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Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity - USD ($) $ in Thousands | Total | Convertible Preferred Stock | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2015 | $ 31,425 |  | $ 1 | $ 162,460 | $ 1 | $ (131,037)
Balance (in shares) at Dec. 31, 2015 |  |  | 762,005 |  |  |
Stock-based compensation expense | 635 |  |  | 635 |  |
Issuance of common stock, net of issuance costs | 957 |  |  | 957 |  |
Issuance of common stock, net of issuance costs, shares |  |  | 39,743 |  |  |
Conversion of convertible securities, value | 1 |  |  | 1 |  |
Conversion of convertible securities, shares |  |  | 8 |  |  |
Unrealized (loss) gain on available-for-sale securities | (2) |  |  |  | (2) |
Net loss | (16,945) |  |  |  |  | (16,945)
Balance at Dec. 31, 2016 | 16,071 |  | $ 1 | 164,053 | (1) | (147,982)
Balance (in shares) at Dec. 31, 2016 |  |  | 801,756 |  |  |
Stock-based compensation expense | 863 |  |  | 863 |  |
Issuance of common stock, net of issuance costs | 5,336 |  |  | 5,336 |  |
Issuance of common stock, net of issuance costs, shares |  |  | 439,880 |  |  |
Issuance of convertible preferred stock, common stock and warrants for follow-on offering, net of issuance costs | 18,563 |  | $ 2 | 18,561 |  |
Issuance of convertible preferred stock, common stock and warrants for follow-on offering, net of issuance costs, shares |  | 13,350 | 1,470,000 |  |  |
Issuance of common stock for follow-on offering S-3, net of issuance costs | 9,684 |  | $ 1 | 9,683 |  |
Issuance of common stock for follow-on offering S-3, net of issuance costs, shares |  |  | 1,105,263 |  |  |
Issuance of common stock upon exercise of warrants | 1,817 |  |  | 1,817 |  |
Issuance of common stock upon exercise of warrants, shares |  |  | 330,331 |  |  |
Conversion of convertible securities, value |  |  | $ 2 | (2) |  |
Conversion of convertible securities, shares |  | (9,670) | 1,934,000 |  |  |
Deemed dividend for preferred stock beneficial conversion feature |  |  |  | 3,951 |  | (3,951)
Unrealized (loss) gain on available-for-sale securities | 1 |  |  |  | $ 1 |
Net loss | (21,561) |  |  |  |  | (21,561)
Balance at Dec. 31, 2017 | $ 30,774 |  | $ 6 | $ 204,262 |  | $ (173,494)
Balance (in shares) at Dec. 31, 2017 |  | 3,680 | 6,081,230 |  |  |

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