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Collaborations - Additional Information (Detail) - USD ($) |  | 1 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Sep. 16, 2013 | Feb. 28, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 08, 2016
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
Contract revenue |  |  | $ 1,018,000 | $ 399,000 |
Pfizer Inc | Collaboration Agreement | Subsequent Event |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
Milestone payment |  | $ 1,000,000 |  |  |
Pfizer Inc | Collaboration Agreement | Maximum |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
Contingent cash payments upon achievement of clinical, regulatory and commercial milestones |  |  |  |  | $ 17,500,000
ISU Abxis |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
Contract revenue |  |  | 300,000 | 400,000 |
Deferred revenue |  |  | 200,000 | 300,000 |
Milestone payments recognized over the estimated remaining period of performance obligation |  |  | 700,000 | 0 |
Milestone Payment Received |  |  | $ 900,000 | $ 0 |
ISU Abxis | Up Front Payment |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
Amount received for research and development process | $ 1,750,000 |  |  |  |

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