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Significant Accounting Policies - Schedule of Accrued Expenses (Detail) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Accounting Policies [Abstract]
Compensation	$ 818	$ 1,832	$ 1,085
Clinical study related costs	653	2,031	1,154
Facility expansion costs		19	1,709
Accrued legal	3,095	964	0
Manufacturing improvement costs	3,137	4,164	0
Other accrued expenses		203	548
Other accrued expenses	414	222
Total accrued expenses and other	$ 8,117	$ 9,213	$ 4,496

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Accrued clinical study related costs current.

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Accrued facility expansion costs current.

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Accrued manufacturing improvement costs.

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Other accrued expenses.

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Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.20)
-URI https://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682

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Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
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Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to services received from employees, such as accrued salaries and bonuses, payroll taxes and fringe benefits. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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Amount of expenses incurred but not yet paid classified as other, due within one year or the normal operating cycle, if longer.

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