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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net income (loss) $ 617,440 $ 3,330
Adjustments to reconcile net income (loss) to net cash used in operating activities:    
Change in estimated constraint on profit-sharing amount 353,526 0
Depreciation and amortization 4,431 3,891
Amortization of intangible assets 399 399
Accretion of discounts on investments, net (1,315) (859)
Noncash lease expense 6,473 4,471
Change in fair value of equity investments 120,019 (164,072)
Change in estimated fair value of contingent consideration 7,890 63,246
Payment for contingent consideration in excess of acquisition date fair value (93,803) (8,140)
Stock-based compensation 77,217 59,413
Other 301 486
Changes in operating assets and liabilities:    
Receivable from collaboration 491,872 (93,003)
Prepaid expenses and other current assets 11,023 1,878
Other assets (3,434) (1,051)
Accounts payable (2,003) (959)
Accrued liabilities and other long-term liabilities 65,144 (13,490)
Operating lease liabilities (2,547) (383)
Deferred revenue (24,506) 89,559
Net cash provided by (used in) operating activities 1,628,127 (55,284)
CASH FLOWS FROM INVESTING ACTIVITIES:    
Proceeds from sale of an equipment 22 0
Purchases of property and equipment (55,432) (8,750)
Purchases of investments (1,069,752) (55,729)
Maturities of investments 84,836 301,243
Proceeds from disposal of an equipment 0 4
Net cash (used in) provided by investing activities (1,040,326) 236,768
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from issuance of common stock in connection with a grant agreement 28,462 0
Proceeds from issuance of common stock in connection with a collaboration agreement 0 85,213
Payment of principal on financing lease obligation (183) (187)
Proceeds from exercise of stock options 3,602 9,635
Issuance of common stock under ESPP 2,066  
Payment of contingent consideration (1,197) 0
Net cash provided by financing activities 32,750 94,661
Net increase in cash, cash equivalents and restricted cash and cash equivalents 620,551 276,145
Cash, cash equivalents and restricted cash and cash equivalents at beginning of period 363,415 451,487
Cash, cash equivalents and restricted cash and cash equivalents at end of period 983,966 727,632
NONCASH INVESTING AND FINANCING ACTIVITIES:    
Common stock issued for payment of contingent consideration 0 1,860
Property and equipment purchases included in accounts payable and accrued liabilities 6,413 4,191
Operating lease liabilities obtained in exchange of right-of-use asset 3,969 90
SUPPLEMENTAL DISCLOSURE OF CASHFLOW INFORMATION    
Cash paid during the period for income tax 191,653 0
RECONCILIATION OF CASH, CASH EQUIVALENTS AND RESTRICTED CASH TO THE CONDENSED CONSOLIDATED BALANCE SHEETS:    
Cash and cash equivalents 963,735 714,521
Restricted cash and cash equivalents, current 12,955 6,112
Restricted cash and cash equivalents, noncurrent 7,276 6,999
Total cash, cash equivalents and restricted cash $ 983,966 $ 727,632