    <SEC-DOCUMENT>0001193125-21-020775-index.html : 20210128
    <SEC-HEADER>0001193125-21-020775.hdr.sgml : 20210128
    <ACCEPTANCE-DATETIME>20210128161131
    ACCESSION NUMBER:		0001193125-21-020775
    CONFORMED SUBMISSION TYPE:	424B5
    PUBLIC DOCUMENT COUNT:		7
    FILED AS OF DATE:		20210128
    DATE AS OF CHANGE:		20210128

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			CATALYST BIOSCIENCES, INC.
    		CENTRAL INDEX KEY:			0001124105
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				562020050
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B5
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-228970
    		FILM NUMBER:		21565074

    	BUSINESS ADDRESS:
    		STREET 1:		611 GATEWAY BLVD., SUITE 710
    		CITY:			SOUTH SAN FRANCISCO
    		STATE:			CA
    		ZIP:			94080
    		BUSINESS PHONE:		650-871-0761

    	MAIL ADDRESS:
    		STREET 1:		611 GATEWAY BLVD., SUITE 710
    		CITY:			SOUTH SAN FRANCISCO
    		STATE:			CA
    		ZIP:			94080

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	TARGACEPT INC
    		DATE OF NAME CHANGE:	20000919
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B5
    <SEQUENCE>1
    <FILENAME>d260304d424b5.htm
    <DESCRIPTION>424B5
    <TEXT>
    Document 1 - file: d260304d424b5.htm

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    <SEQUENCE>2
    <FILENAME>g260304g00a00.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: g260304g00a00.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>g260304g10g27.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: g260304g10g27.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>g260304g29d49.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: g260304g29d49.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>g260304g47o32.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: g260304g47o32.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>g260304g96y01.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: g260304g96y01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>g260304g99a99.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: g260304g99a99.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>