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Collaborations - Additional Information (Detail) - USD ($) $ in Thousands		3 Months Ended
	Sep. 16, 2013	Mar. 31, 2018	Mar. 31, 2017	Jan. 01, 2018	Dec. 31, 2017
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Contract revenue		$ 6	$ 271
Cumulative adjustment to accumulated deficit		178,329			$ 173,494
ISU Abxis
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Contract revenue		0	300
Deferred revenue		0			$ 200
Milestone Payment Received		$ 0	$ 200
ISU Abxis | Difference between Revenue Guidance in Effect before and after Topic 606 | ASU 2014-09
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Cumulative adjustment to accumulated deficit				$ 200
ISU Abxis | Maximum
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Potential milestone payments	$ 2,000
ISU Abxis | Up Front Payment
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Amount received for research and development process	$ 1,750

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Amount of revenue earned from products sold or services provided under the terms of a contract, including, but not limited to, government contracts and construction contracts, classified as other.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 605
-SubTopic 10
-Section S99
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-Section 45
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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187085-122770

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