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Collaborations - Additional Information (Detail) - USD ($)
1 Months Ended 3 Months Ended
May 08, 2020
Jan. 31, 2020
Dec. 31, 2018
Mar. 31, 2022
Mar. 31, 2021
Revenue Recognition Multiple Deliverable Arrangements [Line Items]          
License and collaboration revenue       $ 794,000 $ 1,467,000
Research and development       9,703,000 17,013,000
Deferred revenue, recognized       200,000  
Collaboration          
Revenue Recognition Multiple Deliverable Arrangements [Line Items]          
License and collaboration revenue       794,000 1,467,000
Collaboration | Reimbursable Out-of-Pocket and Personnel Costs Incurred Related to Research Services          
Revenue Recognition Multiple Deliverable Arrangements [Line Items]          
License and collaboration revenue       800,000 1,500,000
Mosaic | Maximum          
Revenue Recognition Multiple Deliverable Arrangements [Line Items]          
Milestone payment related to regulatory and clinical development events $ 4,000,000.0        
ISU Abxis | Amended and Restated License Agreement          
Revenue Recognition Multiple Deliverable Arrangements [Line Items]          
Regulatory and development milestone payment     $ 2,500,000 0  
ISU Abxis | Maximum | Amended and Restated License Agreement          
Revenue Recognition Multiple Deliverable Arrangements [Line Items]          
Milestone payment     19,500,000 0  
Commercial milestone payments     $ 17,000,000.0 0  
Biogen          
Revenue Recognition Multiple Deliverable Arrangements [Line Items]          
License and collaboration revenue       0 0
Biogen | Collaboration          
Revenue Recognition Multiple Deliverable Arrangements [Line Items]          
Research and development       $ 700,000 $ 1,400,000
Biogen | Exclusive License          
Revenue Recognition Multiple Deliverable Arrangements [Line Items]          
Up-front payments received   $ 15,000,000.0      
Biogen | Maximum | Exclusive License          
Revenue Recognition Multiple Deliverable Arrangements [Line Items]          
Development and sales milestone payments   $ 340,000,000.0