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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Convertible Preferred Stock | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2016 | $ 16,071 |  | $ 1 | $ 164,053 | $ (1) | $ (147,982)
Balance (in shares) at Dec. 31, 2016 |  |  | 801,756 |  |  |
Stock-based compensation expense | 863 |  |  | 863 |  |
Issuance of common stock, net of issuance costs | 5,336 |  |  | 5,336 |  |
Issuance of common stock, net of issuance costs, shares |  |  | 439,880 |  |  |
Issuance of convertible preferred stock, common stock and warrants for follow-on offering, net of issuance costs | 18,563 |  | $ 2 | 18,561 |  |
Issuance of convertible preferred stock, common stock and warrants for follow-on offering, net of issuance costs, shares |  | 13,350 | 1,470,000 |  |  |
Issuance of common stock for follow-on offering, net of issuance costs | 9,684 |  | $ 1 | 9,683 |  |
Issuance of common stock for follow-on offering, net of issuance costs, shares |  |  | 1,105,263 |  |  |
Issuance of common stock upon exercise of warrants | 1,817 |  |  | 1,817 |  |
Issuance of common stock upon exercise of warrants, shares |  |  | 330,331 |  |  |
Conversion of preferred stock to common stock |  |  | $ 2 | (2) |  |
Conversion of preferred stock to common stock, shares |  | (9,670) | 1,934,000 |  |  |
Deemed dividend for preferred stock beneficial conversion feature |  |  |  | 3,951 |  | (3,951)
Deemed dividend for preferred stock beneficial conversion feature, shares |  |  | 0 |  |  |
Unrealized gain (loss) on available-for-sale securities | 1 |  |  |  | 1 |
Net loss | (21,561) |  |  |  |  | (21,561)
Balance at Dec. 31, 2017 | 30,774 |  | $ 6 | 204,262 |  | (173,494)
Balance (in shares) at Dec. 31, 2017 |  | 3,680 | 6,081,230 |  |  |
Opening balance adjustment - adoption of ASC 606 at Dec. 31, 2017 | 207 |  |  |  |  | 207
Balance at Dec. 31, 2017 | 30,981 |  | $ 6 | 204,262 |  | (173,287)
Stock-based compensation expense | 2,606 |  |  | 2,606 |  |
Issuance of common stock for follow-on offering, net of issuance costs | 106,762 |  | $ 4 | 106,758 |  |
Issuance of common stock for follow-on offering, net of issuance costs, shares |  |  | 3,382,352 |  |  |
Issuance of common stock upon exercise of warrants | 9,545 |  | $ 2 | 9,543 |  |
Issuance of common stock upon exercise of warrants, shares |  |  | 1,735,419 |  |  |
Conversion of preferred stock to common stock, shares |  | (3,680) | 736,000 |  |  |
Issuance of common stock from stock grants and exercise of stock options | 107 |  |  | 107 |  |
Issuance of common stock from stock grants and exercise of stock options, shares |  |  | 19,506 |  |  |
Conversion of redeemable convertible notes to common stock, value | 3 |  |  | 3 |  |
Conversion of redeemable convertible notes to common stock, shares |  |  | 21 |  |  |
Unrealized gain (loss) on available-for-sale securities | (4) |  |  |  | (4) |
Net loss | (30,055) |  |  |  |  | (30,055)
Balance at Dec. 31, 2018 | $ 119,945 |  | $ 12 | $ 323,279 | $ (4) | $ (203,342)
Balance (in shares) at Dec. 31, 2018 |  |  | 11,954,528 |  |  |

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