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Summary of Option Activity Under Company's Equity Incentive Plans (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Number of Shares Underlying Outstanding Options
Number of Shares Underlying Outstanding Options, Beginning Balance	2,355,615	1,577,541
Number of Shares Underlying Outstanding Options, Options granted	1,493,238	1,091,250
Number of Shares Underlying Outstanding Options, Options exercised	(5,000)	(44,605)
Number of Shares Underlying Outstanding Options, Options forfeited	(1,239,630)	(250,641)
Number of Shares Underlying Outstanding Options, Options expired	(593)	(17,930)
Number of Shares Underlying Outstanding Options, Ending Balance	2,603,630	2,355,615	1,577,541
Number of Shares Underlying Outstanding Options, Exercisable- December 31, 2020	1,513,039
Shares available to be granted - December 31, 2020	3,333,791
Weighted- Average Exercise Price
Weighted- Average Exercise Price, Beginning Balance	$ 8.59	$ 10.85
Weighted- Average Exercise Price, Options granted	5.31	6.26
Weighted- Average Exercise Price, Options exercised	4.63	5.04
Weighted- Average Exercise Price, Options forfeited	6.26	10.32
Weighted- Average Exercise Price, Options expired	566.33	51.12
Weighted- Average Exercise Price, Ending Balance	7.70	$ 8.59	$ 10.85
Weighted- Average Exercise Price, Exercisable - December 31, 2020	$ 9.37
Weighted-Average Remaining Contractual Term (Years)
Weighted-Average Remaining Contractual Term (Years), Outstanding Balance	7 years 5 months 15 days	7 years 11 months 15 days	8 years 1 month 24 days
Weighted Average Remaining Contractual Term, Exercisable - December 31, 2020	6 years 4 months 6 days
Aggregate Intrinsic Value
Aggregate Intrinsic Value, Outstanding		$ 1,337	$ 1,350

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Gross number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options of the plan that expired.

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