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Share-Based Compensation (Details)
$ / shares in Units, $ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2021
USD ($)
$ / shares
shares
Jun. 30, 2020
USD ($)
Jun. 30, 2021
USD ($)
offeringPeriod
$ / shares
shares
Jun. 30, 2020
USD ($)
shares
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses | $ $ 1,721 $ 1,765 $ 3,228 $ 3,625
Employee Stock Purchase Plan [Abstract]        
Shares issued under employee stock purchase plan (in shares) | shares     19,270 14,961
ESPP discount | $     $ 11 $ 11
Employee Stock Purchase Plan        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses | $ 11 11 11 11
Restricted stock units        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses | $ $ 43 309 $ 81 773
Number of Units        
Unvested, at beginning of period (in shares) | shares     14,000  
Granted (in shares) | shares     0  
Vested (in shares) | shares     (4,000)  
Forfeited (in shares) | shares     (2,000)  
Unvested, at end of period (in shares) | shares 8,000   8,000  
Weighted Average Grant Date Fair Value        
Unvested, at beginning of period (in dollars per share)     $ 11.38  
Granted (in dollars per share)     0  
Vested (in dollars per share)     7.54  
Forfeited (in dollars per share)     13.00  
Unvested, at end of period (in dollars per share) $ 13.00   $ 13.00  
Grant date fair value of shares vested during the period | $ $ 30   $ 30  
Unrecognized compensation costs of RSU awards | $ 1   1  
Stock options        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses | $ $ 1,667 1,445 $ 3,136 2,841
Number of Options        
Outstanding at beginning of period (in shares) | shares     3,259,000  
Granted (in shares) | shares     1,211,000  
Exercised, Forfeited, Expired (in shares) | shares     (39,000)  
Outstanding at end of period (in shares) | shares 4,431,000   4,431,000  
Vested or expected to vest at end of period (in shares) | shares 4,246,000   4,246,000  
Exercisable at end of period (in shares) | shares 1,824,000   1,824,000  
Weighted Average Exercise Price        
Outstanding at beginning of period (in dollars per share)     $ 8.14  
Granted (in dollars per share)     4.73  
Exercised, Forfeited, Expired (in dollars per share)     5.63  
Outstanding at end of period (In dollars per share) $ 7.23   7.23  
Vested or expected to vest at end of period (in dollars per share) 7.34   7.34  
Exercisable at end of period (in dollars per share) 9.92   $ 9.92  
Fair Value Assumptions [Abstract]        
Expected dividend yield     0.00%  
Expected term (years)     6 years 1 month 6 days  
Risk-free interest rate     1.00%  
Weighted average grant date fair value (in dollars per share)     $ 3.61  
Additional Disclosures [Abstract]        
Share price (in dollars per share) $ 3.97   $ 3.97  
Intrinsic value of options granted | $     $ 1  
Compensation Cost Not yet Recognized [Abstract]        
Unrecognized compensation expense related to non-vested stock options | $ $ 6,653   $ 6,653  
Unrecognized compensation cost, recognition period     1 year 10 months 24 days  
Stock options | Minimum        
Fair Value Assumptions [Abstract]        
Expected volatility     95.00%  
Additional Disclosures [Abstract]        
Share price (in dollars per share) $ 3.76   $ 3.76  
Stock options | Maximum        
Fair Value Assumptions [Abstract]        
Expected volatility     100.00%  
Additional Disclosures [Abstract]        
Share price (in dollars per share) $ 5.30   $ 5.30  
Employee Stock        
Employee Stock Purchase Plan [Abstract]        
Number of offering periods | offeringPeriod     2  
Offering period     6 months  
Purchase price of common stock as percentage of fair market value     85.00%  
Manufacture and supply        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses | $ $ 71 72 $ 153 135
Research and development        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses | $ 208 183 440 365
Selling, general and administrative        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses | $ $ 1,442 $ 1,510 $ 2,635 $ 3,125