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  <xs:element id="aqst_CommercialExploitationAgreementWithIndiviorMember" abstract="true" name="CommercialExploitationAgreementWithIndiviorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_NumberOf1000AnnualMinimumGuaranteedRoyalties" abstract="false" name="NumberOf1000AnnualMinimumGuaranteedRoyalties" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="aqst_ConsultingFee" abstract="false" name="ConsultingFee" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_CashPaymentRepresenting90DaysOfBasePay" abstract="false" name="CashPaymentRepresenting90DaysOfBasePay" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognizedCurrent" abstract="false" name="TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognizedCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsGrantDateFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_RightToSellCommonStockValue" abstract="false" name="RightToSellCommonStockValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_ComputerNetworkEquipmentAndSoftwareMember" abstract="true" name="ComputerNetworkEquipmentAndSoftwareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_MinimumAnnualRoyaltyReceivable" abstract="false" name="MinimumAnnualRoyaltyReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_AtnahsPharmaUKLimitedMember" abstract="true" name="AtnahsPharmaUKLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_AuditInformationAbstract" abstract="true" name="AuditInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="aqst_PatentLitigationSettlementWithBioDeliverySciencesInternationalIncMember" abstract="true" name="PatentLitigationSettlementWithBioDeliverySciencesInternationalIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_InterestExpenseSaleOfFutureRevenuesExcludingAmortization" abstract="false" name="InterestExpenseSaleOfFutureRevenuesExcludingAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_DurationOfPaymentDomain" abstract="true" name="DurationOfPaymentDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_MaterialAgreementsAbstract" abstract="true" name="MaterialAgreementsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="aqst_ClassOfWarrantOrRightWarrantsExercised" abstract="false" name="ClassOfWarrantOrRightWarrantsExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="aqst_ResearchAndDevelopmentCostsCapitalized" abstract="false" name="ResearchAndDevelopmentCostsCapitalized" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_IntangibleAssetsNetAndOtherAssetsAbstract" abstract="true" name="IntangibleAssetsNetAndOtherAssetsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="aqst_DebtInstrumentAdditionalBorrowingCapacity" abstract="false" name="DebtInstrumentAdditionalBorrowingCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_InventoryPackingMaterialGross" abstract="false" name="InventoryPackingMaterialGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_ManufacturingAndSupplyMember" abstract="true" name="ManufacturingAndSupplyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedOrExpectedToVestAggregateIntrinsicValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedOrExpectedToVestAggregateIntrinsicValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_RedemptionPercentageOfDebtUnderChangeOfControlProvisions" abstract="false" name="RedemptionPercentageOfDebtUnderChangeOfControlProvisions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="aqst_NeurelisIncVAquestiveTherapeuticsIncMember" abstract="true" name="NeurelisIncVAquestiveTherapeuticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_TwelvePointFiveSeniorSecuredNotesDueJune302025Member" abstract="true" name="TwelvePointFiveSeniorSecuredNotesDueJune302025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_IncomeTaxDisclosureLineItems" abstract="true" name="IncomeTaxDisclosureLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="aqst_LincolnParkAgreementMember" abstract="true" name="LincolnParkAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_ContingentConsiderationMilestonePayments" abstract="false" name="ContingentConsiderationMilestonePayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_TradeAndOtherReceivablesNet" abstract="false" name="TradeAndOtherReceivablesNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfOfferingPeriods" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfOfferingPeriods" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="aqst_ProRataPortionOfTargetBonus" abstract="false" name="ProRataPortionOfTargetBonus" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_APICShareBasedPaymentArrangementExerciseOfStockOptions" abstract="false" name="APICShareBasedPaymentArrangementExerciseOfStockOptions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_NinthThroughEighteenthMonthMember" abstract="true" name="NinthThroughEighteenthMonthMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aqst_CreditTermOfTradeReceivables" abstract="false" name="CreditTermOfTradeReceivables" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aqst_StockIssuedDuringPeriodValueWarrantsExercised" abstract="false" name="StockIssuedDuringPeriodValueWarrantsExercised" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_A2020AdditionalNotesMember" abstract="true" name="A2020AdditionalNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_SupplementalAgreementWithIndiviorMember" abstract="true" name="SupplementalAgreementWithIndiviorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_LicenseAgreementTerm" abstract="false" name="LicenseAgreementTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aqst_AssertioHoldingsIncMember" abstract="true" name="AssertioHoldingsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_IssuanceAxis" abstract="true" name="IssuanceAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="aqst_EffectiveIncomeTaxRateReconciliationPermanentDifferencesPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationPermanentDifferencesPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="aqst_RoyaltyReceivable" abstract="false" name="RoyaltyReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_NumberOfUncertainTaxPositions" abstract="false" name="NumberOfUncertainTaxPositions" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="aqst_AccountsReceivableAllowancesCreditsAndPayments" abstract="false" name="AccountsReceivableAllowancesCreditsAndPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_ManufactureAndSupplyCosts" abstract="false" name="ManufactureAndSupplyCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_NetProceedsFromIssuanceOfInitialNotesWarrantsAndFirstOfferRights" abstract="false" name="NetProceedsFromIssuanceOfInitialNotesWarrantsAndFirstOfferRights" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_LicenseAgreementWithSunovionPharmaceuticalsIncMilestonesMember" abstract="true" name="LicenseAgreementWithSunovionPharmaceuticalsIncMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_SaleOfFutureRevenuePolicyTextBlock" abstract="false" name="SaleOfFutureRevenuePolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="aqst_DeferredTaxAssetsAccountsReceivable" abstract="false" name="DeferredTaxAssetsAccountsReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_UnvestedRestrictedStockUnitsMember" abstract="true" name="UnvestedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_HaiscoPharmaceuticalGroupCoLtdUpfrontPaymentMember" abstract="true" name="HaiscoPharmaceuticalGroupCoLtdUpfrontPaymentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_NumberOfSharesReservedForIssuance" abstract="false" name="NumberOfSharesReservedForIssuance" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="aqst_LicenseSupplyAgreementMember" abstract="true" name="LicenseSupplyAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_SeverancePeriod" abstract="false" name="SeverancePeriod" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aqst_LiabilitiesSaleOfFutureRoyaltiesCurrent" abstract="false" name="LiabilitiesSaleOfFutureRoyaltiesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_IntangibleAssetsNetAndOtherAssetsDisclosureTextBlock" abstract="false" name="IntangibleAssetsNetAndOtherAssetsDisclosureTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="aqst_ProceedsFromSaleOfFutureRevenuesNet" abstract="false" name="ProceedsFromSaleOfFutureRevenuesNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_ManufactureAndSupplyRevenueMember" abstract="true" name="ManufactureAndSupplyRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_EffectiveIncomeTaxRateReconciliationTaxCreditReturnToProvisionPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationTaxCreditReturnToProvisionPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="aqst_IssuanceDomain" abstract="true" name="IssuanceDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_ContingentMonetizationAgreementMilestonePayment" abstract="false" name="ContingentMonetizationAgreementMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_LicensingAndSupplyAgreementWithPharmanoviaMember" abstract="true" name="LicensingAndSupplyAgreementWithPharmanoviaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_MilestonePaymentNoLongerReceivable" abstract="false" name="MilestonePaymentNoLongerReceivable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_AutomaticRenewalPeriodOfAgreement" abstract="false" name="AutomaticRenewalPeriodOfAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aqst_DeferredTaxLiabilities481aAdjustment" abstract="false" name="DeferredTaxLiabilities481aAdjustment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="aqst_ProceedsFromIssuancePrivateOffering" abstract="false" name="ProceedsFromIssuancePrivateOffering" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_AccountsReceivableAllowancesProvisionRelatedToSales" abstract="false" name="AccountsReceivableAllowancesProvisionRelatedToSales" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_IncomeTaxDisclosureTable" abstract="true" name="IncomeTaxDisclosureTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="aqst_SaleOfFutureRevenueTextBlock" abstract="false" name="SaleOfFutureRevenueTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="aqst_AccountsReceivableAllowancesAndAccrualsTradeAndOtherReceivablesNet" abstract="false" name="AccountsReceivableAllowancesAndAccrualsTradeAndOtherReceivablesNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_StockIssuedDuringPeriodSharesExerciseOfStockOptions" abstract="false" name="StockIssuedDuringPeriodSharesExerciseOfStockOptions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="aqst_DebtInstrumentPrincipalNumberOfQuarterlyPayments" abstract="false" name="DebtInstrumentPrincipalNumberOfQuarterlyPayments" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="aqst_RepurchaseOfferPercentageOfCashProceedsReceived" abstract="false" name="RepurchaseOfferPercentageOfCashProceedsReceived" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="aqst_EighthMonthMember" abstract="true" name="EighthMonthMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_ClassOfWarrantOrRightWarrantsIssuedDuringPeriod" abstract="false" name="ClassOfWarrantOrRightWarrantsIssuedDuringPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="aqst_DaysOfBasePay" abstract="false" name="DaysOfBasePay" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="aqst_AgreementTerm" abstract="false" name="AgreementTerm" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aqst_EquityDistributionAgreementMember" abstract="true" name="EquityDistributionAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_CLAKemPharmMember" abstract="true" name="CLAKemPharmMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_DeferredTaxAssetsSaleOfFutureRevenue" abstract="false" name="DeferredTaxAssetsSaleOfFutureRevenue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_NumberOfTransactions" abstract="false" name="NumberOfTransactions" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="aqst_DurationOfPaymentAxis" abstract="true" name="DurationOfPaymentAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
</xs:schema>
