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Commitments and Contingencies - Additional Information (Detail)
1 Months Ended 12 Months Ended
Dec. 31, 2018
USD ($)
Feb. 28, 2018
USD ($)
Nov. 30, 2017
ft²
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2013
USD ($)
Aug. 10, 2018
ft²
Dec. 08, 2016
USD ($)
May 20, 2016
USD ($)
Commitments And Contingencies Disclosure [Line Items]                  
Operating lease rent expense       $ 400,000 $ 800,000        
License fees payable           $ 100,000      
South San Francisco, California | New Office Lease Agreement                  
Commitments And Contingencies Disclosure [Line Items]                  
Leased area | ft²     8,606            
Operating lease term of contract     5 years 2 months            
Operating lease commencement date     Feb. 16, 2018            
South San Francisco, California | Office Lease Agreement                  
Commitments And Contingencies Disclosure [Line Items]                  
Leased area | ft²             4,626    
Pfizer Inc | Collaboration Agreement                  
Commitments And Contingencies Disclosure [Line Items]                  
Milestone payment   $ 1,000,000              
Pfizer Inc | Collaboration Agreement | Maximum                  
Commitments And Contingencies Disclosure [Line Items]                  
Obligated to make milestone and royalty payments upon achievement of clinical, regulatory and commercial milestones               $ 17,500,000  
AGC Biologics, Inc | Dalcinonacog alfa (“DalcA”)                  
Commitments And Contingencies Disclosure [Line Items]                  
Contractual obligation payments $ 3,400,000     3,400,000         $ 5,600,000
AGC Biologics, Inc | MarzAA                  
Commitments And Contingencies Disclosure [Line Items]                  
Contractual obligation payments 300,000     300,000         $ 3,800,000
ISU Abxis | Maximum                  
Commitments And Contingencies Disclosure [Line Items]                  
Potential milestone payments       $ 2,000,000          
ISU Abxis | Amended and Restated License Agreement                  
Commitments And Contingencies Disclosure [Line Items]                  
Regulatory and development milestone payment 2,500,000                
ISU Abxis | Amended and Restated License Agreement | Maximum                  
Commitments And Contingencies Disclosure [Line Items]                  
Milestone payment 19,500,000                
Commercial milestone payments $ 17,000,000