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Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017	Jan. 01, 2018	Dec. 31, 2017
Summary Of Significant Accounting Policies [Line Items]
Cumulative adjustment to accumulated deficit	$ 178,329			$ 173,494
Decrease in cash flows from financing activities as compared to previously reported amounts	$ (111,224)	$ 4,970
ASU 2014-09 | ISU Abxis | Difference between Revenue Guidance in Effect before and after Topic 606
Summary Of Significant Accounting Policies [Line Items]
Cumulative adjustment to accumulated deficit			$ 200
ASU 2016-18
Summary Of Significant Accounting Policies [Line Items]
Decrease in cash flows from financing activities as compared to previously reported amounts		$ 6,800

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Summary of significant accounting policies.

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Amount of cash inflow (outflow) of financing activities, excluding discontinued operations. Financing activity cash flows include obtaining resources from owners and providing them with a return on, and a return of, their investment; borrowing money and repaying amounts borrowed, or settling the obligation; and obtaining and paying for other resources obtained from creditors on long-term credit.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 26
-URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3574-108585

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The cumulative amount of the reporting entity's undistributed earnings or deficit.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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