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Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2019 | $ 68,336 | $ 12 | $ 326,810 | $ 34 | $ (258,520)
Balance (in shares) at Dec. 31, 2019 |  | 12,040,835 |  |  |
Stock-based compensation expense | 805 |  | 805 |  |
Stock-based compensation expense |  | 7,817 |  |  |
Issuance of common stock from stock grants and option exercises | 339 |  | 339 |  |
Issuance of common stock from stock grants and option exercises, shares |  | 62,969 |  |  |
Issuance of common stock for public offering, net of issuance costs | 31,986 | $ 5 | 31,981 |  |
Issuance of common stock for public offering, net of issuance costs, shares |  | 5,307,692 |  |  |
Unrealized (loss) gain on available-for-sale debt securities | 106 |  |  | 106 |
Net loss | (4,053) |  |  |  | (4,053)
Balance at Mar. 31, 2020 | 97,519 | $ 17 | 359,935 | 140 | (262,573)
Balance (in shares) at Mar. 31, 2020 |  | 17,419,313 |  |  |
Balance at Dec. 31, 2019 | 68,336 | $ 12 | 326,810 | 34 | (258,520)
Balance (in shares) at Dec. 31, 2019 |  | 12,040,835 |  |  |
Unrealized (loss) gain on available-for-sale debt securities | 7 |  |  |  |
Net loss | (21,301) |  |  |  |
Balance at Jun. 30, 2020 | 108,961 | $ 22 | 388,719 | 41 | (279,821)
Balance (in shares) at Jun. 30, 2020 |  | 22,050,745 |  |  |
Balance at Mar. 31, 2020 | 97,519 | $ 17 | 359,935 | 140 | (262,573)
Balance (in shares) at Mar. 31, 2020 |  | 17,419,313 |  |  |
Stock-based compensation expense | 834 |  | 834 |  |
Stock-based compensation expense |  | 16,048 |  |  |
Issuance of common stock for public offering, net of issuance costs | 27,955 | $ 5 | 27,950 |  |
Issuance of common stock for public offering, net of issuance costs, shares |  | 4,615,384 |  |  |
Unrealized (loss) gain on available-for-sale debt securities | (99) |  |  | (99) |
Net loss | (17,248) |  |  |  | (17,248)
Balance at Jun. 30, 2020 | 108,961 | $ 22 | 388,719 | 41 | (279,821)
Balance (in shares) at Jun. 30, 2020 |  | 22,050,745 |  |  |
Balance at Dec. 31, 2020 | 76,069 | $ 22 | 390,803 | 5 | (314,761)
Balance (in shares) at Dec. 31, 2020 |  | 22,097,820 |  |  |
Stock-based compensation expense | 1,026 |  | 1,026 |  |
Stock-based compensation expense |  | 10,149 |  |  |
Issuance of common stock from stock grants and option exercises | 182 |  | 182 |  |
Issuance of common stock from stock grants and option exercises, shares |  | 38,058 |  |  |
Issuance of common stock for public offering, net of issuance costs | 49,250 | $ 9 | 49,241 |  |
Issuance of common stock for public offering, net of issuance costs, shares |  | 9,185,000 |  |  |
Net loss | (22,438) |  |  |  | (22,438)
Balance at Mar. 31, 2021 | 104,089 | $ 31 | 441,252 | 5 | (337,199)
Balance (in shares) at Mar. 31, 2021 |  | 31,331,027 |  |  |
Balance at Dec. 31, 2020 | 76,069 | $ 22 | 390,803 | 5 | (314,761)
Balance (in shares) at Dec. 31, 2020 |  | 22,097,820 |  |  |
Unrealized (loss) gain on available-for-sale debt securities | (3) |  |  |  |
Net loss | (42,366) |  |  |  |
Balance at Jun. 30, 2021 | 85,164 | $ 31 | 442,258 | 2 | (357,127)
Balance (in shares) at Jun. 30, 2021 |  | 31,349,740 |  |  |
Balance at Mar. 31, 2021 | 104,089 | $ 31 | 441,252 | 5 | (337,199)
Balance (in shares) at Mar. 31, 2021 |  | 31,331,027 |  |  |
Stock-based compensation expense | 983 |  | 983 |  |
Stock-based compensation expense |  | 13,713 |  |  |
Issuance of common stock from stock grants and option exercises | 23 |  | 23 |  |
Issuance of common stock from stock grants and option exercises, shares |  | 5,000 |  |  |
Unrealized (loss) gain on available-for-sale debt securities | (3) |  |  | (3) |
Net loss | (19,928) |  |  |  | (19,928)
Balance at Jun. 30, 2021 | $ 85,164 | $ 31 | $ 442,258 | $ 2 | $ (357,127)
Balance (in shares) at Jun. 30, 2021 |  | 31,349,740 |  |  |

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