<SEC-DOCUMENT>0001209191-14-078604.txt : 20141231
<SEC-HEADER>0001209191-14-078604.hdr.sgml : 20141231
<ACCEPTANCE-DATETIME>20141231172347
ACCESSION NUMBER:		0001209191-14-078604
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		<ITEMS>06b
FILED AS OF DATE:		20141231
DATE AS OF CHANGE:		20141231
EFFECTIVENESS DATE:		20141231

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PIERIS PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001583648
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				300784346
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-231283
		FILM NUMBER:		141319066

	BUSINESS ADDRESS:	
		STREET 1:		LISE-MEITNER-STRASSE 30
		CITY:			FREISING-WEIHENSTEPHAN
		STATE:			2M
		ZIP:			85354
		BUSINESS PHONE:		49 81 6114 11400

	MAIL ADDRESS:	
		STREET 1:		LISE-MEITNER-STRASSE 30
		CITY:			FREISING-WEIHENSTEPHAN
		STATE:			2M
		ZIP:			85354

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Marika Inc.
		DATE OF NAME CHANGE:	20130805
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
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        <entityName>PIERIS PHARMACEUTICALS, INC.</entityName>
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            <street1>30 Lise-Meitner-Strasse</street1>
            <city>Freising-Weihenstephan</city>
            <stateOrCountry>2M</stateOrCountry>
            <stateOrCountryDescription>GERMANY</stateOrCountryDescription>
            <zipCode>85354</zipCode>
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        <issuerPhoneNumber>4.90816E+13</issuerPhoneNumber>
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            <value>2013</value>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stephen</firstName>
                <middleName>S.</middleName>
                <lastName>Yoder</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Pieris Pharmaceuticals, Inc.,</street1>
                <street2>30 Lise-Meitner-Strasse</street2>
                <city>Freising-Weihenstephan</city>
                <stateOrCountry>2M</stateOrCountry>
                <stateOrCountryDescription>GERMANY</stateOrCountryDescription>
                <zipCode>85354</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Executive Officer and President</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Darlene</firstName>
                <middleName>M.</middleName>
                <lastName>Deptula-Hicks</lastName>
            </relatedPersonName>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
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                <firstName>Chau</firstName>
                <lastName>Khuong</lastName>
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            <relatedPersonRelationshipList>
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            <relationshipClarification>Chairman of the Board of Directors</relationshipClarification>
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        <relatedPersonInfo>
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                <firstName>Christina</firstName>
                <lastName>Takke</lastName>
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        <relatedPersonInfo>
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                <firstName>Steven</firstName>
                <lastName>Prelack</lastName>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
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            <dateOfFirstSale>
                <value>2014-12-17</value>
            </dateOfFirstSale>
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        <durationOfOffering>
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        <typesOfSecuritiesOffered>
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        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>2000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Northland Securities, Inc.</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>Trout Capital LLC</associatedBDName>
                <associatedBDCRDNumber>131589</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>45 S. 7th Street, Suite 2000</street1>
                    <city>Minneapolis</city>
                    <stateOrCountry>MN</stateOrCountry>
                    <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                    <zipCode>55402</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Katalyst Securities LLC</recipientName>
                <recipientCRDNumber>112494</recipientCRDNumber>
                <associatedBDName>American Portfolios Financial Services, Inc.</associatedBDName>
                <associatedBDCRDNumber>18487</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>15 Maiden Lane, Room 601</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10038</zipCode>
                </recipientAddress>
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                    <state>AZ</state>
                    <description>ARIZONA</description>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
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                    <description>COLORADO</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
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                    <description>MASSACHUSETTS</description>
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                    <state>MN</state>
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                <associatedBDName>Dinosaur Securities, L.L.C.</associatedBDName>
                <associatedBDCRDNumber>104446</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>470 Park Avenue South</street1>
                    <street2>9th Floor</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10016</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
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                    <state>CA</state>
                    <description>CALIFORNIA</description>
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                    <description>PENNSYLVANIA</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>VA</state>
                    <description>VIRGINIA</description>
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        </salesCompensationList>
        <offeringSalesAmounts>
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            <totalAmountSold>13559020</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>139</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
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                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
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            </findersFees>
            <clarificationOfResponse>Two placement agents and their designees received (i) cash commissions in the aggregate of up to 8% of the offerings gross proceeds and (ii) five-year warrants to purchase an aggregate of 8% of the number of shares sold in the offering.</clarificationOfResponse>
        </salesCommissionsFindersFees>
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            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
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        <signatureBlock>
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                <signatureName>/s/  Darlene M. Deptula-Hicks</signatureName>
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                <signatureDate>2014-12-31</signatureDate>
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</SEC-DOCUMENT>
