<SEC-DOCUMENT>0001140361-23-042067.txt : 20230831
<SEC-HEADER>0001140361-23-042067.hdr.sgml : 20230831
<ACCEPTANCE-DATETIME>20230831161739
ACCESSION NUMBER:		0001140361-23-042067
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		14
CONFORMED PERIOD OF REPORT:	20230829
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Material Modifications to Rights of Security Holders
ITEM INFORMATION:		Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year
ITEM INFORMATION:		Submission of Matters to a Vote of Security Holders
ITEM INFORMATION:		Other Events
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20230831
DATE AS OF CHANGE:		20230831

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CATALYST BIOSCIENCES, INC.
		CENTRAL INDEX KEY:			0001124105
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				562020050
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51173
		FILM NUMBER:		231229253

	BUSINESS ADDRESS:	
		STREET 1:		611 GATEWAY BLVD., SUITE 710
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		650-871-0761

	MAIL ADDRESS:	
		STREET 1:		611 GATEWAY BLVD., SUITE 710
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TARGACEPT INC
		DATE OF NAME CHANGE:	20000919
</SEC-HEADER>
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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 18pt; font-weight: bold;"><span style="font-size: 14pt; font-family: 'Times New Roman';">&#160;</span><span style="font-size: 14pt;">UNITED STATES</span></div>

    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>

    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold;">WASHINGTON, D.C. 20549</div>

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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">&#160;<span style="font-family: 'Times New Roman'; font-weight: bold;">CURRENT REPORT</span></div>

    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934</div>

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            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;"><ix:nonNumeric name="dei:EntityAddressAddressLine1" id="Fact_87c2b8ecfabd4f8cb9b44d568a9a14e3" contextRef="c20230829to20230829">611 Gateway Blvd</ix:nonNumeric><br />
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    <td style="width: 2%; vertical-align: bottom; font-size: 10pt;">&#160;</td>

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    <td style="width: 49.01%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';">(Address of principal executive offices)</div>
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    <td style="width: 2%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 49%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';">(Zip Code)</div>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">Registrant&#8217;s telephone number, including area code: <span style="font-family: 'Times New Roman'; font-weight: bold;">(<ix:nonNumeric name="dei:CityAreaCode" id="Fact_0247a9bc041d434db5c854f516361ff3" contextRef="c20230829to20230829">650</ix:nonNumeric>) <ix:nonNumeric name="dei:LocalPhoneNumber" id="Fact_0262223dcc0b4619937d8026a5f954aa" contextRef="c20230829to20230829">871-0761</ix:nonNumeric></span></div>

    <div style="font-size: 10pt;"><br />
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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Not Applicable</div>

    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">(Former name or former address, if changed since last report)</div>

    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

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        <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; border: none; margin-left: auto; margin-right: auto;" /></div>

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    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"> <br />
    </div>

    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (<span style="font-family: 'Times New Roman'; font-style: italic;">see</span>&#160;General Instruction A.2. below):</div>

    <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
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    <td style="width: auto; vertical-align: top; text-align: left; font-size: 10pt;">
            <div style="font-family: 'Times New Roman';">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</div>
          </td>

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    <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

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    <td style="width: 27pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;"><ix:nonNumeric name="dei:SolicitingMaterial" id="Fact_a583757b92e0426ab5675de8d7b3c43f" contextRef="c20230829to20230829" format="ixt-sec:boolballotbox">&#x2610;</ix:nonNumeric></td>

    <td style="width: auto; vertical-align: top; text-align: left; font-size: 10pt;">
            <div style="font-family: 'Times New Roman';">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</div>
          </td>

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    <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

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    <td style="width: 27pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;"><ix:nonNumeric name="dei:PreCommencementTenderOffer" id="Fact_1e2984f02edd42b88d48ef4316c4906b" contextRef="c20230829to20230829" format="ixt-sec:boolballotbox">&#x2610;</ix:nonNumeric></td>

    <td style="width: auto; vertical-align: top; text-align: left; font-size: 10pt;">
            <div style="font-family: 'Times New Roman';">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</div>
          </td>

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</table>
    <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

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    <td style="width: 27pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;"><ix:nonNumeric name="dei:PreCommencementIssuerTenderOffer" id="Fact_bed13064a0b840de85f62ebc31c1eb6c" contextRef="c20230829to20230829" format="ixt-sec:boolballotbox">&#x2610;</ix:nonNumeric></td>

    <td style="width: auto; vertical-align: top; text-align: left; font-size: 10pt;">
            <div style="font-family: 'Times New Roman';">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</div>
          </td>

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    <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="font-size: 10pt;">
      <div style="text-align: left; font-family: 'Times New Roman';">Securities registered pursuant to Section 12(b) of the Act:</div>

    </div>

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    <td style="width: 34%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; white-space: nowrap;">
            <div style="text-align: center; font-family: 'Times New Roman';">&#160;<span style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">Title of each class</span></div>
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    <td style="width: 2.01%; vertical-align: bottom; font-size: 10pt;">&#160;</td>

    <td style="width: 30%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Trading Symbol(s)</div>
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    <td style="width: 2%; vertical-align: bottom; font-size: 10pt;">&#160;</td>

    <td style="width: 32%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman'; font-size: 10pt;">Name of each exchange on which</div>
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman'; font-size: 10pt;">registered</div>
          </td>

  </tr>

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    <td style="width: 34%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';"><ix:nonNumeric name="dei:Security12bTitle" id="Fact_885af7b15792463197314b84a3adc4ba" contextRef="c20230829to20230829">Common Stock</ix:nonNumeric><br />
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    <td style="width: 2.01%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 30%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';"><ix:nonNumeric name="dei:TradingSymbol" id="Fact_37e6e3b96f78420d97deb1fb42cbcc72" contextRef="c20230829to20230829">CBIO</ix:nonNumeric><br />
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    <td style="width: 2%; vertical-align: top; font-size: 10pt;">&#160;</td>

    <td style="width: 32%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman';"><ix:nonNumeric name="dei:SecurityExchangeName" id="Fact_c324896a5fe54489a5ee084842c8b278" contextRef="c20230829to20230829">NASDAQ</ix:nonNumeric><br />
            </div>
          </td>

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</table>
    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (&#167;230.405 of this chapter) or Rule 12b-2 of
      the Securities Exchange Act of 1934 (&#167;240.12b-2 of this chapter).</div>

    <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Emerging growth company <ix:nonNumeric name="dei:EntityEmergingGrowthCompany" id="Fact_53c522112f954d10ae356ef1a7152893" contextRef="c20230829to20230829" format="ixt-sec:boolballotbox">&#x2610;</ix:nonNumeric></div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised
      financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. &#9744;</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" />
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" /></div>

    </div>

    <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">


  <tr>

    <td style="width: 63pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Item 1.01</td>

    <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
            <div style="font-family: 'Times New Roman'; font-weight: bold;">Entry into a Material Definitive Agreement.</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic; font-weight: bold;">Amendment to Business Combination Agreement</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On August 30, 2023, Catalyst Biosciences, Inc., a Delaware corporation (&#8220;Catalyst&#8221;), GNI USA, Inc., a Delaware corporation (&#8220;GNI USA&#8221;), GNI Group Ltd., a company
      incorporated under the laws of Japan with limited liability (&#8220;GNI Group&#8221;), GNI Hong Kong Limited, a company incorporated under the laws of Hong Kong with limited liability (&#8220;GNI HK&#8221;), Shanghai Genomics, Inc., a company organized under the laws of the
      People&#8217;s Republic of China (&#8220;Shanghai Genomics&#8221;, and collectively with GNI USA, GNI Group and GNI HK, the &#8220;Contributors&#8221;), and Continent Pharmaceuticals Inc., a Cayman Islands company limited by shares (the &#8220;CPI&#8221;), entered into a second amendment
      (the &#8220;Second Amendment&#8221;) to the previously announced Business Combination Agreement, dated as of December 26, 2022, as amended on March 29, 2023 (the &#8220;Business Combination Agreement&#8221;). The Second Amendment modifies the Business Combination Agreement
      by amending and restating Section 8.1(b)(i) to extend the Outside Date (as defined therein) to October 30, 2023.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The foregoing description of the Second Amendment is qualified in its entirety by reference to the full text of the Second Amendment, which is attached hereto as Exhibit
      2.1 and incorporated herein by reference.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" class="DSPFListTable">


  <tr style="vertical-align: top;">

    <td style="text-align: right; vertical-align: top; width: 63pt;">
              <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Item 3.03</div>
            </td>

    <td style="text-align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Material Modification to Rights of Security Holders.</div>
            </td>

  </tr>


</table>
    </div>

    <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">To the extent required by Item 3.03 of Form 8-K, the information contained in Item 5.03 of this Current Report on Form 8-K is incorporated herein by reference.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" class="DSPFListTable">


  <tr style="vertical-align: top;">

    <td style="text-align: right; vertical-align: top; width: 63pt;">
              <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Item 5.03</div>
            </td>

    <td style="text-align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year.</div>
            </td>

  </tr>


</table>
    </div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic; font-weight: bold;">Certificate of Elimination</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On August 31, 2023, Catalyst filed with Secretary of State of the State of Delaware a Certificate of Elimination to the Certificate of Incorporation of Catalyst which,
      effective upon filing, eliminated all matters set forth in the applicable Certificate of Designations with respect to Catalyst&#8217;s Series Y Preferred Stock, par value $0.001 per share (the &#8220;Catalyst Series Y Preferred Stock&#8221;).</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The foregoing description of the Certificate of Elimination does not purport to be complete and is qualified in its entirety by reference to the Certificate of
      Elimination, which is filed as Exhibit 3.1 to this Current Report on Form 8-K and is incorporated herein by reference.</div>

    <div style="text-align: justify; font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Item 5.07 Submission of Matters to a Vote of Security Holders.</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On August 29, 2023, Catalyst held a special meeting of stockholders (the &#8220;Special Meeting&#8221;) to approve, among other things, the previously announced transactions (the
      &#8220;Transactions&#8221;) pursuant to the Business Combination Agreement.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As of the close of business on July 19, 2023, the record date for the Special Meeting, 37,974,892 shares of common stock, par value $0.001 per share (the &#8220;Catalyst
      Common Stock&#8221;), were issued and outstanding and 161,160 shares of Catalyst Series Y Preferred Stock were issued and outstanding. Holders of outstanding shares of Catalyst Series Y Preferred Stock were only entitled to vote such shares on Proposal No.
      4 together with the outstanding shares of Catalyst Common Stock as a single class. Holders of Catalyst Common Stock were entitled to one vote per share, and holders of Catalyst Series Y Preferred Stock were entitled to 250 votes per share.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">At the Special Meeting, there were present, in person or by proxy, holders of 25,256,315 shares of Catalyst Common Stock and holders of 25,256.315 shares of Catalyst
      Series Y Preferred Stock.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The stockholders voted on the following proposals at the Special Meeting. Detailed descriptions of each proposal are included in Catalyst&#8217;s Definitive Proxy Statement on
      Schedule 14A filed with the U.S. Securities and Exchange Commission (the &#8220;SEC&#8221;) on July 20, 2023 (the &#8220;Proxy Statement&#8221;).</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The final voting results with respect to each proposal presented at the Special Meeting is set forth below.</div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br />
    </div>

    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" /></div>

    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 1 &#8211; Approval of the Issuance of Shares of Catalyst Common Stock and Catalyst Convertible Preferred Stock</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst&#8217;s stockholders approved the issuance of shares of Catalyst Common Stock and Catalyst Series X Convertible Preferred Stock, par value $0.001 per share (the
      &#8220;Catalyst Convertible Preferred Stock&#8221;), each pursuant to the terms of the Business Combination Agreement, by the following votes:</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">


  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes Against</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Abstentions</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Broker Non-Votes</div>
          </td>

  </tr>

  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">10,508,917</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">226,149</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">35,448</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">14,485,801</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 2 &#8211; Approval of the Conversion of Catalyst Convertible Preferred Stock into Shares of Catalyst Common Stock</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As previously disclosed in the Proxy Statement, GNI Group and GNI HK, collectively holding 6,266,521 shares of Catalyst Common Stock issued under the Asset Purchase
      Agreement, dated December 26, 2022 and amended on March 29, 2023 (the &#8220;Asset Purchase Agreement&#8221;), were not entitled to vote on Proposal No. 2 for purposes of compliance with the listing rules of The Nasdaq Stock Market (&#8220;Nasdaq&#8221;). After subtracting
      such 6,266,521 shares of Catalyst Common Stock from the total numbers of shares voted on and voted &#8220;for&#8221; Proposal No. 2, Catalyst&#8217;s stockholders approved the conversion of Catalyst Convertible Preferred Stock into shares of Catalyst Common Stock
      pursuant to the Asset Purchase Agreement, by the following votes:</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">


  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes Against</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Abstentions</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Broker Non-Votes</div>
          </td>

  </tr>

  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">4,259,446</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">214,221</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">30,326</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">14,485,801</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">In light of the pending Transactions, GNI Group and GNI HK do not intend to convert their shares of Catalyst Convertible Preferred Stock into shares of Catalyst Common
      Stock until Gyre Therapeutics, Inc. (the post-Transactions entity) receives initial listing approval from Nasdaq upon the closing of the Transactions.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 3 &#8211; Approval of Increasing the Number of Authorized Shares of Catalyst Common Stock</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst&#8217;s stockholders approved the adoption of an amendment to Catalyst&#8217;s restated certificate of incorporation to increase the number of authorized shares of Catalyst
      Common Stock from 100,000,000 shares to 400,000,000 shares, by the following votes:</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <table cellspacing="0" cellpadding="0" border="0" style="border-collapse: collapse; width: 80%; color: #000000; font-family: 'Times New Roman'; font-size: 10pt; text-align: left;">


  <tr>

    <td style="width: 28%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For</div>
          </td>

    <td style="width: 24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes Against</div>
          </td>

    <td style="width: 28%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Abstentions</div>
          </td>

  </tr>

  <tr>

    <td style="width: 28%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">24,355,825</div>
          </td>

    <td style="width: 24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">719,069</div>
          </td>

    <td style="width: 28%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">181,421</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 4 &#8211; Approval of the Reverse Stock Split of Catalyst Common Stock</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst&#8217;s stockholders approved the adoption of an amendment to Catalyst&#8217;s restated certificate of incorporation to effect a reverse stock split of Catalyst&#8217;s issued
      common stock by a ratio of not less than 1-for-10 and not more than 1-for-60, such ratio to be determined in the discretion of Board of Directors of Catalyst (the &#8220;Board&#8221;), by the following votes:</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">


  <tr>

    <td style="width: 37.22%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Holders</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes Against</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Abstentions</div>
          </td>

  </tr>

  <tr>

    <td style="width: 37.22%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">Catalyst Common Stock</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">24,377,875</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">823,859</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">54,581</div>
          </td>

  </tr>

  <tr>

    <td style="width: 37.22%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Catalyst Series Y Preferred Stock</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">6,094,468,750</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">205,964,750</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">13,645,250</div>
          </td>

  </tr>

  <tr>

    <td style="width: 37.22%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst Common Stock +</div>
            <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst Series Y Preferred Stock</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">6,118,846,625</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">206,788,609</div>
          </td>

    <td style="width: 20.93%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">13,699,831</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 5 &#8211; Approval of the Creation a New Class of Non-Voting Common Stock</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst&#8217;s stockholders did not approve the adoption of an amendment to Catalyst&#8217;s restated certificate of incorporation to authorize up to 20,000,000 shares of
      non-voting common stock, par value $0.001 pers share, by the following votes:</div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br />
    </div>

    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" /></div>

    </div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">


  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes Against</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Abstentions</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Broker Non-Votes</div>
          </td>

  </tr>

  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">9,531,069</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">1,187,226</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">52,219</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">14,485,801</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 6 &#8211; Approval of the Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman'; font-style: italic;"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst&#8217;s stockholders approved the adoption of the Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan, by the following votes:</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">


  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes Against</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Abstentions</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Broker Non-Votes</div>
          </td>

  </tr>

  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">10,167,733</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">538,802</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">63,979</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">14,485,801</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 7 &#8211; Approval of Stockholder Action by Written Consent</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst&#8217;s stockholders did not approve the adoption of an amendment to Catalyst&#8217;s restated certificate of incorporation to allow stockholders to act by written consent,
      for so long as GNI USA and its affiliates beneficially own 50% or more of the combined voting power of the outstanding shares of Catalyst Common Stock, by the following votes:</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">


  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes Against</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Abstentions</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Broker Non-Votes</div>
          </td>

  </tr>

  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">9,854,595</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">884,222</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">31,697</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; font-family: 'Times New Roman';">14,485,801</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 8 &#8211; Election of Directors</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst&#8217;s stockholders approved the election of two Class II directors to the Board for three year terms or until their respective successors are elected and qualified
      or until their earlier resignation or removal, by the following votes:</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">


  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Nominee</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes Withheld</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Broker Non-Votes</div>
          </td>

  </tr>

  <tr>

    <td style="width: 25%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Andrea Hunt</div>
          </td>

    <td style="width: 25%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">10,523,301</div>
          </td>

    <td style="width: 25%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">247,213</div>
          </td>

    <td style="width: 25%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">14,485,801</div>
          </td>

  </tr>

  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Nassim Usman, Ph.D.</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">10,536,961</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">233,553</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">14,485,801</div>
          </td>

  </tr>


</table>
    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 9 &#8211; Approval of the Compensation of Catalyst&#8217;s Named Executive Officers</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst&#8217;s stockholders approved the compensation of Catalyst&#8217;s Named Executive Officers on a non-binding, advisory basis by the following votes:</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">


  <tr>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes Against</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Abstentions</div>
          </td>

    <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Broker Non-Votes</div>
          </td>

  </tr>

  <tr>

    <td style="width: 25%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">10,265,419</div>
          </td>

    <td style="width: 25%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">374,990</div>
          </td>

    <td style="width: 25%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">130,105</div>
          </td>

    <td style="width: 25%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">14,485,801</div>
          </td>

  </tr>


</table>
    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 10 &#8211; Advisory Vote on the Frequency of Future Advisory Votes on Executive Compensation</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman'; font-style: italic;"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst&#8217;s stockholders voted on the frequency of future advisory votes on executive compensation on a non-binding, advisory basis by the following votes:</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">


  <tr>

    <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For 1 Year</div>
          </td>

    <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes for 2 Years</div>
          </td>

    <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes for 3 Years</div>
          </td>

    <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Abstentions</div>
          </td>

    <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Broker Non-Votes</div>
          </td>

  </tr>

  <tr>

    <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">10,326,688</div>
          </td>

    <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">43,232</div>
          </td>

    <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">194,114</div>
          </td>

    <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">206,480</div>
          </td>

    <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">14,485,801</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">In light of these voting results, Catalyst plans to hold future advisory votes on executive compensation annually until the next required vote on the frequency of such
      advisory votes, or until the Board otherwise determines that a different frequency is in the best interests of Catalyst and its stockholders.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Proposal 11 &#8211; Ratification of Appointment of Independent Registered Accounting Firm</div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;"> <br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Catalyst&#8217;s stockholders ratified the appointment of EisnerAmper LLP as Catalyst&#8217;s independent registered accounting firm for the fiscal year ending December 31, 2023 by
      the following votes:</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <table cellspacing="0" cellpadding="0" border="0" style="border-collapse: collapse; width: 70%; color: #000000; font-family: 'Times New Roman'; font-size: 10pt; text-align: left;">


  <tr>

    <td style="width: 24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes For</div>
          </td>

    <td style="width: 22%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Votes Against</div>
          </td>

    <td style="width: 24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Abstentions</div>
          </td>

  </tr>

  <tr>

    <td style="width: 24%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">24,862,106</div>
          </td>

    <td style="width: 22%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">349,209</div>
          </td>

    <td style="width: 24%; vertical-align: top; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">45,000</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" /></div>

    </div>

    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">


  <tr>

    <td style="width: 63pt; vertical-align: top; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Item 8.01</td>

    <td style="width: auto; vertical-align: top; text-align: left; font-size: 10pt;">
              <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-weight: bold;">Other Events.</div>
            </td>

  </tr>


</table>
      <div style="font-size: 10pt;">&#160;</div>

    </div>

    <div>
      <div style="text-align: justify; color: #000000; font-family: 'Times New Roman'; font-size: 10pt;">Completion of the Transactions is subject to receipt of required regulatory approvals, including approval from the China Securities Regulatory
        Commission (&#8220;CSRC&#8221;) pursuant to the Trial Administrative Measures of Overseas Securities Offering and Listing by Domestic Enterprises (the &#8220;Trial Measures&#8221;), No. 1 to No. 5 Supporting Guidance Rules, the Notes on the Trial Measures, the Notice on
        Administration Arrangements for the Filing of Overseas Listings by Domestic Enterprises and the relevant CSRC Answers to Reporter Questions on the official website of CSRC. These regulations established a filing-based regime to regulate overseas
        offerings and listings by PRC domestic companies. Catalyst has not yet received approval from the CSRC to complete its previously announced Transactions. While Catalyst anticipates that it will receive CSRC approval prior to the Outside Date (as
        defined in the Business Combination Agreement), there can be no assurance this will occur.</div>

      <div style="font-size: 10pt;">&#160;</div>

    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic; font-weight: bold;">Forward-Looking Statements</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">This document contains &#8220;forward-looking statements&#8221; within the meaning of the Private Securities Litigation Reform Act of 1995.&#160; You can identify these statements and
      other forward-looking statements in this document by words such as &#8220;may&#8221;, &#8220;will&#8221;, &#8220;would&#8221;, &#8220;expect&#8221;, &#8220;anticipate&#8221;, &#8220;believe&#8221;, &#8220;estimate&#8221;, &#8220;plan&#8221;, &#8220;intend&#8221;, &#8220;continue&#8221;, or similar words, expressions or the negative of such terms or other comparable
      terminology. These statements include, but are not limited to, expectations regarding the receipt of required regulatory approvals, including approval from the CSRC, for the closing of the Transactions, the benefits of the Transactions involving
      Catalyst, the Contributors, the Minority Holders (as defined in the Business Combination Agreement) and CPI, including the combined company&#8217;s future financial and operating results, plans, objectives, expectations and intentions and other statements
      that are not historical facts. Such statements are based upon the current beliefs and expectations of Catalyst&#8217;s management and are subject to significant risks and uncertainties. Actual results may differ from those set forth in the forward-looking
      statements.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The following factors, among others, could cause actual results and the timing of events to differ materially from those anticipated in such forward-looking statements
      as a result of these risks and uncertainties, which include, without limitation: (i) the risk that the conditions to the closing of the Transactions are not satisfied; (ii) uncertainties as to the timing of the consummation of the Transactions and
      the ability of each of Catalyst, the Contributors, the Minority Holders and CPI to consummate the Transactions, as applicable; (iii) uncertainties regarding the timing of receipt of required regulatory approvals, including approval from the CSRC, for
      the Transactions, including the possibility that the Transactions do not close when expected or at all because required regulatory approvals, including approval from the CSRC, are not received on a timely basis or at all (and the risk that such
      approvals may result in the imposition of conditions that could adversely affect Catalyst, the Contributors, the Minority Holders and/or CPI and/or reduce or eliminate the anticipated benefits of the Transactions); (iv) risks related to Catalyst&#8217;s
      ability to manage its operating expenses and expenses associated with the Transactions; (v) risks related to Catalyst&#8217;s ability to regain compliance with Nasdaq listing standards and remain listed on Nasdaq; (vi) unexpected costs, charges or expenses
      resulting from the Transactions; (vii) potential adverse reactions or changes to business relationships resulting from the announcement or completion of the Transactions; (viii) risks related to the inability of the combined company to obtain
      sufficient additional capital to continue to advance the product candidates and preclinical programs of Catalyst; and (ix) risks associated with the possible failure to realize certain anticipated benefits of the Transactions, including with respect
      to future financial and operating results. Additional risks and factors are identified under &#8220;Risk Factors&#8221; in Catalyst&#8217;s Annual Report on Form 10-K filed on March 30, 2023 and subsequent reports filed with the SEC, and identified under &#8220;Risk
      Factors&#8221; in the Proxy Statement.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">You should not rely upon forward-looking statements as predictions of future events because these statements are based on assumptions that may not come true and are
      speculative by their nature. Neither the Contributors, the Minority Holders or CPI undertakes an obligation to update any of the forward-looking information included in this document, whether as a result of new information, future events, changed
      expectations or otherwise.</div>

    <div style="font-size: 10pt;"><br />
    </div>

    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" /></div>

    </div>

    <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">


  <tr>

    <td style="width: 63pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Item 9.01</td>

    <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
            <div style="font-family: 'Times New Roman'; font-weight: bold;">Exhibits.</div>
          </td>

  </tr>


</table>
    <div style="font-size: 10pt;"><br />
    </div>

    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">(d) Exhibits</div>

    <div style="text-align: justify;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">EXHIBIT INDEX</div>

      <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
        </span></div>

    </div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">


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    <td style="width: 10%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: justify; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-weight: bold;">Exhibit </div>
            <div style="text-align: justify; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-weight: bold;">Number</div>
          </td>

    <td style="width: 1%; vertical-align: top; font-size: 10pt; white-space: nowrap;">&#160;</td>

    <td style="width: 89%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-weight: bold;">Description</div>
          </td>

  </tr>

  <tr>

    <td style="width: 10%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: justify; color: rgb(0, 0, 0); font-family: 'Times New Roman';"><a href="brhc20058284_ex2-1.htm">2.1</a></div>
          </td>

    <td style="width: 1%; vertical-align: top; font-size: 10pt; white-space: nowrap;">&#160;</td>

    <td style="width: 89%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: left; font-family: 'Times New Roman';">Second Amendment to Business Combination Agreement, dated as of August 30, 2023, by and among Catalyst, GNI USA, GNI Group, GNI HK, Shanghai Genomics and CPI.</div>
          </td>

  </tr>

  <tr>

    <td style="width: 10%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: justify; color: rgb(0, 0, 0); font-family: 'Times New Roman';"><a href="brhc20058284_ex3-1.htm">3.1</a></div>
          </td>

    <td style="width: 1%; vertical-align: top; font-size: 10pt; white-space: nowrap;">&#160;</td>

    <td style="width: 89%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: left; font-family: 'Times New Roman';">Certificate of Elimination for Catalyst&#8217;s Series Y Preferred Stock.</div>
          </td>

  </tr>

  <tr>

    <td style="width: 10%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: justify; color: rgb(0, 0, 0); font-family: 'Times New Roman';">104</div>
          </td>

    <td style="width: 1%; vertical-align: top; font-size: 10pt; white-space: nowrap;">&#160;</td>

    <td style="width: 89%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Cover Page Interactive Data File (formatted as Inline XBRL).</div>
          </td>

  </tr>


</table>
    <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

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      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" /></div>

    </div>

    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">SIGNATURES</div>

    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <div style="text-align: left; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the
      undersigned hereunto duly authorized.</div>

    <div style="text-align: left; text-indent: 36pt;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">


  <tr>

    <td style="width: 46.41%; vertical-align: bottom; font-size: 10pt;">&#160;</td>

    <td style="width: 53.59%; vertical-align: bottom; font-size: 10pt;" colspan="2">
            <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">CATALYST BIOSCIENCES, INC.</div>
          </td>

  </tr>

  <tr>

    <td style="width: 46.41%; vertical-align: bottom; font-size: 10pt;">&#160;</td>

    <td style="width: 53.59%; vertical-align: bottom; font-size: 10pt;" colspan="2">&#160;</td>

  </tr>

  <tr>

    <td style="width: 46.41%; vertical-align: bottom; font-size: 10pt;">
            <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Date: August 31, 2023</div>
          </td>

    <td style="width: 5.5%; vertical-align: bottom; font-size: 10pt;">
            <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">By:</div>
          </td>

    <td style="width: 48.1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
            <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">/s/ Nassim Usman, Ph.D.</div>
          </td>

  </tr>

  <tr>

    <td style="width: 46.41%; vertical-align: bottom; font-size: 10pt;"><br />
          </td>

    <td style="width: 5.5%; vertical-align: bottom; font-size: 10pt;">
            <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Name:</div>
          </td>

    <td style="width: 48.1%; vertical-align: bottom; font-size: 10pt;">
            <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Nassim Usman, Ph.D.</div>
          </td>

  </tr>

  <tr>

    <td style="width: 46.41%; vertical-align: bottom; font-size: 10pt;"><br />
          </td>

    <td style="width: 5.5%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Title:</div>
          </td>

    <td style="width: 48.1%; vertical-align: bottom; font-size: 10pt;">
            <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman';">President and Chief Executive Officer</div>
          </td>

  </tr>


</table>
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman';"> </span><span style="font-size: 10pt;"><br />
      </span></div>

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<DOCUMENT>
<TYPE>EX-2.1
<SEQUENCE>2
<FILENAME>brhc20058284_ex2-1.htm
<DESCRIPTION>EXHIBIT 2.1
<TEXT>
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    <div style="text-align: right; text-indent: 187.35pt; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Exhibit 2.1</div>
    <div style="font-size: 10pt;"><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">SECOND AMENDMENT TO BUSINESS COMBINATION AGREEMENT</div>
    <div style="font-size: 10pt;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">This Second Amendment to Business Combination Agreement (this &#8220;<font style="font-family: 'Times New Roman';"><u>Second Amendment</u></font>&#8221;) is dated
      as of August 30, 2023, with respect to that certain Business Combination Agreement (the &#8220;<font style="font-family: 'Times New Roman';"><u>Business Combination Agreement</u></font>&#8221;), dated as of December 26, 2022, as amended on March 29, 2023, by and
      among Catalyst Biosciences, Inc., a Delaware corporation (&#8220;<font style="font-family: 'Times New Roman';"><u>Parent</u></font>&#8221;), GNI USA, Inc., a Delaware corporation (&#8220;<font style="font-family: 'Times New Roman';"><u>GNI USA</u></font>&#8221;), GNI Group
      Ltd., a company incorporated under the laws of Japan with limited liability (&#8220;<font style="font-family: 'Times New Roman';"><u>GNI Group</u></font>&#8221;), GNI Hong Kong Limited, a company incorporated under the laws of Hong Kong with limited liability (&#8220;<font style="font-family: 'Times New Roman';"><u>GNI HK</u></font>&#8221;), Shanghai Genomics, Inc., a company organized under the laws of the People&#8217;s Republic of China (&#8220;<font style="font-family: 'Times New Roman';"><u>Shanghai Genomics</u></font>&#8221;, and
      collectively with GNI USA, GNI Group and GNI HK, the &#8220;<font style="font-family: 'Times New Roman';"><u>Contributors</u></font>,&#8221; and each a &#8220;<font style="font-family: 'Times New Roman';"><u>Contributor</u></font>&#8221;), the individuals listed on Annex A
      thereto and Continent Pharmaceuticals Inc., a Cayman Islands company limited by shares (the &#8220;<font style="font-family: 'Times New Roman';"><u>Company</u></font>&#8221;).&#160; Capitalized terms used but not defined herein shall have the respective meanings
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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">RECITALS</div>
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    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">WHEREAS, Section 8.4 of the Business Combination Agreement provides that it may be amended, modified or supplemented by Parent, the Contributors and
      the Company by action taken or authorized by their respective boards of directors or equivalent at any time prior to the Effective Time, whether before or after the Parent Stockholder Approval has been obtained, and by an instrument in writing
      specifically designated as an amendment thereto, signed on behalf of each of the parties in interest at the time of the amendment.</div>
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    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">NOW, THEREFORE, in consideration of the premises, and of the mutual agreements contained herein, and intending to be legally bound hereby, Parent, the
      Contributors and the Company hereby agree as follows:</div>
    <div style="font-size: 10pt;">&#160;</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">ARTICLE&#160;I<font style="font-family: 'Times New Roman';"><br>
        AMENDMENT</font></div>
    <div style="font-size: 10pt;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Section&#160;1.1</font><font style="font-size: 10pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: 'Times New Roman';"><font style="font-family: 'Times New Roman';"><u>Amendment</u></font>.&#160; Section 8.1(b)(i) of the Business Combination Agreement is hereby amended and restated as follows:</font></font></div>
    <div style="font-size: 10pt;">&#160;</div>
    <div style="text-align: justify; margin-left: 72pt; font-family: 'Times New Roman'; font-size: 10pt;">if the Transactions shall not have been consummated on or before October 30, 2023 (the &#8220;<font style="font-family: 'Times New Roman';"><u>Outside Date</u></font>&#8221;);
      <font style="font-family: 'Times New Roman';"><u>provided</u></font>, that the right to terminate this Agreement pursuant to this <font style="font-family: 'Times New Roman';"><u>Section 8.1(b)(i)</u></font> shall not be available to any party whose
      failure to fulfill in any material respect any of its obligations under this Agreement has been the primary cause of, or the primary factor that resulted in, the failure of the Transactions to be consummated by the Outside Date;</div>
    <div style="font-size: 10pt;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Section&#160;1.2</font><font style="font-size: 10pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <font style="font-family: 'Times New Roman';"><font style="font-family: 'Times New Roman';"><u>Effect of Amendment; Counterparts</u></font>.&#160; Except as specifically modified herein, the Business Combination Agreement remains in full force and effect.&#160; This Second Amendment may be executed in one or more
          counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument, with the same effect as if the signatures thereto were in the same instrument.&#160; Article IX of the Business
          Combination Agreement is hereby incorporated by reference.</font></font></div>
    <div style="font-size: 10pt;">&#160;</div>
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    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">IN WITNESS WHEREOF, the parties have each caused this Second Amendment to be duly executed as of the date first written above.</div>
    <div style="font-size: 10pt;">&#160;</div>
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          <td style="width: 50%; vertical-align: top; font-size: 10pt;">&#160;</td>
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            <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold;"><u><font style="font-size: 10pt; font-family: 'Times New Roman';">PARENT</font><font style="font-size: 10pt;">:</font></u></div>
          </td>
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          <td rowspan="1" style="width: 50%; vertical-align: top; font-size: 10pt;">&#160;</td>
          <td colspan="3" rowspan="1" style="vertical-align: top;">&#160;</td>
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            <div style="text-align: justify; font-family: 'Times New Roman'; font-weight: bold;">CATALYST BIOSCIENCES, INC.</div>
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        <tr>
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          <td style="width: 3%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">By:</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-bottom: 2px solid black; font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">/s/ Nassim Usman, Ph.D.</div>
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          <td style="width: 3%; vertical-align: top; font-size: 10pt;">&#160;</td>
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            <div style="text-align: justify; font-family: 'Times New Roman';">Name:</div>
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            <div style="text-align: justify; font-family: 'Times New Roman';">Nassim Usman, Ph.D.</div>
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          <td style="width: 3%; vertical-align: top; font-size: 10pt;">&#160;</td>
          <td style="width: 5%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">Title:</div>
          </td>
          <td style="width: 42%; vertical-align: top; font-size: 10pt;">
            <div style="text-align: justify; font-family: 'Times New Roman';">President and Chief Executive Officer</div>
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    <div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">[<font style="font-family: 'Times New Roman'; font-style: italic;">Signature Page to Second Amendment to Business Combination Agreement</font>]</div>
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    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">IN WITNESS WHEREOF, <font style="font-size: 10pt;">the parties have each caused this Second Amendment to be duly executed as of the date first
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            <td style="width: 50%; vertical-align: top; font-size: 10pt;">&#160;</td>
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              <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold;"><u><font style="font-size: 10pt; font-family: 'Times New Roman';">CONTRIBUTORS</font><font style="font-size: 10pt;">:</font></u></div>
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            <td rowspan="1" colspan="3" style="vertical-align: top;">&#160;</td>
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                  <td style="width: 50%; vertical-align: top; font-size: 10pt;">&#160;</td>
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                  <td style="width: 50%; vertical-align: top; font-size: 10pt;">&#160;</td>
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              </font></div>
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                      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold;"><u><font style="font-size: 10pt; font-family: 'Times New Roman';">COMPANY</font></u><font style="font-size: 10pt;">:</font></div>
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                      <div style="text-align: left; font-family: 'Times New Roman';">By:</div>
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                      <div style="text-align: left; font-family: 'Times New Roman';">/s/ Ying Luo</div>
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                    <td style="width: 50%; vertical-align: top; font-size: 10pt;">&#160;</td>
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                      <div style="text-align: left; font-family: 'Times New Roman';">Name:</div>
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                    <td style="width: 50%; vertical-align: top; font-size: 10pt;">&#160;</td>
                    <td style="width: 3%; vertical-align: top; font-size: 10pt;">&#160;</td>
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                      <div style="text-align: left; font-family: 'Times New Roman';">Title:</div>
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                <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">[<font style="font-family: 'Times New Roman'; font-style: italic;">Signature Page to Second Amendment to Business Combination Agreement</font>]</div>
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    <div style="text-align: left; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">IN WITNESS WHEREOF, the parties have each caused this Second Amendment to be duly executed as of the date first written above.</div>
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              <div style="text-align: left; font-family: 'Times New Roman';">/s/ Yuwen Wu</div>
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<DOCUMENT>
<TYPE>EX-3.1
<SEQUENCE>3
<FILENAME>brhc20058284_ex3-1.htm
<DESCRIPTION>EXHIBIT 3.1
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    <div style="text-align: right; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Exhibit 3.1</div>
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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">CATALYST BIOSCIENCES, INC.</div>
    <div style="text-align: center; color: rgb(5, 5, 5); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">CERTIFICATE OF ELIMINATION</div>
    <div style="text-align: center; color: rgb(5, 5, 5); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">OF</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">SERIES Y PREFERRED STOCK</div>
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    <div style="text-align: center; color: rgb(5, 5, 5); font-family: 'Times New Roman'; font-size: 10pt;">Pursuant to Section 151(g) of the</div>
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      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; color: rgb(0, 0, 0);">Pursuant to the provisions of Section 151(g) of the
          General Corporation Law of the State of Delaware (the &#8220;<u>General Corporation Law</u>&#8221;), </font><font style="font-size: 10pt;">Catalyst Biosciences, Inc. (the &#8220;<font style="font-family: 'Times New Roman';"><u>Company</u></font>&#8221;), a corporation organized and existing
          under and by virtue of the provisions of the General Corporation Law, <font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">hereby certifies as follows:</font></font></div>
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            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">1.</td>
            <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
              <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman';">That, at a meeting of the Board of Directors of the Company, resolutions were duly adopted setting forth the proposed elimination of the series of stock as set forth
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    <div style="text-align: justify; margin-left: 72pt; font-family: 'Times New Roman'; font-size: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold; font-variant: small-caps;">Now, Therefore Be It</font><font style="font-size: 10pt;">&#160;<font style="font-family: 'Times New Roman'; font-weight: bold; font-variant: small-caps; color: rgb(5, 5, 5);">Resolved</font>, that, the officers of the Company be, and each of them hereby is, authorized,
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            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">2.</td>
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              <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman';">That the Certificate of Designation with respect to the Series Y Preferred Stock was filed with the Secretary of State of the State of Delaware on June 20, 2023 (the
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            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">3.</td>
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              <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman';">That none of the authorized shares of the Series Y Preferred Stock are outstanding, and none will be issued.</div>
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            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">4.</td>
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              <div style="font-family: 'Times New Roman'; font-size: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; color: rgb(0, 0, 0);">That, in accordance with the provisions of Section 151(g) of the General Corporation
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    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">IN WITNESS WHEREOF</font><font style="font-size: 10pt;">,
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            <div style="text-align: justify; font-family: 'Times New Roman';">/s/ Nassim Usman, Ph.D.</div>
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  </link:labelLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>6
<FILENAME>cbio-20230829_pre.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii"?>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_WrittenCommunications" xlink:label="WrittenCommunications" xlink:title="WrittenCommunications" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="WrittenCommunications" xlink:title="presentation: CoverAbstract to WrittenCommunications" order="25.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SolicitingMaterial" xlink:label="SolicitingMaterial" xlink:title="SolicitingMaterial" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="SolicitingMaterial" xlink:title="presentation: CoverAbstract to SolicitingMaterial" order="26.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementTenderOffer" xlink:label="PreCommencementTenderOffer" xlink:title="PreCommencementTenderOffer" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="PreCommencementTenderOffer" xlink:title="presentation: CoverAbstract to PreCommencementTenderOffer" order="27.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementIssuerTenderOffer" xlink:label="PreCommencementIssuerTenderOffer" xlink:title="PreCommencementIssuerTenderOffer" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="PreCommencementIssuerTenderOffer" xlink:title="presentation: CoverAbstract to PreCommencementIssuerTenderOffer" order="28.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
  </link:presentationLink>
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</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>7
<FILENAME>R1.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="include/report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
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</head>
<body>
<span style="display: none;">v3.23.2</span><table class="report" border="0" cellspacing="2" id="idm140235343375312">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Document and Entity Information<br></strong></div></th>
<th class="th"><div>Aug. 29, 2023</div></th>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CoverAbstract', window );"><strong>Cover [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentType', window );">Document Type</a></td>
<td class="text">8-K<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AmendmentFlag', window );">Amendment Flag</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Aug. 29,  2023<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CurrentFiscalYearEndDate', window );">Current Fiscal Year End Date</a></td>
<td class="text">--12-31<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityFileNumber', window );">Entity File Number</a></td>
<td class="text">000-51173<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">Catalyst Biosciences, Inc.<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0001124105<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityIncorporationStateCountryCode', window );">Entity Incorporation, State or Country Code</a></td>
<td class="text">DE<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityTaxIdentificationNumber', window );">Entity Tax Identification Number</a></td>
<td class="text">56-2020050<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine1', window );">Entity Address, Address Line One</a></td>
<td class="text">611 Gateway Blvd<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine2', window );">Entity Address, Address Line Two</a></td>
<td class="text">Suite 120<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressCityOrTown', window );">Entity Address, City or Town</a></td>
<td class="text">South San Francisco<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressStateOrProvince', window );">Entity Address, State or Province</a></td>
<td class="text">CA<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressPostalZipCode', window );">Entity Address, Postal Zip Code</a></td>
<td class="text">94080<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CityAreaCode', window );">City Area Code</a></td>
<td class="text">650<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_LocalPhoneNumber', window );">Local Phone Number</a></td>
<td class="text">871-0761<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Title of 12(b) Security</a></td>
<td class="text">Common Stock<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">CBIO<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NASDAQ<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_WrittenCommunications', window );">Written Communications</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SolicitingMaterial', window );">Soliciting Material</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementTenderOffer', window );">Pre-commencement Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementIssuerTenderOffer', window );">Pre-commencement Issuer Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_AmendmentFlag">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CityAreaCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Area code of city</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CityAreaCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CoverAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Cover page.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CoverAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CurrentFiscalYearEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>End date of current fiscal year in the format --MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CurrentFiscalYearEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:gMonthDayItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period.  The format of the date is YYYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentType">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 1 such as Attn, Building Name, Street Name</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine2">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 2 such as Street or Suite number</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine2</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressCityOrTown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the City or Town</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressCityOrTown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressPostalZipCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Code for the postal or zip code</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressPostalZipCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressStateOrProvince">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the state or province.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressStateOrProvince</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:stateOrProvinceItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:centralIndexKeyItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityEmergingGrowthCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFileNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFileNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fileNumberItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityIncorporationStateCountryCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Two-character EDGAR code representing the state or country of incorporation.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityIncorporationStateCountryCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarStateCountryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityRegistrantName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityTaxIdentificationNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityTaxIdentificationNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:employerIdItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_LocalPhoneNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Local phone number for entity.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_LocalPhoneNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementIssuerTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 13e<br> -Subsection 4c<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementIssuerTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14d<br> -Subsection 2b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_Security12bTitle">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Title of a 12(b) registered security.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_Security12bTitle</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:securityTitleItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SecurityExchangeName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the Exchange on which a security is registered.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection d1-1<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SecurityExchangeName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarExchangeCodeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SolicitingMaterial">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Section 14a<br> -Number 240<br> -Subsection 12<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SolicitingMaterial</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_TradingSymbol">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Trading symbol of an instrument as listed on an exchange.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_TradingSymbol</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:tradingSymbolItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_WrittenCommunications">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Securities Act<br> -Number 230<br> -Section 425<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_WrittenCommunications</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
