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Restructuring - Additional Information (Detail)
$ in Thousands
 1 Months Ended 3 Months Ended 6 Months Ended
Jun. 05, 2023
USD ($)
Mar. 08, 2023
USD ($)
Jan. 12, 2023
USD ($)
Jun. 30, 2023
USD ($)
Mar. 31, 2023
USD ($)
Feb. 28, 2023
USD ($)
May 31, 2022
USD ($)
Mar. 31, 2022
Employee
Nov. 30, 2021
Jun. 30, 2022
USD ($)
Mar. 31, 2022
USD ($)
Jun. 30, 2023
USD ($)
Jun. 30, 2022
USD ($)
Restructuring Cost And Reserve [Line Items]                          
Percent of employees terminated                 35.00%        
Number of Employees terminated | Employee               22          
Remaining number of full time employees | Employee               5          
Proceeds from Sale of Intangible Assets                       $ 1,000  
Gain (loss) on disposal                   $ 57,245   4,736 $ 57,245
Amount of dividend payment     $ 7,600                    
Contingent Value Rights Agreement                          
Restructuring Cost And Reserve [Line Items]                          
Distribution to CVR holders from asset sale proceeds $ 3,500 $ 200     $ 200                
Amount of dividend payment $ 3,500 $ 200   $ 3,500                  
Vertex Pharmaceuticals Incorporated                          
Restructuring Cost And Reserve [Line Items]                          
Proceeds from Sale of Intangible Assets             $ 60,000            
Upfront payment received             55,000            
Post closing indemnification obligation             5,000            
Gain (loss) on disposal             $ 57,400            
Transaction costs                   2,600      
GCBP Asset Purchase Agreement                          
Restructuring Cost And Reserve [Line Items]                          
Proceeds from Sale of Intangible Assets           $ 6,000              
Upfront payment received           1,000              
Post closing indemnification obligation           5,000              
Gain (loss) on disposal           $ 4,700              
Transaction costs                       $ 800  
Dren Bio, Inc. and Copia Scientific, LLC                          
Restructuring Cost And Reserve [Line Items]                          
Total consideration for sales agreements                   400     400
Gain (loss) on disposal                   $ (200)     $ (200)
Operating Expense                          
Restructuring Cost And Reserve [Line Items]                          
Restructuring costs                     $ 1,000