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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Nov. 30, 2025 | Nov. 30, 2024 | Nov. 30, 2023 | Nov. 30, 2022
Pay vs Performance Disclosure |  |  |  |
Pay vs Performance Disclosure, Table | PAY VERSUS PERFORMANCE DISCLOSURE In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officer, who is our CEO, and Non-CEO NEOs and Company performance for the fiscal years listed below. We did not use any financial performance measures to link Compensation Actually Paid to our performance in 2025. Therefore, this disclosure presents neither a Tabular List of most important financial performance measures nor a Company-Selected Measure. The Compensation Committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the years shown.
Year |  |  | Summary Compensation Table Total for CEO(1) ($) |  |  | Compensation Actually Paid to CEO(1)(2)(3) ($) |  |  | Average Summary Compensation Table Total for Non-CEO NEOs(1) ($) |  |  | Average Compensation Actually Paid to Non-CEO NEOs(1)(2)(3) ($) |  |  | Value of Initial Fixed $100 Investment based on:(4) |  |  | Net Income ($ Millions)
| TSR ($) |  |  | Peer GroupTSR ($) |
2025 |  |  | 6,374,138 |  |  | (1,068,786) |  |  | 2,352,655 |  |  | 532,257 |  |  | 61.35 |  |  | 125.52 |  |  | (264)
2024 |  |  | 5,812,862 |  |  | 23,306,422 |  |  | 2,022,275 |  |  | 6,666,424 |  |  | 76.72 |  |  | 99.40 |  |  | (194)
2023 |  |  | 4,363,120 |  |  | (913,889) |  |  | 1,622,372 |  |  | 125,731 |  |  | 21.58 |  |  | 82.24 |  |  | (144)
2022 |  |  | 9,416,222 |  |  | (5,024,024) |  |  | 4,066,182 |  |  | 916,179 |  |  | 42.99 |  |  | 91.46 |  |  | (180)
(1) | Arthur T. Sands was our CEO for each year presented. The individuals comprising the Non-CEO NEOs for each year presented are listed below.
2022 |  |  | 2023 |  |  | 2024 |  |  | 2025
Hans van Houte |  |  | Hans van Houte |  |  | Hans van Houte |  |  | Hans van Houte
Gwenn M. Hansen |  |  | Gwenn M. Hansen |  |  | Gwenn M. Hansen |  |  | Gwenn M. Hansen
|  |  | Christine Ring |  |  | Christine Ring |  |  |
(2) | The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.
(3) | Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the CEO and the Non-CEO PEOs as set forth below. Equity values are calculated in accordance with ASC 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards column set forth in the Summary Compensation Table.
Year |  |  | Summary Compensation Table Total for CEO ($) |  |  | Exclusion of Stock Awards and Option Awards for CEO ($) |  |  | Inclusion of Equity Values for CEO ($) |  |  | Compensation Actually Paid to CEO ($)
2025 |  |  | 6,374,138 |  |  | (5,166,196) |  |  | (2,276,728) |  |  | (1,068,786)
Year |  |  | Average Summary Compensation Table Total for Non-CEO NEOs ($) |  |  | Average Exclusion of Stock Awards and Option Awards for Non-CEO NEOs ($) |  |  | Average Inclusion of Equity Values for Non-CEO NEOs ($) |  |  | Average Compensation Actually Paid to Non-CEO NEOs ($)
2025 |  |  | 2,352,655 |  |  | (1,509,449) |  |  | (310,949) |  |  | 532,257
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
Year |  |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for CEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for CEO ($) |  |  | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for CEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for CEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for CEO ($) |  |  | Total - Inclusion of Equity Values for CEO ($)
2025 |  |  | 3,807,662 |  |  | (2,076,528) |  |  | 731,131 |  |  | (4,738,993) |  |  | 0 |  |  | (2,276,728)
Year |  |  | Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-CEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-CEO NEOs ($) |  |  | Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-CEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-CEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-CEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-CEO NEOs ($)
2025 |  |  | 1,257,842 |  |  | (525,876) |  |  | 192,332 |  |  | (1,235,247) |  |  | 0 |  |  | (310,949)
(4) | The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report. The comparison assumes $100 was invested for the period starting November 30, 2021, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance.
Company Selected Measure Name | did not use any financial performance measures |  |  |
Named Executive Officers, Footnote |
(1) | Arthur T. Sands was our CEO for each year presented. The individuals comprising the Non-CEO NEOs for each year presented are listed below.
2022 |  |  | 2023 |  |  | 2024 |  |  | 2025
Hans van Houte |  |  | Hans van Houte |  |  | Hans van Houte |  |  | Hans van Houte
Gwenn M. Hansen |  |  | Gwenn M. Hansen |  |  | Gwenn M. Hansen |  |  | Gwenn M. Hansen
|  |  | Christine Ring |  |  | Christine Ring |  |  |
Peer Group Issuers, Footnote |
(4) | The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report. The comparison assumes $100 was invested for the period starting November 30, 2021, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance.
PEO Total Compensation Amount | $ 6,374,138 | $ 5,812,862 | $ 4,363,120 | $ 9,416,222
PEO Actually Paid Compensation Amount | $ (1,068,786) | 23,306,422 | (913,889) | (5,024,024)
Adjustment To PEO Compensation, Footnote |
(3) | Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the CEO and the Non-CEO PEOs as set forth below. Equity values are calculated in accordance with ASC 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards column set forth in the Summary Compensation Table.
Year |  |  | Summary Compensation Table Total for CEO ($) |  |  | Exclusion of Stock Awards and Option Awards for CEO ($) |  |  | Inclusion of Equity Values for CEO ($) |  |  | Compensation Actually Paid to CEO ($)
2025 |  |  | 6,374,138 |  |  | (5,166,196) |  |  | (2,276,728) |  |  | (1,068,786)
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
Year |  |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for CEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for CEO ($) |  |  | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for CEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for CEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for CEO ($) |  |  | Total - Inclusion of Equity Values for CEO ($)
2025 |  |  | 3,807,662 |  |  | (2,076,528) |  |  | 731,131 |  |  | (4,738,993) |  |  | 0 |  |  | (2,276,728)
Non-PEO NEO Average Total Compensation Amount | $ 2,352,655 | 2,022,275 | 1,622,372 | 4,066,182
Non-PEO NEO Average Compensation Actually Paid Amount | $ 532,257 | 6,666,424 | 125,731 | 916,179
Adjustment to Non-PEO NEO Compensation Footnote |
(3) | Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the CEO and the Non-CEO PEOs as set forth below. Equity values are calculated in accordance with ASC 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards column set forth in the Summary Compensation Table.
Year |  |  | Average Summary Compensation Table Total for Non-CEO NEOs ($) |  |  | Average Exclusion of Stock Awards and Option Awards for Non-CEO NEOs ($) |  |  | Average Inclusion of Equity Values for Non-CEO NEOs ($) |  |  | Average Compensation Actually Paid to Non-CEO NEOs ($)
2025 |  |  | 2,352,655 |  |  | (1,509,449) |  |  | (310,949) |  |  | 532,257
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
Year |  |  | Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-CEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-CEO NEOs ($) |  |  | Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-CEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-CEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-CEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-CEO NEOs ($)
2025 |  |  | 1,257,842 |  |  | (525,876) |  |  | 192,332 |  |  | (1,235,247) |  |  | 0 |  |  | (310,949)
Compensation Actually Paid vs. Total Shareholder Return | Relationship Between CEO and Non-CEO NEO Compensation Actually Paid and Total Shareholder Return (“TSR”) The following chart sets forth the relationship between Compensation Actually Paid to our CEO, the average of Compensation Actually Paid to our Non-CEO NEOs, and the cumulative TSR over the three most recently completed fiscal years for the Company and the NASDAQ Biotechnology Index TSR. |  |  |
Compensation Actually Paid vs. Net Income | Relationship Between CEO and Non-CEO NEO Compensation Actually Paid and Net Income The following chart sets forth the relationship between Compensation Actually Paid to our CEO, the average of Compensation Actually Paid to our Non-CEO NEOs, and our net income during the three most recently completed fiscal years. |  |  |
Total Shareholder Return Vs Peer Group | Relationship Between CEO and Non-CEO NEO Compensation Actually Paid and Total Shareholder Return (“TSR”) The following chart sets forth the relationship between Compensation Actually Paid to our CEO, the average of Compensation Actually Paid to our Non-CEO NEOs, and the cumulative TSR over the three most recently completed fiscal years for the Company and the NASDAQ Biotechnology Index TSR. |  |  |
Total Shareholder Return Amount | $ 61.35 | 76.72 | 21.58 | 42.99
Peer Group Total Shareholder Return Amount | 125.52 | 99.4 | 82.24 | 91.46
Net Income (Loss) | $ (264,000,000) | $ (194,000,000) | $ (144,000,000) | $ (180,000,000)
PEO Name | Arthur T. Sands | Arthur T. Sands | Arthur T. Sands | Arthur T. Sands
Equity Awards Adjustments, Footnote | The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
Year |  |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for CEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for CEO ($) |  |  | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for CEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for CEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for CEO ($) |  |  | Total - Inclusion of Equity Values for CEO ($)
2025 |  |  | 3,807,662 |  |  | (2,076,528) |  |  | 731,131 |  |  | (4,738,993) |  |  | 0 |  |  | (2,276,728)
Year |  |  | Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-CEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-CEO NEOs ($) |  |  | Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-CEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-CEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-CEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-CEO NEOs ($)
2025 |  |  | 1,257,842 |  |  | (525,876) |  |  | 192,332 |  |  | (1,235,247) |  |  | 0 |  |  | (310,949)
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | $ (5,166,196) |  |  |
PEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (2,276,728) |  |  |
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 3,807,662 |  |  |
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (2,076,528) |  |  |
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 731,131 |  |  |
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (4,738,993) |  |  |
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (1,509,449) |  |  |
Non-PEO NEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (310,949) |  |  |
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 1,257,842 |  |  |
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (525,876) |  |  |
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | 192,332 |  |  |
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | (1,235,247) |  |  |
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount | $ 0 |  |  |

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