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Summary of Option Activity Under Company's Equity Incentive Plans (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Number of Shares Underlying Outstanding Options
Number of Shares Underlying Outstanding Options, Beginning Balance	821,741	140,990
Number of Shares Underlying Outstanding Options, Options granted	612,050	742,000
Number of Shares Underlying Outstanding Options, Options exercised	(12,716)
Number of Shares Underlying Outstanding Options, Options canceled/forfeited	(43,315)	(61,249)
Number of Shares Underlying Outstanding Options, Options expired	(15,783)
Number of Shares Underlying Outstanding Options, Ending Balance	1,361,977	821,741	140,990
Number of Shares Underlying Outstanding Options, Exercisable- December 31, 2018	414,584
Number of Shares Underlying Outstanding Options, Vested and expected to vest - December 31, 2018	1,361,977
Shares available to be granted - December 31, 2018	1,295,144
Weighted- Average Exercise Price
Weighted- Average Exercise Price, Beginning Balance	$ 13.69	$ 128.25
Weighted- Average Exercise Price, Options granted	13.13	4.56
Weighted- Average Exercise Price, Options exercised	4.17
Weighted- Average Exercise Price, Options Canceled/forfeited	7.76	165.63
Weighted- Average Exercise Price, Options expired	158.81
Weighted- Average Exercise Price, Ending Balance	12.04	$ 13.69	$ 128.25
Weighted- Average Exercise Price, Exercisable - December 31, 2018	17.98
Weighted- Average Exercise Price, Vested and expected to vest - December 31, 2018	$ 12.04
Weighted-Average Remaining Contractual Term (Years)
Weighted-Average Remaining Contractual Term (Years), Outstanding Balance	8 years 8 months 15 days	9 years 2 months 1 day	3 years 11 months 4 days
Aggregate Intrinsic Value
Aggregate Intrinsic Value, Outstanding	$ 6,376
Aggregate Intrinsic Value, Options exercised	213
Aggregate Intrinsic Value, Outstanding	$ 2,294	$ 6,376

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares.

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Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Gross number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Number of fully vested and expected to vest exercisable options that may be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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