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Restructuring - Additional Information (Detail) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Nov. 30, 2021 | May 31, 2022 USD ($) | Mar. 31, 2022 Employee | Mar. 31, 2022 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($)
Restructuring Cost And Reserve [Line Items] |  |  |  |  |  |
Percent of employees terminated | 35.00% |  |  |  |  |
Severance costs and expenses |  |  |  |  |  | $ 400
Charges related to write off of prepaid manufacturing cost |  |  |  |  |  | 3,800
Restructuring liability |  |  |  |  |  | $ 200
Number of employees terminated | Employee |  |  | 22 |  |  |
Remaining number of full time employees | Employee |  |  | 5 |  |  |
Gain (loss) on disposal |  |  |  |  | $ 57,186 |
Proceeds from the sale of complement portfolio to Vertex |  |  |  |  | 55,000 |
Dren Bio, Inc. and Copia Scientific, LLC |  |  |  |  |  |
Restructuring Cost And Reserve [Line Items] |  |  |  |  |  |
Total consideration for sales agreements |  |  |  |  | 500 |
Gain (loss) on disposal |  |  |  |  | (200) |
Vertex Pharmaceuticals Incorporated |  |  |  |  |  |
Restructuring Cost And Reserve [Line Items] |  |  |  |  |  |
Gain (loss) on disposal |  | $ 57,400 |  |  |  |
Proceeds from the sale of complement portfolio to Vertex |  | 60,000 |  |  |  |
Upfront payment received |  | 55,000 |  |  |  |
Post closing indemnification obligation |  | $ 5,000 |  |  |  |
Transaction costs |  |  |  |  | $ 2,600 |
Operating Expense |  |  |  |  |  |
Restructuring Cost And Reserve [Line Items] |  |  |  |  |  |
Severance and other charges |  |  |  | $ 1,000 |  |

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