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Stock Based Compensation (Tables)

9 Months Ended

Sep. 30, 2018

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Summary of Option Activity Under Company's Equity Incentive Plans

The following table summarizes stock option activity under the Company’s equity incentive plans and related information: 

		Number of Shares Underlying Outstanding Options				Weighted- Average Exercise Price				Weighted-Average Remaining Contractual Term (Years)
Outstanding — December 31, 2017			821,741			$	13.69				9.17
Options granted			564,050			$	13.43
Options exercised			(7,707	)		$	4.63
Options expired			(15,667	)		$	158.94
Options canceled/forfeited			(43,315	)		$	7.76
Outstanding — September 30, 2018			1,319,102			$	12.10				8.92
Exercisable — September 30, 2018			344,273			$	19.48				8.06

Summary of Weighted Average Valuation Assumptions Used to Estimate Fair Value of Employee Stock Options

The fair value of employee stock options was estimated using the following weighted-average assumptions for the nine months ended September 30, 2018 and 2017:

		Nine Months Ended September 30,
		2018				2017
Employee Stock Options:
Risk-free interest rate			2.66	%			2.02	%
Expected term (in years)			5.97				5.99
Dividend yield			—				—
Volatility			93.60	%			110.42	%
Weighted-average fair value of stock options granted		$	10.28			$	3.79

Summary of Stock-Based Compensation Recognized

Total stock-based compensation recognized was as follows (in thousands):

		Three Months Ended September 30,								Nine Months Ended September 30,
		2018				2017				2018				2017
Research and development		$	161			$	62			$	413			$	97
General and administrative(1)			541				263				1,445				459
Total stock-based compensation		$	702			$	325			$	1,858			$	556

(1) 2018 includes $0.1 million in modification stock-based compensation expense related to a Board member’s departure.

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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