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INTERIM CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) - USD ($) | 3 Months Ended | 6 Months Ended
--- | --- | ---
Mar. 31, 2019 | Mar. 31, 2018 | Mar. 31, 2019 | Mar. 31, 2018
Operating expenses |  |  |  |
General and administrative | $ 2,061,251 | $ 1,489,450 | $ 3,822,559 | $ 2,887,253
Research and development | 6,078,786 | 3,245,023 | 11,790,996 | 5,939,335
Total operating expenses | (8,140,037) | (4,734,473) | (15,613,555) | (8,826,588)
Other income (expenses) |  |  |  |
Grant income | 74,527 |  | 149,055 |
Interest income, net | 51,465 | 28,647 | 130,265 | 59,023
Foreign exchange gain (loss), net | 54,199 | (18,337) | 49,693 | (6,358)
Total other income, net | 180,191 | 10,310 | 329,013 | 52,665
Net loss before provision for income taxes | (7,959,846) | (4,724,163) | (15,284,542) | (8,773,923)
Income tax expense | (48,048) | (27,861) | (56,765) | (37,266)
Net loss and comprehensive loss | $ (8,007,894) | $ (4,752,024) | $ (15,341,307) | $ (8,811,189)
Loss per share |  |  |  |
Basic and diluted (in dollars per share) | $ (0.17) | $ (0.11) | $ (0.33) | $ (0.2)
Weighted average number of shares outstanding |  |  |  |
Basic and diluted (in shares) | 47,134,686 | 44,545,523 | 46,726,649 | 44,210,591

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