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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Convertible Preferred Stock | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2017 | $ 30,774 |  | $ 6 | $ 204,262 |  | $ (173,494)
Balance (in shares) at Dec. 31, 2017 |  | 3,680 | 6,081,230 |  |  |
Opening balance adjustment - adoption of ASC 606 at Dec. 31, 2017 | 207 |  |  |  |  | 207
Balance at Dec. 31, 2017 | 30,981 |  | $ 6 | 204,262 |  | (173,287)
Stock-based compensation expense | 2,606 |  | 6,790 | 2,606 |  |
Issuance of common stock for follow-on offering, net of issuance costs | 106,762 |  | $ 4 | 106,758 |  |
Issuance of common stock for follow-on offering, net of issuance costs, shares |  |  | 3,382,352 |  |  |
Issuance of common stock upon exercise of warrants | 9,545 |  | $ 2 | 9,543 |  |
Issuance of common stock upon exercise of warrants, shares |  |  | 1,735,419 |  |  |
Conversion of preferred stock to common stock, shares |  | (3,680) | 736,000 |  |  |
Issuance of common stock from stock grants and option exercises | 107 |  |  | 107 |  |
Issuance of common stock from stock grants and option exercises |  |  | 12,716 |  |  |
Conversion of redeemable convertible notes to common stock | 3 |  |  | 3 |  |
Conversion of redeemable convertible notes to common stock, shares |  |  | 21 |  |  |
Unrealized gain (loss) on available-for-sale debt securities | (4) |  |  |  | $ (4) |
Net loss | (30,055) |  |  |  |  | (30,055)
Balance at Dec. 31, 2018 | 119,945 |  | $ 12 | 323,279 | (4) | (203,342)
Balance (in shares) at Dec. 31, 2018 |  |  | 11,954,528 |  |  |
Stock-based compensation expense | 3,204 |  | $ 24,235 | 3,204 |  |
Issuance of common stock from stock grants and option exercises | 327 |  |  | 327 |  |
Issuance of common stock from stock grants and option exercises |  |  | 62,072 |  |  |
Unrealized gain (loss) on available-for-sale debt securities | 38 |  |  |  | 38 |
Net loss | (55,178) |  |  |  |  | (55,178)
Balance at Dec. 31, 2019 | $ 68,336 |  | $ 12 | $ 326,810 | $ 34 | $ (258,520)
Balance (in shares) at Dec. 31, 2019 |  |  | 12,040,835 |  |  |

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