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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Convertible Preferred Stock
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Balance at Dec. 31, 2016 $ 16,071   $ 1 $ 164,053 $ (1) $ (147,982)
Balance (in shares) at Dec. 31, 2016     801,756      
Stock-based compensation expense 863     863    
Issuance of common stock, net of issuance costs 5,336     5,336    
Issuance of common stock, net of issuance costs, shares     439,880      
Issuance of convertible preferred stock, common stock and warrants for follow-on offering, net of issuance costs 18,563   $ 2 18,561    
Issuance of convertible preferred stock, common stock and warrants for follow-on offering, net of issuance costs, shares   13,350 1,470,000      
Issuance of common stock for follow-on offering, net of issuance costs 9,684   $ 1 9,683    
Issuance of common stock for follow-on offering, net of issuance costs, shares     1,105,263      
Issuance of common stock upon exercise of warrants 1,817     1,817    
Issuance of common stock upon exercise of warrants, shares     330,331      
Conversion of preferred stock to common stock     $ 2 (2)    
Conversion of preferred stock to common stock, shares   (9,670) 1,934,000      
Deemed dividend for preferred stock beneficial conversion feature       3,951   (3,951)
Deemed dividend for preferred stock beneficial conversion feature, shares     0      
Unrealized gain (loss) on available-for-sale securities 1       1  
Net loss (21,561)         (21,561)
Balance at Dec. 31, 2017 30,774   $ 6 204,262   (173,494)
Balance (in shares) at Dec. 31, 2017   3,680 6,081,230      
Opening balance adjustment - adoption of ASC 606 at Dec. 31, 2017 207         207
Balance at Dec. 31, 2017 30,981   $ 6 204,262   (173,287)
Stock-based compensation expense 2,606     2,606    
Issuance of common stock for follow-on offering, net of issuance costs 106,762   $ 4 106,758    
Issuance of common stock for follow-on offering, net of issuance costs, shares     3,382,352      
Issuance of common stock upon exercise of warrants 9,545   $ 2 9,543    
Issuance of common stock upon exercise of warrants, shares     1,735,419      
Conversion of preferred stock to common stock, shares   (3,680) 736,000      
Issuance of common stock from stock grants and exercise of stock options 107     107    
Issuance of common stock from stock grants and exercise of stock options, shares     19,506      
Conversion of redeemable convertible notes to common stock, value 3     3    
Conversion of redeemable convertible notes to common stock, shares     21      
Unrealized gain (loss) on available-for-sale securities (4)       (4)  
Net loss (30,055)         (30,055)
Balance at Dec. 31, 2018 $ 119,945   $ 12 $ 323,279 $ (4) $ (203,342)
Balance (in shares) at Dec. 31, 2018     11,954,528