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v3.23.3

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2023 | Sep. 30, 2022
CASH FLOWS FROM OPERATING ACTIVITIES: |  |
Net (loss) income | $ (499,144) | $ 617,440
Adjustments to reconcile net (loss) income to net cash (used in) provided by operating activities: |  |
Change in estimated constraint on profit-sharing amount | (28,101) | 353,526
Depreciation and amortization | 14,573 | 4,431
Amortization of intangible assets | 399 | 399
Accretion of discounts on investments, net | (10,057) | (1,315)
Payment of contingent consideration in excess of acquisition date fair value | 0 | (93,803)
Noncash lease expense | 6,218 | 6,473
Change in fair value of equity investments | 20,895 | 120,019
Change in estimated fair value of contingent consideration | (637) | 7,890
Stock-based compensation | 83,044 | 77,217
In-process research and development impairment | 6,899 | 0
Long-lived assets impairment | 7,474 | 0
Other | (578) | 301
Changes in operating assets and liabilities: |  |
Receivable from collaboration | 3,041 | 491,872
Prepaid expenses and other current assets | 54,194 | 11,023
Other assets | (150) | (3,434)
Accounts payable | (1,895) | (2,003)
Accrued liabilities and other long-term liabilities | (316,918) | 65,144
Operating lease liabilities | (9,910) | (2,547)
Deferred revenue | (205) | (24,506)
Net cash (used in) provided by operating activities | (670,858) | 1,628,127
CASH FLOWS FROM INVESTING ACTIVITIES: |  |
Proceeds from sale of an equipment | 0 | 22
Purchases of property and equipment | (20,038) | (55,432)
Purchases of investments | (1,197,199) | (1,069,752)
Maturities of investments | 1,486,677 | 84,836
Net cash provided by (used in) investing activities | 269,440 | (1,040,326)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |
Proceeds from issuance of common stock in connection with a grant agreement | 0 | 28,462
Payment of principal on financing lease obligation | (200) | (183)
Proceeds from exercise of stock options | 3,395 | 3,602
Issuance of common stock under ESPP | 2,605 | 2,066
Contributions from noncontrolling interest owners | 100 | 0
Increase in ownership interest in a subsidiary | (100) | 0
Payment of contingent consideration | 0 | (1,197)
Net cash provided by financing activities | 5,800 | 32,750
Net (decrease) increase in cash, cash equivalents and restricted cash and cash equivalents | (395,618) | 620,551
Cash, cash equivalents and restricted cash and cash equivalents at beginning of period | 867,968 | 363,415
Cash, cash equivalents and restricted cash and cash equivalents at end of period | 472,350 | 983,966
RECONCILIATION OF CASH, CASH EQUIVALENTS AND RESTRICTED CASH AND CASH EQUIVALENTS TO THE CONDENSED CONSOLIDATED BALANCE SHEETS: |  |
Cash and cash equivalents | 452,100 | 963,735
Restricted cash and cash equivalents, current | 13,193 | 12,955
Restricted cash and cash equivalents, noncurrent | 7,057 | 7,276
Total cash, cash equivalents and restricted cash and cash equivalents | $ 472,350 | $ 983,966

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