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Collaborations - Additional Information (Detail) - USD ($) | 1 Months Ended | 3 Months Ended | 6 Months Ended
--- | --- | --- | ---
Jan. 31, 2020 | Dec. 31, 2018 | Jun. 30, 2021 | Jun. 30, 2020 | Jun. 30, 2021 | Jun. 30, 2020
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
License and collaboration revenue |  |  | $ 1,132,000 | $ 1,658,000 | $ 2,599,000 | $ 18,024,000
Deferred revenue, recognized |  |  |  |  | 1,300 |
License |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
License and collaboration revenue |  |  |  | 23,000 |  | 15,068,000
License | Transfer of Exclusive License and Related Know-How |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
License and collaboration revenue |  |  |  |  |  | 15,000,000.0
Exclusive License |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
License and collaboration revenue |  |  |  |  |  | 100,000
Collaboration |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
License and collaboration revenue |  |  | 1,132,000 | 1,635,000 | 2,599,000 | 2,956,000
Collaboration | Reimbursable Out-of-Pocket and Personnel Costs Incurred Related to Research Services |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
License and collaboration revenue |  |  | $ 1,100,000 | $ 1,600,000 | 2,600,000 | $ 3,000,000.0
ISU Abxis | Amended and Restated License Agreement |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Regulatory and development milestone payment |  | $ 2,500,000 |  |  | 0 |
ISU Abxis | Amended and Restated License Agreement | Maximum |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Milestone payment |  | 19,500,000 |  |  | 0 |
Commercial milestone payments |  | $ 17,000,000.0 |  |  | 0 |
Biogen |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
License and collaboration revenue |  |  |  |  | $ 0 |
Biogen | License and Collaboration Agreement (the “Biogen Agreement”) |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Research services |  |  |  |  | 30 months |
Research services option to extend |  |  |  |  | 12 months |
Biogen | Exclusive License |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Up-front payments received | $ 15,000,000.0 |  |  |  |  |
Biogen | Exclusive License | Maximum |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Development and sales milestone payments | $ 340,000,000.0 |  |  |  |  |

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