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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Income Statement [Abstract]    
Contract revenue $ 1,018 $ 399
Operating expenses:    
Research and development 12,847 11,555
General and administrative 9,993 9,262
Total operating expenses 22,840 20,817
Loss from operations (21,822) (20,418)
Interest and other income, net 261 3,473
Net loss (21,561) (16,945)
Deemed dividend for convertible preferred stock beneficial conversion feature (3,951)  
Net loss attributable to common stockholders $ (25,512) $ (16,945)
Net loss per share attributable to common stockholders, basic and diluted $ (7.45) $ (21.75)
Shares used to compute net loss per share attributable to common stockholders, basic and diluted 3,423,901 779,166