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Collaborations - Additional Information (Detail) - USD ($) $ in Thousands		1 Months Ended		12 Months Ended
	Dec. 18, 2019	Jan. 31, 2020	Dec. 31, 2018	Dec. 31, 2021	Dec. 31, 2020
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
License and collaboration revenue				$ 7,338	$ 20,948
Deferred revenue, recognized				2,000
License
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
License and collaboration revenue					15,100
License | Transfer of Exclusive License and Related Know-How
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
License and collaboration revenue					15,000
Exclusive License
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
License and collaboration revenue					100
Collaboration
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
License and collaboration revenue				7,338	5,848
Collaboration | Reimbursable Out-of-Pocket and Personnel Costs Incurred Related to Research Services
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
License and collaboration revenue				7,300	$ 5,800
ISU Abxis | Amended and Restated License Agreement
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Regulatory and development milestone payment			$ 2,500	0
ISU Abxis | Amended and Restated License Agreement | Maximum
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Milestone payment			19,500	0
Commercial milestone payments			$ 17,000	0
Biogen
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
License and collaboration revenue				$ 0
Biogen | License and Collaboration Agreement (the “Biogen Agreement”)
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Research services	30 months
Research services option to extend	12 months
Biogen | Exclusive License
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Up-front payments received		$ 15,000
Biogen | Exclusive License | Maximum
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Development and sales milestone payments		$ 340,000

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