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Balance Sheet Components - Schedule of Accrued and Other Liabilities (Details) - USD ($) $ in Thousands | Sep. 30, 2022 | Dec. 31, 2021
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Balance Sheet Related Disclosures [Abstract] |  |
Milestone payable | $ 0 | $ 95,000
Net profit-sharing amount | 61,684 | 0
Accrued income taxes | 98,189 | 6,217
Accrued royalties | 27,771 | 58,672
Research and development expenses | 40,116 | 28,073
Payroll and related expenses | 23,714 | 29,753
Other professional and consulting expenses | 5,633 | 2,791
Operating lease liabilities, current | 4,115 | 3,927
Excess funds payable under grant agreements | 0 | 1,825
Other accrued expenses | 21,394 | 10,254
Total accrued and other liabilities | $ 282,616 | $ 236,512

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