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Collaborations - Additional Information (Detail) - USD ($) |  | 1 Months Ended | 3 Months Ended | 6 Months Ended
--- | --- | --- | --- | ---
May 08, 2020 | Jun. 30, 2022 | Jan. 31, 2020 | Dec. 31, 2018 | Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |  |
Research and development |  |  |  |  | $ 1,871,000 | $ 15,389,000 | $ 11,574,000 | $ 32,402,000
Deferred revenue, recognized |  |  |  |  |  |  | 200,000 |
Mosaic Biosciences Inc | Maximum |  |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |  |
Milestone payment related to regulatory and clinical development events | $ 4,000,000.0 |  |  |  |  |  |  |
ISU Abxis | Amended and Restated License Agreement |  |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |  |
Regulatory and development milestone payment |  |  |  | $ 2,500,000 |  |  | 0 |
ISU Abxis | Maximum | Amended and Restated License Agreement |  |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |  |
Milestone payment |  |  |  | 19,500,000 |  |  | 0 |
Commercial milestone payments |  |  |  | $ 17,000,000.0 |  |  | 0 |
Biogen | Collaboration |  |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |  |
Research and development |  |  |  |  |  | $ 1,100,000 | 700,000 | $ 2,600,000
Biogen | Exclusive License |  |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |  |
Up-front payments received |  |  | $ 15,000,000.0 |  |  |  |  |
Biogen | Termination Agreement |  |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |  |
Forgiveness of accounts receivable, net |  | $ 600,000 |  |  | 600,000 |  | $ 600,000 |
Payments to cash |  | $ 10,000 |  |  |  |  |  |
Biogen | Termination Agreement | General and Administrative |  |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |  |
Settlement expense |  |  |  |  | $ 600,000 |  |  |
Biogen | Maximum | Exclusive License |  |  |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |  |  |
Development and sales milestone payments |  |  | $ 340,000,000.0 |  |  |  |  |

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