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Collaborations - Additional Information (Detail) - USD ($) |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
May 08, 2020 | Jun. 30, 2022 | Jan. 31, 2020 | Dec. 31, 2018 | Dec. 31, 2022 | Dec. 31, 2021
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Deferred revenue, recognized |  |  |  |  | $ 200,000 |
Collaboration |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
License and collaboration revenue |  |  |  |  | 794,000 | $ 7,338,000
Mosaic Biosciences Inc | Maximum |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Milestone payment related to regulatory and clinical development events | $ 4,000,000.0 |  |  |  |  |
ISU Abxis | Amended and Restated License Agreement |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Regulatory and development milestone payment |  |  |  | $ 2,500,000 | 0 |
ISU Abxis | Maximum | Amended and Restated License Agreement |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Milestone payment |  |  |  | 19,500,000 | 0 |
Commercial milestone payments |  |  |  | $ 17,000,000.0 | 0 |
Biogen |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
License and collaboration revenue |  |  |  |  | 0 | 0
Biogen | Collaboration | Reimbursable Out-of-Pocket and Personnel Costs Incurred Related to Research Services |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
License and collaboration revenue |  |  |  |  | 800,000 | $ 7,300,000
Biogen | Exclusive License |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Up-front payments received |  |  | $ 15,000,000.0 |  |  |
Biogen | Termination Agreement |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Forgiveness of accounts receivable, net |  | $ 600,000 |  |  |  |
Payments to cash |  | $ 10,000 |  |  |  |
Biogen | Termination Agreement | General and Administrative |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Settlement expense |  |  |  |  | $ 600,000 |
Biogen | Maximum | Exclusive License |  |  |  |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |  |  |  |
Development and sales milestone payments |  |  | $ 340,000,000.0 |  |  |

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