<SEC-DOCUMENT>0001140361-23-014819.txt : 20230330
<SEC-HEADER>0001140361-23-014819.hdr.sgml : 20230330
<ACCEPTANCE-DATETIME>20230330161207
ACCESSION NUMBER:		0001140361-23-014819
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		15
CONFORMED PERIOD OF REPORT:	20230329
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20230330
DATE AS OF CHANGE:		20230330

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CATALYST BIOSCIENCES, INC.
		CENTRAL INDEX KEY:			0001124105
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				562020050
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51173
		FILM NUMBER:		23780813

	BUSINESS ADDRESS:	
		STREET 1:		611 GATEWAY BLVD., SUITE 710
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		650-871-0761

	MAIL ADDRESS:	
		STREET 1:		611 GATEWAY BLVD., SUITE 710
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TARGACEPT INC
		DATE OF NAME CHANGE:	20000919
</SEC-HEADER>
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<TYPE>8-K
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      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 14pt; font-weight: bold;">UNITED STATES</div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold;">WASHINGTON, D.C. 20549</div>

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        <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; border: none; margin-left: auto; margin-right: auto;" /></div>

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      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">
        <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; border: none; margin-left: auto; margin-right: auto;" /></div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">CURRENT REPORT</div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934</div>

      <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
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      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">(Exact Name of Registrant as Specified in Charter)</div>

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    <td style="width: 2%; vertical-align: bottom; font-size: 10pt;">&#160;</td>

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              <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';">(Address of Principal Executive Offices)</div>
            </td>

    <td style="width: 2%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 49%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';">(Zip Code)</div>
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      <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
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      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">Registrant&#8217;s telephone number, including area code: <span style="font-family: 'Times New Roman'; font-weight: bold;">(<ix:nonNumeric name="dei:CityAreaCode" id="Fact_2d9ef6abc65a42748669cff1e6175cb7" contextRef="c20230329to20230329">650</ix:nonNumeric>) <ix:nonNumeric name="dei:LocalPhoneNumber" id="Fact_f8d59ed8904641e7a50460ac00dac96d" contextRef="c20230329to20230329">871-0761</ix:nonNumeric></span></div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">&#160;<span style="font-family: 'Times New Roman'; font-weight: bold;">Not Applicable</span></div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">(Former Name or Former Address, if Changed Since Last Report)</div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;"> <br />
      </div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">
        <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; border: none; margin-left: auto; margin-right: auto;" /> </div>

      <div style="font-size: 10pt;"><br />
      </div>

      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions
        (<span style="font-family: 'Times New Roman'; font-style: italic;">see</span> General Instruction A.2. below):</div>

      <div style="text-align: left;">
<div><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><br /></div>

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                </td>

    <td style="width: auto; vertical-align: top;">
                  <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</div>
                </td>

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        </div>

        <div style="text-align: left; text-indent: -54pt; margin-left: 72pt;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><br />
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                  <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"><ix:nonNumeric name="dei:SolicitingMaterial" id="Fact_661b10a16c1a40a7a39ab788b19e2c22" contextRef="c20230329to20230329" format="ixt-sec:boolballotbox">&#x2612;</ix:nonNumeric><br />
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                </td>

    <td style="width: auto; vertical-align: top;">
                  <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</div>
                </td>

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        </div>

        <div style="text-align: left; text-indent: -54pt; margin-left: 72pt;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><br />
        </div>

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    <td style="width: 18pt; vertical-align: top; text-align: right;">
                  <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"><ix:nonNumeric name="dei:PreCommencementTenderOffer" id="Fact_1b5fc8f3ec724e699a62e7a5ecb62c8e" contextRef="c20230329to20230329" format="ixt-sec:boolballotbox">&#x2610;</ix:nonNumeric><br />
                  </div>
                </td>

    <td style="width: auto; vertical-align: top;">
                  <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</div>
                </td>

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        </div>

      </div>

      <div style="text-align: left; text-indent: -54pt; margin-left: 72pt;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><br />
      </div>

      <div>
        <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">


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    <td style="width: 18pt; vertical-align: top; text-align: right;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"><ix:nonNumeric name="dei:PreCommencementIssuerTenderOffer" id="Fact_161f0cde9151479888530f32d68081e2" contextRef="c20230329to20230329" format="ixt-sec:boolballotbox">&#x2610;</ix:nonNumeric><br />
                </div>
              </td>

    <td style="width: auto; vertical-align: top;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</div>
              </td>

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      </div>

      <div style="text-align: left; text-indent: -54pt; margin-left: 72pt;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><br />
      </div>

      <div style="font-size: 10pt;">
        <div style="text-align: left; font-family: 'Times New Roman';">Securities registered pursuant to Section 12(b) of the Act:</div>

      </div>

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    <td style="width: 32%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; white-space: nowrap;">
              <div style="text-align: center; font-family: 'Times New Roman';">&#160;<span style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">Title of each class</span></div>
            </td>

    <td style="width: 2%; vertical-align: bottom; font-size: 10pt;">&#160;</td>

    <td style="width: 32%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Trading Symbol(s)</div>
            </td>

    <td style="width: 2%; vertical-align: bottom; font-size: 10pt;">&#160;</td>

    <td style="width: 32%; vertical-align: bottom; border-bottom: #000000 2px solid;">
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman'; font-size: 10pt;">Name of each exchange on which</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman'; font-size: 10pt;">registered</div>
            </td>

  </tr>

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    <td style="width: 32%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';"><ix:nonNumeric name="dei:Security12bTitle" id="Fact_b67501e8e7d94e8682afb306961260e2" contextRef="c20230329to20230329">Common Stock</ix:nonNumeric><br />
              </div>
            </td>

    <td style="width: 2%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 32%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';"><ix:nonNumeric name="dei:TradingSymbol" id="Fact_30d9228b4a1348bea751191048ff95e3" contextRef="c20230329to20230329">CBIO</ix:nonNumeric><br />
              </div>
            </td>

    <td style="width: 2%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 32%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';"><span style="-sec-ix-hidden:Fact_571e1bca8c504de682acaa1364a3dc1d">The Nasdaq Capital Market</span><br />
              </div>
            </td>

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      <div style="font-size: 10pt;"><br />
      </div>

      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (&#167;230.405 of this chapter) or Rule 12b-2
        of the Securities Exchange Act of 1934 (&#167;240.12b-2 of this chapter).</div>

      <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
        </span></div>

      <div style="text-align: left; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">Emerging growth company <ix:nonNumeric name="dei:EntityEmergingGrowthCompany" id="Fact_ef74070e492d494ba277730ff7a94b72" contextRef="c20230329to20230329" format="ixt-sec:boolballotbox">&#x2610;</ix:nonNumeric></div>

      <div style="text-align: left; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;"><span style="font-family: 'Times New Roman';"> <br />
        </span></div>
<div>
      If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange
      Act.&#9744;</div>
</div>

    <div> <div><br /></div>

      <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" />
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div style="page-break-after: always;" class="BRPFPageBreak">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" /></div>

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    <td style="width: 54pt; vertical-align: top;"><span style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</span><span style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold; color: #000000;">Item 1.01</span></td>

    <td style="width: auto; vertical-align: top; text-align: left; font-size: 10pt;">
              <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-weight: bold;">Entry into a Material Definitive Agreement.</div>
            </td>

  </tr>


</table>
      <div style="font-size: 10pt;">&#160;</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On March 29, 2023, Catalyst Biosciences, Inc., a Delaware corporation (&#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">Catalyst</span></span>&#8221;), GNI USA, Inc., a
        Delaware corporation (&#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">GNI USA</span></span>&#8221;), GNI Group Ltd., a company incorporated under the laws of Japan with limited liability (&#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">GNI Group</span></span>&#8221;),





        GNI Hong Kong Limited, a company incorporated under the laws of Hong Kong with limited liability (&#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">GNI HK</span></span>&#8221;), Shanghai Genomics, Inc., a company organized under the laws of the People&#8217;s
        Republic of China (&#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">Shanghai Genomics</span></span>&#8221;, and collectively with GNI USA, GNI Group and GNI HK, the &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">Contributors</span></span>,&#8221; and each a &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">Contributor</span></span>&#8221;), the individuals (each, a &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">Minority Holder</span></span>&#8221; and collectively, the &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">Minority





            Holders</span></span>&#8221;) listed on Annex A thereto and Continent Pharmaceuticals Inc., a Cayman Islands company limited by shares (the &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">CPI</span></span>&#8221;), entered into an amendment (the &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">BCA Amendment</span></span>&#8221;) to the previously announced Business Combination Agreement, dated as of December 26, 2022 (the &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">Business Combination Agreement</span></span>&#8221;).





        The BCA Amendment modifies the Business Combination Agreement, among other things, by (i) amending and restating Section 1.5 in connection with the treatment of the Operating Company Options (as defined therein); (ii) amending and restating Section
        6.3, Section 7.1(e) and Section 8.3(a)(i) in connection with the preparation and filing of the proxy statement and the Resale Shelf Registration Statement (as defined therein); (iii) amending and restating Section 8.1(b)(i) to extend the Outside
        Date (as defined therein) to September 30, 2023; and (iv) amending and restating Section 8.3(a)(ii) in connection with the reimbursement of certain operating expenses of Parent.</div>

      <div style="font-size: 10pt;">&#160;</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The foregoing description of the BCA Amendment is qualified in its entirety by reference to the full text of the BCA Amendment, a copy of which is included as Exhibit
        2.1 to this Current Report on Form 8-K and incorporated herein by reference.</div>

      <div style="font-size: 10pt;">&#160;</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On March 29, 2023, Catalyst, GNI Group and GNI HK entered into an agreement and amendment (the &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">Agreement and
            Amendment</span></span>&#8221;) to the previously announced Asset Purchase Agreement, dated as of December 26, 2022 (the &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">F351 Agreement</span></span>&#8221;). Among other things, the Agreement and Amendment (i)
        modifies the F351 Agreement by amending and restating Section 4.1 in connection with the preparation and filing of the proxy statement and the Resale Shelf Registration Statement (as defined therein) and (ii) provides for the extension of the
        deadline for the cash settlement of the Conversion Shares as set forth in Catalyst&#8217;s Certificate of Designation of Preferences, Rights and Limitations of the Series X Convertible Preferred Stock to September 30, 2023.</div>

      <div style="font-size: 10pt;">&#160;</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The foregoing description of the Agreement and Amendment is qualified in its entirety by reference to the full text of the Agreement and Amendment, a copy of which is
        included as Exhibit 2.2 to this Current Report on Form 8-K and incorporated herein by reference.</div>

      <div style="font-size: 10pt;">&#160;</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On March 29, 2023, Catalyst executed an amendment to Contingent Value Rights Agreement (the &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">CVR Agreement Amendment</span></span>&#8221;)





        to the previously announced Contingent Value Rights Agreement, dated as of December 26, 2022 (the &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">CVR Agreement</span></span>&#8221;). The CVR Agreement Amendment amends certain definition set forth in
        Section 1.1 of the CVR Agreement to give effect to Catalyst&#8217;s sale of certain assets under the GCB APA (as defined in the CVR Agreement Amendment).</div>

      <div style="font-size: 10pt;">&#160;</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The foregoing description of the CVR Agreement Amendment is qualified in its entirety by reference to the full text of the CVR Agreement Amendment, a copy of which is
        included as Exhibit 2.3 to this Current Report on Form 8-K and incorporated herein by reference.</div>

      <div style="font-size: 10pt;">&#160;</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">No Offer or Solicitation</div>

      <div style="font-size: 10pt;"><br />
      </div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">This Current Report on Form 8-K is not intended to be, and does not constitute, an offer to sell or the solicitation of an offer to subscribe for or buy or an
        invitation to purchase or subscribe for any securities or the solicitation of any vote in any jurisdiction pursuant to the proposed transactions or otherwise, nor shall there be any sale, issuance or transfer of securities in any jurisdiction in
        contravention of applicable law. No offer of securities shall be made except by means of a prospectus meeting the requirements of the Securities Act of 1933, as amended. Subject to certain exceptions to be approved by the relevant regulators or
        certain facts to be ascertained, the public offer will not be made directly or indirectly, in or into any jurisdiction where to do so would constitute a violation of the laws of such jurisdiction, or by use of the mails or by any means or
        instrumentality (including without limitation, facsimile transmission, telephone and the internet) of interstate or foreign commerce, or any facility of a national securities exchange, of any such jurisdiction.</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br />
      </div>

      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" /></div>

      </div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Important Additional Information Will be Filed with the SEC</div>

      <div style="font-size: 10pt;"><br />
      </div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">In connection with the proposed transactions between Catalyst, the Contributors, the Minority Holders and CPI, Catalyst intends to file relevant materials with the
        U.S. Securities and Exchange Commission (the &#8220;<span style="font-family: 'Times New Roman';"><span style="text-decoration: underline;">SEC</span></span>&#8221;), including a proxy statement and registration statement on Form S-3 that will contain a prospectus of Catalyst. CATALYST URGES ITS
        INVESTORS AND STOCKHOLDERS TO READ THESE MATERIALS CAREFULLY AND IN THEIR ENTIRETY WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT CATALYST, CPI, THE PROPOSED TRANSACTIONS AND RELATED MATTERS. Investors and
        stockholders will be able to obtain free copies of the proxy statement and prospectus and other documents filed by Catalyst with the SEC (when they become available) through the website maintained by the SEC at <span style="text-decoration: underline;"><span style="font-family: 'Times New Roman';">www.sec.gov</span>.</span> In addition, investors and stockholders will be able to obtain free copies of the proxy statement and prospectus and other documents filed by Catalyst with the SEC by contacting Catalyst Biosciences, Inc. at
        611 Gateway Blvd. Suite 120, South San Francisco, California 94080. Investors and stockholders are urged to read the proxy statement and prospectus and the other relevant materials when they become available before making any voting or investment
        decision with respect to the proposed transactions.</div>

      <div style="font-size: 10pt;"><br />
      </div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Participants in the Solicitation</div>

      <div style="font-size: 10pt;"><br />
      </div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst, the Contributors, the Minority Holders, the entities held by the Minority Holders, and CPI, and their respective directors and executive officers may be
        considered participants in the solicitation of proxies in connection with the proposed transactions. Information about Catalyst&#8217;s directors and executive officers is included in Catalyst&#8217;s most recent Annual Report on Form 10-K, including any
        information incorporated therein by reference, as filed with the SEC, the proxy statement for Catalyst&#8217;s 2022 annual meeting of stockholders, and Catalyst&#8217;s Form 8-K filed with the SEC on December 27, 2022. Additional information regarding the
        persons who may be deemed participants in the solicitation of proxies will be included in the proxy statement and prospectus relating to the proposed transactions when it is filed with the SEC. These documents can be obtained free of charge from
        the sources indicated above.</div>

      <div style="font-size: 10pt;"><br />
      </div>

      <div style="font-size: 10pt;">
        <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">


  <tr>

    <td style="width: 54pt; vertical-align: top;"><span style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</span><span style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold; color: #000000;">Item 9.01</span></td>

    <td style="width: auto; vertical-align: top; text-align: left;">
                <div style="color: #000000; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Financial Statements and Exhibits</div>
              </td>

  </tr>


</table>
      </div>

      <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
        </span></div>

      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">(d) Exhibits</div>

      <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
        </span></div>

      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">


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    <td style="width: 7%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: left; color: #000000; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Exhibit</div>
              <div style="text-align: left; color: #000000; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Number</div>
            </td>

    <td style="width: 1.54%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 91%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-weight: bold;">Description</div>
            </td>

  </tr>

  <tr>

    <td style="width: 7%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: left; font-family: 'Times New Roman';"><a href="brhc10050607_ex2-1.htm">2.1</a></div>
            </td>

    <td style="width: 1.54%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 91%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: justify; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Amendment to Business Combination Agreement, dated as of March 29, 2023, by and among Catalyst, GNI USA, GNI Group, GNI HK, Shanghai Genomics, the Minority
                Holders and CPI.</div>
            </td>

  </tr>

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    <td style="width: 7%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 1.54%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 91%; vertical-align: top; font-size: 10pt;">&#160;</td>

  </tr>

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    <td style="width: 7%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: left; font-family: 'Times New Roman';"><a href="brhc10050607_ex2-2.htm">2.2</a></div>
            </td>

    <td style="width: 1.54%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 91%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: justify; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Agreement and Amendment to Asset Purchase Agreement, dated as of March 29, 2023, by and among Catalyst, GNI Group and GNI HK.</div>
            </td>

  </tr>

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    <td style="width: 7%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 1.54%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 91%; vertical-align: top; font-size: 10pt;">&#160;</td>

  </tr>

  <tr>

    <td style="width: 7%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: left; font-family: 'Times New Roman';"><a href="brhc10050607_ex2-3.htm">2.3</a></div>
            </td>

    <td style="width: 1.54%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 91%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: justify; font-family: 'Times New Roman';">Amendment to Contingent Value Rights Agreement, <span style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">dated as of March 29, 2023, executed by Catalyst.</span></div>
            </td>

  </tr>

  <tr>

    <td style="width: 7%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 1.54%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 91%; vertical-align: top; font-size: 10pt;">&#160;</td>

  </tr>

  <tr>

    <td style="width: 7%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: left; font-family: 'Times New Roman';">104</div>
            </td>

    <td style="width: 1.54%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 91%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: justify; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101)</div>
            </td>

  </tr>


</table>
      <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
        </span></div>

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      </div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">SIGNATURES</div>

      <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
        </span></div>

      <div style="text-align: left; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the
        undersigned hereunto duly authorized.</div>

      <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
        </span></div>

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    <td style="width: 50%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 50%; vertical-align: top; font-size: 10pt;" colspan="2">
              <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">CATALYST BIOSCIENCES, INC.</div>
            </td>

  </tr>

  <tr>

    <td style="width: 50%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 3%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 47%; vertical-align: top; font-size: 10pt;">&#160;</td>

  </tr>

  <tr>

    <td style="width: 50%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Date: March 30, 2023</div>
            </td>

    <td style="width: 3%; vertical-align: top; font-size: 10pt;">
              <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">By:</div>
            </td>

    <td style="width: 47%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
              <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">/s/ Nassim Usman, Ph.D.</div>
            </td>

  </tr>

  <tr>

    <td style="width: 50%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 3%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 47%; vertical-align: top;">
              <div style="text-align: left; color: #000000; font-family: 'Times New Roman'; font-size: 10pt;">Nassim Usman, Ph.D.</div>
              <div style="text-align: left; color: #000000; font-family: 'Times New Roman'; font-size: 10pt;">President and Chief Executive Officer</div>
            </td>

  </tr>


</table>
      <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
        </span></div>

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      </span></div>

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<DOCUMENT>
<TYPE>EX-2.1
<SEQUENCE>2
<FILENAME>brhc10050607_ex2-1.htm
<DESCRIPTION>EXHIBIT 2.1
<TEXT>
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000;">
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      <div class="page-content">
        <div style="margin: 0px 0px 0px 0pt;" class="block-main">
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;" class="h1">
            <hr noshade="noshade" align="center" style="height: 4px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: right;" class="h1"> Exhibit 2.1<br>
          </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;" class="h1">AMENDMENT TO BUSINESS COMBINATION AGREEMENT</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">This Amendment to Business Combination Agreement (this &#8220;<u>Amendment</u>&#8221;)






            is dated as of March&#160;29, 2023, with respect to that certain Business Combination Agreement (the &#8220;<u>Business Combination Agreement</u>&#8221;), dated as of December&#160;26, 2022, by and among Catalyst Biosciences, Inc., a Delaware corporation (&#8220;<u>Parent</u>&#8221;),






            GNI USA, Inc., a Delaware corporation (&#8220;<u>GNI USA</u>&#8221;), GNI Group Ltd., a company incorporated under the laws of Japan with limited liability (&#8220;<u>GNI Group</u>&#8221;), GNI Hong Kong Limited, a company incorporated under the laws of Hong Kong with
            limited liability (&#8220;<u>GNI HK</u>&#8221;), Shanghai Genomics, Inc., a company organized under the laws of the People&#8217;s Republic of China (&#8220;<u>Shanghai Genomics</u>&#8221;, and collectively with GNI USA, GNI Group and GNI HK, the &#8220;<u>Contributors</u>,&#8221; and
            each a &#8220;<u>Contributor</u>&#8221;), the individuals (each, a &#8220;<u>Minority Holder</u>&#8221; and collectively, the &#8220;<u>Minority Holders</u>&#8221;) listed on Annex&#160;A thereto and Continent Pharmaceuticals Inc., a Cayman Islands company limited by shares (the &#8220;<u>Company</u>&#8221;).







            Capitalized terms used but not defined herein shall have the respective meanings ascribed to such terms in the Business Combination Agreement.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;" class="h1">RECITALS</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">WHEREAS, Section&#160;8.4 of the Business Combination Agreement
            provides that it may be amended, modified or supplemented by Parent, the Contributors and the Company by action taken or authorized by their respective boards of directors or equivalent at any time prior to the Effective Time, whether before or
            after the Parent Stockholder Approval has been obtained, and by an instrument in writing specifically designated as an amendment thereto, signed on behalf of each of the parties in interest at the time of the amendment; <u>provided</u>, <u>however</u>,
            that any amendment to &#8206;Section&#160;1.1, &#8206;Section&#160;1.4, &#8206;Article&#160;V, &#8206;Section&#160;6.3(c), &#8206;Section&#160;6.3(d), and &#8206;Section&#160;8.4 (to the extent such amendment pertains to &#8206;Section&#160;1.1, &#8206;Section&#160;1.4, &#8206;Article&#160;V, &#8206;Section&#160;6.3(c), &#8206;Section&#160;6.3(d)) must also be
            approved by the Minority Holders.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">NOW, THEREFORE, in consideration of the premises, and of the
            mutual agreements contained herein, and intending to be legally bound hereby, Parent, the Contributors, the Minority Holders and the Company hereby agree as follows: </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;" class="h1">ARTICLE I<br>
          </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 0pt; text-align: center;" class="h1">AMENDMENT</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 7pt; margin-left: 0pt; text-indent: 20pt;" class="para">Section 1.1&#8195;<u>Amendments</u>. </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">(a)&#8195;The reference to &#8220;Form&#160;S-4&#8221; in the Index of Defined Terms of
            the Business Combination Agreement shall be deleted.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">(b)&#8195;The following references shall be added into the Index of
            Defined Terms of the Business Combination Agreement: </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 0pt;" class="fpara">&#160;</div>
          <table cellspacing="0" cellpadding="0" id="ze2502e8dfc11419eb218a0c061e38c8c" style="border-collapse: collapse; width: 428pt; margin-left: auto; margin-right: auto;" class="fintab">

              <tr>
                <td style="width: 89.72%; text-align: left; vertical-align: bottom; padding-top: 6pt; padding-bottom: 3pt; background-color: #CCEEFF;">
                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 0pt; margin-left: 0pt;" class="fpara">Proxy Clearance Date</div>
                </td>
                <td style="width: 2.77%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3pt; background-color: #CCEEFF;" class="gutter">&#8203;</td>
                <td style="width: 2.77%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3pt; background-color: #CCEEFF;" class="gutter">&#8203;</td>
                <td style="width: 4.73%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 6pt; padding-bottom: 3pt; background-color: #CCEEFF;">
                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 0pt; margin-left: -0.01pt;" class="fpara">6.3(a)</div>
                </td>
              </tr>
              <tr>
                <td style="width: 89.72%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;">
                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 0pt; margin-left: 0pt;" class="fpara">Resale Shelf Registration Statement</div>
                </td>
                <td style="width: 2.77%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;" class="gutter">&#8203;</td>
                <td style="width: 2.77%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;" class="gutter">&#8203;</td>
                <td style="width: 4.73%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;">
                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 0pt; margin-left: -0.01pt;" class="fpara">6.3(c)</div>
                </td>
              </tr>

          </table>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt;" class="para">(c)&#8195;Section&#160;1.5 of the Business Combination Agreement is hereby amended and restated
            as follows: </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 40pt;" class="fpara"><u>Treatment of Operating Company Options</u>. </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-align: justify;" class="fpara">At the Effective Time, each option to purchase common shares of the Operating
            Company (the &#8220;<u>Operating</u><u>&#160;</u><u>Company Common Shares</u>&#8221;) granted under any employee or director stock option, stock purchase or equity compensation plan, arrangement or agreement of the Operating Company (each, an &#8220;<u>Operating
              Company</u><u>&#160;</u><u>Option</u>&#8221;), that is outstanding immediately prior to the Effective Time, shall be terminated and replaced with an option granted under Parent&#8217;s 2023 Omnibus Incentive Plan that is substantially similar in all material
            respects to the terms and conditions applicable to the Operating Company Options (including with respect to vesting and forfeiture). Prior to the Effective Time, the Company shall take, or cause to be taken, all actions necessary or appropriate
            to give effect to the provisions of this <u>Section&#160;1.5</u>, including causing the Operating Company to terminate its 2021 Stock Incentive Plan effective as of the Effective Time.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 0pt; text-indent: 20pt;" class="para">(d)&#8195;Section&#160;6.3 of the Business Combination Agreement is hereby amended and restated
            as follows:</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 40pt;" class="fpara"><u>Preparation of Proxy Statement and Resale Shelf Registration Statement; Stockholders&#8217; Meeting</u> </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(a) &#8195;As promptly as practicable after the date of this
            Agreement, Parent shall file with the SEC a proxy statement (as amended or supplemented from time to time, the &#8220;<u>Proxy Statement</u>&#8221;) to be sent to the </div>
          <div style="clear: both; margin-top: 9pt; margin-bottom: 9pt;" class="BRPFPageBreakArea">
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          </div>
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      </div>
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    <div style="margin: auto; position: relative; text-align: left;" class="page"><a name="ny20006478x1_prem14a_300-annexa_pg69"></a>
      <div class="page-content">
        <div style="margin: 0px 0px 0px 0pt;" class="block-main">
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6.75pt; margin-left: 40pt; text-align: justify;" class="para">stockholders of Parent relating to the special meeting of Parent&#8217;s stockholders
            (the &#8220;<u>Parent Stockholders </u><u>Meeting</u>&#8221;) to be held to consider the Parent Stockholder Matters; provided, that it is understood and agreed that the Contributors shall prepare the initial draft of the Proxy Statement. Parent shall file
            the definitive Proxy Statement with the SEC and cause the Proxy Statement to be mailed to its stockholders of record, at such time as reasonably agreed by the Contributors and the Company promptly (and in any event within five (5) Business
            Days) following (x) in the event the preliminary Proxy Statement is not reviewed by the SEC, the expiration of the waiting period in Rule&#160;14a-6(a) under the Securities Exchange Act or (y) in the event the preliminary Proxy Statement is reviewed
            by the SEC, receipt of oral or written notification of the completion of the review by the SEC (the date in (x) or (y), the &#8220;<u>Proxy Clearance Date</u>&#8221;). </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(b) &#8195;Parent covenants and agrees that the Proxy Statement (and
            the letter to stockholders, notice of meeting and form of proxy included therewith) will (i) comply as to form in all material respects with the requirements of applicable U.S. federal securities laws and the DGCL, and (ii) with regard to the
            information provided in the Proxy Statement by Parent, will not contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary in order to make the statements made therein, in light
            of the circumstances under which they were made, not misleading.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(c) &#8195;As promptly as practicable following March&#160;29, 2023, Parent
            shall file with the SEC a registration statement on Form&#160;S-3 or similar short form registration statement that may be available at such time or its successor form, or, if Parent is ineligible to use Form&#160;S-3, a registration statement on
            Form&#160;S-1, for an offering to be made on a continuous basis pursuant to Rule&#160;415 of the Securities Act registering the resale of the securities from time to time pursuant to any method or combination of methods legally available to, and
            requested by, the Contributors and the Minority Holders then held by such holders that are not then covered by an effective resale registration statement (the &#8220;<u>Resale Shelf Registration </u><u>Statement</u>&#8221;); <u>provided</u>, that it is
            understood and agreed that the Contributors shall prepare the initial draft of the Resale Registration Statement. Parent will advise the Contributors promptly after it receives oral or written notice thereof of the time when the Resale
            Registration Statement has become effective or any amendment or supplement thereto has been filed, the issuance of any stop order, the suspension of the qualification of the Parent Common Stock registered on the Resale Registration Statement
            for offering or sale in any jurisdiction or any oral or written request by the SEC for amendment of the Resale Registration Statement or comments thereon and responses thereto or requests by the SEC for additional information, and will promptly
            provide the other with copies of any written communication from the SEC or any state securities commission and a reasonable opportunity to participate in the responses thereto. The Contributors covenant and agree that all information concerning
            the Contributors, the Company and Further Challenger furnished by the Contributors, and the Minority Holders covenant and agree, individually and not with respect to each other, that all information concerning the Minority Holders and the
            Entities, and included in the Proxy Statement and the Resale Registration Statement will (i) comply as to form in all material respects with the requirements of applicable U.S. federal securities laws and the DGCL, and (ii) will not contain any
            untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary in order to make the statements made therein, in light of the circumstances under which they were made, not misleading. Parent
            shall use its reasonable best efforts to have the Resale Registration Statement declared effective by the SEC under the Securities Act as promptly as practicable after such filing and to keep the Resale Registration Statement effective until
            all securities covered by the Resale Registration Statement are sold in accordance with the intended plan of distribution set forth in the Resale Registration Statement or supplement to the prospectus or such securities have been withdrawn.
            Parent shall also take any action (other than qualifying to do business in any jurisdiction in which it is not now so qualified or filing a general consent to service of process) required to be taken under any applicable state securities or
            &#8220;blue sky&#8221; laws in connection with the registration of the Parent Common Stock and the Contributors shall furnish all information concerning Contributors as may be reasonably requested in connection with any such action.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(d) &#8195;Parent shall use its reasonable best efforts to respond
            promptly to any comments or requests of the SEC or its staff relating to the Proxy Statement and the Resale Registration Statement; provided, that any comments or request of the SEC or its staff which relate to disclosures contained in the
            Proxy Statement or the Resale Registration Statement and which were provided by the Minority Holders or the Contributors will be promptly addressed by the Contributors. No filing of, or amendment or supplement to, the Proxy Statement or the
            Resale Registration Statement will be made by Parent, without providing the </div>
          <div style="clear: both; margin-top: 9pt; margin-bottom: 9pt;" class="BRPFPageBreakArea">
            <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">2</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
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          </div>
        </div>
      </div>
    </div>
    <div style="margin: auto; position: relative; text-align: left;" class="page"><a name="ny20006478x1_prem14a_300-annexa_pg70"></a>
      <div class="page-content">
        <div style="margin: 0px 0px 0px 0pt;" class="block-main">
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6.75pt; margin-left: 40pt; text-align: justify;" class="para">Contributors a reasonable opportunity to review and comment thereon and without
            the Contributors&#8217; prior approval (which shall not be unreasonably withheld, conditioned, or delayed). If at any time prior to the Effective Time any information relating to the Contributors, the Minority Holders or Parent, or any of their
            respective Affiliates, officers or directors, should be discovered by the Company or Parent that should be set forth in an amendment or supplement to either of the Proxy Statement or the Resale Registration Statement, so that any of such
            documents would not contain any misstatement of a material fact or omit to state any material fact necessary to make the statements therein, in light of the circumstances under which they were made, not misleading, the party that discovers such
            information shall promptly notify the other parties hereto and an appropriate amendment or supplement describing such information shall promptly be filed with the SEC and, to the extent required under applicable Law, disseminated to
            stockholders of Parent; <u>provided</u>, that the delivery of such notice and the filing of any such amendment or supplement shall not affect or be deemed to modify any representation or warranty made by any party hereunder or otherwise affect
            the remedies available hereunder to any party.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(e) &#8195;As promptly as practicable after the Proxy Clearance Date,
            Parent shall duly call, give notice of, convene and hold the Parent Stockholders Meeting to consider and vote to approve the Parent Stockholder Matters pursuant to the terms of this Agreement (and such Parent Stockholders Meeting shall in any
            event be no later than forty-five (45)&#160;calendar days after the Proxy Clearance Date). Parent may postpone or adjourn the Parent Stockholders Meeting solely (i)&#160;with the consent of the Contributors; (ii)&#160;(A) due to the absence of a quorum or (B)
            if Parent has not received proxies representing a sufficient number of shares for the Parent Stockholder Approval, whether or not a quorum is present, to solicit additional proxies; or (iii)&#160;to allow reasonable additional time for the filing
            and mailing of any supplemental or amended disclosure which the Parent Board has determined in good faith after consultation with outside legal counsel is necessary under applicable Law and for such supplemental or amended disclosure to be
            disseminated and reviewed by Parent&#8217;s stockholders prior to the Parent Stockholders Meeting; <u>provided</u>, that Parent may not postpone or adjourn the Parent Stockholders Meeting more than a total of two times pursuant to clause&#160;(ii)(A)
            and/or clause (ii)(B) of this Section. Notwithstanding the foregoing, Parent shall, at the request of Contributors, to the extent permitted by Law, adjourn the Parent Stockholders Meeting to a date specified by the Contributors for the absence
            of a quorum or if the Parent has not received proxies representing a sufficient number of shares for the Parent Stockholder Approval; provided, that Parent shall not be required to adjourn the Parent Stockholders Meeting more than one (1) time
            pursuant to this sentence, and no such adjournment pursuant to this sentence shall be required to be for a period exceeding ten (10) Business Days. Parent, through the Parent Board, shall (i) recommend to its stockholders that they vote to
            approve the Parent Stockholder Matters, (ii) include such recommendation in the Proxy Statement and (iii) publicly reaffirm such recommendation within 24&#160;hours after a request to do so by the Contributors. Without limiting the generality of the
            foregoing, Parent agrees that (x) Parent shall use its reasonable best efforts to solicit proxies to obtain the Parent Stockholder Approval and (y) its obligations pursuant to this &#8206;<u>Section&#160;6.3</u> shall not be affected by the commencement,
            public proposal, public disclosure or communication to Parent or any other Person of any Acquisition Proposal.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 0pt; text-indent: 20pt;" class="para">(e)&#8195;Section&#160;7.1(e) of the Business Combination Agreement is hereby amended and
            restated as follows:</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 40pt;" class="fpara">[Intentionally omitted].</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 0pt; text-indent: 20pt;" class="para">(f)&#8195;Section&#160;8.1(b)(i) of the Business Combination Agreement is hereby amended and
            restated as follows:</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-align: justify;" class="fpara">if the Transactions shall not have been consummated on or before September&#160;30,
            2023 (the &#8220;<u>Outside </u><u>Date</u>&#8221;); provided, that the right to terminate this Agreement pursuant to this &#8206;<u>Section&#160;8.1(b)(i)</u> shall not be available to any party whose failure to fulfill in any material respect any of its
            obligations under this Agreement has been the primary cause of, or the primary factor that resulted in, the failure of the Transactions to be consummated by the Outside Date;</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 0pt; text-indent: 20pt;" class="para">(g)&#8195;Section&#160;8.3(a)(i) of the Business Combination Agreement is hereby amended and
            restated as follows:</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-align: justify;" class="fpara">the expenses incurred in connection with the filing, printing and mailing of the
            Proxy Statement and the Resale Registration Statement, and all filing and other fees paid to the SEC or in respect of the HSR Act, in each case in connection with the Transactions (other than attorneys&#8217; fees, accountants&#8217; fees and related
            expenses), shall be shared equally by Parent and the Company;</div>
          <div style="clear: both; margin-top: 9pt; margin-bottom: 9pt;" class="BRPFPageBreakArea">
            <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">3</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
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        </div>
      </div>
    </div>
    <div style="margin: auto; position: relative; text-align: left;" class="page"><a name="ny20006478x1_prem14a_300-annexa_pg71"></a>
      <div class="page-content">
        <div style="margin: 0px 0px 0px 0pt;" class="block-main">
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt;" class="para">(h)&#8195;Section&#160;8.3(a)(ii) of the Business Combination Agreement is hereby amended and
            restated as follows:</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-align: justify;" class="fpara">the Contributors shall, on a joint and several basis, reimburse Parent for ongoing
            operating expenses in excess of $500,000 (but not to exceed $1,000,000) in the aggregate, where such expenses are solely incurred between the date of this Agreement and the Closing; <u>provided</u>, that such expenses shall be set forth on a
            budget that is approved by the Parent Board after the date of this Agreement and delivered to the Company within 30&#160;days of the date of this Agreement, and the aggregate sum of such reimbursed amounts shall be distributed to the stockholders of
            Parent pursuant to the terms of the CVR Agreement; <u>provided</u>, <u>further</u>, that, notwithstanding the foregoing, the Contributors shall, on a joint and several basis, reimburse Parent for all ongoing operating expenses incurred
            between July&#160;20, 2023 and the Closing. Operating expenses in excess of $1,000,000 (if any) incurred by Parent, where such expenses are solely incurred between the date of this Agreement and July&#160;20, 2023, shall be borne equally by the Company
            and Parent; <u>provided</u>, that any such expenses shall be approved by the Parent Board. Expenses that were incurred prior to the date of this Agreement, in whole or in part, shall not be subject to this Section&#160;8.3(a)(ii) or the
            cost-reimbursement or cost-sharing provisions hereunder. All expenses required to be paid pursuant to this <u>Section 8.3(a)(ii)</u> shall be made no later than three (3) Business Days prior to the Closing by wire transfer of immediately
            available funds to an account designated by Parent.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">Section 1.2&#8195;<u>Effect of Amendment; Counterparts</u>. Except as
            specifically modified herein, the Business Combination Agreement remains in full force and effect. This Amendment may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together shall constitute
            one and the same instrument, with the same effect as if the signatures thereto were in the same instrument. Article IX of the Business Combination Agreement is hereby incorporated by reference.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 20.5pt; text-align: center;" class="h1">[<font style="font-style: italic;">Remainder of Page Intentionally Left Blank; Signature Pages Follow</font>]</div>
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        </div>
      </div>
    </div>
    <div style="margin: auto; position: relative; text-align: left;" class="page"><a name="ny20006478x1_prem14a_300-annexa_pg72"></a>
      <div class="page-content">
        <div style="margin: 0px 0px 0px 0pt;" class="block-main">
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">IN WITNESS WHEREOF, the parties have each caused this
            Amendment to be duly executed as of the date first written above. </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 0pt;" class="fpara">&#160;</div>
          <table cellspacing="0" cellpadding="0" id="z82233ecc4b4046a88000d5fcffb634ba" style="border-collapse: collapse; width: 468pt; margin-left: auto; margin-right: auto;" class="txttab">

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                </td>
                <td style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3pt;" class="gutter">&#8203;</td>
                <td style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3pt;" class="gutter">&#8203;</td>
                <td style="width: 51.28%; text-align: left; vertical-align: bottom; padding-top: 6pt; padding-bottom: 3pt;" colspan="4">
                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt;" class="fpara"><u>PARENT</u>:<font style="font-weight: normal;">&#160;</font></div>
                </td>
              </tr>
              <tr>
                <td style="width: 46.15%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;">
                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;" class="fpara">&#160;</div>
                </td>
                <td style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;" class="gutter">&#8203;</td>
                <td style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;" class="gutter">&#8203;</td>
                <td style="width: 2.56%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;">
                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;" class="fpara">&#160;</div>
                </td>
                <td style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;" class="gutter">&#8203;</td>
                <td style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;" class="gutter">&#8203;</td>
                <td style="width: 46.15%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;">
                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;" class="fpara">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 46.15%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;">
                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;" class="fpara">&#160;</div>
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        <div style="text-align: center;"><font style="font-family: 'Times New Roman'; font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;">7</font></div>
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<DOCUMENT>
<TYPE>EX-2.2
<SEQUENCE>3
<FILENAME>brhc10050607_ex2-2.htm
<DESCRIPTION>EXHIBIT 2.2
<TEXT>
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            <div style="text-align: right;">Exhibit 2.2<br>
            </div>
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          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;" class="h1"> AGREEMENT AND AMENDMENT TO ASSET PURCHASE AGREEMENT</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">This Agreement and Amendment to Asset Purchase Agreement (this &#8220;<u>Agreement






              and Amendment</u>&#8221;) is dated as of March&#160;29, 2023, with respect to (i) that certain Asset Purchase Agreement (the &#8220;<u>F351 Agreement</u>&#8221;), dated as of December&#160;26, 2022, by and among Catalyst Biosciences, Inc., a Delaware corporation (&#8220;<u>CBIO</u>&#8221;),






            GNI Group Ltd., a company incorporated under the laws of Japan with limited liability (&#8220;<u>GNI Group</u>&#8221;) and GNI Hong Kong Limited, a company incorporated under the laws of Hong Kong with limited liability (&#8220;<u>GNI HK</u>&#8221; and collectively
            with GNI Group, the &#8220;<u>GNI Parties</u>&#8221;) and (ii) the CBIO Certificate of Designation of Preferences, Rights and Limitations of Series X Convertible Preferred Stock, filed with the Secretary of State of the State of Delaware on December&#160;27,
            2022 (the &#8220;<u>Certificate of Designation</u>&#8221;). Capitalized terms used but not defined herein shall have the respective meanings ascribed to such terms in the F351 Agreement and Certificate of Designation. </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: center; font-weight: bold;" class="para">RECITALS </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">WHEREAS, Section 5.7 of the F351 Agreement provides that it may be amended,
            modified or supplemented by the parties thereto by action taken or authorized by their governing bodies at any time, whether before or after the Buyer Stockholder Approval has been obtained, and by an instrument in writing specifically
            designated as an amendment thereto, signed on behalf of each of the parties in interest at the time of the amendment; <u>provided</u>, <u>however</u>, that after the Buyer Stockholder Approval has been obtained, no amendment shall be made
            that pursuant to applicable Law requires further approval or adoption by the GNI Parties or the stockholders of CBIO, as applicable, without such further approval or adoption. </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">WHEREAS, as of the date hereof, the GNI Parties hold 12,340 shares of
            Series X Convertible Preferred Stock and have agreed to extend the deadline for the cash settlement of the Conversion Shares set forth in Section 6(d)(iii) of the Certificate of Designation.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">NOW, THEREFORE, in consideration of the premises, and of the mutual
            agreements contained herein, and intending to be legally bound hereby, CBIO and the GNI Parties hereby agree as follows:</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 20.5pt; text-align: center;" class="h1">ARTICLE I<br>
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          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 0pt; text-align: center;" class="h1">AMENDMENT TO F351 AGREEMENT</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 7.5pt; margin-left: 0pt; text-indent: 20pt;" class="para">Section 1.1&#8195;<u>Amendments</u>.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8.5pt; margin-left: 0pt; text-indent: 20pt;" class="para">(a)&#8195;The reference to &#8220;Form S-4&#8221; in the Index of Defined Terms of the F351 Agreement shall be
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          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 0pt; text-indent: 20pt;" class="para">(b)&#8195;The following references shall be added into the Index of Defined Terms of the F351
            Agreement:</div>
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                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 0pt; margin-left: -0.01pt;" class="fpara">4.1(a) </div>
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          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt;" class="para">(c)&#8195;Section 4.1 of the F351 Agreement is hereby amended and restated as follows:</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 20pt; text-indent: 20pt;" class="para"><u>Preparation of Proxy Statement and Resale Shelf Registration Statement; Stockholders&#8217;
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          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(a) &#8195;As promptly as practicable after the date of this Agreement, Buyer
            shall (i) file with the SEC a proxy statement (as amended or supplemented from time to time, the &#8220;<u>Proxy Statement</u>&#8221;) to be sent to the stockholders of Buyer relating to the special meeting of Buyer&#8217;s stockholders (the &#8220;<u>Buyer
              Stockholders </u><u>Meeting</u>&#8221;) to be held to consider the Buyer Stockholder Matters and (ii) set a preliminary record date for the Buyer Stockholders Meeting and commence a broker search pursuant to Section&#160;14a-13 of the Exchange Act in
            connection therewith; provided, that it is understood and agreed that the Sellers shall prepare the initial draft of the Proxy Statement. Buyer shall file the definitive Proxy Statement with the SEC and cause the Proxy Statement to be mailed to
            its stockholders of record, at such time as reasonably agreed by the Sellers promptly (and in any event within five (5) Business Days) following (x) in the event the preliminary Proxy Statement is not reviewed by the SEC, the expiration of the
            waiting period in Rule 14a-6(a) under the Securities Exchange Act or (y) in the event the preliminary Proxy Statement is reviewed by the SEC, receipt of oral or written notification of the completion of the review by the SEC (the date in (x) or
            (y), the &#8220;<u>Proxy Clearance Date</u>&#8221;).</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(b) &#8195;Buyer covenants and agrees that the Proxy Statement (and the letter
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          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6.75pt; margin-left: 40pt; text-align: justify;" class="para">information provided in the Proxy Statement by Buyer, will not contain any untrue
            statement of a material fact or omit to state any material fact required to be stated therein or necessary in order to make the statements made therein, in light of the circumstances under which they were made, not misleading.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(c) &#8195;As promptly as practicable following March&#160;29, 2023, Buyer shall file
            with the SEC a registration statement on Form&#160;S-3 or similar short form registration statement that may be available at such time or its successor form, or, if Buyer is ineligible to use Form&#160;S-3, a registration statement on Form&#160;S-1, for an
            offering to be made on a continuous basis pursuant to Rule&#160;415 of the Securities Act registering the resale of the Buyer Common Stock to be issued pursuant to this Agreement from time to time pursuant to any method or combination of methods
            legally available to, and requested by, the Sellers (the &#8220;<u>Resale Shelf </u><u>Registration Statement</u>&#8221;); <u>provided</u>, that it is understood and agreed that the Sellers shall prepare the initial draft of the Resale Registration
            Statement. Buyer will advise the Sellers promptly after it receives oral or written notice thereof of the time when the Resale Registration Statement has become effective or any amendment or supplement thereto has been filed, the issuance of
            any stop order, the suspension of the qualification of the Buyer Common Stock registered on the Resale Registration Statement for offering or sale in any jurisdiction or any oral or written request by the SEC for amendment of the Resale
            Registration Statement or comments thereon and responses thereto or requests by the SEC for additional information, and will promptly provide the other with copies of any written communication from the SEC or any state securities commission and
            a reasonable opportunity to participate in the responses thereto. The Sellers covenant and agree that all information concerning the Sellers and the Purchased Assets furnished by the Sellers and included in the Proxy Statement and the Resale
            Registration Statement will (i) comply as to form in all material respects with the requirements of applicable U.S. federal securities laws and the DGCL, and (ii) will not contain any untrue statement of a material fact or omit to state any
            material fact required to be stated therein or necessary in order to make the statements made therein, in light of the circumstances under which they were made, not misleading. Buyer shall use its reasonable best efforts to have the Resale
            Registration Statement declared effective by the SEC under the Securities Act as promptly as practicable after such filing and to keep the Resale Registration Statement effective until all securities covered by the Resale Registration Statement
            are sold in accordance with the intended plan of distribution set forth in the Resale Registration Statement or supplement to the prospectus or such securities have been withdrawn. Buyer shall also take any action (other than qualifying to do
            business in any jurisdiction in which it is not now so qualified or filing a general consent to service of process) required to be taken under any applicable state securities or &#8220;blue sky&#8221; laws in connection with the registration of the Buyer
            Common Stock and the Sellers shall furnish all information concerning the Sellers as may be reasonably requested in connection with any such action.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(d) &#8195;Buyer shall use its reasonable best efforts to respond promptly to
            any comments or requests of the SEC or its staff relating to the Proxy Statement and the Resale Registration Statement; <u>provided</u>, that any comments or request of the SEC or its staff which relate to disclosures contained in the Proxy
            Statement or the Resale Registration Statement and which were provided by the Sellers will be promptly addressed by the Sellers. No filing of, or amendment or supplement to, the Proxy Statement or the Resale Registration Statement will be made
            by Buyer, without providing the Sellers a reasonable opportunity to review and comment thereon and without the Sellers&#8217; prior approval (which shall not be unreasonably withheld, conditioned, or delayed). If at any time prior to the Effective
            Time any information relating to the Sellers or Buyer, or any of their respective Affiliates, officers or directors, should be discovered by the Sellers or Buyer that should be set forth in an amendment or supplement to either of the Proxy
            Statement or the Resale Registration Statement, so that any of such documents would not contain any misstatement of a material fact or omit to state any material fact necessary to make the statements therein, in light of the circumstances under
            which they were made, not misleading, the party that discovers such information shall promptly notify the other parties hereto and an appropriate amendment or supplement describing such information shall promptly be filed with the SEC and, to
            the extent required under applicable Law, disseminated to stockholders of Buyer; <u>provided</u>, that the delivery of such notice and the filing of any such amendment or supplement shall not affect or be deemed to modify any representation or
            warranty made by any party hereunder or otherwise affect the remedies available hereunder to any party.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(e) &#8195;As promptly as practicable after the Proxy Clearance Date, Buyer
            shall duly call, give notice of, convene and hold the Buyer Stockholders Meeting to consider and vote to approve the Buyer Stockholder Matters pursuant to the terms of this Agreement and the BC Agreement (and such Buyer Stockholders </div>
          <div style="clear: both; margin-top: 9pt; margin-bottom: 9pt;" class="BRPFPageBreakArea">
            <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">2</font></div>
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      </div>
    </div>
    <div style="margin: auto; position: relative; text-align: left;" class="page"><a name="ny20006478x1_prem14a_301-annexb_pg46"></a>
      <div class="page-content">
        <div style="margin: 0px 0px 0px 0pt;" class="block-main">
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6.75pt; margin-left: 40pt; text-align: justify;" class="para">Meeting shall in any event be no later than forty-five (45) calendar days after the Proxy
            Clearance Date). Buyer may postpone or adjourn the Buyer Stockholders Meeting solely (i) with the consent of the Sellers; (ii) (A) due to the absence of a quorum or (B) if Buyer has not received proxies representing a sufficient number of
            shares for the Buyer Stockholder Approval, whether or not a quorum is present, to solicit additional proxies; or (iii) to allow reasonable additional time for the filing and mailing of any supplemental or amended disclosure which the Buyer
            Board has determined in good faith after consultation with outside legal counsel is necessary under applicable Law and for such supplemental or amended disclosure to be disseminated and reviewed by Buyer&#8217;s stockholders prior to the Buyer
            Stockholders Meeting; <u>provided</u>, that Buyer may not postpone or adjourn the Buyer Stockholders Meeting more than a total of two times pursuant to clause (ii)(A) and/or clause (ii)(B) of this <u>Section&#160;4.1(e)</u>. Notwithstanding the
            foregoing, Buyer shall, at the request of the Sellers, to the extent permitted by Law, adjourn the Buyer Stockholders Meeting to a date specified by the Sellers for the absence of a quorum or if Buyer has not received proxies representing a
            sufficient number of shares for the Buyer Stockholder Approval; <u>provided</u>, that Buyer shall not be required to adjourn the Buyer Stockholders Meeting more than one (1) time pursuant to this sentence, and no such adjournment pursuant to
            this sentence shall be required to be for a period exceeding ten (10) Business Days. Buyer, through the Buyer Board, shall (i) recommend to its stockholders that they vote to approve the Buyer Stockholder Matters, (ii) include such
            recommendation in the Proxy Statement and (iii) publicly reaffirm such recommendation within 24&#160;hours after a request to do so by the Sellers. Without limiting the generality of the foregoing, Buyer shall use its reasonable best efforts to
            solicit proxies to obtain the Buyer Stockholder Approval.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 40pt; text-indent: 20pt; text-align: justify;" class="para">(f) &#8195;Each Seller agrees that it shall, at the Buyer Stockholders Meeting,
            however called, or in connection with any written consent of the Buyer Stockholders, vote or consent (or cause to be voted or consented), in person or by proxy, all shares of Buyer Common Stock owned by such Seller (i) in favor of the approval
            of the Buyer Stockholder Matters and any other actions contemplated by this Agreement and the BC Agreement and any actions required in furtherance hereof and thereof, including delivering a written consent, (ii) against approval of any proposal
            made in opposition to, or in competition with, the Buyer Stockholder Matters, and (iii) against any other proposal, action, or transaction that would impede, frustrate, prevent or materially delay the consummation of the transactions
            contemplated by the BC Agreement. Each Seller agrees irreparable damage would occur in the event that such Seller does not perform the provisions of this <u>Section&#160;4.1(f)</u> in accordance with its terms or otherwise breaches such provisions,
            and accordingly, Buyer would be entitled to the equitable remedies under <u>Section&#160;5.13</u>.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">Section 1.2&#8195;<u>Effect of Amendment</u>. Except as specifically modified
            herein, the F351 Agreement remains in full force and effect.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;" class="h1">ARTICLE II<br>
          </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 0pt; text-align: center;" class="h1">AGREEMENT ON CASH SETTLEMENT EXTENSION</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">Section 2.1&#8195;<u>Cash Settlement Extension</u>. As of the date hereof, the
            GNI Parties hold 12,340 shares of Series X Convertible Preferred Stock. The GNI Parties and CBIO hereby agree to extend the deadline for the cash settlement of the Conversion Shares as set forth in Section 6(d)(iii) of the Certificate of
            Designation as follows:</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: justify;" class="para">(a) &#8195;If, at any time after the earlier of (i) receipt of Stockholder
            Approval or (ii) September&#160;30, 2023, CBIO fails to deliver to the GNI Parties such certificate or certificates, or electronically deliver (or cause its transfer agent to electronically deliver) such shares in the case of a DWAC Delivery,
            pursuant to Section&#160;&#8206;6(d)(i) of the Certificate of Designation on or prior to the third (3rd) Trading Day after the Share Delivery Date applicable to such conversion (other than a failure caused by incorrect or incomplete information provided
            by the GNI Parties to CBIO), then, unless the GNI Parties have rescinded the applicable Notice of Stock Conversion pursuant to Section&#160;6(d)(i) of the Certificate of Designation, CBIO shall, at the request of the GNI Parties, pay an amount equal
            to the Fair Value (as defined therein) of such undelivered shares, with such payment to be made within two Business Days from the date of request by the GNI Parties, whereupon CBIO&#8217;s obligations to deliver such shares underlying the Notice of
            Stock Conversion shall be extinguished.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: justify;" class="para">(b) &#8195;If any of the GNI Parties assigns any or all of its rights, interests
            and obligations in the Series&#160;X Convertible Preferred Stock and/or Conversion Shares to any of its Affiliates, then all references herein to such GNI Party shall be deemed references to such other Affiliate. Any preferences, rights and
            limitations of Series&#160;X Convertible Preferred Stock set forth in the Certificate of Designation will be binding upon, inure to the benefit of, and be enforceable by, the parties and their respective successors and assigns.</div>
          <div style="clear: both; margin-top: 9pt; margin-bottom: 9pt;" class="BRPFPageBreakArea">
            <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">3</font></div>
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      </div>
    </div>
    <div style="margin: auto; position: relative; text-align: left;" class="page"><a name="ny20006478x1_prem14a_301-annexb_pg47"></a>
      <div class="page-content">
        <div style="margin: 0px 0px 0px 0pt;" class="block-main">
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">Section 2.2&#8195;<u>Effect of Agreement</u>. Except as specifically agreed
            herein, the preferences, rights and limitations of Series&#160;X Convertible Preferred Stock set forth in the Certificate of Designation remain unchanged and in full force and effect.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 20.5pt; text-align: center;" class="h1">ARTICLE III<br>
          </div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 0pt; text-align: center;" class="h1">GENERAL PROVISIONS</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">Section 3.1&#8195;<u>Counterparts</u>. This Agreement and Amendment may be
            executed in one or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument, with the same effect as if the signatures thereto were in the same instrument.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8.5pt; margin-left: 0pt; text-indent: 20pt;" class="para">Section 3.2&#8195;<u>General Provisions</u>. Article&#160;V of the F351 Agreement is hereby incorporated
            by reference.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 20.5pt; text-align: center;" class="h1">[<font style="font-style: italic;">Remainder of Page Intentionally Left Blank; Signature Pages Follow</font>]</div>
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            <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">4</font></div>
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    <div style="margin: auto; position: relative; text-align: left;" class="page"><a name="ny20006478x1_prem14a_301-annexb_pg48"></a>
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          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">IN WITNESS WHEREOF, the parties have each caused this Agreement and
            Amendment to be duly executed as of the date first written above.</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 8pt; margin-left: 0pt;" class="fpara">&#160;</div>
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                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt;" class="fpara"><u>CBIO</u>:<font style="font-weight: normal;">&#160;</font></div>
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                <td style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;" class="gutter">&#8203;</td>
                <td style="width: 46.15%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;">
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                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt;" class="fpara">CATALYST BIOSCIENCES, INC.<font style="font-weight: normal;">&#160;</font></div>
                </td>
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                <td style="width: 46.15%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;">
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                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;" class="fpara">&#160;</div>
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                <td style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt;" class="gutter">&#8203;</td>
                <td style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt;" class="gutter">&#8203;</td>
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                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 0pt; margin-left: 0pt;" class="fpara">By: </div>
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                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 0pt; margin-left: 0pt;" class="fpara">/s/ Nassim Usman, Ph.D. </div>
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                  <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 0pt; margin-left: 0pt;" class="fpara">Name:&#8194;Nassim Usman, Ph.D. </div>
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        <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 9.47pt; text-align: center;" class="unknown">[<font style="font-style: italic;">Signature Page to Agreement and Amendment to Asset Purchase Agreement</font>]<br>
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    <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">6</font>
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<DOCUMENT>
<TYPE>EX-2.3
<SEQUENCE>4
<FILENAME>brhc10050607_ex2-3.htm
<DESCRIPTION>EXHIBIT 2.3
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          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: right;" class="h1"> Exhibit 2.3<br>
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          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;" class="h1">AMENDMENT TO CONTINGENT VALUE RIGHTS AGREEMENT</div>
          <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;" class="para">This Amendment to Contingent Value Rights Agreement (this &#8220;<u>Amendment</u>&#8221;)




            is dated as of March&#160;29, 2023 (the &#8220;<u>Effective Date</u>&#8221;), with respect to that certain Contingent Value Rights Agreement (the &#8220;<u>CVR Agreement</u>&#8221;), dated December&#160;26, 2022, between Catalyst Biosciences, Inc., a Delaware corporation (the &#8220;<u>Company</u>&#8221;),

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<title></title>
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<body>
<span style="display: none;">v3.23.1</span><table class="report" border="0" cellspacing="2" id="idm140343487912176">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Document and Entity Information<br></strong></div></th>
<th class="th"><div>Mar. 29, 2023</div></th>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CoverAbstract', window );"><strong>Cover [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentType', window );">Document Type</a></td>
<td class="text">8-K<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AmendmentFlag', window );">Amendment Flag</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Mar. 29,  2023<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityFileNumber', window );">Entity File Number</a></td>
<td class="text">000-51173<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">Catalyst Biosciences, Inc.<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0001124105<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityIncorporationStateCountryCode', window );">Entity Incorporation, State or Country Code</a></td>
<td class="text">DE<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityTaxIdentificationNumber', window );">Entity Tax Identification Number</a></td>
<td class="text">56-2020050<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine1', window );">Entity Address, Address Line One</a></td>
<td class="text">611 Gateway Blvd<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine2', window );">Entity Address, Address Line Two</a></td>
<td class="text">Suite 120<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressCityOrTown', window );">Entity Address, City or Town</a></td>
<td class="text">South San Francisco<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressStateOrProvince', window );">Entity Address, State or Province</a></td>
<td class="text">CA<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressPostalZipCode', window );">Entity Address, Postal Zip Code</a></td>
<td class="text">94080<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CityAreaCode', window );">City Area Code</a></td>
<td class="text">650<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_LocalPhoneNumber', window );">Local Phone Number</a></td>
<td class="text">871-0761<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Title of 12(b) Security</a></td>
<td class="text">Common Stock<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">CBIO<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NASDAQ<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_WrittenCommunications', window );">Written Communications</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SolicitingMaterial', window );">Soliciting Material</a></td>
<td class="text">true<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementTenderOffer', window );">Pre-commencement Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementIssuerTenderOffer', window );">Pre-commencement Issuer Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_AmendmentFlag">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CityAreaCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Area code of city</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CityAreaCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CoverAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Cover page.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CoverAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period.  The format of the date is YYYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentType">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 1 such as Attn, Building Name, Street Name</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine2">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 2 such as Street or Suite number</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine2</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressCityOrTown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the City or Town</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressCityOrTown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressPostalZipCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Code for the postal or zip code</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressPostalZipCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressStateOrProvince">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the state or province.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressStateOrProvince</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:stateOrProvinceItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:centralIndexKeyItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityEmergingGrowthCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFileNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFileNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fileNumberItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityIncorporationStateCountryCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Two-character EDGAR code representing the state or country of incorporation.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityIncorporationStateCountryCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarStateCountryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Local phone number for entity.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 13e<br> -Subsection 4c<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14d<br> -Subsection 2b<br></p></div>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Title of a 12(b) registered security.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b<br></p></div>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the Exchange on which a security is registered.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection d1-1<br></p></div>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Section 14a<br> -Number 240<br> -Subsection 12<br></p></div>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Trading symbol of an instrument as listed on an exchange.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Securities Act<br> -Number 230<br> -Section 425<br></p></div>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
