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Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2018
Equity [Abstract] |
Summary of Warrant Activity | The following is a summary of warrant activity for the year ended December 31, 2018 and 2017:
|  | Number of Shares |  |  |  |  |
|  | Underlying Warrants |  |  | Exercise Price |
Outstanding — December 31, 2016 |  |  | 12,039 |  |  | $ | 145.11 |
Issued |  |  | 2,070,000 |  |  | $ | 5.50 |
Exercised |  |  | (330,331 | ) |  | $ | 5.50 |
Outstanding — December 31, 2017 |  |  | 1,751,708 |  |  |  |  |
Issued |  |  | — |  |  |  |  |
Exercised |  |  | (1,735,419 | ) |  | $ | 5.50 |
Forfeited/Cancelled (1) |  |  | (6,095 | ) |  | $ | 5.50 |
Outstanding — December 31, 2018 |  |  | 10,194 |  |  | $ | 155.73 |
(1) | In April 2018, 4,250 warrants were forfeited. In November 2018, 1,845 warrants were cancelled by Healthcare Ventures VIII.

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- Definition Tabular disclosure of warrants or rights issued. Warrants and rights outstanding are derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. The main difference between warrants and call options is that warrants are issued and guaranteed by the company, whereas options are exchange instruments and are not issued by the company. Also, the lifetime of a warrant is often measured in years, while the lifetime of a typical option is measured in months. Disclose the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(i)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section S99 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6784392&loc=d3e188667-122775 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=68057994&loc=d3e25284-112666 + Details
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