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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Operating Activities    
Net loss $ (30,055) $ (21,561)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 2,606 863
Depreciation and amortization 149 173
Loss on disposal of property and equipment 116 18
Changes in operating assets and liabilities:    
Prepaid and other current assets (2,895) (351)
Accounts receivable   7
Deposits   (128)
Accounts payable 500 (90)
Accrued compensation and other accrued liabilities 850 1,287
Deferred revenue (6) (118)
Deferred rent 182 (40)
Net cash flows used in operating activities (28,553) (19,940)
Investing Activities    
Proceeds from maturities of short-term investments 127,967 14,300
Purchase of short-term investments (198,912) (25,472)
Purchases of property and equipment (376) (23)
Net cash flows used in investing activities (71,321) (11,195)
Financing Activities    
Payments for the redemption of redeemable convertible notes (5,082) (14,318)
Proceeds from issuance of common stock, net of issuance costs   5,336
Proceeds from issuance of preferred stock, common stock and warrants for follow-on offering, net of issuance costs   18,563
Proceeds from exercise of stock options and issuance of stock grants 107  
Proceeds from exercise of warrants 9,545 1,817
Net cash flows provided by financing activities 111,332 21,082
Net increase (decrease) in cash and cash equivalents 11,458 (10,053)
Cash, cash equivalents and restricted cash at beginning of the period 19,805 [1] 29,858
Cash, cash equivalents and restricted cash at end of the period [1] 31,263 19,805
Supplemental Disclosure of Non-Cash Investing and Financing Activities:    
Deemed dividend for convertible preferred stock beneficial conversion feature   3,951
Adoption of ASC 606 207  
Conversion of redeemable convertible notes to common stock 3  
Unrealized loss/gain on investments 4 1
Follow-on Offering    
Financing Activities    
Proceeds from issuance of common stock, net of issuance costs $ 106,762 $ 9,684
[1] The following table provides a reconciliation of cash and restricted cash to amounts reported within the condensed consolidated balance sheets: