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Collaborations - Additional Information (Detail) - USD ($) $ in Thousands |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
Dec. 18, 2019 | Jan. 31, 2020 | Dec. 31, 2018 | Dec. 31, 2021 | Dec. 31, 2020
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
License and collaboration revenue |  |  |  | $ 7,338 | $ 20,948
Deferred revenue, recognized |  |  |  | 2,000 |
License |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
License and collaboration revenue |  |  |  |  | 15,100
License | Transfer of Exclusive License and Related Know-How |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
License and collaboration revenue |  |  |  |  | 15,000
Exclusive License |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
License and collaboration revenue |  |  |  |  | 100
Collaboration |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
License and collaboration revenue |  |  |  | 7,338 | 5,848
Collaboration | Reimbursable Out-of-Pocket and Personnel Costs Incurred Related to Research Services |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
License and collaboration revenue |  |  |  | 7,300 | $ 5,800
ISU Abxis | Amended and Restated License Agreement |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
Regulatory and development milestone payment |  |  | $ 2,500 | 0 |
ISU Abxis | Amended and Restated License Agreement | Maximum |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
Milestone payment |  |  | 19,500 | 0 |
Commercial milestone payments |  |  | $ 17,000 | 0 |
Biogen |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
License and collaboration revenue |  |  |  | $ 0 |
Biogen | License and Collaboration Agreement (the “Biogen Agreement”) |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
Research services | 30 months |  |  |  |
Research services option to extend | 12 months |  |  |  |
Biogen | Exclusive License |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
Up-front payments received |  | $ 15,000 |  |  |
Biogen | Exclusive License | Maximum |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |
Development and sales milestone payments |  | $ 340,000 |  |  |

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