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Collaboration revenue (Tables) | 9 Months Ended
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Sep. 30, 2022
Revenue Recognition [Abstract] |
Schedule of Collaboration revenue | During the three and nine months ended September 30, 2022, the Company recorded profit-sharing amounts and profit-sharing amounts constrained as components of collaboration revenue in the unaudited condensed consolidated statements of operations, as follows:
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2022 |  |  | 2021 |  |  | 2022 |  |  | 2021 |
|  | (in thousands) |
Collaboration revenue, net |  |  |  |  |  |  |  |  |  |  |  |
Profit-sharing amount |  | $ | 291,226 |  |  | $ | 102,398 |  |  | $ | 1,863,374 |  |  | $ | 107,731 |
Profit-sharing amount constrained |  |  | (2,431 | ) |  |  | — |  |  |  | (399,864 | ) |  |  | — |
Profit-sharing amount previously constrained, released |  |  | 20,350 |  |  |  | — |  |  |  | 20,350 |  |  |  | — |
Total collaboration revenue, net |  | $ | 309,145 |  |  | $ | 102,398 |  |  | $ | 1,483,860 |  |  | $ | 107,731 |

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