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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Operating Activities    
Net loss $ (15,083) $ (5,042)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 829 606
Depreciation and amortization 45 33
Loss on disposal of property and equipment   116
Changes in operating assets and liabilities:    
Prepaid and other current assets 96 (407)
Accounts payable (966) 690
Accrued compensation and other accrued liabilities 100 (1,225)
Change in operating lease liability and right-of-use asset 21  
Deferred rent   128
Deferred revenue   (6)
Net cash flows used in operating activities (14,958) (5,107)
Investing Activities    
Proceeds from maturities of short-term investments 48,274 13,937
Purchase of investments (39,596) (12,936)
Purchases of property and equipment (15) (198)
Net cash flows provided by investing activities 8,663 803
Financing Activities    
Payments for the redemption of redeemable convertible notes   (5,082)
Issuance of common stock for secondary public offering, net of issuance costs   106,761
Issuance of common stock from stock grants and option exercises 106  
Proceeds from exercise of warrants   9,545
Net cash flow provided by financing activities 106 111,224
Net increase (decrease) in cash, cash equivalents and restricted cash (6,189) 106,920
Cash, cash equivalents and restricted cash at beginning of the period 31,263 19,805
Cash, cash equivalents and restricted cash at end of the period [1] 25,074 126,725
Supplemental Disclosure of Non-Cash Investing and Financing Activities:    
Adoption of ASC 606   207
Conversion of redeemable convertible notes to common stock   3
Unrealized gain on investments 17 $ 4
Right-of-use asset and operating lease liability recorded upon the adoption of ASC 842, net $ 2,052  
[1] The following table provides a reconciliation of cash and restricted cash to amounts reported within the condensed consolidated balance sheets: