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Consolidated Statements of Cash Flows - USD ($)
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Operating Activities    
Net loss $ (21,561,000) $ (16,945,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 863,000 635,000
Depreciation and amortization 173,000 389,000
Loss (Gain) on sale of assets 18,000 (2,231,000)
Gain on extinguishment of redeemable convertible notes 0 (99,000)
Change in fair value of derivative liability   (1,057,000)
Changes in operating assets and liabilities:    
Prepaid and other current assets (351,000) 956,000
Accounts receivable 7,000 461,000
Deposits (128,000)  
Accounts payable (90,000) (102,000)
Accrued compensation and other accrued liabilities 1,287,000 (60,000)
Deferred revenue (118,000) (400,000)
Deferred rent (40,000) (19,000)
Net cash flows used in operating activities (19,940,000) (18,472,000)
Investing Activities    
Proceeds from maturities of short-term investments 14,300,000 10,002,000
Purchase of investments (25,472,000) (13,401,000)
Proceeds from sale of assets   1,674,000
Change in restricted cash (57,000) (5,000)
Proceeds from sale of property and equipment 0 890,000
Purchases of property and equipment (23,000) (468,000)
Net cash flows used in investing activities (11,252,000) (1,308,000)
Financing Activities    
Release of restricted cash due to conversion and redemption of redeemable convertible notes 14,318,000 14,330,000
Payments for the redemption of redeemable convertible notes (14,318,000) (14,340,000)
Proceeds from issuance of common stock, net of issuance costs 5,336,000 958,000
Proceeds from issuance of preferred stock, common stock and warrants for follow-on offering, net of issuance costs 18,563,000  
Proceeds from exercise of warrants 1,817,000  
Net cash flows provided by financing activities 35,400,000 948,000
Net increase (decrease) in cash and cash equivalents 4,208,000 (18,832,000)
Cash and cash equivalents at beginning of year 10,264,000 29,096,000
Cash and equivalents at end of year 14,472,000 10,264,000
Supplemental Disclosure of Non-Cash Investing and Financing Information:    
Deemed dividend for convertible preferred stock beneficial conversion feature 3,951,000  
Unrealized (Gain) Loss on investments 1,000 $ (2,000)
S-3    
Financing Activities    
Proceeds from issuance of common stock, net of issuance costs $ 9,684,000