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Collaborations - Additional Information (Detail) - USD ($) |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Sep. 16, 2013 | Dec. 31, 2018 | Feb. 28, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Jan. 01, 2018 | Dec. 08, 2016
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |
Contract revenue |  |  |  | $ 6,000 | $ 1,018,000 |  |
Milestone payment received |  |  |  | 1,500,000 |  |  |
Cumulative adjustment to accumulated deficit |  | $ (203,342,000) |  | (203,342,000) | (173,494,000) |  |
Pfizer Inc | Collaboration Agreement |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |
Milestone payment |  |  | $ 1,000,000 |  |  |  |
Pfizer Inc | Collaboration Agreement | Maximum |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |
Contingent cash payments upon achievement of clinical, regulatory and commercial milestones |  |  |  |  |  |  | $ 17,500,000
ISU Abxis |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |
Contract revenue |  |  |  | 0 | 300,000 |  |
Milestone payment received |  |  |  | 0 | 900,000 |  |
Deferred revenue |  | 0 |  | $ 0 | $ 200,000 |  |
ISU Abxis | Up Front Payment |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |
Amount received for research and development process | $ 1,750,000 |  |  |  |  |  |
ISU Abxis | Difference between Revenue Guidance in Effect before and after Topic 606 | ASU 2014-09 |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |
Cumulative adjustment to accumulated deficit |  |  |  |  |  | $ 200,000 |
ISU Abxis | Amended and Restated License Agreement |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |
Regulatory and development milestone payment |  | 2,500,000 |  |  |  |  |
ISU Abxis | Amended and Restated License Agreement | Maximum |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |
Milestone payment |  | 19,500,000 |  |  |  |  |
Commercial milestone payments |  | $ 17,000,000 |  |  |  |  |

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