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Stock-Based Awards (Tables) | 9 Months Ended
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Sep. 30, 2022
Summary of Assumptions Used for Estimating the Fair Value of Stock Options Granted | The fair value of stock options granted to employees was estimated on the date of grant using the Black-Scholes option-pricing model with the following assumptions:
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2022 |  |  | 2021 |  |  | 2022 |  |  | 2021 |
Expected term of options (in years) |  |  | 6.1 |  |  | 5.3 - 6.1 |  |  | 5.3 - 6.1 |  |  | 5.3 - 6.1 |
Expected stock price volatility |  | 110.6% - 110.8% |  |  | 106.9% - 111.5% |  |  | 103.8% - 111.2% |  |  | 103.1% - 111.5% |
Risk-free interest rate |  | 3.0% - 3.6% |  |  | 0.8% - 1.0% |  |  | 1.6% - 3.6% |  |  | 0.6% - 1.2% |
Expected dividend yield |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Summary of Stock-based Compensation Expense | The following table sets forth the total stock-based compensation expense for all awards granted to employees and non-employees and the ESPP in the unaudited condensed consolidated statements of operations:
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2022 |  |  | 2021 |  |  | 2022 |  |  | 2021 |
|  | (in thousands) |
Research and development |  | $ | 12,607 |  |  | $ | 11,165 |  |  | $ | 39,791 |  |  | $ | 30,455 |
Selling, general and administrative |  |  | 12,207 |  |  |  | 11,779 |  |  |  | 37,426 |  |  |  | 28,958 |
Total stock-based compensation |  | $ | 24,814 |  |  | $ | 22,944 |  |  | $ | 77,217 |  |  | $ | 59,413 |

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- Definition Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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