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Collaboration and License Agreements - Collaboration revenue (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2023 | Sep. 30, 2022 | Sep. 30, 2023 | Sep. 30, 2022
Profit-sharing amount |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |
Total collaboration revenue, net | $ (6,038) | $ 291,226 | $ (7,198) | $ 1,863,374
Profit-sharing amount constrained |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |
Total collaboration revenue, net | 0 | (2,431) | 0 | (399,864)
Profit-sharing amount previously constrained, released |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |
Total collaboration revenue, net | 1,651 | 20,350 | 35,606 | 20,350
Collaboration revenue |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |
Total collaboration revenue, net | $ (4,387) | $ 309,145 | $ 28,408 | $ 1,483,860

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