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Summary of Option Activity Under Company's Equity Incentive Plans (Detail) - $ / shares	9 Months Ended	12 Months Ended
	Sep. 30, 2018	Dec. 31, 2017
Number of Shares Underlying Outstanding Options
Number of Shares Underlying Outstanding Options, Beginning Balance	821,741
Number of Shares Underlying Outstanding Options, Options granted	564,050
Number of Shares Underlying Outstanding Options, Options exercised	(7,707)
Number of Shares Underlying Outstanding Options, Options expired	(15,667)
Number of Shares Underlying Outstanding Options, Options canceled/forfeited	(43,315)
Number of Shares Underlying Outstanding Options, Ending Balance	1,319,102	821,741
Number of Shares Underlying Outstanding Options, Exercisable - June 30, 2018	344,273
Weighted- Average Exercise Price
Weighted- Average Exercise Price, Beginning Balance	$ 13.69
Weighted- Average Exercise Price, Options granted	13.43
Weighted- Average Exercise Price, Options exercised	4.63
Weighted- Average Exercise Price, Options expired	158.94
Weighted- Average Exercise Price, Options Canceled/forfeited	7.76
Weighted- Average Exercise Price, Ending Balance	12.10	$ 13.69
Weighted- Average Exercise Price, Exercisable - June 30, 2018	$ 19.48
Weighted-Average Remaining Contractual Term (Years)
Weighted-Average Remaining Contractual Term (Years), Outstanding Balance	8 years 11 months 1 day	9 years 2 months 1 day
Weighted-Average Remaining Contractual Term (Years), Exercisable - June 30, 2018	8 years 21 days

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Gross number of share options (or share units) granted during the period.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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