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Share-Based Compensation (Tables)
6 Months Ended
Jun. 30, 2021
Share-based Payment Arrangement [Abstract]  
Share-based Compensation Expense
The Company recognized share-based compensation in its Condensed Consolidated Statements of Operations and Comprehensive Loss during 2021 and 2020 as follows:

 Three Months Ended
June 30,
Six Months Ended
June 30,
 2021202020212020
Manufacture and supply$71 $72 $153 $135 
Research and development208 183 440 365 
Selling, general and administrative1,442 1,510 2,635 3,125 
Total share-based compensation expenses$1,721 $1,765 $3,228 $3,625 
Share-based compensation from:
Restricted stock units$43 $309 $81 $773 
Stock options1,667 1,445 3,136 2,841 
Employee stock purchase plan11 11 11 11 
Total share-based compensation expenses$1,721 $1,765 $3,228 $3,625 
Restricted Stock Units Awards
The following tables provide information about the Company’s restricted stock unit and stock option activity during the six-month period ended June 30, 2021:

Restricted Stock Unit Awards (RSUs):Number of
Units
Weighted
Average
Grant Date Fair
Value
 (in thousands) 
Unvested as of December 31, 202014 $11.38 
Granted— — 
Vested(4)$7.54 
Forfeited(2)$13.00 
Unvested as of June 30, 2021$13.00 
Grant date fair value of shares vested during the period$30 
Unrecognized compensation costs as of June 30, 2021$
Stock Option Activity
Unrecognized compensation costs related to awards of RSUs are expected to be recognized over a weighted-average period of less than one year.

Stock Option Awards:Number of
Options
Weighted Average
Exercise Price
 (in thousands)
Outstanding as of December 31, 20203,259 $8.14 
Granted1,211 $4.73 
Exercised, Forfeited, Expired(39)$5.63 
Outstanding as of June 30, 20214,431 $7.23 
Vested and expected to vest as of June 30, 20214,246 $7.34 
Exercisable as of June 30, 20211,824 $9.92 
Valuation Assumptions for Determination of Fair Value of Options
The fair values of stock options granted during the six months ended June 30, 2021 were estimated using the Black-Scholes pricing model based on the following assumptions:

Expected dividend yield— %
Expected volatility
95% - 100%
Expected term (years)6.1
Risk-free interest rate1.0 %