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Share-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2022
Share-Based Payment Arrangement [Abstract] |
Summary of Share-Based Compensation Expense | The Company recognized share-based compensation in its Consolidated Statements of Operations during the periods presented as follows:
Expense classification: | Year Ended December 31, 2022 |  | Year Ended December 31, 2021
Manufacture and supply | $ | 203 |  |  | $ | 313 |
Research and development | 672 |  |  | 881 |
Selling, general and administrative | 3,506 |  |  | 5,625 |
Total share-based compensation expenses | $ | 4,381 |  |  | $ | 6,819 |
Share-based compensation from: |  |  |
Restricted Stock Units | 127 |  |  | 81 |
Stock Options | 4,244 |  |  | 6,714 |
Employee Stock Purchase Plan | 10 |  |  | 24 |
Total share-based compensation expenses | $ | 4,381 |  |  | $ | 6,819 |
Summary of Restricted Stock Units | The following table summarizes the Company’s awards of restricted stock units for the years during 2021 and 2022:
| Number of Units |  | Weighted Average Grant Date Fair Value Per Share
| (In thousands) |  |
Unvested, December 31, 2020 | 14 |  | $ | 11.38 |
Granted | — |  | — |
Forfeited | (2) |  | 13.00 |
Vested | (12) |  | 11.14 |
Unvested, December 31, 2021 | — |  |
Granted | 192 |  | 2.37 |
Forfeited | (20) |  | 2.21 |
Vested | (10) |  | 2.55 |
Unvested, December 31, 2022 | 162 |  | $ | 2.38 |
Summary of Stock Option Activity | The following table summarizes the Company’s stock option activity for the years during 2021 and 2022:
(in 000s, except share price data) | Number of Options |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Term in Years |  | Aggregate Intrinsic Value
Outstanding at December 31, 2020 | 3,259 |  |  | $ | 8.14 |  |  | 8.42 |  | $ | 2,978 |
Granted | 1,212 |  |  | $ | 4.73 |  |  |  |  |
Forfeited and Expired | (264) |  | $ | 7.52 |  |  |  |  |
Exercised | (61) |  |  |  |  |  |  |
Outstanding at December 31, 2021 | 4,146 |  |  | $ | 7.28 |  |  | 7.88 |  | $ | 1,423 |
Granted | 2,015 |  |  | 1.83 |  |  |  |  |
Forfeited and Expired | (133) |  |  | $ | 7.81 |  |  |  |  |
Exercised | — |  |  | $ | — |  |  |  |  |
Outstanding at December 31, 2022 | 6,028 |  |  | $ | 5.48 |  |  | 7.50 |  | $ | 38 |
Vested and expected to vest at December 31, 2022 | 5,877 |  |  | $ | 5.57 |  |  | 7.46 |  | $ | 36 |
Exercisable at December 31, 2022 | 3,652 |  |  | $ | 7.42 |  |  | 6.57 |  | $ | — |
Summary of Stock Option Valuation Assumptions | The fair values of stock options granted were estimated using the Black-Scholes model based on the following assumptions:
| Year Ended December 31,
| 2022 |  | 2021
Expected dividend yield | 0% |  | 0%
Expected volatility | 100% |  | 100%
Expected term (years) | 5.50 | - | 6.13 |  | 5.50 | - | 6.00
Risk-free interest rate | 2.0% | —% | 4.3% |  | 0.5% | —% | 1.5%
Exercise prices | $0.71 | - | $2.55 |  | $3.76 | - | $5.30

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