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Stock-Based Awards - Summary of Stock-based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Total stock-based compensation $ 24,814 $ 22,944 $ 77,217 $ 59,413
Research and Development Expense        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Total stock-based compensation 12,607 11,165 39,791 30,455
General and Administrative        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Total stock-based compensation $ 12,207 $ 11,779 $ 37,426 $ 28,958