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Related Parties - Additional Information (Detail) - USD ($)
$ in Millions
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Mosaic | Strategic Research Collaboration to Develop Intravitreal Anti-Complement Factor 3 (C3) Products        
Related Party Transaction [Line Items]        
Expenses related to collaboration $ 0.5 $ 0.0 $ 0.9 $ 0.0