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Restructuring - Additional Information (Detail)
$ in Thousands
 1 Months Ended 3 Months Ended
Mar. 08, 2023
USD ($)
Mar. 31, 2023
USD ($)
Feb. 28, 2023
USD ($)
May 31, 2022
USD ($)
Mar. 31, 2022
Employee
Nov. 30, 2021
Mar. 31, 2023
USD ($)
Jun. 30, 2022
USD ($)
Mar. 31, 2022
USD ($)
Restructuring Cost And Reserve [Line Items]                  
Percent of employees terminated           35.00%      
Number of Employees terminated | Employee         22        
Remaining number of full time employees | Employee         5        
Proceeds from Sale of Intangible Assets             $ 1,000    
Gain (loss) on disposal             4,736    
Contingent Value Rights Agreement                  
Restructuring Cost And Reserve [Line Items]                  
Distribution to CVR holders from asset sale proceeds $ 200 $ 200              
Vertex Pharmaceuticals Incorporated                  
Restructuring Cost And Reserve [Line Items]                  
Proceeds from Sale of Intangible Assets       $ 60,000          
Upfront payment received       55,000          
Post closing indemnification obligation       5,000          
Gain (loss) on disposal       $ 57,400          
Transaction costs               $ 2,600  
GCBP Asset Purchase Agreement                  
Restructuring Cost And Reserve [Line Items]                  
Proceeds from Sale of Intangible Assets     $ 6,000            
Upfront payment received     1,000            
Post closing indemnification obligation     5,000            
Gain (loss) on disposal     $ 4,700            
Transaction costs             $ 800    
Operating Expense                  
Restructuring Cost And Reserve [Line Items]                  
Restructuring costs                 $ 1,000