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Fair Values of Stock Options Estimated Using Black-Scholes Valuation Model (Detail) - Employee Stock Option - $ / shares
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Black Scholes Method Used [Line Items]    
Risk-free interest rate 2.40% 1.57%
Expected term (in years) 6 years 3 days 6 years 14 days
Dividend yield 0.00% 0.00%
Volatility 109.32% 73.28%
Weighted-average fair value of stock options granted $ 12.34 $ 21.15