<SEC-DOCUMENT>0001140361-24-036410.txt : 20240808
<SEC-HEADER>0001140361-24-036410.hdr.sgml : 20240808
<ACCEPTANCE-DATETIME>20240808162320
ACCESSION NUMBER:		0001140361-24-036410
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20240806
FILED AS OF DATE:		20240808
DATE AS OF CHANGE:		20240808

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Epstein David M.
		CENTRAL INDEX KEY:			0001488668
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51173
		FILM NUMBER:		241188778

	MAIL ADDRESS:	
		STREET 1:		OSI PHARMACEUTICALS, INC.
		STREET 2:		41 PINELAWN ROAD
		CITY:			MELVILLE
		STATE:			NY
		ZIP:			11747

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GYRE THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001124105
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				562020050
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		12770 HIGH BLUFF DRIVE, SUITE 150
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
		BUSINESS PHONE:		(619) 949-3681

	MAIL ADDRESS:	
		STREET 1:		12770 HIGH BLUFF DRIVE, SUITE 150
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CATALYST BIOSCIENCES, INC.
		DATE OF NAME CHANGE:	20150820

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TARGACEPT INC
		DATE OF NAME CHANGE:	20000919
</SEC-HEADER>
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<TYPE>3
<SEQUENCE>1
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<DESCRIPTION>FORM 3
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    <periodOfReport>2024-08-06</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001124105</issuerCik>
        <issuerName>GYRE THERAPEUTICS, INC.</issuerName>
        <issuerTradingSymbol>GYRE</issuerTradingSymbol>
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        <reportingOwnerId>
            <rptOwnerCik>0001488668</rptOwnerCik>
            <rptOwnerName>Epstein David M.</rptOwnerName>
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            <rptOwnerStreet1>C/O GYRE THERAPEUTICS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>12770 HIGH BLUFF DRIVE, SUITE 150</rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92130</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
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    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Ruoyu Chen, as attorney-in-fact for David M. Epstein</signatureName>
        <signatureDate>2024-08-08</signatureDate>
    </ownerSignature>
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<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
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<DESCRIPTION>EXHIBIT 24
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    <div style="text-align: right; font-weight: bold;">Exhibit 24</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">POWER OF ATTORNEY</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Know all by these presents that the undersigned hereby constitutes and appoints each of Han Ying, Ruoyu Chen, Yang Zheng, Branden Berns, and Ryan
      Murr, and any of their substitutes, signing singly, as the undersigned&#8217;s true and lawful attorney-in-fact to:</div>
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          <td style="width: 18pt; vertical-align: top;">1.</td>
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            <div>prepare, execute in the undersigned&#8217;s name and on the undersigned&#8217;s behalf, and submit to the U.S. Securities and Exchange Commission (the &#8220;SEC&#8221;) a Form ID, including amendments
              thereto, and any other document necessary or appropriate to obtain codes, passwords, and passphrases enabling the undersigned to make electronic filings with the SEC of reports require by the Securities Exchange Act of 1934 or any rule or
              regulation of the SEC;</div>
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    <div>&#160;</div>
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          <td style="width: 18pt; vertical-align: top;">2.</td>
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            <div>execute for and on behalf of the undersigned, in the undersigned&#8217;s capacity as a director, officer and/or ten percent stockholder of Gyre Therapeutics, Inc. (the &#8220;Company&#8221;), Forms 3,
              4, and 5 in accordance with Section 16(a) of the Securities Exchange Act of 1934 and the rules thereunder;</div>
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    <div>&#160;</div>
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          <td style="width: 18pt; vertical-align: top;">3.</td>
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            <div>do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4, or 5, complete and execute any
              amendment or amendments thereto, and timely file such form with the SEC and any securities exchange or similar authority; and</div>
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    <div>&#160;</div>
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            <div>take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or
              legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions
              as such attorney-in-fact may approve in such attorney-in-fact&#8217;s discretion.</div>
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    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever
      requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation,
      hereby ratifying and confirming all that each such attorney-in-fact, or such attorney-in-fact&#8217;s substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted.&#160; The
      undersigned also ratifies hereby any action previously taken by each attorney-in-fact that would have been authorized by this power of attorney if it has been in effect at the time such action was taken.&#160; The undersigned acknowledges that each
      attorney-in-fact, in serving in such capacity at the request of the undersigned, is not assuming, nor is the Company assuming, any of the undersigned&#8217;s responsibilities to comply with Section 16 of the Securities Exchange Act of 1934, as amended.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms 3, 4, and 5 with respect to the
      undersigned&#8217;s holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to each of the foregoing attorneys-in-fact.</div>
    <div>&#160;</div>
    <div style="text-align: justify;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of August 6, 2024.</div>
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            <div>By:</div>
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            <div>/s/ David Epstein, Ph.D.</div>
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            <div>Name: David Epstein, Ph.D.</div>
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