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Restructuring - Additional Information (Detail)
$ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Nov. 30, 2021
May 31, 2022
USD ($)
Mar. 31, 2022
Employee
Mar. 31, 2022
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Restructuring Cost And Reserve [Line Items]            
Percent of employees terminated 35.00%          
Severance costs and expenses           $ 400
Charges related to write off of prepaid manufacturing cost           3,800
Restructuring liability           $ 200
Number of employees terminated | Employee     22      
Remaining number of full time employees | Employee     5      
Gain (loss) on disposal         $ 57,186  
Proceeds from the sale of complement portfolio to Vertex         55,000  
Dren Bio, Inc. and Copia Scientific, LLC            
Restructuring Cost And Reserve [Line Items]            
Total consideration for sales agreements         500  
Gain (loss) on disposal         (200)  
Vertex Pharmaceuticals Incorporated            
Restructuring Cost And Reserve [Line Items]            
Gain (loss) on disposal   $ 57,400        
Proceeds from the sale of complement portfolio to Vertex   60,000        
Upfront payment received   55,000        
Post closing indemnification obligation   $ 5,000        
Transaction costs         $ 2,600  
Operating Expense            
Restructuring Cost And Reserve [Line Items]            
Severance and other charges       $ 1,000