<SEC-DOCUMENT>0001140361-24-015774.txt : 20240328
<SEC-HEADER>0001140361-24-015774.hdr.sgml : 20240328
<ACCEPTANCE-DATETIME>20240327210030
ACCESSION NUMBER:		0001140361-24-015774
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20240328
DATE AS OF CHANGE:		20240327
EFFECTIVENESS DATE:		20240328

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GYRE THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001124105
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				562020050
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-278291
		FILM NUMBER:		24793097

	BUSINESS ADDRESS:	
		STREET 1:		12770 HIGH BLUFF DRIVE, SUITE 150
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
		BUSINESS PHONE:		(619) 949-3681

	MAIL ADDRESS:	
		STREET 1:		12770 HIGH BLUFF DRIVE, SUITE 150
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CATALYST BIOSCIENCES, INC.
		DATE OF NAME CHANGE:	20150820

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TARGACEPT INC
		DATE OF NAME CHANGE:	20000919
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>ef20025363_s8.htm
<DESCRIPTION>S-8
<TEXT>
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  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">As filed with the Securities and Exchange Commission on March 27, 2024</div>
  <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">Registration No. 333-</div>
  <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">
    <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;">
    <div style="text-align: center; font-size: 14pt;">UNITED STATES</div>
    <div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">WASHINGTON, D.C.&#160; 20549</div>
      <div style="text-align: left;">&#160;</div>
      <div style="text-align: left;">
        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"> </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">UNDER</div>
      <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">
        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"> </div>
      <div>&#160;</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;">Gyre Therapeutics, Inc.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"> </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z1981325175a74d7eb688ac9fd0efbaa1">

          <tr>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">Delaware</div>
            </td>
            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">56-2020050</div>
            </td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or Other Jurisdiction of</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Incorporation or Organization)</div>
            </td>
            <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td rowspan="1" style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Identification No.)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Gyre Therapeutics, Inc.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">12770 High Bluff Drive, Suite 150</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">San Diego, California 92130</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: normal;">(Address, including zip code, of registrant&#8217;s principal executive offices)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: normal;">(Full title of the plan)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Han Ying, Ph.D.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Chief Executive Officer</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Gyre Therapeutics, Inc.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">12770 High Bluff Drive, Suite 150</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">San Diego, California 92130</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(619) 949-3681</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: normal;">&#160;(Name, address and telephone number (including area code) of agent for service)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0);">Copy to:</div>
      <div>&#160;</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Sean Feller</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Gibson, Dunn &amp; Crutcher LLP</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">2029 Century Park East, Suite 4000</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Los Angeles, CA 90067-3026</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(310) 552-8500</div>
      <div>
        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;">&#160;</div>
      <div style="text-align: left; color: rgb(0, 0, 0); font-weight: normal;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth
        company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer&#8221;, &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
      <div style="text-align: left;"><font style="color: rgb(0, 0, 0);"> </font><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z8c8a62372dce435a9c0a015a2ab6254a">

          <tr>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">Large accelerated filer</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9744;</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">Accelerated filer</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9744;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 25%; vertical-align: middle;">&#160;</td>
            <td style="width: 25%; vertical-align: middle;">&#160;</td>
            <td style="width: 25%; vertical-align: middle;">&#160;</td>
            <td style="width: 25%; vertical-align: middle;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9746;</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">Smaller reporting company</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9746;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">Emerging growth company</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9744;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <font style="color: rgb(0, 0, 0);"></font>
      <div>
        <div style="text-align: left;"><font style="font-weight: normal;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
            accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.&#160; &#9744;</font></div>
        <div style="text-align: left;"><font style="font-weight: normal;"> <br>
          </font></div>
        <div style="text-align: left;">
          <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><font style="font-weight: normal;"> </font></div>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div style="page-break-after: always;" class="BRPFPageBreak">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">EXPLANATORY NOTE</div>
      <div style="font-weight: normal;">&#160;</div>
      <div style="text-align: left; text-indent: 36pt;"><font style="color: rgb(0, 0, 0); font-weight: normal;">This Registration Statement on Form S-8 (this &#8220;Registration Statement&#8221;) is being filed pursuant to General Instruction E to Form S-8 for the
          purpose of registering an additional 3,829,780 shares of common stock, par value $0.001 per share (&#8220;Common Stock&#8221;), of Gyre Therapeutics, Inc., a Delaware corporation (&#8220;Registrant&#8221;) under the Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan
          (the &#8220;Plan&#8221;), pursuant to the provisions of the Plan providing for an automatic increase in the number of shares reserved and available for issuance under the Plan on January 1, 2024. In accordance with General Instruction E to Form S-8, this
          Registration Statement hereby incorporates by reference the contents of the Registrant&#8217;s Registration Statement on Form S-8 filed by the Company with respect to the Plan on October 31, 2023 (</font><font style="font-weight: normal;">SEC File No.
          333-275222<font style="color: rgb(0, 0, 0);">), together with all exhibits filed therewith or incorporated therein by reference.</font></font></div>
      <div>&#160;</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">PART II</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
      <div>&#160;</div>
      <div>
        <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="z4d2953a353494fd58a9a2b9515b70119" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;">

            <tr style="vertical-align: top;">
              <td style="text-align: right; vertical-align: top; width: 36pt;">
                <div style="text-align: left; color: #000000; font-weight: bold;">Item 8.</div>
              </td>
              <td style="text-align: left; vertical-align: top; width: auto;">
                <div style="color: #000000; font-weight: bold;">Exhibits.</div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z77d8c06b1676417bae981c64caedd8c1">

          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);"><u>Exhibit No.</u></div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);"><u>Exhibit Description</u></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.1</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312506103288/dex41.htm">Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Registration
                  Statement on Form S-3/A filed on October 24, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.2</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312515297752/d24322dex31.htm">Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit
                  3.2 to the Registrant&#8217;s Registration Statement on Form S-3/A filed on October 24, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.3</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312517037156/d326649dex31.htm">Second Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to
                  Exhibit 3.3 to the Registrant&#8217;s Registration Statement on Form S-3/A filed on October 24, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.4</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex3-1.htm">Third Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by
                  reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on October 30, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.5</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036122046943/brhc10045912_ex3-1.htm">Certificate of Designation of Series X Convertible Preferred Stock (incorporated by reference to Exhibit 3.4 to the Registrant&#8217;s
                  Registration Statement on Form S-3/A filed on October 24, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.6</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex3-2.htm">Amendment to Certificate of Designation of Preferences, Rights and Limitations of Series X Convertible Preferred Stock (incorporated by
                  reference to Exhibit 3.2 to the Registrant&#8217;s Current Report on Form 8-K filed on October 30, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.7</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123030517/brhc20054638_ex3-1.htm">Certificate of Designation of Preferences, Rights and Limitations of Series Y Preferred Stock (incorporated by reference to Exhibit 3.1
                  to the Registrant&#8217;s Current Report on Form 8-K filed on June 20, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.8</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123042067/brhc20058284_ex3-1.htm">Certificate of Elimination of Series Y Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on
                  Form 8-K filed on August 31, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.9</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312517121994/d375894dex31.htm">Certificate of Designation of Preferences, Rights and Limitations of Series A Convertible Preferred Stock (incorporated by reference to Exhibit
                  3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on April 13, 2017).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.10</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000095017024037242/gyre-ex3_6b.htm">Certificate of Elimination of Series A Preferred Stock (incorporated by reference to Exhibit 3.6(b) to the Registrant&#8217;s Annual Report on Form
                  10-K filed on March 27, 2024).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.11</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex3-3.htm">Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Registrant&#8217;s Current Report on Form 8-K
                  filed on October 30, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">5.1*</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="ef20025363_ex5-1.htm">Opinion of Gibson, Dunn &amp; Crutcher LLP.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">23.1*</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="ef20025363_ex23-1.htm">Consent of Grant Thornton Zhitong Certified Public Accountants LLP.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">23.2*</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="ef20025363_ex5-1.htm">Consent of Gibson, Dunn &amp; Crutcher LLP (included in Exhibit 5.1).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">24.1*</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="text-align: justify;"><a href="#POWEROFATTORNEY">Power of Attorney (included on the signature page hereto).</a><a name="PowerofAttorneyincludedon"><!--Anchor--></a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">99.1</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="text-align: justify;"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex10-2.htm">Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan (incorporated by reference to Exhibit 10.15 to the
                  Registrant&#8217;s Annual Report on Form 10-K filed on March 27, 2024).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">107*</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="text-align: justify;"><a href="ef20025363_ex107-1.htm">Filing Fee Table.</a></div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
      <div style="text-align: justify; color: #000000;">
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      <div style="text-align: center; color: #000000; font-weight: bold;"> SIGNATURES</div>
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      <div style="text-align: left; text-indent: 36pt; color: rgb(0, 0, 0); font-weight: normal;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all
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            <td style="width: 60%; vertical-align: top;">&#160;</td>
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              <div style="color: rgb(0, 0, 0);">/s/ Han Ying </div>
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      <div style="text-align: center; color: #000000; font-weight: bold;">POWER OF ATTORNEY<a name="POWEROFATTORNEY"><!--Anchor--></a></div>
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        <div style="text-align: left; text-indent: 36pt; color: rgb(0, 0, 0); font-weight: normal;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Han Ying and Ruoyu Chen, or either of them,
          severally, the individual&#8217;s true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments, including
          post-effective amendments, to this Registration Statement, and any registration statement relating to the offering covered by this Registration Statement and filed pursuant to Rule 462(b) under the Securities Act of 1933, and to file the same,
          with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and
          thing requisite and necessary to be done, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents or their substitute or substitutes may
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        <div style="text-align: left; text-indent: 36pt; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated on March 27, 2024.</div>
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            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
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            <td style="width: 15%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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              <div style="color: rgb(0, 0, 0);">March 27, 2024</div>
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          <tr>
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            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
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            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td style="width: 40%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: middle; padding-bottom: 2px;">&#160;</td>
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              &#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
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            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td style="width: 40%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 23%; vertical-align: top;">&#160;</td>
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            <td style="width: 15%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: middle; padding-bottom: 2px;">&#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" rowspan="2" style="width: 23%; vertical-align: top;">
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              &#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
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            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td style="width: 40%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 23%; vertical-align: top;">&#160;</td>
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            <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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            <td style="width: 15%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: middle; padding-bottom: 2px;">&#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" rowspan="2" style="width: 23%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">March 27, 2024</div>
              &#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
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            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td style="width: 40%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 23%; vertical-align: top;">&#160;</td>
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            <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000;">/s/ Thomas Eastling </div>
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            <td style="width: 15%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: middle; padding-bottom: 2px;">&#160;</td>
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              <div style="color: rgb(0, 0, 0);">Director</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" rowspan="2" style="width: 23%; vertical-align: top;">
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              &#160;</td>
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              <div style="color: rgb(0, 0, 0);">Thomas Eastling</div>
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            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
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          <tr>
            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td style="width: 40%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 23%; vertical-align: top;">&#160;</td>
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            <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000;">/s/ Nassim Usman </div>
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            <td style="width: 15%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: middle; padding-bottom: 2px;">&#160;</td>
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              <div style="color: rgb(0, 0, 0);">Director</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" rowspan="2" style="width: 23%; vertical-align: top;">
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              &#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
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            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
            <td style="width: 40%; vertical-align: middle;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 23%; vertical-align: top;">&#160;</td>
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            <td rowspan="1" colspan="1" style="width: 1%; vertical-align: middle; padding-bottom: 2px;">&#160;</td>
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            <td rowspan="1" colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" rowspan="2" style="width: 23%; vertical-align: top;"><br>
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            <td rowspan="1" colspan="2" style="vertical-align: top;">Songjiang Ma</td>
            <td rowspan="1" colspan="1" style="width: 1%; vertical-align: middle;">&#160;</td>
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            <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Rodney L. Nussbaum</td>
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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>ef20025363_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
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    <div style="text-align: right;"><font style="font-weight: normal;">Exhibit 5.1</font><br>
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        <div style="color: rgb(0, 0, 0);">March 27, 2024</div>
        <div>&#160;</div>
        <div style="color: rgb(0, 0, 0);">Gyre Therapeutics, Inc.</div>
        <div style="color: rgb(0, 0, 0);">12770 High Bluff Drive, Suite 150</div>
        <div style="color: rgb(0, 0, 0);">San Diego, California 92130</div>
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              <td style="width: 37.8pt; vertical-align: top; color: rgb(0, 0, 0);">Re:</td>
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                <div style="color: rgb(0, 0, 0);">Gyre Therapeutics, Inc.</div>
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                  <div style="color: rgb(0, 0, 0);">Registration Statement on Form S-8</div>
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        <div style="color: rgb(0, 0, 0);">Ladies and Gentlemen:</div>
        <div>&#160;</div>
        <div style="text-align: justify; color: rgb(0, 0, 0);">We have examined the Registration Statement on Form S-8 (the &#8220;Registration Statement&#8221;) of Gyre Therapeutics, Inc., a Delaware corporation (the &#8220;Company&#8221;), to be filed with the Securities and
          Exchange Commission (the &#8220;Commission&#8221;) pursuant to the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), in connection with the offering by the Company of up to 3,829,780&#160;shares of the Company&#8217;s common stock, par value $0.001 per share
          (the &#8220;Common Stock&#8221;), under the Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan (the &#8220;Plan&#8221;).</div>
        <div>&#160;</div>
        <div style="text-align: justify; color: rgb(0, 0, 0);">We have examined the originals, or photostatic or certified copies, of such records of the Company and certificates of officers of the Company and of public officials and such other documents
          as we have deemed relevant and necessary as the basis for the opinions set forth below. In our examination, we have assumed the genuineness of all signatures, the legal capacity and competency of all natural persons, the authenticity of all
          documents submitted to us as originals and the conformity to original documents of all documents submitted to us as copies. We have also assumed that there are no agreements or understandings between or among the Company and any participants in
          the Plan that would expand, modify or otherwise affect the terms of the Plan or the respective rights or obligations of the participants thereunder. Finally, we have assumed the accuracy of all other information provided to us by the Company
          during the course of our investigations, on which we have relied in issuing the opinion expressed below.</div>
        <div>&#160;</div>
        <div style="text-align: justify; color: rgb(0, 0, 0);">Based upon the foregoing examination and in reliance thereon, and subject to the qualifications, assumptions and limitations stated herein and in reliance on the statements of fact contained in
          the documents that we have examined, we are of the opinion that the Common Stock, when issued and sold in accordance with the terms set forth in the Plan, as applicable, and against payment therefor in accordance with the terms of the form of
          agreement documenting the awards under which the Common Stock may be issued, and when the Registration Statement has become effective under the Securities Act, will be validly issued, fully paid and non-assessable.</div>
        <div>&#160;</div>
        <div style="color: rgb(0, 0, 0);">We render no opinion herein as to matters involving the laws of any jurisdiction other than the Delaware General Corporation Law (the &#8220;DGCL&#8221;). This opinion is limited to the effect of the current state of the DGCL
          and the facts as they currently exist. We assume no obligation to revise or supplement this opinion in the event of future changes in such laws or the interpretations thereof or such facts. We express no opinion regarding any state securities
          laws or regulations.</div>
        <div style="color: rgb(0, 0, 0);"> <br>
        </div>
        <div style="color: rgb(0, 0, 0);"> <br>
        </div>
        <div style="text-align: center;"><font style="font-size: 6pt;"><font style="font-size: 8pt;">Abu Dhabi </font>&#9744; <font style="font-size: 8pt;">Beijing <font style="font-size: 6pt;">&#9744;</font> Brussels <font style="font-size: 6pt;">&#9744;</font> Century
              City <font style="font-size: 6pt;">&#9744;</font> Dallas <font style="font-size: 6pt;">&#9744;</font> Denver <font style="font-size: 6pt;">&#9744;</font> Dubai <font style="font-size: 6pt;">&#9744;</font> Frankfurt <font style="font-size: 6pt;">&#9744;</font> Hong
              Kong <font style="font-size: 6pt;">&#9744;</font> Houston <font style="font-size: 6pt;">&#9744;</font> London <font style="font-size: 6pt;">&#9744;</font> Los Angeles<br>
              Munich <font style="font-size: 6pt;">&#9744;</font> New York <font style="font-size: 6pt;">&#9744;</font> Orange County <font style="font-size: 6pt;">&#9744;</font> Palo Alto <font style="font-size: 6pt;">&#9744;</font> Paris <font style="font-size: 6pt;">&#9744;</font>
              Riyadh <font style="font-size: 6pt;">&#9744;</font> San Francisco <font style="font-size: 6pt;">&#9744;</font> Singapore <font style="font-size: 6pt;">&#9744;</font> Washington, D.C.</font></font> <br>
        </div>
        <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div class="BRPFPageFooter" style="width: 100%;"></div>
          <div class="BRPFPageBreak" style="page-break-after: always;">
            <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
          <div class="BRPFPageHeader" style="width: 100%;"></div>
        </div>
        <div style="color: rgb(0, 0, 0);"> <img width="164" border="0" height="18" src="image00003.jpg"></div>
        <div style="color: rgb(0, 0, 0);"> <br>
        </div>
        <div style="color: rgb(0, 0, 0);">We consent to the filing of this opinion as an exhibit to the Registration Statement, and we further consent to the use of our name in the Registration Statement and the prospectus that forms a part thereof. In
          giving these consents, we do not thereby admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the Rules and Regulations of the Commission.</div>
        <div>&#160;</div>
        <div style="color: rgb(0, 0, 0);">Very truly yours,</div>
        <div style="color: rgb(0, 0, 0);"> <br>
        </div>
        <div style="color: rgb(0, 0, 0);">
          <div style="color: #000000;">/s/ Gibson, Dunn &amp; Crutcher LLP</div>
        </div>
        <div style="color: rgb(0, 0, 0);"> <br>
        </div>
        <div>&#160;</div>
        <div>
          <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
      </div>
      <font style="font-weight: normal;"> </font></div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>ef20025363_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Financial Solution Inc.
         Document created using Broadridge PROfile 24.3.1.5224
         Copyright 1995 - 2024 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <hr noshade="noshade" align="center" style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;">
    <div style="text-align: right;">Exhibit 23.1<br>
    </div>
    <div style="text-align: right;"> <br>
    </div>
    <div>
      <div style="text-align: justify; font-weight: bold;">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</div>
      <div><br>
      </div>
      <div style="text-align: justify;">We have issued our report dated March 27, 2024, with respect to the consolidated financial statements included in the Annual Report of Gyre Therapeutics, Inc. on Form 10-K for the years ended December 31, 2023, which
        is incorporated by reference in this Registration Statement. We consent to the incorporation by reference of the said report in this Registration Statement.</div>
      <div><br>
      </div>
      <div style="text-align: justify;">/s/ Grant Thornton Zhitong Certified Public Accountants LLP</div>
      <div><br>
      </div>
      <div style="text-align: justify;">Beijing, China</div>
      <div style="text-align: justify;">March 27, 2024</div>
      <div style="text-align: justify;"> <br>
      </div>
      <div style="text-align: justify;"> <br>
      </div>
      <div style="text-align: justify;">
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"> </div>
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</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>ef20025363_ex107-1.htm
<DESCRIPTION>EXHIBIT 107.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Financial Solution Inc.
         Document created using Broadridge PROfile 24.3.1.5224
         Copyright 1995 - 2024 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <hr noshade="noshade" align="center" style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;">
    <div style="text-align: right;">Exhibit 107.1<br>
    </div>
    <div><br>
    </div>
    <div>
      <div style="text-align: center; margin-right: 12pt; color: rgb(0, 0, 0); font-weight: bold;">Calculation of Filing Fee Tables</div>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; color: #000000;">(Form Type)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Gyre Therapeutics, Inc.</div>
      <div style="text-align: center; color: #000000;">(Exact Name of Registrant as Specified in its Charter)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000;"><u>Table 1: Newly Registered Securities</u></div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 9%; vertical-align: bottom; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Security Type</div>
            </td>
            <td style="width: 22.49%; vertical-align: bottom; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-size: 8pt;"><font style="font-size: 10pt; font-weight: bold;">Security Class Title</font><font style="font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></font></div>
            </td>
            <td style="width: 11.14%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-size: 8pt;"><font style="font-size: 10pt; font-weight: bold;">Fee Calculation Rule</font><font style="font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></font></div>
            </td>
            <td style="width: 12.19%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-size: 8pt;"><font style="font-size: 10pt; font-weight: bold;">Amount Registered</font><font style="font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></font></div>
            </td>
            <td style="width: 8.04%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Proposed Maximum</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Offering Price Per Unit</div>
            </td>
            <td style="width: 12%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Maximum</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Aggregate</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Offering Price</div>
            </td>
            <td style="width: 17.34%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0) rgb(0, 0, 0) rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Fee Rate</div>
            </td>
            <td style="width: 9.1%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Amount of</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Registration Fee</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">Equity</div>
            </td>
            <td style="width: 22.49%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="margin-left: 1.8pt; color: rgb(0, 0, 0);">Common stock, par value $0.001 per share</div>
            </td>
            <td style="width: 11.14%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; text-indent: -12pt; margin-left: 12pt; color: rgb(0, 0, 0);">Rule 457(a)</div>
            </td>
            <td style="width: 12.19%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; text-indent: -12pt; margin-left: 12pt; color: rgb(0, 0, 0);">3,829,780</div>
            </td>
            <td style="width: 8.04%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; text-indent: -12pt; margin-left: 12pt; color: rgb(0, 0, 0);">$17.05</div>
            </td>
            <td style="width: 12%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; text-indent: -12pt; margin-left: 12pt; color: rgb(0, 0, 0);">$65,297,749</div>
            </td>
            <td style="width: 17.34%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0);">$147.60 per $1,000,000</div>
            </td>
            <td style="width: 9.1%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; text-indent: -12pt; margin-left: 12pt; color: rgb(0, 0, 0);">$9,637.95</div>
            </td>
          </tr>
          <tr>
            <td style="vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Total Offering Amounts</div>
            </td>
            <td style="width: 8.04%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 12%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; text-indent: -12pt; margin-left: 12pt; color: rgb(0, 0, 0);">$65,297,749</div>
            </td>
            <td style="width: 17.34%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 9.1%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; text-indent: -12pt; margin-left: 12pt; color: rgb(0, 0, 0);">$9,637.95</div>
            </td>
          </tr>
          <tr>
            <td style="vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Total Fee Offsets</div>
            </td>
            <td style="width: 8.04%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 12%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 17.34%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 9.1%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; text-indent: -12pt; margin-left: 12pt; color: rgb(0, 0, 0);">&#8212;</div>
            </td>
          </tr>
          <tr>
            <td style="vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Net Fee Due</div>
            </td>
            <td style="width: 8.04%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 12%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 17.34%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 9.1%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; text-indent: -12pt; margin-left: 12pt; color: rgb(0, 0, 0);">$9,637.95</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 18pt;">&#160;</td>
            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), this Registration Statement on Form S-8 shall also cover such indeterminate number of additional shares of common
                stock, par value $0.001 per share (the &#8220;Common Stock&#8221;) of Gyre Therapeutics, Inc. as may become issuable to prevent dilution in the event of stock splits, stock dividends or similar transactions pursuant to the terms of the Gyre
                Therapeutics, Inc. 2023 Omnibus Incentive Plan (the &#8220;Plan&#8221;).</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Calculated solely for the purpose of determining the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and based on the average of the high and low sale prices of the Common Stock, as
                quoted on The Nasdaq Capital Market on March 25, 2024.</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Represents 3,829,780 shares of Common Stock reserved for issuance under the Plan.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div><br>
      </div>
      <div>
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
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<TYPE>GRAPHIC
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