XML 84 R63.htm IDEA: XBRL DOCUMENT
v3.8.0.1

Subsequent Events - Additional Information (Detail) - USD ($) |  |  |  |  |  |  |  |  | 12 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Mar. 15, 2018 | Mar. 02, 2018 | Feb. 19, 2018 | Feb. 15, 2018 | Feb. 13, 2018 | Dec. 22, 2017 | Dec. 20, 2017 | Apr. 12, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Mar. 05, 2018 | Feb. 21, 2018 | Feb. 20, 2018 | May 20, 2016
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock price, per share |  |  |  |  |  |  |  | $ 5.28 |  |  |  |  |  |  |
Net proceeds from sale of common stock |  |  |  |  |  | $ 9,700,000 |  | $ 18,600,000 |  | $ 5,336,000 | $ 958,000 |  |  |  |
Redeemable convertible notes, outstanding balance |  |  |  |  |  |  |  |  |  | $ 5,085,000 | $ 19,403,000 |  |  |  |
Preferred stock, shares outstanding |  |  |  |  |  |  |  |  |  | 3,680 | 0 |  |  |  |
Number of warrants remaining |  |  |  |  |  |  |  |  |  | 1,751,708 | 12,039 |  |  |  |
Proceeds received from warrants exercised |  |  |  |  |  |  |  |  |  | $ 1,817,000 |  |  |  |  |
Scenario Forecast |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds received from warrants exercised |  |  |  |  |  |  |  |  | $ 9,300,000 |  |  |  |  |  |
AGC Biologics, Inc |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contractual obligation payments |  |  |  |  |  |  |  |  |  | $ 700,000 |  |  |  |  | $ 3,800,000
Convertible Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible notes, maturity date |  |  |  |  |  |  |  |  |  | Feb. 19, 2018 |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Firm commitment underwritten public offering shares |  |  |  |  |  |  | 1,105,263 |  |  |  |  |  |  |  |
Issuance of stock, shares |  |  |  |  |  | 1,105,263 |  | 1,470,000 |  | 439,880 | 39,743 |  |  |  |
Common stock price, per share |  |  |  |  |  | $ 9.50 |  |  |  |  |  |  |  |  |
Conversion of convertible securities, shares |  |  |  |  |  |  |  |  |  | 1,934,000 | 8 |  |  |  |
Common Stock | Overallotment Option |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of stock, shares |  |  |  |  |  |  |  | 540,000 |  |  |  |  |  |  |
Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from sale of common stock |  |  |  | $ 106,700,000 |  |  |  |  |  |  |  |  |  |  |
Redeemable convertible notes, outstanding balance |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0 |
Preferred stock, shares outstanding | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Remaining outstanding warrants called |  |  |  |  |  |  |  |  |  |  |  | 254,628 |  |  |
Number of warrants remaining | 45,628 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event | AGC Biologics, Inc |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contractual obligation payments |  |  |  |  |  |  |  |  |  |  |  |  | $ 5,600,000 |  |
Subsequent Event | Convertible Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible notes, maturity date |  |  | Feb. 19, 2018 |  |  |  |  |  |  |  |  |  |  |  |
Redeemable convertible notes, outstanding balance |  |  | $ 0 |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Firm commitment underwritten public offering shares |  |  |  |  | 2,941,176 |  |  |  |  |  |  |  |  |  |
Issuance of stock, shares |  |  |  | 3,382,352 |  |  |  |  |  |  |  |  |  |  |
Common stock price, per share |  |  |  | $ 34.00 |  |  |  |  |  |  |  |  |  |  |
Preferred stock called for conversion |  | 3,580 |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of convertible securities, shares | 716,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event | Common Stock | Overallotment Option |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of stock, shares |  |  |  | 441,176 |  |  |  |  |  |  |  |  |  |  |

X
- Definition Firm commitment underwritten public offering shares. + References No definition available. + Details
Name: | cbio_FirmCommitmentUnderwrittenPublicOfferingShares
Namespace Prefix: | cbio_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration

X
- Definition Stock called during period shares conversion of convertible securities. + References No definition available. + Details
Name: | cbio_StockCalledDuringPeriodSharesConversionOfConvertibleSecurities
Namespace Prefix: | cbio_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration

X
- Definition Number of securities into which each warrant or right may be converted. For example, but not limited to, each warrant may be converted into two shares. + References No definition available. + Details
Name: | us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByEachWarrantOrRight
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition Number of warrants or rights outstanding. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(i)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 + Details
Name: | us-gaap_ClassOfWarrantOrRightOutstanding
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition Amount of contractual obligation, including but not limited to, long-term debt, capital lease obligations, operating lease obligations, purchase obligations, and other commitments. + References No definition available. + Details
Name: | us-gaap_ContractualObligation
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition Carrying value as of the balance sheet date of the portion of long-term debt due within one year or the operating cycle if longer identified as Convertible Notes Payable. Convertible Notes Payable is a written promise to pay a note which can be exchanged for a specified amount of another, related security, at the option of the issuer and the holder. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.20) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
Name: | us-gaap_ConvertibleNotesPayableCurrent
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition Date when the debt instrument is scheduled to be fully repaid, in CCYY-MM-DD format. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22(a)(2)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
Name: | us-gaap_DebtInstrumentMaturityDate
Namespace Prefix: | us-gaap_
Data Type: | xbrli:dateItemType
Balance Type: | na
Period Type: | duration

X
- Definition Aggregate share number for all nonredeemable preferred stock (or preferred stock redeemable solely at the option of the issuer) held by stockholders. Does not include preferred shares that have been repurchased. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(28)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
Name: | us-gaap_PreferredStockSharesOutstanding
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
Name: | us-gaap_ProceedsFromIssuanceOfCommonStock
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition The cash inflow associated with the amount received from holders exercising their stock warrants. + References No definition available. + Details
Name: | us-gaap_ProceedsFromWarrantExercises
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Price of a single share of a number of saleable stocks of a company. + References No definition available. + Details
Name: | us-gaap_SharePrice
Namespace Prefix: | us-gaap_
Data Type: | num:perShareItemType
Balance Type: | na
Period Type: | instant

X
- Definition Number of shares issued during the period as a result of the conversion of convertible securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.3-04) -URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187085-122770 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.29-30) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84159872&loc=d3e21463-112644 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=84159872&loc=d3e21475-112644 + Details
Name: | us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration

X
- Definition Number of new stock issued during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(29)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84159872&loc=d3e21463-112644 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(28)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.3-04) -URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187085-122770 + Details
Name: | us-gaap_StockIssuedDuringPeriodSharesNewIssues
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration

X
- Definition Detail information of subsequent event by type. User is expected to use existing line items from elsewhere in the taxonomy as the primary line items for this disclosure, which is further associated with dimension and member elements pertaining to a subsequent event. + References No definition available. + Details
Name: | us-gaap_SubsequentEventLineItems
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Details
Name: | us-gaap_StatementScenarioAxis=us-gaap_ScenarioForecastMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_CounterpartyNameAxis=cbio_AGCBiologicsIncMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleDebtMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_StatementEquityComponentsAxis=us-gaap_CommonStockMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_SubsidiarySaleOfStockAxis=us-gaap_OverAllotmentOptionMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_SubsequentEventTypeAxis=us-gaap_SubsequentEventMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |