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Reconciliation of Statutory Federal Income Tax (benefit) Rate to Company's Effective Tax Rate (Detail)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Income Tax Disclosure [Abstract]    
Tax at statutory federal rate (34.00%) (34.00%)
State Tax (benefit)—net of federal benefit (0.00%) (1.12%)
Permanent differences 0.60% (7.95%)
R&D credits (1.64%) (3.16%)
Derecognition due to Sec. 382 and 383 limitations 54.08% (0.00%)
Change in valuation allowance (52.90%) 46.66%
Federal tax rate change 33.89% (0.00%)
Other (0.03%) (0.43%)