715 </TD></TR></TABLE><BR>
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  <TR vAlign=top>
    <TD align=left><B>Re:</B> </TD>
    <TD align=left width="95%"><B>Anavex Life Sciences Corp.</B> </TD></TR>
  <TR vAlign=top>
    <TD align=left>&nbsp; </TD>
    <TD align=left width="95%"><B>Registration Statement on Form S-1</B>
</TD></TR>
  <TR vAlign=top>
    <TD align=left>&nbsp; </TD>
    <TD align=left width="95%"><B>Filed April 11, 2014</B> </TD></TR>
  <TR vAlign=bottom>
    <TD align=center>&nbsp;</TD>
    <TD align=left width="95%"><STRONG>Response Dated May 22,
      2014</STRONG>&nbsp;&nbsp;</TD></TR>
  <TR vAlign=top>
    <TD align=left>&nbsp; </TD>
    <TD align=left width="95%"><B>File No. 333-195225</B> </TD></TR></TABLE>
<P align=justify>Ladies and Gentlemen: </P>
<P align=justify>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Anavex Life Sciences Corp. (the
&#147;<U>Company</U>&#148;) confirms receipt of the letter dated June 5, 2014 from the
staff (the &#147;<U>Staff</U>&#148;) of the U.S. Securities and Exchange Commission (the
&#147;<U>Commission</U>&#148;) with respect to the above-referenced filing (the
&#147;<U>Registration Statement</U>). We are responding to the Staff&#146;s comments as
set forth below. The Company&#146;s responses to the Staff&#146;s comments are in
identical numerical sequence. For the convenience of the Staff, each comment is
repeated verbatim with the Company&#146;s response immediately following:</P>
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    <TD align=left >
      <P align=justify>COMMENT 1. </P></TD>
    <TD align=right width="85%">
      <P align=justify>We note your response to comment 4 and the proposed
      disclosure you have provided to address the comment. Please revise the
      sixth column of your table to provide the total value of the shares
      underlying the convertible note by multiplying the conversion price on the
      date of sale by the total number of shares the selling shareholders may
      receive under the convertible note. </P></TD></TR>
  <TR>
    <TD >&nbsp; </TD>
    <TD width="85%">&nbsp; </TD>
  </TR>
  <TR vAlign=top>
    <TD align=left >
      <P align=justify><B>RESPONSE:</B> </P></TD>
    <TD align=right width="85%">
      <P align=justify><B>In response to the Staff&#146;s comment above, we have
      revised the table to include a</B> <B>column that provides the total value
      of the shares underlying the convertible debenture by</B> <B>multiplying the
      conversion price on the date of sale by the total number of shares</B>
      <B>the selling shareholder may receiver under its convertible
      debenture.</B> </P></TD></TR></TABLE><BR>
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  <TR vAlign=top>
    <TD align=left>United States Securities and Exchange Commission </TD></TR>
  <TR vAlign=top>
    <TD align=left>June 13, 2014 </TD></TR>
  <TR vAlign=top>
    <TD align=left>Page 2 </TD></TR></TABLE><BR>
<DIV>
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  <TR vAlign=top>
    <TD align=center bgColor=#eeeeee><B>Selling</B> <BR><B>Security</B>
      <BR><B>Holder</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Market</B> <BR><B>Price
      Per</B> <BR><B>Share </B><B><SUP>(1)</SUP></B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Type of</B>
      <BR><B>Security </B><B><SUP>(2)</SUP></B> <BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Conversion</B>
      <BR><B>Price </B><B><SUP>(3)</SUP></B> <BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Total Possible</B>
      <BR><B>Shares</B> <BR><B>Underlying</B> <BR><B>Securities
      </B><B><SUP>(4)</SUP></B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Combined</B>
      <BR><B>Market</B> <BR><B>Price</B><B><SUP>(5)</SUP></B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Total Value</B> <BR><B>of
      Shares </B><B><SUP>(6)</SUP></B> <BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Total</B>
      <BR><B>Possible</B> <BR><B>Discount</B> <BR><B>To Market</B>
      <BR><B>Price</B><B><SUP>(7)</SUP></B> </TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#ffffff rowSpan=4><BR><BR><BR><B>Auriga</B>
      <BR><B>Global</B> <BR><B>Investors SU,</B> <BR><B>SA</B>
    <BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#ffffff
      rowSpan=4><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>3,333,334</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,466,666.96</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,000,000.20</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$466,666.76</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>3,333,333</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,466,666.52</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$999,999.90</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$466,666.62</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>3,333,333</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,466,666.52</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,399,999.86</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$66,666.66</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>-</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>10,000,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$4,400,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$3,399,999.96</B>
      <BR><BR></TD>
    <TD align=center width="12%"
      bgColor=#ffffff><BR><BR><B>$1,000,000.</B><B>04</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#eeeeee rowSpan=4><BR><BR><BR><B>Auriga</B>
      <BR><B>Investors-</B> <BR><B>Montserrat</B> <BR><B>Global Fund</B>
      <BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#eeeeee
      rowSpan=4><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>1,666,667</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$733,333.48</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$500,000.10</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$233,333.38</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>1,666,667</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$733,333.48</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$500,000.10</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$233,333.38</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>1,666,667</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$733,333.48</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$700,000.14</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$33,333.34</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>-</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>5,000,001</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$2,200,000.44</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$1,700,000.34</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$500,000.10</B>
      <BR><BR></TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#ffffff rowSpan=4><BR><BR><BR><BR><B>Hudson Bay</B>
      <BR><B>Master Fund</B> <BR><B>LTD</B> <BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#ffffff
      rowSpan=4><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>5,000,000</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$2,200,000</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,500,000</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$700,000</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>5,000,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$2,200,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,500,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$700,000</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>5,000,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$2,200,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$2,100,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$100,000</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>-</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>15,000,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$660,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$5,100,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$1,500,000</B>
      <BR><BR></TD></TR></TABLE></DIV><BR>
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  <TR vAlign=top>
    <TD align=left>United States Securities and Exchange Commission </TD></TR>
  <TR vAlign=top>
    <TD align=left>June 13, 2014 </TD></TR>
  <TR vAlign=top>
    <TD align=left>Page 3 </TD></TR></TABLE><BR>
<DIV>
<TABLE
style="BORDER-COLOR: black; FONT-SIZE: 8pt; BORDER-COLLAPSE: collapse; "
borderColor=#000000 cellSpacing=0 cellPadding=3 width="100%" border=1>

  <TR vAlign=top>
    <TD align=left bgColor=#eeeeee rowSpan=4><BR><BR><BR><B>DAFNA</B>
      <BR><B>LifeScience</B> <BR><B>LP</B> <BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#eeeeee
      rowSpan=4><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>2,580,400</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$1,135,376</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$774,120</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$361,256</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>2,580,400</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$1,135,376</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$774,120</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$361,256</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>2,580,400</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$1,135,376</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$1,083,768</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$51,608</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>-</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>7,741,200</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$3,406,128</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$2,632,008</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$774,120</B>
      <BR><BR></TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#ffffff rowSpan=4><BR><BR><BR><B>DAFNA</B>
      <BR><B>LifeScience</B> <BR><B>Market</B> <BR><B>Neutral L.P.</B>
      <BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#ffffff
      rowSpan=4><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>462,000</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$203,280</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$138,600</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$64,680</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>462,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$203,280</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$138,600</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$64,680</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>462,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$203,280</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$194,040</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$9,240</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>-</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>1,386,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$609,840</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$471,240</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$138,600</B>
      <BR><BR></TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#eeeeee rowSpan=4><BR><BR><BR><B>DAFNA</B>
      <BR><B>LifeScience</B> <BR><B>Select L.P.</B> <BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#eeeeee
      rowSpan=4><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>1,957,600</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$861,344</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$587,280</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$274,064</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>1,957,600</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$861,344</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$587,280</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$274,064</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>1,957,600</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$861,344</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$822,192</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$39,152</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>-</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>5,872,800</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$2,584,032</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$1,996,752</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$587,280</B>
      <BR><BR></TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#ffffff rowSpan=3><BR><BR><B>Joann</B>
      <BR><B>Mostovoy</B> <BR></TD>
    <TD align=left width="12%" bgColor=#ffffff rowSpan=3><BR><BR><B>$0.44</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>1,666,667</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$733,333.48</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$500,000.10</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$233,333.38</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>1,666,667</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$733,333.48</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$500,000.10</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$233,333.38</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series B</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.42</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>1,666,667</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$733,333.48</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$700,000.14</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$33,333.34</B>
  </TD></TR></TABLE></DIV><BR>
<HR style="PAGE-BREAK-AFTER: always" align=center width="100%" color=black
noShade SIZE=5>
<!--$$/page=--><A name=page_4></A><BR>
<TABLE
style="BORDER-COLOR: black; FONT-SIZE: 10pt; BORDER-COLLAPSE: collapse; "
cellSpacing=0 cellPadding=0 width="100%" border=0>

  <TR vAlign=top>
    <TD align=left>United States Securities and Exchange Commission </TD></TR>
  <TR vAlign=top>
    <TD align=left>June 13, 2014 </TD></TR>
  <TR vAlign=top>
    <TD align=left>Page 4 </TD></TR></TABLE><BR>
<DIV>
<TABLE
style="BORDER-COLOR: black; FONT-SIZE: 8pt; BORDER-COLLAPSE: collapse; "
borderColor=#000000 cellSpacing=0 cellPadding=3 width="100%" border=1>

  <TR vAlign=top>
    <TD align=left bgColor=#ffffff rowSpan=2><BR><BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#ffffff
    rowSpan=2><BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff>&nbsp; </TD>
    <TD align=center width="12%" bgColor=#ffffff>&nbsp; </TD>
    <TD align=center width="12%" bgColor=#ffffff>&nbsp; </TD>
    <TD align=center width="12%" bgColor=#ffffff>&nbsp; </TD>
    <TD align=center width="12%" bgColor=#ffffff>&nbsp; </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>-</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>5,000,001</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$2,200,000.44</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$1,700,000.34</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$500,000.10</B>
      <BR><BR></TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#eeeeee rowSpan=4><BR><BR><BR><B>Sabby</B>
      <BR><B>Healthcare</B> <BR><B>Volatility</B> <BR><B>Master Fund,</B>
      <BR><B>Ltd.</B> <BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#eeeeee
      rowSpan=4><BR><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>6,666,667</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$2,933,333.48</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$2,000,000.10</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$933,333.38</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>6,666,667</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$2,933,333.48</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$2,000,000.10</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$933,333.38</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>6,666,667</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$2,933,333.48</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$2,800,000.14</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$133,333.34</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>-</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>20,000,001</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$8,800,000.44</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$6,800,000.34</B>
      <BR><BR></TD>
    <TD align=center width="12%"
      bgColor=#eeeeee><BR><BR><B>$2,000,000.</B><B>10</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#ffffff rowSpan=4><BR><BR><BR><B>Sabby</B>
      <BR><B>Volatility</B> <BR><B>Warrant</B> <BR><B>Master Fund,</B>
      <BR><B>Ltd.</B> <BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#ffffff
      rowSpan=4><BR><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>3,333,334</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,466,666.96</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,000,000.20</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$466,666.76</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>3,333,333</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,466,666.52</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$999,999.90</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$466,666.62</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>3,333,333</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,466,666.52</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$1,399,999.86</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$66,666.66</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>-</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>10,000,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$4,400,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$3,399,999.96</B>
      <BR><BR></TD>
    <TD align=center width="12%"
      bgColor=#ffffff><BR><BR><B>$1,000,000.</B><B>04</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#eeeeee rowSpan=4><BR><BR><BR><B>Sphera</B>
      <BR><B>Global</B> <BR><B>Healthcare</B> <BR><B>Master Fund</B>
    <BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#eeeeee
      rowSpan=4><BR><BR><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>6,310,667</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$2,776,693.48</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$1,893,200.10</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$883,493.38</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>6,310,667</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$2,776,693.48</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$1,893,200.10</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$883,493.38</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>6,310,667</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$2,776,693.48</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$2,650,480.14</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$126,213.34</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>-</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>18,932,001</B>
    <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$8,330,080.44</B>
      <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$6,436,880.34</B>
      <BR></TD>
    <TD align=center width="12%"
      bgColor=#eeeeee><BR><BR><B>$1,893,200.</B><B>10</B>
</TD></TR></TABLE></DIV><BR>
<HR style="PAGE-BREAK-AFTER: always" align=center width="100%" color=black
noShade SIZE=5>
<!--$$/page=--><A name=page_5></A><BR>
<TABLE
style="BORDER-COLOR: black; FONT-SIZE: 10pt; BORDER-COLLAPSE: collapse; "
cellSpacing=0 cellPadding=0 width="100%" border=0>

  <TR vAlign=top>
    <TD align=left>United States Securities and Exchange Commission </TD></TR>
  <TR vAlign=top>
    <TD align=left>June 13, 2014 </TD></TR>
  <TR vAlign=top>
    <TD align=left>Page 5 </TD></TR></TABLE><BR>
<DIV>
<TABLE
style="BORDER-COLOR: black; FONT-SIZE: 8pt; BORDER-COLLAPSE: collapse; "
borderColor=#000000 cellSpacing=0 cellPadding=3 width="100%" border=1>

  <TR vAlign=top>
    <TD align=left bgColor=#eeeeee>&nbsp; </TD>
    <TD align=left width="12%" bgColor=#eeeeee>&nbsp; </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee>&nbsp; </TD>
    <TD align=center width="12%" bgColor=#eeeeee>&nbsp; </TD>
    <TD align=center width="12%" bgColor=#eeeeee>&nbsp; </TD>
    <TD align=center width="12%" bgColor=#eeeeee>&nbsp; </TD>
    <TD align=center width="12%" bgColor=#eeeeee>&nbsp; </TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#ffffff rowSpan=4><BR><BR><BR><B>HFR HE</B>
      <BR><B>Sphera</B> <BR><B>Global</B> <BR><B>Healthcare</B> <BR><B>Master
      Trust</B> <BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#ffffff
      rowSpan=4><BR><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>356,000</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$156,640</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$106,800</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$49,840</B> </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>356,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$156,640</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$106,800</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$49,840</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>356,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$156,640</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$149,520</B> <BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><B>$7,120</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#ffffff><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>-</B> <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>1,068,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$469,920</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$363,120</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#ffffff><BR><BR><B>$106,800</B>
      <BR><BR></TD></TR>
  <TR vAlign=top>
    <TD align=left bgColor=#eeeeee rowSpan=4><BR><BR><BR><B>Maxim</B>
      <BR><B>Partners</B> <BR><B>LLC</B> <BR><BR><BR><BR></TD>
    <TD align=left width="12%" bgColor=#eeeeee
      rowSpan=4><BR><BR><BR><BR><B>$0.44</B> <BR><BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>-</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee>&nbsp; &nbsp; &nbsp; &nbsp;
      &nbsp; &nbsp; &nbsp; &nbsp;<B>-</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>-</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>-</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee>&nbsp; </TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series A</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.30</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>500,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$220,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$150,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$70,000</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$0.42</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>500,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$220,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$210,000</B> <BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>$10,000</B> <BR></TD></TR>
  <TR vAlign=top>
    <TD align=center width="12%" bgColor=#eeeeee><B>Debenture</B>
      <BR><B>/Series A</B> <BR><B>Warrant/</B> <BR><B>Series B</B>
      <BR><B>Warrant</B> </TD>
    <TD align=center width="12%" bgColor=#eeeeee><B>-</B> <BR><BR><BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>1,000,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$440,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$360,000</B>
      <BR><BR></TD>
    <TD align=center width="12%" bgColor=#eeeeee><BR><BR><B>$80,000</B>
      <BR><BR></TD></TR></TABLE></DIV>
<P align=justify><B><SUP>(1) </SUP></B><B>Market price per share of the Common
Stock underlying the Securities on the date of the sale of the Securities.
<BR></B><B><SUP>(2) </SUP></B><B>The shares of Common Stock being registered
underlie Debentures, Series A Warrants and Series B Warrants.
<BR></B><B><SUP>(3)</SUP></B><B>Conversion/exercise price per share of the
underlying Common Stock on the date of the sale of the Securities is calculated
using the fixed conversion/exercise price per share set forth in the
Securities.<BR></B><B><SUP>(4) </SUP></B><B>Total possible shares underlying the
Securities (assuming no interest payments and complete conversion throughout the
term). Note: the number listed does not take into account that each Selling
Security Holder is subject to a 4.99% conversion cap, except for Sphera Global
Healthcare Master Fund and HFR HE Sphera Global Healthcare Master Trust, which
are subject to a 9.99% conversion cap.<BR></B><B><SUP>(5) </SUP></B><B>Combined
market price of the total number of shares underlying the Securities, calculated
by using the Common Stock&#146;s market price per share on the date of the sale of
the Securities multiplied by the total possible shares underlying the
Securities. <BR></B><B><SUP>(6) </SUP></B><B>Total value of shares underlying
the Securities using the conversion price on the date of sale multiplied by the
total number of shares the Selling Security Holders may receive under the
Securities. Note: the Debentures and Warrants have fixed conversion prices.
</B></P>
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  <TR vAlign=top>
    <TD align=left>United States Securities and Exchange Commission </TD></TR>
  <TR vAlign=top>
    <TD align=left>June 13, 2014 </TD></TR>
  <TR vAlign=top>
    <TD align=left>Page 6 </TD></TR></TABLE>
<P align=justify><B><SUP>(7) </SUP></B><B>Total possible discount to the market
price as of the date of the sale of the Securities calculated by subtracting the
total  on the date of the sale of the Securities from the
combined market price of the total number of shares underlying the Securities on
that date. </B></P>
<TABLE
style="BORDER-COLOR: black; FONT-SIZE: 10pt; BORDER-COLLAPSE: collapse; "
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  <TR vAlign=top>
    <TD align=left >
      <P align=justify>COMMENT 2. </P></TD>
    <TD align=left width="85%">
      <P align=justify>Please revise your proposed tabular disclosure to reflect
      any provisions in the convertible note that could result in a change in
      the conversion price per share upon the occurrence of certain events.
      Please also identify any such provisions in the convertible note. In this
      regard, we note the disclosure in your Form 8-K filed March 19, 2014 with
      respect to the Securities Purchase Agreement indicating that the initial
      conversion price for the debentures is subject to adjustment for
      distributions payable in shares of common stock, subdivisions of
      outstanding shares of common stock into larger number of shares,
      combinations, and reclassification events. </P></TD></TR>
  <TR>
    <TD >&nbsp; </TD>
    <TD width="85%">&nbsp; </TD>
  </TR>
  <TR vAlign=top>
    <TD align=left >
      <P align=justify><B>RESPONSE:</B> </P></TD>
    <TD align=left width="85%">
      <P align=justify><B>In response to the Staff&#146;s comment above, the Company
      notes that there are no set,</B> <B>or prescribed, pre-determined
      adjustments to the conversion price per share</B> <B>under the convertible
      debentures that can be represented in tabular form.</B> <B>Pursuant to the
      terms of the convertible debentures (Section 5(a)), there are four</B>
      <B>(4) circumstances in which the conversion price of such instruments
      would change,</B> <B>which is intended to maintain the initial ratio of
      conversion shares to be issued</B> <B>relative to the initial conversion
      price. Such four circumstances are: If the</B> <B>Company, at any time
      while the convertible debenture is outstanding: (i) pays a</B> <B>stock
      dividend or otherwise makes a distribution or distributions payable in
      shares</B> <B>of the Company&#146;s common stock (&#147;</B><B><U>Common
      Stock</U></B><B>&#148;) on shares of Common Stock</B> <B>or any common stock
      equivalents (which, do not include any shares of Common</B> <B>Stock
      issued by the Company upon conversion of the convertible debentures),
      (ii)</B> <B>subdivides the number of outstanding shares of Common Stock
      into a larger</B> <B>number of shares, (iii) combines (including by way of
      a reverse stock split) the</B> <B>number of outstanding shares of Common
      Stock into a smaller number of shares</B> <B>or (iv) issues, in the event
      of a reclassification of shares of the Common Stock, any</B> <B>shares of
      capital stock of the Company, then the conversion price shall be</B>
      <B>multiplied by a fraction of which the numerator shall be the number of
      shares of</B> <B>Common Stock outstanding immediately before such event,
      and of which the</B> <B>denominator shall be the number of shares of
      Common Stock outstanding</B> <B>immediately after such event (which
      effectively maintains the initial ratio of</B> <B>conversion shares issued
      to debt amount outstanding under each such convertible</B>
      <B>debenture).</B> </P></TD></TR></TABLE>
<P align=center>********************************* </P>
<P align=justify>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In addition, we acknowledge that
we are responsible for the accuracy and adequacy of the disclosures made. We
formally acknowledge that: </P>
<P align=justify>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#149; The adequacy and accuracy of
the disclosure in filing is the responsibility of the Company. </P>
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<TABLE
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  <TR vAlign=top>
    <TD align=left>United States Securities and Exchange Commission </TD></TR>
  <TR vAlign=top>
    <TD align=left>June 13, 2014 </TD></TR>
  <TR vAlign=top>
    <TD align=left>Page 7 </TD></TR></TABLE>
<P align=justify>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#149; Staff comments or changes to
disclosure in response to Staff comments do not foreclose the Commission from
taking any action with respect to the filing. </P>
<P align=justify>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#149; The Company may not assert
Staff comments as a defense in any proceeding initiated by the Commission or any
person under the federal securities laws of the United States. </P>
<P align=justify>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We trust this response
satisfactorily responds to your request. Should you require further information,
please contact our legal counsel Clayton E. Parker, Esq. of K&amp;L Gates LLP at
305.539.3306. </P>
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  <TR vAlign=top>
    <TD align=left >&nbsp;</TD>
    <TD align=left width="50%">Sincerely, </TD></TR>
  <TR>
    <TD >&nbsp;</TD>
    <TD width="50%">&nbsp; </TD></TR>
  <TR vAlign=top>
    <TD align=left >&nbsp;</TD>
    <TD align=left width="50%"><B>ANAVEX LIFE SCIENCES CORP.</B> </TD></TR>
  <TR>
    <TD >&nbsp;</TD>
    <TD width="50%">&nbsp; </TD></TR>
  <TR vAlign=top>
    <TD align=left >&nbsp;</TD>
    <TD align=left width="50%"><U>/s/ Christopher Missling, PhD.</U> </TD></TR>
  <TR vAlign=top>
    <TD align=left >&nbsp;</TD>
    <TD align=left width="50%">Name: Christopher Missling, PhD. </TD></TR>
  <TR vAlign=top>
    <TD align=left >&nbsp;</TD>
    <TD align=left width="50%">Title: Chief Executive Officer
</TD></TR></TABLE><BR>
<TABLE
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cellSpacing=0 cellPadding=0 width="100%" border=0 BCLLIST>

  <TR>
    <TD vAlign=top width="5%">cc: </TD>
    <TD>
      <P align=justify>Clayton E. Parker, Esq. of K&amp;L Gates LLP</P></TD></TR>
  <TR>
    <TD width="5%"></TD>
    <TD>
      <P align=justify>Austin Stephenson, SEC Division of Corporation
    Finance</P></TD></TR></TABLE><BR>
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