<SEC-DOCUMENT>0001140361-24-028107.txt : 20240530
<SEC-HEADER>0001140361-24-028107.hdr.sgml : 20240530
<ACCEPTANCE-DATETIME>20240530160606
ACCESSION NUMBER:		0001140361-24-028107
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		9
FILED AS OF DATE:		20240530
DATE AS OF CHANGE:		20240530

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GYRE THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001124105
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				562020050
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-279822
		FILM NUMBER:		241005208

	BUSINESS ADDRESS:	
		STREET 1:		12770 HIGH BLUFF DRIVE, SUITE 150
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
		BUSINESS PHONE:		(619) 949-3681

	MAIL ADDRESS:	
		STREET 1:		12770 HIGH BLUFF DRIVE, SUITE 150
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CATALYST BIOSCIENCES, INC.
		DATE OF NAME CHANGE:	20150820

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TARGACEPT INC
		DATE OF NAME CHANGE:	20000919
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>ny20028941x2_s3.htm
<DESCRIPTION>S-3
<TEXT>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 540pt;"><a name="ny20028941x2_s3_100-regcov_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 540pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 25pt; text-align: center;">As filed with the Securities and Exchange Commission on May&#160;30, 2024. </div><div class="regno" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 1pt; text-align: right;">Registration No. 333-&#8195;&#8195;&#8195; </div></div></div><div class="block-frill" style="width: 540pt; margin-left: 0pt;"><div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 2pt solid #000000; margin-top: 1pt; margin-bottom: 1pt; margin-left: auto; margin-right: auto;"> </div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 1pt solid #000000; margin-bottom: 1pt; margin-left: auto; margin-right: auto; margin-top: 4pt;"> </div></div></div><div class="block-main" style="width: 540pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 14pt; font-weight: bold; margin-top: 9.5pt; text-align: center;">UNITED STATES <br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 14pt; font-weight: bold; margin-top: 0pt; text-align: center;">SECURITIES AND EXCHANGE COMMISSION <br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 14pt; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-size: 12pt;">Washington, D.C. 20549 </font></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 16pt; font-weight: bold; margin-top: 2pt; text-align: center;">FORM S-3 <br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 16pt; font-weight: bold; margin-top: 0pt; text-align: center;">REGISTRATION STATEMENT <br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 16pt; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-size: 12pt; font-style: italic;">UNDER</font><font style="font-size: 12pt; font-weight: normal;"> </font><br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 16pt; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-size: 12pt; font-style: italic;">THE SECURITIES ACT OF 1933</font><font style="font-size: 12pt; font-weight: normal;"> </font></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold; margin-top: 2pt; text-align: center;">Gyre Therapeutics, Inc. <br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-size: 10pt;">(Exact name of registrant as specified in its charter) </font></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: -2pt; margin-left: 0pt; text-align: left;"> </div><table cellspacing="0" cellpadding="0" class="txttab" style="border-collapse: collapse; width: 540pt; margin-left: auto; margin-right: auto;"><tr><td style="width: 48.89%; text-align: center; vertical-align: top; padding-top: 6pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">Delaware</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 48.89%; text-align: center; vertical-align: bottom; padding-top: 6pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">56-2020050</div></td></tr><tr><td style="width: 48.89%; text-align: center; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">(State or other jurisdiction of<br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">incorporation or organization) </div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 48.89%; text-align: center; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">(I.R.S. Employer<br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">Identification Number)</div></td></tr></table><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 2pt; text-align: center;">12770 High Bluff Drive<br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">Suite 150<br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">San Diego, CA 92130<br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">(858) 567-7770<br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">&#8195;<br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">(Address, including zip code, and telephone number, including area code, of registrant&#8217;s principal executive offices)</div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 2pt; text-align: center;">Han Ying, Ph.D. <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">Chief Executive Officer <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">Gyre Therapeutics, Inc. <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">12770 High Bluff Drive <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">Suite 150 <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">San Diego, CA 92130 <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">(858) 567-7770<br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">&#8195; <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 0pt; text-align: center;">(Name, address, including zip code, and telephone number, including area code, of agent for service) </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-style: italic; font-weight: bold; margin-top: 2pt; text-align: center;">Copies to:<br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-style: italic; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-style: normal; font-weight: normal;">&#8195; </font><br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-style: italic; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-style: normal;">Ryan A. Murr </font><br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-style: italic; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-style: normal;">Branden C. Berns </font><br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-style: italic; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-style: normal;">Gibson, Dunn &amp; Crutcher LLP </font><br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-style: italic; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-style: normal;">One Embarcadero Center, Suite 2600 </font><br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-style: italic; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-style: normal;">San Francisco, CA 94111-3715 </font><br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-style: italic; font-weight: bold; margin-top: 0pt; text-align: center;"><font style="font-style: normal;">(415) 393-8200 </font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; font-weight: bold; margin-top: 2pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Approximate date of commencement of proposed sale to the public: <font style="font-weight: normal;">From time to time after this registration statement becomes </font><font style="font-weight: normal;">effective. </font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; margin-top: 2pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If the only securities being registered on this Form&#160;are being offered pursuant to dividend or interest reinvestment plans, please check the following box. <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; margin-top: 2pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If any of the securities being registered on this Form&#160;are to be offered on a delayed or continuous basis pursuant to Rule&#160;415 under the Securities Act of 1933, as amended, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box: &#x2612; </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; margin-top: 2pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If this Form&#160;is filed to register additional securities for an offering pursuant to Rule&#160;462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; margin-top: 2pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If this Form&#160;is a post-effective amendment filed pursuant to Rule&#160;462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; margin-top: 2pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If this Form&#160;is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule&#160;462(e) under the Securities Act, check the following box. <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; margin-top: 2pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If this Form&#160;is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule&#160;413(b) under the Securities Act, check the following box. <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9.6pt; margin-top: 2pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule&#160;12b-2 of the Exchange Act. 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font-family: 'Times New Roman', Times, serif; font-size: 1pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">&#8201;<font style="font-size: 9pt;">&#x2610;</font></div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 40%; text-align: left; vertical-align: bottom; padding-top: 6pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt;">&#160;</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 24.44%; text-align: left; vertical-align: bottom; padding-top: 6pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Accelerated filer</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 2.22%; text-align: left; vertical-align: bottom; padding-top: 6pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 1pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">&#8201;<font style="font-size: 9pt;">&#x2610;</font><font style="font-size: 9pt;"> </font></div></td></tr><tr><td style="width: 22.22%; text-align: left; vertical-align: top; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Non-accelerated filer</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 2.22%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">&#x2612;</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 40%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt;">&#160;</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 24.44%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Smaller reporting company</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 2.22%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">&#x2612; </div></td></tr><tr><td style="width: 22.22%; text-align: left; vertical-align: top; padding-top: 2pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt;">&#160;</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 2.22%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt;">&#160;</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 40%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt;">&#160;</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 24.44%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Emerging growth company</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.11%; 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font-size: 9.6pt; font-weight: bold; margin-top: 2pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment that specifically states that this registration statement shall thereafter become effective in accordance with Section&#160;8(a) of the Securities Act of 1933, as amended, or until this registration statement shall become effective on such date as the Commission, acting pursuant to said Section&#160;8(a), may determine.<font style="font-weight: normal;"> </font></div></div><div class="block-frill" style="width: 540pt; margin-top: 12pt; margin-left: 0pt;"><div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 1pt solid #000000; margin-top: 1pt; margin-bottom: 1pt; margin-left: auto; margin-right: auto;"> </div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 2pt solid #000000; margin-bottom: 1pt; margin-left: auto; margin-right: auto; margin-top: 4pt;"> </div></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 456pt;"><a name="ny20028941x2_s3_101-cov_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 456pt; margin-left: 0pt;"><div class="h1" style="color: #FC0014; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><div style="font-family: Arial, Helvetica, sans-serif; text-align: left; margin-bottom: 12pt;">The information in this prospectus is not complete and may be changed. We may not sell these securities or accept an offer to buy these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and it is not soliciting offers to buy these securities in any jurisdiction where such offer or sale is not permitted.</div>SUBJECT TO COMPLETION, DATED MAY 30, 2024<font style="color: #000000;"> </font></div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-weight: bold; margin-top: 19.5pt; margin-left: 0pt; text-align: left;">PROSPECTUS</div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 13.25pt; text-align: center;"><img style="height: 45px; width: 175px;" src="logo_gyre.jpg"><br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">&#8201; <br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-weight: bold; margin-top: 20.5pt; text-align: center;">COMMON STOCK <br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-weight: bold; margin-top: 0pt; text-align: center;">PREFERRED STOCK <br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-weight: bold; margin-top: 0pt; text-align: center;">DEBT SECURITIES <br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-weight: bold; margin-top: 0pt; text-align: center;">WARRANTS <br></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-weight: bold; margin-top: 0pt; text-align: center;">UNITS </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">From time to time, we may issue, in one or more series or classes, up to $150,000,000 in aggregate principal amount of our common stock, preferred stock, debt securities, warrants and/or units, at prices and on terms that we will determine at the time of the offering. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">This prospectus provides you with a general description of the securities we may offer. Each time we offer securities, we will provide specific terms of the securities offered in a supplement to this prospectus. We may also authorize one or more free writing prospectuses to be provided to you in connection with these offerings. The prospectus supplement and any related free writing prospectus may also add, update or change information contained in this prospectus. We may not sell any securities under this prospectus without delivery of the applicable prospectus supplement. If information in any prospectus supplement is inconsistent with the information in this prospectus, then the information in that prospectus supplement will apply and will supersede the information in this prospectus. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">You should read this prospectus, the applicable prospectus supplement and any related free writing prospectus carefully, as well as any documents incorporated by reference, before you invest in any of the securities being offered. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our shares of common stock are listed on The Nasdaq Capital Market (&#8220;Nasdaq&#8221;) under the symbol &#8220;GYRE.&#8221; The last reported sale price of our common stock on Nasdaq on May&#160;28, 2024 was $10.15 per share. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Investing in our securities involves a high degree of risk. You should review carefully the risks and uncertainties described under the heading &#8220;Risk Factors&#8221; contained in this prospectus beginning on page <a href="#tRF">6</a> and any applicable prospectus supplement, and under similar headings in the other documents that are incorporated by reference into this prospectus.<font style="font-weight: normal;"> </font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.<font style="font-weight: normal;"> </font></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 218.5pt; text-align: center;">Prospectus dated &#8195;&#8195;&#8195;, 2024</div></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_102-toc_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;">Table of Contents </div><a name="TOC"><!--Anchor--></a><table cellspacing="0" cellpadding="0" class="fintab" style="margin-top: 4pt; border-collapse: collapse; width: 468pt; margin-left: auto; margin-right: auto;"><tr class="header"><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 6pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold;">&#160;</div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt;">&#8203;</td><td class="gutter" style="width: 2.09%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td style="width: 3.51%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Page </div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tATP">ABOUT THIS PROSPECTUS<font style="padding-left: 4.33pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tATP"><font style="padding-left: 5pt;">1</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tFLS">CAUTIONARY STATEMENT REGARDING FORWARD LOOKING STATEMENTS<font style="padding-left: 4.51pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tFLS"><font style="padding-left: 5pt;">2</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tTC">THE COMPANY<font style="padding-left: 2.66pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tTC"><font style="padding-left: 5pt;">5</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tRF">RISK FACTORS<font style="padding-left: 4.32pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tRF"><font style="padding-left: 5pt;">6</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tUOP">USE OF PROCEEDS<font style="padding-left: 0.07pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tUOP"><font style="padding-left: 5pt;">7</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tDP">DIVIDEND POLICY<font style="padding-left: 1.2pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tDP"><font style="padding-left: 5pt;">8</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tSMO">SECURITIES WE MAY OFFER<font style="padding-left: 4.33pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tSMO"><font style="padding-left: 5pt;">9</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tDOS">DESCRIPTION OF SECURITIES<font style="padding-left: 3.42pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tDOS">10</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tPOD">PLAN OF DISTRIBUTION<font style="padding-left: 3.98pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tPOD">22</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tLM">LEGAL MATTERS<font style="padding-left: 3.22pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tLM">24</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tEXP">EXPERTS<font style="padding-left: 1.77pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tEXP">24</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tWYC">WHERE YOU CAN FIND MORE INFORMATION<font style="padding-left: 3.84pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tWYC">25</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tICI">INCORPORATION OF CERTAIN INFORMATION BY REFERENCE <font style="padding-left: 4.68pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tICI">26</a></div></td></tr></table></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_103-about_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tATP"><!--Anchor--></a>ABOUT THIS PROSPECTUS </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">This prospectus is a part of a registration statement on Form&#160;S-3 that we filed with the Securities and Exchange Commission (the &#8220;SEC&#8221; or the &#8220;Commission&#8221;) utilizing a &#8220;shelf&#8221; registration process. Under this shelf registration process, we may sell any combination of the securities described in this prospectus in one or more offerings up to a total dollar amount of $150,000,000. This prospectus provides you with a general description of the securities we may offer. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Each time we sell securities under this prospectus, we will provide a prospectus supplement that will contain specific information about the terms of that offering. We may also authorize one or more free writing prospectuses to be provided to you that may contain material information relating to these offerings. The prospectus supplement and any related free writing prospectus that we may authorize to be provided to you may also add, update or change information contained in this prospectus or in any documents that we have incorporated by reference into this prospectus. You should carefully read both this prospectus and any prospectus supplement together with additional information under the headings &#8220;Where You Can Find More Information&#8221; and &#8220;Incorporation of Certain Information by Reference.&#8221; </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We have not authorized anyone to provide you with any information other than that contained or incorporated by reference in this prospectus and any applicable prospectus supplement, along with the information contained in any free writing prospectuses we have authorized for use in connection with a specific offering. We take no responsibility for, and can provide no assurance as to the reliability of, any other information that others may give you. This prospectus is an offer to sell only the securities offered hereby, but only under circumstances and in jurisdictions where it is lawful to do so. This prospectus, any applicable supplement to this prospectus or any related free writing prospectus do not constitute an offer to sell or the solicitation of an offer to buy any securities other than the registered securities to which they relate, nor do this prospectus, any applicable supplement to this prospectus or any related free writing prospectus constitute an offer to sell or the solicitation of an offer to buy securities in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">You should not assume that the information contained in this prospectus, any applicable prospectus supplement or any related free writing prospectus is accurate on any date subsequent to the date set forth on the front of the document or that any information we have incorporated by reference is correct on any date subsequent to the date of the document incorporated by reference, even though this prospectus, any applicable prospectus supplement or any related free writing prospectus is delivered, or securities are sold, on a later date. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Unless the context otherwise requires, we use the terms &#8220;Gyre,&#8221; &#8220;company,&#8221; &#8220;we,&#8221; &#8220;us,&#8221; and &#8220;our&#8221; in this prospectus to refer to Gyre Therapeutics, Inc. and, where appropriate, our subsidiaries. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">1<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_104-fls_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tFLS"><!--Anchor--></a>CAUTIONARY STATEMENT CONCERNING FORWARD-LOOKING STATEMENTS </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">This prospectus, including the documents that we incorporate by reference, contains &#8220;forward-looking statements&#8221; within the meaning of Section&#160;27A of the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), and Section&#160;21E of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;). All statements, other than statements of historical facts contained in this prospectus, including statements concerning our plans, objectives, goals, strategies, future events, future revenues or performance, financing needs, business trends and other information referred to in the section entitled &#8220;Risk Factors&#8221; in this prospectus and the sections entitled &#8220;Business,&#8221; &#8220;Risk Factors&#8221; and &#8220;Management&#8217;s Discussion and Analysis of Financial Condition and Results of Operations&#8221; in our Annual Report on Form&#160;10-K for the year ended December&#160;31, 2023, which is incorporated by reference herein, are forward-looking statements. Forward-looking statements generally relate to future events or our future financial or operating performance. In some cases, you can identify forward-looking statements by terms such as &#8220;may,&#8221; &#8220;might,&#8221; &#8220;will,&#8221; &#8220;objective,&#8221; &#8220;intend,&#8221; &#8220;should,&#8221; &#8220;could,&#8221; &#8220;can,&#8221; &#8220;would,&#8221; &#8220;expect,&#8221; &#8220;believe,&#8221; &#8220;design,&#8221; &#8220;estimate,&#8221; &#8220;predict,&#8221; &#8220;potential,&#8221; &#8220;plan,&#8221; &#8220;anticipate,&#8221; &#8220;target,&#8221; &#8220;forecast,&#8221; or the negative of these terms, and similar expressions intended to identify forward-looking statements. Forward-looking statements are not historical facts and reflect our current views with respect to future events and are based on assumptions and subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">There are a number of risks, uncertainties and other important factors that could cause our actual results to differ materially from the forward-looking statements contained in this prospectus. Such risks, uncertainties and other important factors include, among others, the risks, uncertainties and factors set forth in &#8220;Risk Factors,&#8221; and the following risks, uncertainties and factors: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the ability of our clinical trials to demonstrate safety and efficacy of our product candidates and other positive results; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our ability to develop a pipeline of product candidates to address unmet needs in the treatment of organ fibrosis and other inflammatory diseases; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the timing, progress and results of clinical trials for F351 (Hydronidone) from the Phase 2a trial, F573&#160;from the Phase 2 clinical trial, ETUARY from the Phase 2/3 clinical trial, and other product candidates we may develop, including statements regarding the timing of initiation and completion of studies or trials and related preparatory work, the period during which the results of the studies or trials will become available and research and development programs; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the timing, scope and likelihood of regulatory filings and approvals, including timing of investigational new drugs (an &#8220;IND&#8221; or &#8220;INDs&#8221;) and final U.S. Food &amp; Drug Administration approval of F351 for the treatment of liver fibrosis associated with nonalcoholic steatohepatitis (&#8220;NASH&#8221;) and chronic hepatitis B (&#8220;CHB&#8221;), ETUARY for the treatment of dermatomyositis-related interstitial lung disease (&#8220;DM-ILD&#8221;) and sclerosis-related interstitial lung disease (&#8220;SSc-ILD&#8221;), F528 for the treatment of chronic obstructive pulmonary disease, F230 for the treatment of pulmonary arterial hypertension, and any other future product candidates; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the timing, scope or likelihood of foreign regulatory filings and approvals; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our expectations regarding the future pursuit of product development efforts, including whether we will pursue such efforts, estimates regarding the expenses, future revenue, timing of any future revenue, capital requirements and need for additional financing related to such efforts, the timing of and our ability to pursue such efforts and our plans to develop and, if approved, subsequently commercialize any product candidates resulting from such efforts; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our expectations regarding our ability to fund our operating expenses and capital expenditure requirements with our cash and investments; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our ability to develop and advance current product candidates and programs into, and successfully complete, clinical studies; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our manufacturing, commercialization and marketing capabilities and strategy; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">plans relating to commercializing our product candidates, if approved, including the geographic areas of focus and sales strategy; </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">2<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_104-fls_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6.75pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the need to hire additional personnel and our ability to attract and retain such personnel; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the size of the market opportunity for our product candidates, including estimates of the number of patients who suffer from the diseases we are targeting; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">expectations regarding the approval and use of our product candidates in combination with other drugs; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">expectations regarding the potential for accelerated approval or other expedited regulatory designation; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our competitive position and the success of competing therapies that are or may become available; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">estimates of the number of patients that we will enroll in our clinical trials; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the beneficial characteristics and the potential safety, efficacy and therapeutic effects of our product candidates; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our ability to obtain and maintain regulatory approval of our product candidates and our expectations regarding particular lines of therapy; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">plans relating to the further development of our product candidates, including additional indications we may pursue; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">existing regulations and regulatory developments in the People&#8217;s Republic of China (the &#8220;PRC&#8221;), the United States, Europe (the &#8220;EU&#8221;), and other jurisdictions; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our intellectual property position, including the scope of protection we are able to establish and maintain for intellectual property rights covering ETUARY, F351, F573, F528, and F230, and other product candidates we may develop, including the extensions of existing patent terms where available, the validity of intellectual property rights held by third parties and our ability not to infringe, misappropriate or otherwise violate any third-party intellectual property rights; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our continued reliance on third parties to conduct additional clinical trials of our product candidates and for the manufacture of our product candidates for clinical trials; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our relationships with patient advocacy groups, key opinion leaders, regulators, the research community and payors; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our ability to obtain and negotiate favorable terms of, any collaboration, licensing or other arrangements that may be necessary or desirable to develop, manufacture or commercialize our product candidates; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the pricing and reimbursement of ETUARY, F351, F573, F528, and F230, and other product candidates we may develop, if approved; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the rate and degree of market acceptance and clinical utility of F351, and other product candidates the Company may develop; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our estimates regarding expenses, future revenue, capital requirements and needs for additional financing; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our financial performance; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the period over which we estimate our existing cash will be sufficient to fund our planned operating expenses and capital expenditure requirements; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">expectations about the continued listing of our common stock on Nasdaq; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the impact of laws and regulations; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">expectations regarding the period during which we will qualify as a smaller reporting company under the Exchange Act. </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">3<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_104-fls_pg3"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">There may be other factors that may cause our actual results to differ materially from the forward-looking statements, including factors disclosed in &#8220;Risk Factors&#8221; and &#8220;Management&#8217;s Discussion and Analysis of Financial Condition and Results of Operations&#8221; in our Annual Report on Form&#160;10-K for the year ended December&#160;31, 2023, which is incorporated by reference herein. You should evaluate all forward-looking statements made in this prospectus in the context of these risks and uncertainties. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">These factors should not be construed as exhaustive and should be read in conjunction with the other cautionary statements that are included in this prospectus, any accompanying prospectus supplement, information incorporated by reference herein or therein, and any related free-writing prospectus. In addition, we cannot assure you that we will realize the results, benefits or developments that we expect or anticipate or, even if substantially realized, that they will result in the consequences or affect us or our business in the way expected. All forward-looking statements contained in this prospectus are made as of the date of hereof and we undertake no obligation to publicly update or review any forward-looking statements to reflect subsequent events or circumstances. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">4<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_105-company_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tTC"><!--Anchor--></a>THE COMPANY </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We are a financially-sustainable pharmaceutical company with a record of financial success that develops and commercializes small-molecule anti-inflammatory and anti-fibrotic drugs targeting organ diseases, focusing specifically on organ fibrosis. Fibrotic diseases represent a large patient population with significant unmet medical needs. Fibrosis involves a complex, multi-stage process with multiple pathways. While there are numerous potential targets for anti-fibrotic therapy, both established and emerging, addressing a single molecular pathway may not be sufficient to prevent, halt, or reverse fibrosis. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our strategy is to use our experience in the successful development and commercialization of ETUARY&#174; (Pirfenidone) to expand into new indications and develop similar drug candidates. Pirfenidone, the first&#160;anti-fibrotic drug approved for idiopathic pulmonary fibrosis (&#8220;IPF&#8221;) in Japan, the EU, the United States, and the PRC, is a small molecule drug that inhibits the synthesis of TGF-&#223;1, TNF-&#945;, and other fibrosis and inflammation modulators. We have obtained approval for ETUARY (pirfenidone) in the PRC for IPF. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Beijing Continent Pharmaceuticals Co., Ltd., a company organized under the laws of the People&#8217;s Republic of China (d/b/a Gyre Pharmaceuticals, Inc.) (&#8220;Gyre Pharmaceuticals&#8221;) successfully advanced Pirfenidone from R&amp;D to commercialization in the PRC for the treatment of IPF. ETUARY&#8217;s annual sales have consistently grown each year, reaching $112.1&#160;million in 2023. In addition to IPF, Pirfenidone is undergoing three additional Phase&#160;3&#160;studies for connective tissue disease associated with interstitial lung disease to broaden its indications and market: SSc-ILD, DM-ILD and pneumoconiosis. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">F351, our lead development candidate, is a structural derivative of ETUARY (Pirfenidone). It is a new oral chemical entity with an anti-fibrotic, TGF-&#223;1-targeting mechanism of action, for which we hold patents in major markets. Studies suggest that F351 and its major metabolites have minimal drug-drug interaction risks. Despite potential efficacy in IPF, we are prioritizing F351 for the treatment of liver fibrosis due to the large potential addressable market and significant unmet need. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Gyre Pharmaceuticals has completed a Phase 2 trial of F351 in the PRC for CHB-associated liver fibrosis. The Phase 2 trial showed that F351 was well-tolerated without notable toxicity and patients treated showed statistically-significant improvement of liver fibrosis, with the best efficacy results achieved at 270 mg/day dosing. Based on these results, a confirmatory Phase 3 trial is ongoing in the PRC. The enrollment of 248&#160;patients for the confirmatory Phase 3 trial has been completed, with last patient out expected in 2024 and clinical results expected by early 2025. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">In the United States, we have completed a Phase 1 clinical trial of F351 in healthy volunteers. We are preparing an IND application and expect to submit it in late 2024. Following results from the PRC Phase 3 trial in CHB-associated liver fibrosis and pending approval of our IND, we expect to initiate a Phase 2a trial to evaluate F351 for the treatment of NASH-associated liver fibrosis in 2025. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 20.5pt; margin-left: 0pt; text-align: left;">Corporate Information </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We were incorporated in Delaware in 1997 as a wholly-owned subsidiary of R.J. Reynolds Tobacco Company. In August&#160;2000, we became an independent company when we issued and sold stock to venture capital investors. On August&#160;20, 2015, pursuant to the merger agreement between Targacept, Inc. and Catalyst Biosciences, Inc. (&#8220;Private Catalyst&#8221;), we acquired Private Catalyst and on August&#160;20, 2015, we changed our name from Targacept, Inc. to Catalyst Biosciences, Inc. On October&#160;30, 2023, we consummated a business combination pursuant to which we acquired an indirect controlling interest in Gyre Pharmaceuticals. At the closing, we changed our name from Catalyst Biosciences, Inc. to Gyre Therapeutics, Inc. Our principal executive offices are located at 12770 High Bluff Drive, Suite 150, San Diego, CA 92130, and our telephone number is (858) 567-7770. Our website address is www.gyretx.com. We do not incorporate the information on, or accessible through, our website into this prospectus, and you should not consider any information on, or accessible through, our website as part of this prospectus. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">5<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_106-risk_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tRF"><!--Anchor--></a>RISK FACTORS </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Investing in our securities involves risks. You should carefully consider the risks, uncertainties and other factors described in our most recent Annual Report on Form&#160;10-K, as supplemented and updated by subsequent Quarterly Reports on Form&#160;10-Q and Current Reports on Form&#160;8-K that we have filed or will file with the SEC, and in other documents which are incorporated by reference into this prospectus, as well as the risk factors and other information contained in or incorporated by reference into any accompanying prospectus supplement before investing in any of our securities. Our business, financial condition, results of operations, cash flows or prospects could be materially and adversely affected by any of these risks. The risks and uncertainties described in the documents incorporated by reference herein are not the only risks and uncertainties that you may face. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">For more information about our SEC filings, please see &#8220;Where You Can Find More Information&#8221; and &#8220;Incorporation of Certain Information by Reference.&#8221; </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">6<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_107-use_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tUOP"><!--Anchor--></a>USE OF PROCEEDS </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We will retain broad discretion over the use of the net proceeds from the sale of the securities offered hereby. Unless otherwise specified in a prospectus supplement accompanying this prospectus, the net proceeds from the sale by us of the securities to which this prospectus relates will be used for development, manufacturing and scale-up, as well as for working capital and general corporate purposes. We may also use a portion of the proceeds to license, acquire or invest in new programs or for drug development activities related to such programs, however, we have no current commitments to do so. Our expected use of proceeds from the sale of the securities offered hereby represents our current intentions based on our present plans and business condition. As of the date of this prospectus, we cannot predict with certainty all of the particular uses for the proceeds to be received from the sale of the securities offered hereby or the amounts that we will actually spend on the uses set forth above. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Pending the use of the net proceeds, we may invest the proceeds in interest-bearing, investment-grade securities, certificates of deposit or government securities. When we offer and sell the securities to which this prospectus relates, the prospectus supplement related to such offering will set forth our intended use of the proceeds, if any, received from the sale of such securities. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">7<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_107-use_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tDP"><!--Anchor--></a>DIVIDEND POLICY </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We have no present intention to pay cash dividends on our common stock for the foreseeable future. Any determination to pay dividends to holders of our common stock will be at the discretion of our board of directors and will depend on many factors, including our financial condition, results of operations, liquidity, earnings, projected capital and other cash requirements, legal requirements, restrictions in the agreements governing any indebtedness we may enter into, business prospects and other factors that our board of directors deems relevant. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">8<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_107-use_pg3"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tSMO"><!--Anchor--></a>SECURITIES WE MAY OFFER </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">This prospectus contains summary descriptions of the securities we may offer from time to time. These summary descriptions are not meant to be complete descriptions of each security. The particular terms of any security will be described in the applicable prospectus supplement. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">9<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tDOS"><!--Anchor--></a>DESCRIPTION OF SECURITIES </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The following is a summary of the material terms of our capital stock, as well as other material terms of certain provisions of Delaware law, our fourth amended and restated certificate of incorporation (as amended from time to time, our &#8220;certificate of incorporation&#8221;), and our amended and restated bylaws (as amended from time to time, our &#8220;bylaws&#8221;). This summary does not purport to be complete and is qualified in its entirety by the provisions of our certificate of incorporation and our bylaws. For more information on how you can obtain our certificate of incorporation and our bylaws, see the heading &#8220;Where You Can Find Additional Information.&#8221; </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our authorized capital stock consists of 400,000,000 shares of common stock, par value $0.001 per share, and 5,000,000 shares of preferred stock, par value $0.001 per share. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 8pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">As of May&#160;1, 2024, 85,490,116 shares of our common stock were issued and outstanding. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 13pt; margin-left: 0pt; text-align: left;">Common Stock </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our certificate of incorporation authorizes the issuance of up to 400,000,000 shares of our common stock. All outstanding shares of our common stock are validly issued, fully paid and nonassessable. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 13pt; margin-left: 0pt; text-align: left;">Dividends </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Subject to preferential dividend rights of any other class or series of stock, the holders of shares of our common stock are entitled to receive dividends, including dividends of our stock, as and when declared by our board of directors, subject to any limitations imposed by law and to the rights of the holders, if any, of our preferred stock. On September&#160;20, 2022, we paid a special, one-time cash dividend of approximately $45.0&#160;million (or $1.43 per share) to our common stockholders of record as of the close of business on September&#160;6, 2022. On January&#160;12, 2023, we paid a special, one-time cash dividend of approximately $7.6&#160;million (or $0.24 per share) to our common stockholders of record as of the close of business on January&#160;5, 2023. In June&#160;2023, we distributed $3.5&#160;million, which reflected, in connection with an asset purchase agreement with Vertex Pharmaceuticals Inc. (&#8220;Vertex&#8221;), the hold-back amount received from Vertex less expenses and a reserve for potential tax liabilities, to holders of the contingent value right issued to our stockholders of record on January&#160;5, 2023. We do not anticipate paying periodic cash dividends on our common stock for the foreseeable future. Any future determination about the payment of dividends will be made at the discretion of our board of directors and will depend upon our earnings, if any, capital requirements, operating and financial conditions and on such other factors as the board of directors deems relevant. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 12.5pt; margin-left: 0pt; text-align: left;">Liquidation </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">In the event we are liquidated, dissolved or our affairs are wound up, after we pay or make adequate provision for all of our known debts and liabilities, each holder of our common stock will be entitled to share ratably in all assets that remain, subject to any rights that are granted to the holders of any class or series of preferred stock. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 12.5pt; margin-left: 0pt; text-align: left;">Voting Rights </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">For all matters submitted to a vote of stockholders, each holder of our common stock is entitled to one vote for each share registered in his or her name. Except as may be required by law and in connection with some significant actions, such as mergers, consolidations, or amendments to our restated certificate of incorporation that affect the rights of stockholders, holders of our common stock vote together as a single class. There is no cumulative voting in the election of our directors, which means that, subject to any rights to elect directors that are granted to the holders of any class or series of preferred stock, a plurality of the votes cast at a meeting of stockholders at which a quorum is present is sufficient to elect a director. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 12.5pt; margin-left: 0pt; text-align: left;">Other Rights and Restrictions </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Subject to the preferential rights of any other class or series of stock, all shares of our common stock have equal dividend, distribution, liquidation and other rights, and have no preference, appraisal or exchange rights, except for any appraisal rights provided by Delaware law. Furthermore, holders of our common stock have no conversion, sinking fund or redemption rights, or preemptive rights to subscribe for any of our securities. Our restated certificate of incorporation and our bylaws do not restrict the ability of a holder of our common stock to transfer his or her shares of our common stock. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">10<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The rights, powers, preferences and privileges of holders of our common stock are subject to, and may be adversely affected by, the rights of holders of shares of any series of preferred stock which we may designate and issue in the future. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 16pt; margin-left: 0pt; text-align: left;">Listing </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 7pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our common stock is listed on Nasdaq under the symbol &#8220;GYRE.&#8221; </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 16pt; margin-left: 0pt; text-align: left;">Transfer Agent and Registrar </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The transfer agent for our common stock is Equiniti Trust Company, LLC. Its address is 6201 15th Avenue, Brooklyn, NY 11219. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 16pt; margin-left: 0pt; text-align: left;">Description of Preferred Stock </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Under our restated certificate of incorporation, we have authority, subject to any limitations prescribed by law and without further stockholder approval, to issue from time to time up to 5,000,000 shares of preferred stock, par value $0.001 per share, in one or more series. On December&#160;22, 2022, we designated 123,418&#160;shares of our preferred stock as &#8220;Series&#160;X Convertible Preferred Stock&#8221; (hereinafter referred to as, &#8220;Convertible Preferred Stock&#8221;). As of May&#160;1, 2024, there were no shares of preferred stock issued and outstanding. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Pursuant to our restated certificate of incorporation, we are authorized to issue &#8220;blank check&#8221; preferred stock, which may be issued from time to time in one or more series upon authorization by our board of directors. Our board of directors, without further approval of the stockholders, is authorized to fix the designation, powers, preferences, relative, participating optional or other special rights, and any qualifications, limitations and restrictions applicable to each series of the preferred stock. The issuance of preferred stock, while providing flexibility in connection with possible acquisitions and other corporate purposes could, among other things, adversely affect the voting power or rights of the holders of our common stock and, under certain circumstances, make it more difficult for a third party to gain control of us, discourage bids for our common stock at a premium or otherwise adversely affect the market price of the common stock. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 16.5pt; margin-left: 0pt; text-align: left;">Series&#160;X Convertible Preferred Stock </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 7pt; margin-left: 0pt; text-align: left;">Conversion </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Under our restated certificate of incorporation, (i) effective as of 5:00 p.m. (New York City time) on the second business day after the date on which such stockholder approval is received, each share of Convertible Preferred Stock then outstanding automatically converts into approximately 10,000 of common stock, and (ii)&#160;at any time thereafter at the option of the holder thereof, into approximately 10,000 shares of common stock, in the case of each of (i) and (ii) subject to certain beneficial ownership limitations, including that a holder of Convertible Preferred Stock is prohibited from converting shares of Convertible Preferred Stock into shares of common stock if, as a result of such conversion, such holder, together with its affiliates, would beneficially own more than a specified percentage (to be initially set at 9.9% and thereafter adjusted by the holder between to a number between 4.9% and 19.9%) of the total number of shares of common stock issued and outstanding immediately after giving effect to such conversion. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 16.5pt; margin-left: 0pt; text-align: left;">Voting Rights </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Except as otherwise provided in the Certificate of Designation of Preferences, Rights and Limitations of Series&#160;X Convertible Preferred Stock, filed with the Secretary of State of the State of Delaware on December&#160;27, 2022, as amended on October&#160;30, 2023 (as amended, &#8220;Certificate of Designation&#8221;) or as otherwise required by the Delaware General Corporation Law (&#8220;DGCL&#8221;), Convertible Preferred Stock does not have voting rights. However, as long as any shares of Convertible Preferred Stock are outstanding, in addition to any other requirement of the DGCL or our restated certificate of incorporation, we shall not, without the affirmative vote of the holders of a majority of the then outstanding shares of Convertible Preferred Stock, (i) alter or change adversely the powers, preferences or rights given to Convertible Preferred Stock or alter or amend the Certificate of Designation, amend or repeal any provision of or add any provision to, our restated certificate of incorporation or our bylaws, or file any articles of amendment, certificate of designations, preferences, limitations and relative rights of any series of preferred stock, if such action would adversely alter or change the preferences, rights, </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">11<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg3"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-align: left;">privileges or powers of, or restrictions provided for the benefit of Convertible Preferred Stock, regardless of whether any of the foregoing actions shall be by means of amendment to our restated certificate of incorporation or by merger, consolidation or otherwise, (ii) issue further shares of Convertible Preferred Stock or increase or decrease (other than by conversion) the number of authorized shares of Convertible Preferred Stock, (iii)&#160;at any time while at least 30% of the originally issued Convertible Preferred Stock remains issued and outstanding, consummate either: (A) any Fundamental Transaction (as defined in the Certificate of Designation) or (B)&#160;any merger or consolidation of the combined company with or into another entity or any stock sale to, or other business combination in which the combined company&#8217;s stockholders immediately before such transaction do not hold at least a majority of the capital stock of the combined company immediately after such transaction, or (iv)&#160;enter into any agreement with respect to any of the foregoing. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 14.5pt; margin-left: 0pt; text-align: left;">Dividends </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Holders of Convertible Preferred Stock shall be entitled to receive when, as and if dividends are declared and paid on shares of common stock, an equivalent dividend (with the same dividend declaration date and payment date), calculated on an as-converted basis without regard to the Beneficial Ownership Limitation (as defined in the Certificate of Designation), provided, however, in no event shall holders of Convertible Preferred Stock be entitled to receive (a) the &#8220;rights&#8221; distributed pursuant to the Contingent Value Rights Agreement, dated December&#160;26, 2022, as amended on March&#160;29, 2023 (as amended, the &#8220;CVR Agreement&#8221;) or any amounts paid under the CVR Agreement, or (b) cash distributions declared by the combined company on or prior to the closing of the transactions contemplated by the Business Combination Agreement, dated as of December&#160;26, 2022, as amended on March&#160;29, 2023 and August&#160;30, 2023, by and among us, GNI USA, Inc., a Delaware corporation, GNI Group Ltd., a company incorporated under the laws of Japan with limited liability, GNI Hong Kong Limited, a company incorporated under the laws of Hong Kong with limited liability, Shanghai Genomics, Inc., a company organized under the laws of the People&#8217;s Republic of China, the Minority Holders (as defined therein) and Continent Pharmaceuticals Inc., a Cayman Islands company limited by shares. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 14.5pt; margin-left: 0pt; text-align: left;">Liquidation </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Convertible Preferred Stock ranks (i) senior to any class or series of capital stock of the combined company hereafter created specifically ranking by its terms junior to any Convertible Preferred Stock; (ii) on parity with common stock and any class or series of capital stock of the combined company hereafter created specifically ranking by its terms on parity with Convertible Preferred Stock; and (iii) junior to (A) any class or series of capital stock of the combined company hereafter created specifically ranking by its terms senior to any Convertible Preferred Stock or (B) any &#8220;rights&#8221; distributed pursuant to the CVR Agreement or any amounts paid under the CVR Agreement, in each case, as to distributions of assets upon liquidation, dissolution or winding up of the combined company, whether voluntarily or involuntarily. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 15pt; margin-left: 0pt; text-align: left;">Certain Effects of Authorized but Unissued Stock </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We have shares of common stock and preferred stock available for future issuance without stockholder approval, subject to any limitations imposed by the listing requirements of Nasdaq. We may issue these additional shares for a variety of corporate purposes, including future public or private offerings to raise additional capital or to facilitate corporate acquisitions or for payment as a dividend on our capital stock. The existence of unissued and unreserved preferred stock may enable our board of directors to issue shares of preferred stock with terms that could render more difficult or discourage a third-party attempt to obtain control of us by means of a merger, tender offer, proxy contest or otherwise, thereby protecting the continuity of our management. In addition, if we issue preferred stock, the issuance could adversely affect the voting power of holders of common stock and the likelihood that holders of common stock will receive dividend payments or payments upon liquidation. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 15pt; margin-left: 0pt; text-align: left;">Anti-Takeover Effects of Provisions of Our Charter Documents </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our restated certificate of incorporation provides for our board of directors to be divided into three&#160;classes serving staggered terms. Approximately one-third of our board of directors will be elected each year. The provision for a classified board could prevent a party who acquires control of a majority of the outstanding voting stock from obtaining control of the board of directors until the second annual stockholders meeting following the date the acquirer obtains the controlling stock interest. The classified board provision could </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">12<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg4"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-align: left;">discourage a potential acquirer from making a tender offer or otherwise attempting to obtain control of the Company and could increase the likelihood that incumbent directors will retain their positions. Our restated certificate of incorporation provides that directors may be removed with or without cause only by the affirmative vote of the holders of at least 66 2/3% of the voting power of all outstanding stock entitled to vote in the election of directors, voting together as a single class. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our restated certificate of incorporation requires that certain amendments to the restated certificate of incorporation and amendments by the stockholders of our bylaws require the affirmative vote of holders of at least 66 2/3% of the then outstanding stock entitled to vote generally in the election of directors, voting together as a single class. These provisions could discourage a potential acquirer from making a tender offer or otherwise attempting to obtain control of the Company and could delay changes in management. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our bylaws establish an advance notice procedure for stockholder proposals to be brought before an annual stockholders meeting, including proposed nominations of persons for election to our board of directors. At an annual stockholders meeting, stockholders may only consider proposals or nominations specified in the notice of meeting or brought before the meeting by or at the direction of our board of directors. Stockholders may also consider a proposal or nomination by a person who was a stockholder of record on the record date for the meeting, who is entitled to vote at the meeting and who has given to the Secretary of the Company timely written notice, in proper form, of his or her intention to bring that business before the annual stockholders meeting. Our bylaws do not give our board of directors the power to approve or disapprove stockholder nominations of candidates or proposals regarding other business to be conducted at a special or annual meeting of the stockholders. However, our bylaws may have the effect of precluding the conduct of business at a meeting if the proper procedures are not followed. These provisions may also discourage or deter a potential acquirer from conducting a solicitation of proxies to elect the acquirer&#8217;s own slate of directors or otherwise attempting to obtain control of the Company. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our bylaws provide that only our board of directors, the chairperson of the board, the President or the Chief Executive Officer may call a special meeting of stockholders. Because our stockholders do not have the right to call a special meeting, a stockholder could not force stockholder consideration of a proposal over the opposition of our board of directors by calling a special meeting of stockholders prior to such time as a majority of our board of directors, the chairperson of the board, the President or the Chief Executive Officer believed the matter should be considered or until the next annual meeting provided that the requestor met the notice requirements. The restriction on the ability of stockholders to call a special meeting means that a proposal to replace the board also could be delayed until the next annual stockholders meeting. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our restated certificate of incorporation does not allow stockholders to act by written consent without a meeting. Without the availability of stockholder&#8217;s actions by written consent, a holder controlling a majority of our capital stock would not be able to amend our bylaws or remove directors without holding a stockholders&#8217; meeting. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 20.5pt; margin-left: 0pt; text-align: left;">Section&#160;203 of the Delaware General Corporation Law </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We are subject to the provisions of Section&#160;203 of the DGCL (&#8220;Section&#160;203&#8221;). Under Section&#160;203, we would generally be prohibited from engaging in any business combination with any interested stockholder for a period of three years following the time that this stockholder became an interested stockholder unless: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">prior to this time, our board of directors approved either the business combination or the transaction that resulted in the stockholder becoming an interested stockholder; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">upon completion of the transaction that resulted in the stockholder becoming an interested stockholder, the interested stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the transaction commenced, excluding shares owned by persons who are directors and also officers, and by employee stock plans in which employee participants do not have the right to determine confidentially whether shares held subject to the plan will be tendered in a tender or exchange offer; or </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">at or subsequent to such time, the business combination is approved by our board of directors and authorized at a special or annual stockholders meeting, and not by written consent, by the affirmative vote of at least 66 2/3% of the outstanding voting stock that is not owned by the interested stockholder. </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">13<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg5"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Under Section&#160;203, a &#8220;business combination&#8221; includes: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any merger or consolidation involving the corporation and the interested stockholder; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any sale, transfer, pledge or other disposition of 10% or more of the assets of the corporation involving the interested stockholder; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any transaction that results in the issuance or transfer by the corporation of any stock of the corporation to the interested stockholder, subject to limited exceptions; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any transaction involving the corporation that has the effect of increasing the proportionate share of the stock of any class or series of the corporation beneficially owned by the interested stockholder; or </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the receipt by the interested stockholder of the benefit of any loans, advances, guarantees, pledges or other financial benefits provided by or through the corporation. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">In general, Section&#160;203 defines an interested stockholder as an entity or person beneficially owning 15% or more of the outstanding voting stock of the corporation and any entity or person affiliated with or controlling or controlled by such entity or person. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 20pt; margin-left: 0pt; text-align: left;">Limitation of Liability and Indemnification </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our restated certificate of incorporation provides that our directors shall not be personally liable to us or our stockholders for monetary damages for any breach of fiduciary duty as a director, except for liability for breach of the director&#8217;s duty of loyalty to us or our stockholders, for acts or omissions not in good faith or involving intentional misconduct or a knowing violation of law, for payment of dividends or approval of stock purchases or redemptions that are prohibited by the DGCL, or for any transaction from which the director derived an improper personal benefit. Under the DGCL, our directors have a fiduciary duty to us that is not eliminated by this provision of the restated certificate of incorporation and, in appropriate circumstances, equitable remedies such as injunctive or other forms of non-monetary relief will remain available. This provision also does not affect our directors&#8217; responsibilities under any other laws, such as federal securities laws or state or federal environmental laws. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Section&#160;145 of the DGCL empowers a corporation to indemnify its directors and officers against expenses (including attorneys&#8217; fees), judgments, fines and amounts paid in settlements actually and reasonably incurred by them in connection with any action, suit or proceeding brought by third parties by reason of the fact that they were or are directors or officers of the corporation, if they acted in good faith, in a manner they reasonably believed to be in or not opposed to the best interests of the corporation and, with respect to any criminal action or proceeding, had no reasonable cause to believe that their conduct was unlawful. The DGCL provides further that the indemnification permitted thereunder shall not be deemed exclusive of any other rights to which the directors and officers may be entitled under the corporation&#8217;s bylaws, any agreement, a vote of stockholders or otherwise. Our restated certificate of incorporation provides that, to the fullest extent permitted by Section&#160;145 of the DGCL, we shall indemnify any person who is or was a director or officer of us, or is or was serving at our request as a director, officer or trustee of another corporation, partnership, joint venture, trust, employee benefit plan or other enterprise, against the expenses, liabilities or other matters referred to in or covered by Section&#160;145 of the DGCL. Our bylaws provide that we will indemnify any person who was or is a party or threatened to be made a party to any proceeding by reason of the fact that such person is or was a director or officer of us or is or was serving at our request as a director, officer or trustee of another corporation, partnership, joint venture, trust, employee benefit plan or other enterprise to the fullest extent permitted by the DGCL. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">In addition, we have entered into indemnification agreements with each of our directors and with certain of our executive officers. Pursuant to the indemnification agreements, we have agreed to indemnify and hold harmless these directors and officers to the fullest extent permitted by the DGCL. The agreements generally cover expenses that a director or officer incurs or amounts that a director or officer becomes obligated to pay because of any proceeding to which he or she is made or threatened to be made a party or participant by reason of his or her service as a current or former director, officer, employee or agent of the Company. The agreements also provide for the advancement of expenses to the directors and officers subject to specified conditions. There are certain exceptions to our obligation to indemnify the directors and officers, including any intentional malfeasance or act where the director or officer did not in good faith believe he or she was acting in our best interests, with respect to &#8220;short-swing&#8221; profit claims under Section&#160;16(b) of the 1934 Act and, with certain exceptions, with respect to proceedings that he or she initiates. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">14<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg6"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Section&#160;145 of the DGCL also empowers a corporation to purchase insurance for its officers and directors for such liabilities. We maintain liability insurance for our officers and directors. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 13pt; margin-left: 0pt; text-align: left;">Choice of Forum </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our bylaws require that the Court of Chancery of the State of Delaware (or, in the event that the Court of Chancery does not have jurisdiction, the federal district court for the District of Delaware or other state courts of the State of Delaware) be the sole and exclusive forum for the following types of actions or proceedings under Delaware statutory or common law: (1) any derivative action or proceeding brought on our behalf; (2) any action asserting a claim of breach of a fiduciary duty owed by, or other wrongdoing by, any current or former director, officer, employee or stockholder to us or our stockholders; (3) any action asserting a claim against us arising pursuant to any provision of the DGCL or as to which the DGCL confers jurisdiction on the Court of Chancery of the State of Delaware, our certificate of incorporation or our bylaws (as either may be amended from time to time); (4) any action to interpret, apply, enforce or determine the validity of the certificate of incorporation or our bylaws (as either may be amended from time to time); or (5) any action asserting a claim against us governed by the internal affairs doctrine. This provision would not apply to claims brought to enforce a duty or liability created by the Exchange Act or any other claim for which the federal courts have exclusive jurisdiction. Our bylaws provide further that the federal district courts of the United States will be the exclusive forum for the resolution of any complaint asserting a cause of action against us or any director, officer, employee or agent of us arising under the Securities Act. Although we believe these provisions benefit us by providing increased consistency in the application of Delaware law for the specified types of actions and proceedings, the provisions may have the effect of discouraging lawsuits against us or our directors or officers. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 13pt; margin-left: 0pt; text-align: left;">Debt Securities </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The paragraphs below describe the general terms and provisions of the debt securities we may issue. When we offer to sell a particular series of debt securities, we will describe the specific terms of the securities in a supplement to this prospectus, including any additional covenants or changes to existing covenants relating to such series. The prospectus supplement also will indicate whether the general terms and provisions described in this prospectus apply to a particular series of debt securities. You should read the actual indenture if you do not fully understand a term or the way we use it in this prospectus. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If we issue debt securities at a discount from their principal amount, then, for purposes of calculating the aggregate initial offering price of the offered securities issued under this prospectus, we will include only the initial offering price of the debt securities and not the principal amount of the debt securities. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We have summarized below the material provisions of the indenture, or indicated which material provisions will be described in the related prospectus supplement. The prospectus supplement relating to any particular securities offered will describe the specific terms of the securities, which may be in addition to or different from the general terms summarized in this prospectus. We have included the form of the indenture as an exhibit to our registration statement of which this prospectus is a part, and it is incorporated into this prospectus by reference. Because the summary in this prospectus and in any prospectus supplement does not contain all of the information that you may find useful, you should read the documents relating to the securities that are described in this prospectus or in any applicable prospectus supplement. Please read &#8220;Where You Can Find More Information&#8221; in this prospectus to find out how you can obtain a copy of those documents. References below to an &#8220;indenture&#8221; are references to the indenture, as supplemented, under which a particular series of debt securities is issued. As used under this caption, the term &#8220;debt securities&#8221; includes the debt securities being offered by this prospectus and all other debt securities issued by us under the indenture. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 12.5pt; margin-left: 0pt; text-align: left;">General </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 7pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">does not limit the amount of debt securities that we may issue; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">allows us to issue debt securities in one or more series; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">does not require us to issue all of the debt securities of a series at the same time; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">allows us to reopen a series to issue additional debt securities without the consent of the holders of the debt securities of such series. </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">15<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg7"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The prospectus supplement for each offering of debt securities will provide the following terms, where applicable: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the title of the debt securities and whether they are senior, senior subordinated or subordinated debt securities; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the aggregate principal amount of the debt securities being offered and any limit on their aggregate principal amount, and, if the series is to be issued at a discount from its face amount, the method of computing the accretion of such discount; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the price at which the debt securities will be issued, expressed as a percentage of the principal and, if other than the full principal amount thereof, the portion of the principal amount thereof payable upon declaration of acceleration of the maturity thereof or, if applicable, the portion of the principal amount of such debt securities that is convertible into common stock or preferred stock or the method by which any such portion shall be determined; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">if convertible, the terms on which such debt securities are convertible, including the initial conversion price or rate or the method of calculation, how and when the conversion price or exchange ratio may be adjusted, whether conversion or exchange is mandatory, at the option of the holder or at our option, the conversion or exchange period, and any other provision in relation thereto, and any applicable limitations on the ownership or transferability of common stock or preferred stock received on conversion; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the date or dates, or the method for determining the date or dates, on which the principal of the debt securities will be payable; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the fixed or variable interest rate or rates of the debt securities, or the method by which the interest rate or rates is determined; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the date or dates, or the method for determining the date or dates, from which interest will accrue; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the dates on which interest will be payable; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the record dates for interest payment dates, or the method by which we will determine those dates; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the persons to whom interest will be payable; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the basis upon which interest will be calculated if other than that of a 360-day year of twelve 30-day months; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">Any collateral securing the performance of our obligations under the debt securities; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the place or places where the principal of, premium, if any, and interest on, the debt securities will be payable; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">where the debt securities may be surrendered for registration of transfer or conversion or exchange; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">where notices or demands to or upon us in respect of the debt securities and the applicable indenture may be served; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any provisions regarding our right to redeem or purchase debt securities or the right of holders to require us to redeem or purchase debt securities; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any right or obligation we have to redeem, repay or purchase the debt securities pursuant to any sinking fund or analogous provision; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the currency or currencies (including any composite currency) in which the debt securities are denominated and payable if other than U.S. dollars, and the currency or currencies (including any composite currency) in which principal, premium, if any, and interest, if any, will be payable, and if such payments may be made in a currency other than that in which the debt securities are denominated, the manner for determining such payments, including the time and manner of determining the exchange </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">16<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg8"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="bl" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 40pt; text-align: left;">rate between the currency in which such securities are denominated and the currency in which such securities or any of them may be paid, and any additions to, modifications of or deletions from the terms of the debt securities to provide for or to facilitate the issuance of debt securities denominated or payable in a currency other than U.S. dollars; </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the amount of payments of principal of, premium, if any, or interest on, the debt securities may be determined according to an index, formula or other method and how such amounts will be determined; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the debt securities will be in registered form, bearer form or both, and the terms of these forms; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the debt securities will be issued in whole or in part in the form of a global security and, if applicable, the identity of the depositary for such global security; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any provision for electronic issuance of the debt securities or issuance of the debt securities in uncertificated form; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether and upon what terms the debt securities of such series may be defeased or discharged, if different from the provisions set forth in the indenture for the series to which the supplemental indenture or authorizing resolution relates; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any provisions granting special rights to holders of securities upon the occurrence of such events as specified in the applicable prospectus supplement; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any deletions from, modifications of, or additions to our events of default or covenants or other provisions set forth in the indenture for the series to which the supplemental indenture or authorizing resolution relates; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any other material terms of the debt securities, which may be different from the terms set forth in this prospectus. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may issue debt securities at a discount below their principal amount and provide for less than the entire principal amount thereof to be payable upon declaration of acceleration of the maturity of the debt securities. We refer to any such debt securities throughout this prospectus as &#8220;original issue discount securities.&#8221; The applicable prospectus supplement will describe the U.S. federal income tax consequences and other relevant considerations applicable to original issue discount securities. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Neither the Delaware General Corporation Law nor our governing instruments define the term &#8220;substantially all&#8221; as it relates to the sale of assets. Additionally, Delaware cases interpreting the term &#8220;substantially all&#8221; rely upon the facts and circumstances of each particular case. Consequently, to determine whether a sale of &#8220;substantially all&#8221; of our assets has occurred, a holder of debt securities must review the financial and other information that we have disclosed to the public. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The applicable prospectus supplement will also describe any material covenants to which a series of debt securities will be subject and the applicability of those covenants to any of our subsidiaries to be restricted thereby, which are referred to herein as &#8220;restricted subsidiaries.&#8221; The applicable prospectus supplement will also describe provisions for restricted subsidiaries to cease to be restricted by those covenants. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 20pt; margin-left: 0pt; text-align: left;">Events of Default </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Unless the applicable prospectus supplement states otherwise, when we refer to &#8220;events of default&#8221; as defined in the indentures with respect to any series of debt securities, we mean: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our failure to pay interest on any debt security of such series when the same becomes due and payable and the continuance of any such failure for a period of 30 days; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our failure to pay the principal or premium of any debt security of such series when the same becomes due and payable at maturity, upon acceleration, redemption or otherwise; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our failure or the failure of any restricted subsidiary to comply with any of its agreements or covenants in, or provisions of, the debt securities of such series or the indenture (as they relate thereto) and such failure continues for a period of 60 days after our receipt of notice of the default from the trustee or </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">17<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg9"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="bl" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 40pt; text-align: left;">from the holders of at least 25 percent in aggregate principal amount of the then outstanding debt securities of that series (except in the case of a default with respect to the provisions of the indenture regarding the consolidation, merger, sale, lease, conveyance or other disposition of all or substantially all of the assets of us (or any other provision specified in the applicable supplemental indenture or authorizing resolution), which will constitute an event of default with notice but without passage of time); or </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">certain events of bankruptcy, insolvency or reorganization occur with respect to Gyre or any restricted subsidiary of Gyre that is a significant subsidiary (as defined in the indenture). </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If an event of default occurs and is continuing with respect to debt securities of any series outstanding, then the trustee or the holders of 25% or more in principal amount of the outstanding debt securities of that series will have the right to declare the principal amount of all the debt securities of that series to be due and payable immediately. However, the holders of at least a majority in principal amount of outstanding debt securities of such series may rescind and annul such declaration and its consequences, except an acceleration due to nonpayment of principal or interest on such series, if the rescission would not conflict with any judgment or decree and if all existing events of default with respect to such series have been cured or waived. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture also provides that the holders of at least a majority in principal amount of the outstanding debt securities of any series, by notice to the trustee, may, on behalf of all holders, waive any existing default and its consequences with respect to such series of debt securities, other than any event of default in payment of principal or interest. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will require the trustee to give notice to the holders of debt securities within 90 days after the trustee obtains knowledge of a default that has occurred and is continuing. However, the trustee may withhold notice to the holders of any series of debt securities of any default, except a default in payment of principal or interest, if any, with respect to such series of debt securities, if the trustee considers it in the interest of the holders of such series of debt securities to do so. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The holders of a majority of the outstanding principal amount of the debt securities of any series will have the right to direct the time, method and place of conducting any proceedings for any remedy available to the trustee with respect to such series, subject to limitations specified in the indenture. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 20pt; margin-left: 0pt; text-align: left;">Amendment, Supplement and Waiver </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Without notice to or the consent of any holder, we and the trustee may amend or supplement the indenture or the debt securities of a series: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to cure any ambiguity, omission, defect or inconsistency; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to comply with the provisions of the indenture regarding the consolidation, merger, sale, lease, conveyance or other disposition of all or substantially all of our assets; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to provide that specific provisions of the indenture shall not apply to a series of debt securities not previously issued or to make a change to specific provisions of the indenture that only applies to any series of debt securities not previously issued or to additional debt securities of a series not previously issued; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to create a series and establish its terms; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to provide for uncertificated debt securities in addition to or in place of certificated debt securities; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to release a guarantor in respect of any series which, in accordance with the terms of the indenture applicable to such series, ceases to be liable in respect of its guarantee; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to add a guarantor subsidiary in respect of any series of debt securities; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to secure any series of debt securities; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to add to the covenants of Gyre for the benefit of the holders or surrender any right or power conferred upon Gyre; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to appoint a successor trustee with respect to the securities; </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">18<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg10"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6.75pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to comply with requirements of the SEC in order to effect or maintain the qualification of the indenture under the Trust Indenture Act; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to make any change that does not adversely affect the rights of holders; or </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to conform the provisions of the indenture to the final offering document in respect of any series of debt securities. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will provide that we and the trustee may amend or supplement any provision of the debt securities of a series or of the indenture relating to such series with the written consent of the holders of at least a majority in principal amount of the outstanding debt securities of such series. However, without the consent of each holder of a debt security the terms of which are directly amended, supplemented or waived, an amendment, supplement or waiver may not: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">reduce the amount of debt securities of such series whose holders must consent to an amendment, supplement or waiver; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">reduce the rate of or extend the time for payment of interest, including defaulted interest; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">reduce the principal of or extend the fixed maturity of any debt security or alter the provisions with respect to redemptions or mandatory offers to repurchase debt securities of a series in a manner adverse to holders; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">make any change that adversely affects any right of a holder to convert or exchange any debt security into or for shares of our common stock or other securities, cash or other property in accordance with the terms of such security; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">modify the ranking or priority of the debt securities of the relevant series; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">release any guarantor of any series from any of its obligations under its guarantee or the indenture otherwise than in accordance with the terms of the indenture; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">make any change to any provision of the indenture relating to the waiver of existing defaults, the rights of holders to receive payment of principal and interest on the debt securities, or to the provisions regarding amending or supplementing the indenture or the debt securities of a particular series with the written consent of the holders of such series, except to increase the percentage required for modification or waiver or to provide for consent of each affected holder of debt securities of such series; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">waive a continuing default or event of default in the payment of principal of or interest on the debt securities; or </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">make any debt security payable at a place or in money other than that stated in the debt security, or impair the right of any holder of a debt security to bring suit as permitted by the indenture. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The holders of a majority in aggregate principal amount of the outstanding debt securities of such series may, on behalf of all holders of debt securities of that series, waive any existing default under, or compliance with, any provision of the debt securities of a particular series or of the indenture relating to a particular series of debt securities, other than any event of default in payment of interest or principal. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 14pt; margin-left: 0pt; text-align: left;">Defeasance </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will permit us to terminate all our respective obligations under the indenture as they relate to any particular series of debt securities, other than the obligation to pay interest, if any, on and the principal of the debt securities of such series and certain other obligations, at any time by: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">depositing in trust with the trustee, under an irrevocable trust agreement, money or government obligations in an amount sufficient to pay principal of and interest, if any, on the debt securities of such series to their maturity or redemption; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">complying with other conditions, including delivery to the trustee of an opinion of counsel to the effect that holders will not recognize income, gain or loss for federal income tax purposes as a result of our exercise of such right and will be subject to federal income tax on the same amount and in the same manner and at the same times as would have been the case otherwise. </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">19<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg11"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will also permit us to terminate all of our respective obligations under the indenture as they relate to any particular series of debt securities, including the obligations to pay interest, if any, on and the principal of the debt securities of such series and certain other obligations, at any time by: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">depositing in trust with the trustee, under an irrevocable trust agreement, money or government obligations in an amount sufficient to pay principal and interest, if any, on the debt securities of such series to their maturity or redemption; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">complying with other conditions, including delivery to the trustee of an opinion of counsel to the effect that (A) we have received from, or there has been published by, the Internal Revenue Service a ruling, or (B) since the date such series of debt securities were originally issued, there has been a change in the applicable federal income tax law, in either case to the effect that, and based thereon such opinion of counsel shall state that, holders will not recognize income, gain or loss for federal income tax purposes as a result of our exercise of such right and will be subject to federal income tax on the same amount and in the same manner and at the same times as would have been the case otherwise. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">In addition, the indenture will permit us to terminate substantially all our respective obligations under the indenture as they relate to a particular series of debt securities by depositing with the trustee money or government obligations sufficient to pay all principal and interest on such series at its maturity or redemption date if the debt securities of such series will become due and payable at maturity within one year or are to be called for redemption within one year of the deposit. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 14.5pt; margin-left: 0pt; text-align: left;">Transfer and Exchange </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">A holder will be able to transfer or exchange debt securities only in accordance with the indenture. The registrar may require a holder, among other things, to furnish appropriate endorsements and transfer documents, and to pay any taxes and fees required by law or permitted by the indenture. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 14.5pt; margin-left: 0pt; text-align: left;">Concerning the Trustee </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will contain limitations on the rights of the trustee, should it become our creditor, to obtain payment of claims in specified cases or to realize on property received in respect of any such claim as security or otherwise. The indenture will permit the trustee to engage in other transactions; however, if it acquires any conflicting interest, it must eliminate such conflict or resign. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will provide that in case an event of default occurs and is not cured, the trustee will be required, in the exercise of its power, to use the degree of care of a prudent person in similar circumstances in the conduct of such person&#8217;s own affairs. The trustee shall be under no obligation to exercise any of the rights or powers vested in it by the indenture at the request or direction of any of the holders pursuant to the indenture, unless such holders shall have offered to the trustee security or indemnity satisfactory to the trustee against the costs, expenses and liabilities which might be incurred by it in compliance with such request or direction. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 15pt; margin-left: 0pt; text-align: left;">No Recourse Against Others </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will provide that there is no recourse under any obligation, covenant or agreement in the applicable indenture or with respect to any debt security against any of our or our successor&#8217;s past, present or future stockholders, employees, officers or directors. </div><div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 15pt; margin-left: 0pt; text-align: left;">Governing Law </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 7pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The laws of the State of New York will govern the indenture and the debt securities. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 15pt; margin-left: 0pt; text-align: left;">Warrants </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may issue warrants for the purchase of common stock, preferred stock and/or debt securities in one or more series, from time to time. We may issue warrants independently or together with common stock, preferred stock and/or debt securities, and the warrants may be attached to or separate from those securities. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If we issue warrants, they will be evidenced by warrant agreements or warrant certificates issued under one or more warrant agreements, which are contracts between us and an agent for the holders of the warrants. We urge you to read the prospectus supplement related to any series of warrants we may offer, as well as the </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">20<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_108-description_pg12"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-align: left;">complete warrant agreement and warrant certificate that contain the terms of the warrants. If we issue warrants, forms of warrant agreements and warrant certificates relating to warrants for the purchase of common stock, preferred stock and debt securities will be incorporated by reference into the registration statement of which this prospectus is a part from reports we would subsequently file with the SEC. </div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 20.5pt; margin-left: 0pt; text-align: left;">Units </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may issue units consisting of any combination of the other types of securities offered under this prospectus in one or more series. We may evidence each series of units by unit certificates that we will issue under a separate agreement. We may enter into unit agreements with a unit agent. Each unit agent will be a bank or trust company that we select. We will indicate the name and address of the unit agent in the applicable prospectus supplement relating to a particular series of units. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The following description, together with the additional information included in any applicable prospectus supplement, summarizes the general features of the units that we may offer under this prospectus. You should read any prospectus supplement and any free writing prospectus that we may authorize to be provided to you related to the series of units being offered, as well as the complete unit agreements that contain the terms of the units. Specific unit agreements will contain additional important terms and provisions and we will file as an exhibit to the registration statement of which this prospectus is a part, or will incorporate by reference from another report that we file with the SEC, the form of each unit agreement relating to units offered under this prospectus. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If we offer any units, certain terms of that series of units will be described in the applicable prospectus supplement, including, without limitation, the following, as applicable: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the title of the series of units; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">identification and description of the separate constituent securities comprising the units; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the price or prices at which the units will be issued; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the date, if any, on and after which the constituent securities comprising the units will be separately transferable; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">a discussion of certain U.S. federal income tax considerations applicable to the units; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any other terms of the units and their constituent securities. </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">21<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_109-plan_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tPOD"><!--Anchor--></a>PLAN OF DISTRIBUTION </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may sell the securities from time to time pursuant to underwritten public offerings, negotiated transactions, block trades or a combination of these methods. We may sell the securities to or through underwriters or dealers, through agents, or directly to one or more purchasers. We may distribute securities from time to time in one or more transactions: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">at a fixed price or prices, which may be changed; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">at market prices prevailing at the time of sale; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">at prices related to such prevailing market prices; or </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">at negotiated prices. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may also sell equity securities covered by this registration statement in an &#8220;at the market offering&#8221; as defined in Rule&#160;415(a)(4) under the Securities Act. Such offering may be made into an existing trading market for such securities in transactions at other than a fixed price, either: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">on or through the facilities of Nasdaq or any other securities exchange or quotation or trading service on which such securities may be listed, quoted or traded at the time of sale; and/or </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to or through a market maker otherwise than on Nasdaq or such other securities exchanges or quotation or trading services. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 8.5pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Such at the market offerings, if any, may be conducted by underwriters acting as principal or agent. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">A prospectus supplement or supplements (and any related free writing prospectus that we may authorize to be provided to you) will describe the terms of the offering of the securities, including, to the extent applicable: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the name or names of any underwriters, dealers or agents, if any; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the purchase price of the securities and the proceeds we will receive from the sale; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any options under which underwriters may purchase additional securities from us; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any agency fees or underwriting discounts and other items constituting agents&#8217; or underwriters&#8217; compensation; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any public offering price; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any discounts or concessions allowed or re-allowed or paid to dealers; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any securities exchange or market on which the securities may be listed. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Only underwriters named in the prospectus supplement are underwriters of the securities offered by the prospectus supplement. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If underwriters are used in the sale, they will acquire the securities for their own account and may resell the securities from time to time in one or more transactions at a fixed public offering price or at varying prices determined at the time of sale. The obligations of the underwriters to purchase the securities will be subject to the conditions set forth in the applicable underwriting agreement. We may offer the securities to the public through underwriting syndicates represented by managing underwriters or by underwriters without a syndicate. Subject to certain conditions, the underwriters will be obligated to purchase all of the securities offered by the prospectus supplement. Any public offering price and any discounts or concessions allowed or re-allowed or paid to dealers may change from time to time. We may use underwriters with whom we have a material relationship. We will describe in the prospectus supplement, naming the underwriter, the nature of any such relationship. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may sell securities directly or through agents we designate from time to time. We will name any agent involved in the offering and sale of securities, and we will describe any commissions we will pay the agent in the prospectus supplement. Unless the prospectus supplement states otherwise, our agent will act on a best-efforts basis for the period of its appointment. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">22<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_109-plan_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may authorize agents or underwriters to solicit offers by certain types of institutional investors to purchase securities from us at the public offering price set forth in the prospectus supplement pursuant to delayed delivery contracts providing for payment and delivery on a specified date in the future. We will describe the conditions to these contracts and the commissions we must pay for solicitation of these contracts in the prospectus supplement. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may provide agents and underwriters with indemnification against civil liabilities related to offerings pursuant to this prospectus, including liabilities under the Securities Act, or contribution with respect to payments that the agents or underwriters may make with respect to these liabilities. Agents and underwriters may engage in transactions with, or perform services for, us in the ordinary course of business. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">All securities we offer, other than our shares of common stock, will be new issues of securities with no established trading market. Any underwriters may make a market in these securities, but will not be obligated to do so and may discontinue any market making at any time without notice. We cannot guarantee the liquidity of the trading markets for any securities. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Any underwriter may engage in overallotment, stabilizing transactions, short covering transactions and penalty bids in accordance with Regulation M under the Exchange Act. Overallotment involves sales in excess of the offering size, which create a short position. Stabilizing transactions permit bids to purchase the underlying security so long as the stabilizing bids do not exceed a specified maximum. Short covering transactions involve purchases of the securities in the open market after the distribution is completed to cover short positions. Penalty bids permit the underwriters to reclaim a selling concession from a dealer when the securities originally sold by the dealer are purchased in a stabilizing or covering transaction to cover short positions. Those activities may cause the price of the securities to be higher than it would otherwise be. If commenced, the underwriters may discontinue any of the activities at any time. These transactions may be effected on any exchange or over-the-counter market or otherwise. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Any underwriters who are qualified market makers on Nasdaq may engage in passive market making transactions in the securities on Nasdaq in accordance with Rule&#160;103 of Regulation M, during the business day prior to the pricing of the offering, before the commencement of offers or sales of the securities. Passive market makers must comply with applicable volume and price limitations and must be identified as passive market makers. In general, a passive market maker must display its bid at a price not in excess of the highest independent bid for such security; if all independent bids are lowered below the passive market maker&#8217;s bid, however, the passive market maker&#8217;s bid must then be lowered when certain purchase limits are exceeded. Passive market making may stabilize the market price of the securities at a level above that which might otherwise prevail in the open market and, if commenced, may be discontinued at any time. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">23<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_110-legal_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tLM"><!--Anchor--></a>LEGAL MATTERS </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Certain legal matters, including the legality of the securities offered, will be passed upon for us by Gibson, Dunn &amp; Crutcher LLP, San Francisco, California. Additional legal matters may be passed upon for us or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus supplement. </div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 20.5pt; text-align: center;"><a name="tEXP"><!--Anchor--></a>EXPERTS </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The audited consolidated financial statements of Gyre Therapeutics, Inc. for the years ended December 31, 2023 and December 31, 2022 incorporated by reference in this prospectus and elsewhere in the registration statement have been so incorporated by reference in reliance upon the report of Grant Thornton Zhitong Certified Public Accountants LLP, independent registered public accountants, upon the authority of said firm as experts in accounting and auditing.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The consolidated balance sheets of Catalyst Biosciences, Inc. as of December 31, 2022 and 2021, and the related consolidated statements of operations, comprehensive loss, redeemable convertible preferred stock and stockholders' equity (deficit), and cash flows for each of the years then ended, have been audited by EisnerAmper LLP, independent registered public accounting firm, as stated in their report which is incorporated herein by reference, which report includes an explanatory paragraph about the existence of substantial doubt concerning the Company's ability to continue as a going concern. Such financial statements have been incorporated herein by reference in reliance on the report of such firm given upon their authority as experts in accounting and auditing. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">24<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_110-legal_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tWYC"><!--Anchor--></a>WHERE YOU CAN FIND MORE INFORMATION </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We file annual, quarterly and special reports, proxy statements and other information with the SEC, and we have filed with the SEC a registration statement on Form&#160;S-3 under the Securities Act with respect to the securities offered by this prospectus. This prospectus, which forms part of the registration statement, does not contain all of the information included in the registration statement, including its exhibits and schedules. For further information about us and the securities described in this prospectus, you should refer to the registration statement, its exhibits and schedules and our reports, proxies, information statements and other information filed with the SEC. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our filings are available to the public on the Internet, through a database maintained by the SEC at <font style="font-style: italic;">www.sec.gov</font>. We also maintain a website at <font style="font-style: italic;">www.gyretx.com</font>. We have included our website address for the information of prospective investors and do not intend it to be an active link to our website. Information contained on our website does not constitute a part of this prospectus or any applicable prospectus supplement (or any document incorporated by reference herein or therein). </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">25<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_111-incorp_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;"><a name="tICI"><!--Anchor--></a>INCORPORATION OF CERTAIN INFORMATION BY REFERENCE<font style="font-weight: normal;"> </font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The SEC allows us to incorporate by reference much of the information we file with the SEC, which means that we can disclose important information to you by referring you to those publicly available documents. The information that we incorporate by reference in this prospectus is considered to be part of this prospectus. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Because we are incorporating by reference future filings with the SEC, this prospectus is continually updated and those future filings may modify or supersede some of the information included or incorporated in this prospectus. This means that you must look at all of the SEC filings that we incorporate by reference to determine if any of the statements in this prospectus or in any document previously incorporated by reference have been modified or superseded. This prospectus incorporates by reference the documents listed below and any future filings we make with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;) (in each case, other than those documents or the portions of those documents not deemed to be filed) between the date of the initial registration statement and the effectiveness of the registration statement and following the effectiveness of the registration statement until the offering of the securities under the registration statement is terminated or completed, except that we are not incorporating by reference any information furnished (and not filed) with the SEC, including any information furnished pursuant to Items 2.02 or 7.01 of Form&#160;8-K or related exhibits furnished pursuant to Item&#160;9.01 of Form&#160;8-K: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our Annual Report on Form 10-K for the year ended December 31, 2023 filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124105/000095017024037242/gyre-20231231.htm">March&#160;27, 2024</a> (including the portions of our Definitive Proxy Statement on Schedule 14A filed on <a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036124022721/ny20022295x2_def14a.htm">April 29, 2024</a> incorporated by reference therein) and our Annual Report on Form 10-K for the year ended December 31, 2022 filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124105/000156459023004830/cbio-10k_20221231.htm">March&#160;30, 2023</a>;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our Quarterly Reports on Form&#160;10-Q for the quarters ended March 31, 2023, June 30, 2023, September&#160;30, 2023 and March&#160;31, 2024, filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124105/000156459023007276/cbio-10q_20230331.htm">May 15, 2023</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124105/000095017023042218/cbio-20230630.htm">August 14, 2023</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124105/000095017023055695/cbio-20230930.htm">October 26, 2023</a> and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124105/000095017024058642/gyre-20240331.htm">May&#160;13, 2024</a>, respectively; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our Current Reports on Form&#160;8-K and Form&#160;8-K/A, as applicable, filed with the SEC on <a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036124002118/ef20018550_8ka.htm">January&#160;12, 2024</a>, <a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036124002903/ef20019132_8ka.htm">January&#160;19, 2024</a>, <a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036124014493/ef20024709_8k.htm">March&#160;21, 2024</a> (excluding Items 7.01 and 9.01), <a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036124015318/ef20025179_8k.htm">March&#160;26, 2024</a> and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124105/000114036124024799/ef20028687_8k.htm">May&#160;8, 2024</a> (excluding Items 7.01 and 9.01); and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the description of our common stock attached as <a href="https://www.sec.gov/Archives/edgar/data/1124105/000095017024037242/gyre-ex4_1.htm">Exhibit&#160;4.1</a> to our Annual Report on Form&#160;10-K, for the year ended December&#160;31, 2023, filed with the SEC on March&#160;27, 2024, including any amendment or report filed for the purpose of updating such description. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We also incorporate by reference into this prospectus all documents (other than current reports furnished under Item&#160;2.02, Item&#160;7.01 or Item&#160;9.01 of Form&#160;8-K and exhibits filed on such form that are related to such items) that are filed by us with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (i)&#160;after the date of the initial filing of the registration statement of which this prospectus forms a part and prior to effectiveness of the registration statement, and (ii) after the date of this prospectus but prior to the termination of the offering. These documents include, without limitation, Annual Reports on Form&#160;10-K, Quarterly Reports on Form&#160;10-Q, Current Reports on Form&#160;8-K, as well as proxy statements. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">You may request a copy of these filings, at no cost, by contacting us, either orally or in writing, at the following: </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 8.5pt; text-align: center;">Gyre Therapeutics, Inc. <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">12770 High Bluff Drive <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">Suite 150 <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">San Diego, California 92130 <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">(858) 567-7770 </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We maintain a website at <font style="font-style: italic;">www.gyretx.com</font>. Information about us, including our reports filed with the SEC, is available through that site. Such reports are accessible at no charge through our website and are made available as soon as reasonably practicable after such material is filed with or furnished to the SEC. Our website and the information contained on that website, or connected to that website, are not incorporated by reference in this prospectus. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">26<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_111-incorp_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">You may read and copy any materials we file with the SEC at the SEC&#8217;s website mentioned under the heading &#8220;Where You Can Find More Information.&#8221; The information on the SEC&#8217;s website is not incorporated by reference in this prospectus. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">27<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_300-part2_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;">PART II </div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 15.5pt; text-align: center;">INFORMATION NOT REQUIRED IN THE PROSPECTUS </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 12pt; margin-left: 0pt;"><tr><td style="width: 50pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Item&#160;14.<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; text-align: left;">Other Expenses of Issuance and Distribution </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The following table sets forth an estimate of the fees and expenses, other than the underwriting discounts and commissions, payable by the registrant in connection with the issuance and distribution of the securities being registered. All the amounts shown are estimates, except for the SEC registration fee and FINRA filing fee. </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 8pt; margin-left: 0pt; text-align: left;"> </div><table cellspacing="0" cellpadding="0" class="fintab" style="border-collapse: collapse; width: 468pt; margin-left: auto; margin-right: auto;"><tr class="header"><td style="width: 89.74%; text-align: left; vertical-align: bottom; padding-top: 6pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold;">&#160;</div></td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt;">&#8203;</td><td class="gutter" style="width: 1.66%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td style="width: 6.94%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Amount </div></td></tr><tr><td style="width: 89.74%; text-align: left; vertical-align: bottom; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">SEC registration fee*<font style="padding-left: 4.76pt;"></font></div></td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 6.94%; text-align: right; vertical-align: bottom; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: right;">$22,140 </div></td></tr><tr><td style="width: 89.74%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">FINRA filing fee**<font style="padding-left: 2.52pt;"></font></div></td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 6.94%; text-align: right; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: right;">$23,000 </div></td></tr><tr><td style="width: 89.74%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Printing and engraving expenses<font style="padding-left: 4.77pt;"></font></div></td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 6.94%; text-align: right; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: right;">*** </div></td></tr><tr><td style="width: 89.74%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Legal fees and expenses<font style="padding-left: 3.11pt;"></font></div></td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 6.94%; text-align: right; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: right;">*** </div></td></tr><tr><td style="width: 89.74%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Accounting fees and expenses<font style="padding-left: 4.22pt;"></font></div></td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 6.94%; text-align: right; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: right;">*** </div></td></tr><tr><td style="width: 89.74%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Transfer agent and registrar fees and expenses<font style="padding-left: 2.96pt;"></font></div></td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.66%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 6.94%; text-align: right; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: right;">*** </div></td></tr><tr><td style="width: 89.74%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 4.25pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; 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font-family: 'Times New Roman', Times, serif; font-size: 8pt;">***<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: left;">These fees are calculated based on the securities offered and the number of issuances and accordingly cannot be estimated at this time. </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 12pt; margin-left: 0pt;"><tr><td style="width: 50pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Item&#160;15.<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; text-align: left;">Indemnification of Directors and Officers </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The company is a Delaware corporation. Section&#160;145(a) of the Delaware General Corporation Law (the &#8220;DGCL&#8221;) provides that a Delaware corporation may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative, other than an action by or in the right of the corporation, by reason of the fact that such person is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys&#8217; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with such action, suit or proceeding if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the best interests of the corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Section&#160;145(b) of the DGCL provides that a Delaware corporation may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right of the corporation to procure a judgment in its favor by reason of the fact that such person acted in any of the capacities set forth above, against expenses (including attorneys&#8217; fees) actually and reasonably incurred by such person in connection with the defense or settlement of such action or suit if the person acted in good faith and in a manner the person reasonably believed to be in, or not opposed to, the best interests of the corporation, except that no indemnification shall be made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation, unless and only to the extent that the Court of Chancery or the court in which such action or suit was brought shall determine, upon application, that, despite the adjudication of liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the court shall deem proper. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 8pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Further subsections of DGCL Section&#160;145 provide that: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(1)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to the extent a present or former director or officer of a corporation has been successful on the merits or otherwise in the defense of any action, suit or proceeding referred to in subsections (i) and (ii) of Section&#160;145 or in the defense of any claim, issue or matter therein, such person shall be indemnified against expenses, including attorneys&#8217; fees, actually and reasonably incurred by such person in connection therewith; </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">II-1<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_300-part2_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6.75pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(2)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the indemnification and advancement of expenses provided for pursuant to Section&#160;145 shall not be deemed exclusive of any other rights to which those seeking indemnification or advancement of expenses may be entitled under any bylaw, agreement, vote of shareholders or disinterested directors or otherwise; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(3)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the corporation shall have the power to purchase and maintain insurance of behalf of any person who is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against any liability asserted against such person and incurred by such person in any such capacity, or arising out of such person&#8217;s status as such, whether or not the corporation would have the power to indemnify such person against such liability under Section&#160;145. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">As used in this Item&#160;14, the term &#8220;proceeding&#8221; means any threatened, pending or completed action, suit or proceeding, whether or not by or in the right of the company, and whether civil, criminal, administrative, investigative or otherwise. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Section&#160;145 of the DGCL makes provision for the indemnification of officers and directors in terms sufficiently broad to indemnify officers and directors of the company under certain circumstances from liabilities (including reimbursement for expenses incurred) arising under the Securities Act. The company&#8217;s Second Amended and Restated Certificate of Incorporation and Second Amended and Restated Bylaws provide, in effect, that, to the fullest extent and under the circumstances permitted by Section&#160;145 of the DGCL, the company will indemnify any and all of its officers and directors. The company has entered into indemnification agreements with its officers and directors. The company may, in its discretion, similarly indemnify its employees and agents. The company&#8217;s Second Amended and Restated Certificate of Incorporation also relieves the company&#8217;s directors from monetary damages to the company or its shareholders for breach of such director&#8217;s fiduciary duty as a director to the fullest extent permitted by the DGCL. Under Section&#160;102(b)(7) of the DGCL, a corporation may relieve its directors from personal liability to such corporation or its shareholders for monetary damages for any breach of their fiduciary duty as directors except (i) for a breach of the duty of loyalty, (ii) for failure to act in good faith, (iii) for intentional misconduct or knowing violation of law, (iv) for willful or negligent violations of certain provisions in the DGCL imposing certain requirements with respect to stock repurchases, redemptions and dividends or (v) for any transactions from which the director derived an improper personal benefit. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The company has purchased insurance policies that, within the limits and subject to the terms and conditions thereof, cover certain expenses and liabilities that may be incurred by directors and officers in connection with proceedings that may be brought against them as a result of an act or omission committed or suffered while acting as a director or officer of the company. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The underwriting agreements that we may enter into may provide for the indemnification by the underwriters of us and our officers and directors for certain liabilities, including liabilities arising under the Securities Act, and afford certain rights of contribution with respect thereto. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">II-2<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_300-part2_pg3"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6.75pt; margin-left: 0pt;"><tr><td style="width: 50pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Item&#160;16.<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; text-align: left;">Exhibits<font style="font-weight: normal;"> </font></div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">A&#160;list of exhibits filed with this registration statement on Form&#160;S-3 is set forth on the Exhibit&#160;Index and is incorporated herein by reference. </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 8pt; margin-left: 0pt; text-align: left;"> </div><table cellspacing="0" cellpadding="0" class="fintab" style="border-collapse: collapse; width: 468pt; margin-left: auto; margin-right: auto;"><tr class="header"><td style="width: 7.69%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Exhibit No.</div></td><td class="gutter" style="width: 0.64%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; 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padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312506103288/dex41.htm">3.1</a></div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 91.03%; 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text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">II-3<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_300-part2_pg4"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table cellspacing="0" cellpadding="0" class="fintab" style="margin-top: 4pt; border-collapse: collapse; width: 468pt; margin-left: auto; margin-right: auto;"><tr class="header"><td style="width: 7.69%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Exhibit No.</div></td><td class="gutter" style="width: 0.64%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td class="gutter" style="width: 0.64%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td style="width: 91.03%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Description<font style="font-weight: normal;"> </font></div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312516498295/d117011dex45.htm">4.2</a></div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form&#160;of Warrant to Purchase Stock of Catalyst Biosciences, Inc., issued to purchasers of convertible promissory notes (incorporated by reference to Exhibit&#160;4.5 to the Company&#8217;s Form&#160;10-K filed on March&#160;9, 2016). </div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex4-1.htm">4.3</a></div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form&#160;of Warrant to Purchase Series&#160;X Convertible Preferred Stock (incorporated by reference to Exhibit&#160;4.1 to the Company&#8217;s Form&#160;8-K filed on October&#160;30, 2023). </div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="ny20028941x2_ex4-4.htm">4.4</a></div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; 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padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">4.5*</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form&#160;of Debt Securities. </div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">4.6*</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form&#160;of Warrant Agreement and Warrant Certificate. </div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">4.7*</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; 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font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="ny20028941x2_ex5-1.htm">5.1</a></div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Opinion of Gibson, Dunn &amp; Crutcher LLP, relating to base prospectus. </div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="ny20028941x2_ex23-1.htm">23.1</a></div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Consent of Grant Thornton Zhitong Certified Public Accountants LLP, Independent Registered Public Accounting Firm. </div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="ny20028941x2_ex23-2.htm">23.2</a></div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; 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padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="ny20028941x2_ex5-1.htm">23.3</a></div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; 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text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">25.1**</div></td><td class="gutter" style="width: 0.64%; 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border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="ny20028941x2_ex99-1.htm">99.1</a> </div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Unaudited pro forma condensed combined statement of operations of Catalyst Biosciences, Inc. for the year ended December 31, 2023. </div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 7.69%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="ny20028941x2_ex107.htm">107</a></div></td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 0.64%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 91.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Filing&#160;Fee Table.</div></td></tr></table><div><div class="rule-partial" style="height: 0pt; width: 72pt; border-bottom: 1pt solid #000000; margin-bottom: 1pt; margin-right: auto; margin-left: 0pt; margin-top: 16pt;"> </div></div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">*<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: left;">To be filed, if necessary, by amendment or as an exhibit to a document to be incorporated or deemed to be incorporated by reference in this registration statement, including a Current Report on Form&#160;8-K. </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">**<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: left;">To be filed in accordance with the requirements of Section&#160;305(b)(2) of the Trust Indenture Act of 1939, as amended, and the applicable rules thereunder. </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">II-4<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_300-part2_pg5"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6.75pt; margin-left: 0pt;"><tr><td style="width: 50pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Item&#160;17.<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; text-align: left;">Undertakings </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 7pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The undersigned registrant hereby undertakes: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(a)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">(1)&#8195;To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement: </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 40pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(i)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to include any prospectus required by Section&#160;10(a)(3) of the Securities Act; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 40pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(ii)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule&#160;424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective registration statement; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 40pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(iii)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">to include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement; </div></td></tr></table><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 20pt; text-align: left;">provided, however,<font style="font-style: normal;"> that paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) of this section do not apply if the </font><font style="font-style: normal;">information required to be included in a post-effective amendment by those paragraphs is contained in </font><font style="font-style: normal;">reports filed with or furnished to the Commission by the registrant pursuant to Section&#160;13 or Section&#160;15(d) </font><font style="font-style: normal;">of the Exchange Act that are incorporated by reference in the registration statement, or is contained in a </font><font style="font-style: normal;">form of prospectus filed pursuant to Rule&#160;424(b) that is part of the registration statement. </font></div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(2)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial<font style="font-style: italic;"> bona fide</font> offering thereof. </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(3)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(4)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">That, for the purpose of determining liability under the Securities Act to any purchaser: </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 40pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(i)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">Each prospectus filed by the registrant pursuant to Rule&#160;424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration statement; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 40pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(ii)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">Each prospectus required to be filed pursuant to Rule&#160;424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule&#160;430B relating to an offering made pursuant to Rule&#160;415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by Section&#160;10(a) of the Securities Act shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule&#160;430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time shall be deemed to be the initial<font style="font-style: italic;"> bona fide</font> offering thereof.<font style="font-style: italic;"> </font><font style="font-style: italic;">Provided, however,</font> that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date. </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(5)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">That, for the purpose of determining liability of the registrant under the Securities Act to any purchaser </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">II-5<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_300-part2_pg6"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6.75pt; margin-left: 40pt; text-align: left;">in the initial distribution of the securities, the undersigned registrant undertakes that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser: </div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 40pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(i)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule&#160;424; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 40pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(ii)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant; </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 40pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(iii)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">The portion of any other free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 40pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(iv)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">Any other communication that is an offer in the offering made by the undersigned registrant to the purchaser. </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(6)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant&#8217;s annual report pursuant to section 13(a) or section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof. </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(7)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(8)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">That, for purposes of determining any liability under the Securities Act, (i) the information omitted from the form of prospectus filed as part of the registration statement in reliance upon Rule&#160;430A and contained in the form of prospectus filed by the registrant pursuant to Rule&#160;424(b)(l) or (4) or 497(h) under the Securities Act shall be deemed to be a part of the registration statement as of the time it was declared effective; and (ii) each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(9)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">To file an application for the purpose of determining the eligibility of the trustee to act under subsection (a) of Section&#160;310 of the Trust Indenture Act in accordance with the rules and regulations prescribed by the Commission under Section&#160;305(b)(2) of the Trust&#160;Indenture Act. </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 9.47pt; text-align: center;">II-6<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="ny20028941x2_s3_301-sig_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; text-align: center;">SIGNATURES </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form&#160;S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on May&#160;30<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup>, 2024. </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 2pt; margin-left: 0pt; text-align: left;"> </div><table cellspacing="0" cellpadding="0" class="txttab" style="border-collapse: collapse; width: 468pt; margin-left: auto; margin-right: auto;"><tr><td style="width: 46.15%; text-align: left; vertical-align: top; padding-top: 6pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 2pt;">&#8203;</td><td colspan="4" style="width: 51.28%; text-align: left; vertical-align: bottom; padding-top: 6pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">Gyre Therapeutics, Inc.<font style="font-weight: normal;"> </font></div></td></tr><tr><td style="width: 46.15%; text-align: left; vertical-align: top; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 2.56%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 46.15%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 46.15%; text-align: left; vertical-align: top; padding-top: 2pt; padding-bottom: 3.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3.25pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3.25pt;">&#8203;</td><td style="width: 2.56%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 3.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">By:</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3.25pt;">&#8203;</td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-top: 2pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td style="width: 46.15%; text-align: left; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 2pt; padding-bottom: 3.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">/s/ Han Ying </div></td></tr><tr><td style="width: 46.15%; text-align: left; vertical-align: top; padding-top: 3.25pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; 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margin-top: 0pt; margin-left: 0pt; text-align: left;">Han Ying, Ph.D. <br></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><font style="font-style: italic;">Chief Executive Officer</font></div></td></tr></table><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 2pt; text-align: center;"><a name="tPOA"><!--Anchor--></a>POWER OF ATTORNEY </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">KNOW ALL PERSONS BY THESE PRESENTS<font style="font-weight: normal;">, that each person whose signature appears below </font><font style="font-weight: normal;">constitutes and appoints Han Ying, Ph.D. and Ruoyu Chen, and each of them, as true and lawful attorneys-in-fact </font><font style="font-weight: normal;">and agents, with full powers of substitution and resubstitution, for them and in their name, place and stead, in </font><font style="font-weight: normal;">any and all capacities, to sign any and all amendments (including post-effective amendments) to this registration </font><font style="font-weight: normal;">statement (or any registration statement for the same offering that is to be effective upon filing pursuant to </font><font style="font-weight: normal;">Rule&#160;462(b) under the Securities Act of 1933), and to file the same, with all exhibits thereto, and other </font><font style="font-weight: normal;">documents in connection therewith, with the SEC, and generally to do all such things in their names and behalf </font><font style="font-weight: normal;">in their capacities as officers and directors to enable the Gyre Therapeutics, Inc. to comply with the provisions of </font><font style="font-weight: normal;">the Securities Act of 1933 and all requirements of the SEC, granting unto said attorneys-in-fact and agents, and </font><font style="font-weight: normal;">each of them, full power and authority to do and perform each and every act and thing requisite and necessary to </font><font style="font-weight: normal;">be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, </font><font style="font-weight: normal;">ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or </font><font style="font-weight: normal;">substitute, may lawfully do or cause to be done by virtue hereof. </font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 3pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed below by the following persons in the capacities and on the dates indicated. </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 2pt; margin-left: 0pt; text-align: left;"> </div><table cellspacing="0" cellpadding="0" class="txttab" style="border-collapse: collapse; width: 468pt; margin-left: auto; margin-right: auto;"><tr class="header"><td style="width: 30.77%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 3.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Signature</div></td><td class="gutter" style="width: 1.28%; 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<DOCUMENT>
<TYPE>EX-4.4
<SEQUENCE>2
<FILENAME>ny20028941x2_ex4-4.htm
<DESCRIPTION>EXHIBIT 4.4
<TEXT>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Exhibit
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>GYRE
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Debt
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><u>Indenture
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dated
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">as
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>CROSS-REFERENCE
        TABLE </b></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><u>This
        Cross-Reference Table is not a part of the Indenture </u></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></p>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 60%; border-collapse: collapse" align="CENTER" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: bottom">
        <td style="white-space: nowrap; font-size: 10pt; width: 41%"><font style="font-family: Times New Roman, Times, Serif;"><b>TIA Section</b></font></td>
        <td style="width: 2%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="font-size: 10pt; text-align: right; width: 17%"><font style="font-family: Times New Roman, Times, Serif;"><b>Indenture Section</b></font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">310(a)(1)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.10</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(a)(2)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.10</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(a)(3)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">N.A.</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(a)(4)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">N.A.</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(b)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.08; 7.10; 12.02</font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">311(a)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.11</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(b)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.11</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(c)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">N.A.</font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">312(a)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">2.05</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(b)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12.03</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(c)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12.03</font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">313(a)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.06</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(b)(1)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">N.A.</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(b)(2)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.06</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(c)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12.02</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(d)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.06</font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">314(a)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">4.03; 12.02</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(b)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">N.A.</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(c)(1)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12.04</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(c)(2)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12.04</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(c)(3)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">N.A.</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(d)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">N.A.</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(e)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12.05</font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">315(a)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.01(b)</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(b)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.05; 12.02</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(c)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.01(a)</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(d)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7.01(c)</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(e)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">6.11</font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">316(a)(last sentence)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12.06</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(a)(1)(A)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">6.05</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(a)(1)(B)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">6.04</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(a)(2)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">N.A.</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">(b)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">6.07</font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">317(a)(1)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">6.08</font></td>
      </tr>
      <tr>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">6.09</font></td>
      </tr>
      <tr>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">2.04</font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">318(a)</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12.01</font></td>
      </tr>

  </table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">N.A.
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <div style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt" class="BRPFPageBreakArea">
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>TABLE
        OF CONTENTS</b></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><u>This
        Table of Contents is not a part of the Indenture </u></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>ARTICLE
        ONE </b></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>DEFINITIONS
        AND INCORPORATION BY REFERENCE </b></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 10%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="vertical-align: bottom; width: 1%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="width: 82%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="vertical-align: bottom; width: 1%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="width: 6%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 1.01</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Definitions</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">1</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 1.02</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Other Definitions</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">4</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 1.03</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Incorporation by Reference of Trust Indenture Act</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">4</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 1.04</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Rules of Construction</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">4</font></td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: top">
        <td colspan="5">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>ARTICLE
                TWO</b></font>&#160;</p>
        </td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: top">
        <td colspan="5" style="font-size: 10pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif;"><b>THE SECURITIES</b></font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.01</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Form and Dating</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">5</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.02</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Execution and Authentication</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">6</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.03</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Registrar and Paying Agent</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">6</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.04</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Paying Agent to Hold Money in Trust</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right">7</td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.05</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Securityholder Lists</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.06</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Transfer and Exchange</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.07</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Replacement Securities</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">7</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.08</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Outstanding Securities</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">8</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.09</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Temporary Securities</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">8</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.10</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Cancellation</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">8</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.11</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Defaulted Interest</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">8</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.12</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Treasury Securities</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">9</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.13</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">CUSIP/ISIN Numbers</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">9</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.14</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Deposit of Moneys</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">9</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.15</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Book-Entry Provisions for Global Security</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">9</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 2.16</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">No Duty to Monitor</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">10</font></td>
      </tr>

  </table>
  <br>
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 10%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="vertical-align: bottom; width: 1%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="width: 82%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="vertical-align: bottom; width: 1%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="width: 6%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>REDEMPTION</b></font>&#160;</p>
        </td>
      </tr>
      <tr>
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        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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      <tr>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">11</font></td>
      </tr>
      <tr>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">11</font></td>
      </tr>
      <tr>
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      <tr>
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        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12</font></td>
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      <tr>
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        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Deposit of Redemption Price</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12</font></td>
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      <tr>
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        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Securities Redeemed in Part</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12</font></td>
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      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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      <tr style="vertical-align: top">
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      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
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        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Payment of Securities</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">12</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 4.02</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Maintenance of Office or Agency</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">13</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 4.03</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Reports</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">13</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 4.04</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Compliance Certificate</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">13</font></td>
      </tr>
      <tr>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Waiver of Stay, Extension or Usury Laws</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">13</font></td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
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          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></p>
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      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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        <td colspan="5" style="font-size: 10pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif;"><b>SUCCESSOR CORPORATION</b></font></td>
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      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">13</font></td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: top">
        <td colspan="5" style="font-size: 10pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif;"><b>DEFAULTS AND REMEDIES</b></font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 6.01</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Events of Default</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">14</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 6.02</font></td>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">15</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 6.03</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Other Remedies</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">15</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 6.04</font></td>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">15</font></td>
      </tr>
      <tr>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">15</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 6.06</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Limitation on Suits</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">15</font></td>
      </tr>
      <tr>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Rights of Holders to Receive Payment and Convert</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">16</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 6.08</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Collection Suit by Trustee</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">16</font></td>
      </tr>

  </table>
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt; width: 10%"><font style="font-family: Times New Roman, Times, Serif;">Section 6.09</font></td>
        <td style="vertical-align: bottom; width: 1%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt; width: 82%"><font style="font-family: Times New Roman, Times, Serif;">Trustee May File Proofs of Claim</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right; width: 6%"><font style="font-family: Times New Roman, Times, Serif;">16</font></td>
      </tr>
      <tr>
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        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">16</font></td>
      </tr>
      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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        <td style="vertical-align: bottom; width: 1%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="width: 82%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="vertical-align: bottom; width: 1%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="width: 6%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: top">
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        </td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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      <tr style="vertical-align: top">
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      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Duties of Trustee</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">17</font></td>
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      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 7.02</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Rights of Trustee</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">18</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 7.03</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Individual Rights of Trustee</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">19</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 7.04</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Trustee&#8217;s Disclaimer</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right">19</td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 7.05</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Notice of Defaults</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">19</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 7.06</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Reports by Trustee to Holders</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">19</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 7.07</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Compensation and Indemnity</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">19</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 7.08</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Replacement of Trustee</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">20</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 7.09</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Successor Trustee by Merger, etc.</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">20</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 7.10</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Eligibility; Disqualification</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">21</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 7.11</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Preferential Collection of Claims Against Company</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">21</font></td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: top">
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          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>ARTICLE EIGHT</b></font></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></p>
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      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: top">
        <td colspan="5" style="font-size: 10pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif;"><b>DISCHARGE OF INDENTURE</b></font></td>
      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 8.01</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Defeasance upon Deposit of Moneys or Government Obligations</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">21</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 8.02</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Survival of the Company&#8217;s Obligations</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">23</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 8.03</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Application of Trust Money</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">23</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 8.04</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Repayment to the Company</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">23</font></td>
      </tr>
      <tr>
        <td style="vertical-align: top; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 8.05</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Reinstatement</font></td>
        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">23</font></td>
      </tr>

  </table>
  <div style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt" class="BRPFPageBreakArea">
    <div style="TEXT-ALIGN: center" class="BRPFPageNumberArea"><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: normal; COLOR: #000000; FONT-STYLE: normal" class="BRPFPageNumber">&#160;</font></div>
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 9%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="vertical-align: bottom; width: 1%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="width: 82%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="vertical-align: bottom; width: 1%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="width: 7%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: bottom">
        <td colspan="5" style="font-size: 10pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif;"><b>ARTICLE NINE</b></font></td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: bottom">
        <td colspan="5" style="font-size: 10pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif;"><b>RESERVED</b></font></td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: bottom">
        <td colspan="5" style="font-size: 10pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif;"><b>ARTICLE TEN</b></font></td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
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      </tr>
      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: bottom">
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">24</font></td>
      </tr>
      <tr style="vertical-align: bottom">
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        <td style="white-space: nowrap; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">With Consent of Holders</font></td>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">24</font></td>
      </tr>
      <tr style="vertical-align: bottom">
        <td style="padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Section 10.03</font></td>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">25</font></td>
      </tr>
      <tr style="vertical-align: bottom">
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">25</font></td>
      </tr>
      <tr style="vertical-align: bottom">
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; font-size: 10pt; text-align: right">26</td>
      </tr>
      <tr style="vertical-align: bottom">
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">26</font></td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: top">
        <td colspan="5">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>ARTICLE ELEVEN</b></font></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></p>
        </td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
      </tr>
      <tr style="vertical-align: top">
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      <tr>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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      <tr>
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        <td style="vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">26</font></td>
      </tr>
      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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      <tr>
        <td colspan="5"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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        <td colspan="2"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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        <td style="white-space: nowrap; vertical-align: bottom; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">27</font></td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">27</font></td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">27</font></td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">27</font></td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">28</font></td>
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        <td style="white-space: nowrap; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><font style="font-family: Times New Roman, Times, Serif;">Rules by Trustee and Agents</font></td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">28</font></td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">28</font></td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">28</font></td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">28</font></td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">28</font></td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right">29</td>
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        <td style="white-space: nowrap; font-size: 10pt; text-align: right"><font style="font-family: Times New Roman, Times, Serif;">29</font></td>
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      in each case the payment of which is unconditionally guaranteed as a full faith and credit obligation by the United States or
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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      <tr>
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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  </table>
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      <tr>
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      <tr>
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  </table>
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      <tr>
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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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      </tr>

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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">All
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      any time and from time to time after the execution and delivery of this Indenture, the Company may deliver Securities of any series
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      shall authenticate Securities for original issue upon receipt of, and shall be fully protected in relying upon:</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)
      a copy of the resolution or resolutions of the Board of Directors in or pursuant to which the terms and form of the Securities
      were established, certified by the Secretary or an Assistant Secretary of the Company to have been duly adopted by the Board of
      Directors and to be in full force and effect as of the date of such certificate, and if the terms and form of such Securities
      are established by an Officers&#8217; Certificate pursuant to general authorization of the Board of Directors, such Officers&#8217;
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      Trustee shall have the right to decline to authenticate and deliver any Securities under this Section if the Trustee, being advised
      by counsel, determines that such action may not lawfully be taken or if the Trustee in good faith shall determine that such action
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      an office or agency where Securities may be presented for payment (&#8220;<b>Paying Agent</b>&#8221;) and an office or agency
      where notices and demands to or upon the Company in respect of the Securities and this Indenture may be served. The Registrar
      shall keep a register of the Securities and of their transfer and exchange (the &#8220;<b>Security Register</b>&#8221;). The Company
      may have one or more co-Registrars and one or more additional paying agents. The term &#8220;Paying Agent&#8221; includes any
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      Company shall enter into an appropriate agency agreement with any Agent not a party to this Base Indenture. The agreement shall
      implement the provisions of this Indenture that relate to such Agent. The Company shall promptly notify the Trustee in writing
      of the name and address of any such Agent and the Trustee shall have the right to inspect the Securities Register at all reasonable
      times to obtain copies thereof, and the Trustee shall have the right to rely upon such register as to the names and addresses
      of the Holders and the principal amounts and certificate numbers thereof. If the Company fails to maintain a Registrar or Paying
      Agent or fails to give the foregoing notice, the Trustee shall act as such.</font></p>
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      Paying Agent shall hold in trust for the benefit of Securityholders and the Trustee all money held by the Paying Agent for the
      payment of principal of or interest on the Securities, and shall notify the Trustee of any default by the Company in making any
      such payment. If the Company or a Subsidiary acts as Paying Agent, it shall segregate the money and hold it as a separate trust
      fund. The Company at any time may require a Paying Agent to pay all money held by it to the Trustee. Upon doing so the Paying
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      Trustee shall preserve in as current a form as is reasonably practicable the most recent list available to it of the names and
      addresses of Securityholders. If the Trustee is not the Registrar, the Company shall furnish to the Trustee at least five (5)
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      in such form and as of such date as the Trustee may reasonably require of the names and addresses of Securityholders.</font></p>
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      a Security is presented to the Registrar or a co-Registrar with a request to register a transfer, the Registrar shall register
      the transfer as requested if the requirements of Section 8-401(a) of the NYUCC are met and the other provisions of this <u>Section
        2.06</u> are satisfied. Where Securities are presented to the Registrar or a co-Registrar with a request to exchange them for
      an equal principal amount of Securities of other denominations, the Registrar shall make the exchange as requested if the same
      requirements are met. To permit transfers and exchanges, the Trustee shall authenticate Securities at the Registrar&#8217;s request.
      The Registrar need not transfer or exchange any Security selected for redemption or repurchase, except the unredeemed or repurchased
      part thereof if the Security is redeemed or repurchased in part, or transfer or exchange any Securities for a period of 15 days
      before a selection of Securities to be redeemed or repurchased. Any exchange or transfer shall be without charge, except that
      the Company may require payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in relation
      thereto except in the case of exchanges pursuant to <u>2.09</u>, <u>3.06</u>, or <u>10.05</u> not involving any transfer.</font></p>
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      Global Security may be effected only through a book entry system maintained by the Holder of such Global Security (or its agent),
      and that ownership of a beneficial interest in the Security shall be required to be reflected in a book entry.</font></p>
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      the Holder of a Security claims that the Security has been lost, destroyed, mutilated or wrongfully taken, the Company shall issue
      and execute a replacement security and, upon written request of any Officer of the Company, the Trustee shall authenticate such
      replacement Security, <i>provided</i>, in the case of a lost, destroyed or wrongfully taken Security, that the requirements of
      Section 8-405 of the NYUCC are met. If any such lost, destroyed, mutilated or wrongfully taken Security shall have matured or
      shall be about to mature, the Company may, instead of issuing a substitute Security therefor, pay such Security without requiring
      (except in the case of a mutilated Security) the surrender thereof. An indemnity bond must be sufficient in the judgment of the
      Company and the Trustee to protect the Company, the Trustee and any Agent from any loss which any of them may suffer if a Security
      is replaced, including the acquisition of such Security by a bona fide purchaser. The Company and the Trustee may charge for its
      expenses in replacing a Security.</font></p>
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      date, then on and after that date such Securities cease to be outstanding and interest on them ceases to accrue.</font></p>
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      to the foregoing provisions of this Section, each Security delivered under this Indenture upon registration of transfer of or
      in exchange for or in lieu of any other Security shall carry the rights to interest accrued and unpaid, and to accrue, which were
      carried by such other Security.</font></p>
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      Temporary Securities shall be substantially in the form of Definitive Securities but may have variations that the Company considers
      appropriate for temporary Securities. Without unreasonable delay, the Company shall prepare and, upon surrender for cancellation
      of the temporary Security, the Company shall execute and the Trustee shall authenticate Definitive Securities in exchange for
      temporary Securities. Until so exchanged, the temporary Securities shall in all respects be entitled to the same benefits under
      this Indenture as Definitive Securities authenticated and delivered hereunder.</font></p>
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      Company at any time may deliver Securities to the Trustee for cancellation. The Registrar and Paying Agent shall forward to the
      Trustee any Securities surrendered to them for registration of transfer, exchange, redemption, purchase or payment. The Trustee
      and no one else shall cancel and dispose of such cancelled or tendered securities, or retain in accordance with its standard retention
      policy, all Securities surrendered for registration of transfer, exchange, redemption, purchase, payment or cancellation. Unless
      the Authorizing Resolution or supplemental indenture so provides, the Company may not issue new Securities to replace Securities
      that it has previously paid or delivered to the Trustee for cancellation.</font></p>
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      the Company defaults in a payment of interest on the Securities of any Series, it shall pay the defaulted interest <i>plus</i>
      any interest payable on the defaulted interest to the persons who are Securityholders of such Series on a subsequent special record
      date. The Company shall fix such special record date and a payment date which shall be reasonably satisfactory to the Trustee.
      At least 15 days before such special record date, the Company shall mail to each Securityholder of the relevant Series a notice
      that states the record date, the payment date and the amount of defaulted interest to be paid. On or before the date such notice
      is mailed, the Company shall deposit with the Paying Agent money sufficient to pay the amount of defaulted interest to be so paid.
      The Company may pay defaulted interest in any other lawful manner if, after notice given by the Company to the Trustee of the
      proposed payment, such manner of payment shall be deemed practicable by the Trustee.</font></p>
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      determining whether the Holders of the required principal amount of Securities of a Series have concurred in any direction, waiver,
      consent or notice, Securities owned by the Company or any of its Affiliates shall be considered as though they are not outstanding,
      except that for the purposes of determining whether the Trustee shall be protected in relying on any such direction, waiver or
      consent, only Securities which a Trust Officer of the Trustee actually knows are so owned shall be so considered.</font></p>
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      Company in issuing the Securities of any Series may use a &#8220;CUSIP&#8221; and/or &#8220;ISIN&#8221; or other similar number,
      and if so, the Trustee shall use the CUSIP and/or ISIN or other similar number in notices of redemption or exchange as a convenience
      to Holders of such Securities; <i>provided</i> that no representation is hereby deemed to be made by the Trustee as to the correctness
      or accuracy of any such CUSIP and/or ISIN or other similar number printed in the notice or on such Securities, and that reliance
      may be placed only on the other identification numbers printed on such Securities. The Company shall promptly notify the Trustee
      of any change in any CUSIP and/or ISIN or other similar number.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Prior
      to 11:00 a.m., New York City time, on each interest payment date and maturity date with respect to each Series of Securities,
      the Company shall have deposited with the Paying Agent in immediately available funds money in the applicable currency sufficient
      to make cash payments due on such interest payment date or maturity date, as the case may be, in a timely manner which permits
      the Paying Agent to remit payment to the Holders of such Series on such interest payment date or maturity date, as the case may
      be.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Section
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)
      Any Global Security of a Series initially shall (i) be registered in the name of the Depositary or the nominee of such Depositary,
      (ii) be delivered to the Trustee as custodian for such Depositary and (iii) bear any required legends.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Members
      of, or participants in, the Depositary (&#8220;<b>Agent Members</b>&#8221;) shall have no rights under this Indenture with respect
      to any Global Security held on their behalf by the Depositary, or the Trustee as its custodian, or under the Global Security,
      and the Depositary may be treated by the Company, the Trustee and any agent of the Company or the Trustee as the absolute owner
      of the Global Security for all purposes whatsoever. Notwithstanding the foregoing, nothing herein shall prevent the Company, the
      Trustee or any agent of the Company or the Trustee from giving effect to any written certification, proxy or other authorization
      furnished by the Depositary or impair, as between the Depositary and its Agent Members, the operation of customary practices governing
      the exercise of the rights of a Holder of any Security.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)
      Transfers of any Global Security shall be limited to transfers in whole, but not in part, to the Depositary, its successors or
      their respective nominees. Interests of beneficial owners in the Global Security may be transferred or exchanged for Definitive
      Securities in accordance with the rules and procedures of the Depositary. In addition, Definitive Securities shall be transferred
      to all beneficial owners in exchange for their beneficial interests in a Global Security if (i) the Depositary notifies the Company
      that it is unwilling or unable to continue as Depositary for the Global Security or the Depositary has ceased to be a &#8220;clearing
      agency&#8221; registered under the Exchange Act, and a successor depository is not appointed by the Company within 90 days of
      such notice, or (ii) the Company elects, at any time in its sole discretion, to discontinue use of the system of book entry transfer
      through any Depositary. Any Security that is held in the form of a Global Security and that is exchanged pursuant to clause (i)
      above shall be so exchanged in whole and not in part, and any Security that is held in the form of a Global Security and that
      is exchanged pursuant to clause (ii) above may be exchanged in whole or from time to time in part as directed by the Company.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)
      In connection with any transfer or exchange of a portion of the beneficial interest in any Global Security to beneficial owners
      pursuant to <u>paragraph (b)</u>, the Registrar shall (if one or more Definitive Securities are to be issued) reflect on its books
      and records the date and a decrease in the principal amount of the Global Security in an amount equal to the principal amount
      of the beneficial interest in the Global Security to be transferred, and the Company shall execute, and the Trustee shall authenticate
      and deliver, one or more Definitive Securities of like Series and amount.</font></p>
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      In connection with the transfer of an entire Global Security to beneficial owners pursuant to <u>paragraph (b)</u>, the Global
      Security shall be deemed to be surrendered to the Trustee for cancellation, and the Company shall execute, and the Trustee shall
      authenticate and deliver, to each beneficial owner identified by the Depositary in exchange for its beneficial interest in the
      Global Security, an equal aggregate principal amount of Definitive Securities of the same Series in authorized denominations.</font></p>
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      The Holder of any Global Security may grant proxies and otherwise authorize any person, including Agent Members and persons that
      may hold interests through Agent Members, to take any action which a Holder is entitled to take under this Indenture or the Securities
      of such Series.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      Unless otherwise provided in the Authorizing Resolution or supplemental indenture for a particular Series of Securities, each
      Global Security of such Series shall bear legends in substantially the following forms:</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8220;THIS
      GLOBAL SECURITY IS HELD BY THE DEPOSITARY (AS DEFINED IN THE INDENTURE GOVERNING THIS SECURITY) OR ITS NOMINEE IN CUSTODY FOR
      THE BENEFIT OF THE HOLDERS OF BENEFICIAL INTERESTS HEREIN, AND IS NOT TRANSFERABLE TO ANY PERSON UNDER ANY CIRCUMSTANCES EXCEPT
      THAT (I) THE TRUSTEE MAY MAKE ANY SUCH NOTATIONS HEREON AS MAY BE REQUIRED PURSUANT TO THE INDENTURE, (II) THIS GLOBAL SECURITY
      MAY BE EXCHANGED IN WHOLE BUT NOT IN PART PURSUANT TO SECTION 2.06 AND SECTION 2.15 OF THE INDENTURE, (III) THIS GLOBAL SECURITY
      MAY BE DELIVERED TO THE TRUSTEE FOR CANCELLATION PURSUANT TO THE INDENTURE AND (IV) THIS GLOBAL SECURITY MAY BE TRANSFERRED TO
      A SUCCESSOR DEPOSITARY WITH THE PRIOR WRITTEN CONSENT OF THE COMPANY.&#8221;</font></p>
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      AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS
      A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR TO ANOTHER NOMINEE
      OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.
      UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (&#8220;DTC&#8221;),
      TO ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE, OR PAYMENT, ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF
      CEDE &amp; CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE &amp;
      CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE, OR OTHER USE HEREOF
      FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE &amp; CO., HAS AN INTEREST
      HEREIN.&#8221;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
      Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance with any restrictions on transfer imposed
      under this Indenture or under applicable law with respect to any transfer of any interest in any Security (including any transfers
      between or among Agent Members or beneficial owners of interests in any Global Security) other than to require delivery of such
      certificates and other documentation or evidence as are expressly required by, and to do so if and when expressly required by
      the terms of, this Indenture, and to examine the same to determine substantial compliance as to form with the express requirements
      hereof.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      Resolution or supplemental indenture provides otherwise, in accordance with this <u>Article Three</u>.</font></p>
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        5</u> of the Securities, it shall notify the Trustee of the amount of the credit and it shall deliver any Securities not previously
      delivered to the Trustee for cancellation with such notice.</font></p>
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      is to be delivered to Holders (unless a shorter notice shall be satisfactory to the Trustee).</font></p>
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      to be redeemed by lot, pro rata, or such other method the Trustee (or depository, as applicable) considers fair and appropriate
      and in a manner that complies with applicable requirements of the Depositary. The Trustee (or depository, as applicable) shall
      make the selection from Securities outstanding not previously called for redemption and shall promptly notify the Company of the
      serial numbers or other identifying attributes of the Securities so selected. The Trustee (or depository, as applicable) may select
      for redemption portions of the principal of Securities that have denominations larger than the minimum denomination for the Series.
      Securities and portions of them it selects shall be in amounts equal to a permissible denomination for the Series. Provisions
      of this Indenture that apply to Securities called for redemption also apply to portions of Securities called for redemption.</font></p>
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      otherwise provided in the Authorizing Resolution or supplemental indenture relating to a Series, if any Security selected for
      partial redemption is converted into or exchanged for the Company&#8217;s Capital Stock or other securities, cash or other property
      in part before termination of the conversion or exchange right with respect to the portion of the Security so selected, the converted
      portion of such Security shall be deemed (so far as may be) to be the portion selected for redemption. Securities which have been
      converted or exchanged during a selection of Securities to be redeemed shall be treated by the Trustee as outstanding for the
      purpose of such selection.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      least 30 days but not more than 60 days before a redemption date, the Company shall mail a notice of redemption by first-class
      mail, postage prepaid, to each Holder of Securities to be redeemed.</font></p>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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      </tr>

  </table>
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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            place or places where such Securities may be surrendered for conversion or exchange; </font></td>
      </tr>

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      </tr>

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      </tr>

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      </tr>

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        <td style="vertical-align: top; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">that the Securities are being redeemed pursuant to the mandatory redemption or the optional redemption provisions, as
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      </tr>

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      <tr>
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        <td style="vertical-align: top; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">the CUSIP number and/or ISIN or other similar number used to identify the Securities, that no representation is hereby deemed
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      </tr>

  </table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">At
      the Company&#8217;s request, the Trustee shall give the notice of redemption in the Company&#8217;s name and at its expense; <i>provided</i>,
      <i>however</i>, that the Company shall deliver to the Trustee at least 15 days prior to the date on which notice of redemption
      is to be mailed or such shorter period as may be satisfactory to the Trustee, an Officers&#8217; Certificate requesting that the
      Trustee give such notice and setting forth the information to be stated in such notice as provided in the preceding paragraph.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      notice of redemption is mailed, Securities called for redemption become due and payable on the redemption date and at the redemption
      price as set forth in the notice of redemption, which notice, and which obligation to redeem such Securities, may, at the Company&#8217;s
      discretion, be subject to one or more conditions precedent as set forth in such notice. Upon surrender to the Paying Agent, such
      Securities shall be paid at the redemption price, <i>plus</i> accrued and unpaid interest to the redemption date.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      sufficient to pay the redemption price of and accrued interest on all Securities to be redeemed on that date.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      a new Security of the same Series equal in principal amount to the unredeemed portion of the Security surrendered.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>ARTICLE
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Section
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      Company shall pay the principal of, premium, if any, and interest on a Series on the dates, in the currency and in the manner
      provided in the Securities of the Series. An installment of principal, premium, if any, or interest shall be considered paid on
      the date it is due if the Paying Agent holds on that date money in the applicable currency designated for and sufficient to pay
      the installment.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
      Company shall maintain the office or agency required under <u>Section 2.03</u>. The Company shall give prior written notice to
      the Trustee of the location, and any change in the location, of such office or agency. If at any time the Company shall fail to
      maintain any such required office or agency or shall fail to furnish the Trustee with the address thereof, such presentations,
      surrenders, notices and demands may be made or served at the address of the Trustee.</font></p>
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      any time when the Company is subject to the reporting requirements of Section 13 or 15(d) of the Exchange Act, the Company shall
      file with the Trustee, within fifteen (15) days after it actually files the same with the SEC (regardless of when the same is
      required to be filed with the SEC), each annual, quarterly or current report, information or proxy statement other report which
      the Company is required to file with the SEC pursuant to Section 13 or 15(d) of the Exchange Act; <i>provided</i>, <i>however</i>,
      that the Company shall not be required to file or deliver to the Trustee any material for which the Company has sought and received,
      or is seeking, confidential treatment by the SEC; and, <i>provided further</i>, that the Company shall be deemed to have filed
      such information with the Trustee if the Company has filed such information on the SEC&#8217;s EDGAR system (or any successor
      system) and such information is publicly available. The Company also shall comply with the other provisions of TIA Section 314(a).
      The Trustee does not have the duty to review such information, documents or reports, is not considered to have notice of the content
      of such information, documents or reports and does not have a duty to verify the accuracy of such information, documents or reports.</font></p>
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      whatsoever claim or take the benefit or advantage of, any stay or extension law or any usury law or other law that would prohibit
      or forgive the Company from paying all or any portion of the principal of or interest on the Securities of any Series as contemplated
      herein, wherever enacted, now or at any time hereafter in force, or which may affect the covenants or the performance of this
      Indenture; and (to the extent that it may lawfully do so) the Company expressly waives all benefit or advantage of any such law,
      and covenants that it will not hinder, delay or impede the execution of any power herein granted to the Trustee, but will suffer
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      Company will not consolidate or merge with or into, or sell, lease, convey or otherwise dispose of all or substantially all of
      its assets (including by way of liquidation or dissolution), to any Person (in each case other than in a transaction in which
      the Company is the survivor of a consolidation or merger, or the transferee in a sale, lease, conveyance or other disposition)
      unless:</font></p>
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      <tr>
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        <td style="vertical-align: top; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">the Person formed by or surviving such consolidation or merger (if other than the Company), or to which such sale, lease,
            conveyance or other disposition will be made (collectively, the &#8220;<b>Successor</b>&#8221;) assumes by supplemental indenture in a form reasonably satisfactory to the Trustee all of the obligations of the Company under the Securities, as the case may
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      </tr>

  </table>
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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
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      under the Indenture. The Successor may then exercise every power and right of the Company under this Indenture, and except in
      the case of a lease, the Company will be released from all of its liabilities and obligations in respect of the Securities and
      the Indenture. If the Company leases all or substantially all of its assets, the Company will not be released from its obligations
      to pay the principal of and interest, if any, on the Securities.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      or the Holders of at least 25 percent in principal amount of the then outstanding Securities of the applicable Series notify the
      Company and the Trustee, of the Default and (except in the case of a default with respect to <u>Article Five</u> (or any other
      provision specified in the applicable supplemental indenture or Authorizing Resolution)) the Company does not cure the Default
      within 60 days after receipt of the notice. The notice must specify the Default, demand that it be remedied and state that the
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">If
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      </u>above), shall have occurred and be continuing under the Indenture, the Trustee by notice to the Company, or the Holders of
      at least 25 percent in principal amount of the Securities of the applicable Series then outstanding by notice to the Company and
      the Trustee, may declare all Securities of such Series to be due and payable immediately. Upon such declaration of acceleration,
      the amounts due and payable on the Securities of such Series will be due and payable immediately. If an Event of Default with
      respect to the Company specified in <u>subclauses (4)</u> or <u>(5)</u> above occurs, all amounts due and payable on the Securities
      of such Series will ipso facto become and be immediately due and payable without any declaration, notice or other act on the part
      of the Trustee and the Company or any Holder.</font></p>
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      such Series and its consequence (except an acceleration due to nonpayment of principal or interest) if the rescission would not
      conflict with any judgment or decree and if all existing Events of Default (other than the non-payment of accelerated principal)
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      thereon.</font></p>
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      an Event of Default on a Series occurs and is continuing, the Trustee may pursue any available remedy by proceeding at law or
      in equity to collect the payment of principal of or interest on the Series or to enforce the performance of any provision in the
      Securities or this Indenture applicable to the Series.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
      Trustee may maintain a proceeding even if it does not possess any of the Securities or does not produce any of them in the proceeding.
      A delay or omission by the Trustee or any Securityholder in exercising any right or remedy accruing upon an Event of Default shall
      not impair the right or remedy or constitute a waiver of or acquiescence in the Event of Default. No remedy is exclusive of any
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      all the Holders of the Series by notice to the Trustee may waive an existing Default on such Series and its consequences. When
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      any proceeding for any remedy available to the Trustee or exercising any trust or power conferred on it with respect to such Series.
      The Trustee, however, may refuse to follow any direction (i) that conflicts with law or this Indenture, (ii) that, subject to
      <u>Section 7.01</u>, the Trustee determines is unduly prejudicial to the rights of other Securityholders, (iii) that would involve
      the Trustee in personal liability, if there shall be reasonable grounds for believing that adequate indemnity against such liability
      is not reasonably assured to it, or (iv) if the Trustee shall not have been provided with indemnity satisfactory to it.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      </tr>

  </table>
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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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        <td style="vertical-align: top; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">the Holders of at least 25% in principal amount of the outstanding Securities of the Series make a written request to the
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

  </table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&#160;</p>
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      a preference or priority over another Holder of Securities of the same Series (it being understood that the Trustee does not have
      an affirmative duty to ascertain whether or not such actions or forbearances by such Holder are unduly prejudicial to another
      Holder).</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      any other provision of this Indenture, the right of any Holder to receive payment of principal of, premium, if any, and interest
      on any Security, on or after the respective due dates expressed in the Security, or to bring suit for the enforcement of any such
      payment on or after such respective dates, is absolute and unconditional and shall not be impaired or affected without the consent
      of the Holder. Notwithstanding anything to the contrary in this Indenture or the Securities, the right of any Holder of Securities
      to convert such Securities in accordance with this Indenture, or to bring suit for the enforcement of such right, shall not be
      impaired or affected without the consent of the Holder.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      an Event of Default in payment of interest or principal specified in <u>Section 6.01(1)</u> or <u>(2)</u> occurs and is continuing,
      the Trustee may recover judgment in its own name and as trustee of an express trust against the Company for the whole amount of
      principal and interest remaining unpaid.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      Trustee may file such proofs of claim and other papers or documents as may be necessary or advisable in order to have the claims
      of the Trustee (including any claim for the reasonable compensation, expenses, disbursements, and advances of the Trustee, its
      agents and counsel) and the Securityholders allowed in any judicial proceedings relative to the Company or its creditors or Property,
      and unless prohibited by applicable law or regulation, may vote on behalf of the Holders in any election of a Custodian, and shall
      be entitled and empowered to collect and receive any moneys or other Property payable or deliverable on any such claims and to
      distribute the same and any Custodian in any such judicial proceeding is hereby authorized by each Securityholder to make such
      payments to the Trustee. Nothing herein shall be deemed to authorize the Trustee to authorize or consent to or vote for or accept
      or adopt on behalf of any Securityholder any plan of reorganization, arrangement, adjustment or composition affecting the Securities
      or the rights of any Holder or to authorize the Trustee to vote in respect of the claim of any Securityholder except as aforesaid
      for the election of the Custodian.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      the Trustee collects any money pursuant to this Article with respect to Securities of any Series, it shall pay out the money in
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      </tr>
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr style="vertical-align: top">
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      </tr>

  </table>
  <div style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt" class="BRPFPageBreakArea">
    <div style="TEXT-ALIGN: center" class="BRPFPageNumberArea"><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: normal; COLOR: #000000; FONT-STYLE: normal" class="BRPFPageNumber">16</font></div>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      any suit for the enforcement of any right or remedy under this Indenture or in any suit against the Trustee for any action taken
      or omitted by it as Trustee, a court in its discretion may require the filing by any party litigant in the suit of an undertaking
      to pay the costs of the suit, and the court in its discretion may assess reasonable costs, including reasonable attorneys&#8217;
      fees and expenses, against any party litigant in the suit, having the due regard to the merits and good faith of the claims or
      defenses made by the party litigant. This Section does not apply to a suit by the Trustee, a suit by a Holder pursuant to <u>Section
        6.07</u> or a suit by Holders of more than 10% in principal amount of the Series.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>ARTICLE
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>TRUSTEE
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Section
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      If an Event of Default has occurred and is continuing with respect to Securities of any Series, the Trustee shall, prior to the
      receipt of directions from the Holders of a majority in principal amount of the Securities of the Series, exercise its rights
      and powers and use the same degree of care and skill in their exercise as a prudent man would exercise or use under the circumstances
      in the conduct of his own affairs.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)
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      The Trustee need perform only those duties that are specifically set forth in this Indenture and no others and no implied covenants
      or obligations shall be read into this Indenture against the Trustee.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(2)
      In the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the correctness
      of the opinions expressed therein, upon certificates or opinions furnished to the Trustee and conforming to the requirements of
      this Indenture. The Trustee, however, in the case of certificates or opinions specifically required by any provision hereof to
      be furnished to it, shall examine the certificates and opinions to determine whether or not they conform to the requirements of
      this Indenture but need not confirm or investigate the accuracy of mathematical calculations or other facts or matters stated
      therein.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)
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      Trustee was negligent in ascertaining the pertinent facts.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(3)
      The Trustee shall not be liable with respect to any action it takes or omits to take in good faith in accordance with a direction
      received by it pursuant to <u>Section 6.05</u> or any other direction of the Holders permitted hereunder.</font></p>
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      </u>of this Section.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(e)
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <div style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt" class="BRPFPageBreakArea">
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(g)
      None of the provisions contained in this Indenture shall require the Trustee to expend or risk its own funds or otherwise incur
      financial liability in the performance of any of its duties or in the exercise of any of its rights or powers, if there shall
      be reasonable grounds for believing that the repayment of such funds or adequate indemnity against such liability is not reasonably
      assured to it.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Section
        7.02 <u>Rights of Trustee.</u></b></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Subject
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)
      The Trustee may conclusively rely and shall be fully protected in acting or refraining from acting on any document, resolution,
      certificate, instrument, report, or direction believed by it to be genuine and to have been signed or presented by the proper
      person. The Trustee need not investigate any fact or matter stated in the document, resolution, certificate, instrument, report,
      or direction.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      Before the Trustee acts or refrains from acting, it may require an Officers&#8217; Certificate or an Opinion of Counsel or both,
      which shall conform to <u>Sections 12.04</u> and <u>12.05</u> hereof and containing such other statements as the Trustee reasonably
      deems necessary to perform its duties hereunder. The Trustee shall not be liable for any action it takes or omits to take in good
      faith in reliance on the Officers&#8217; Certificate, Opinion of Counsel or any other direction of the Company permitted hereunder.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      The Trustee may act through agents and shall not be responsible for the misconduct or negligence of any agent appointed with due
      care.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      The Trustee shall not be liable for any action taken, suffered or omitted by it in good faith and believed by it to be authorized
      or within the discretion or rights or powers conferred upon it by this Indenture.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      The Trustee may consult with counsel of its selection, and the advice of such counsel or any Opinion of Counsel as to matters
      of law shall be full and complete authorization and protection in respect of any action taken, omitted or suffered by it hereunder
      in good faith and in accordance with the advice or opinion of such counsel.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      Unless otherwise specifically provided in the Indenture, any demand, request, direction or notice from the Company shall be sufficient
      if signed by an Officer of the Company.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      For all purposes under this Indenture, the Trustee shall not be deemed to have notice or knowledge of any Event of Default unless
      written notice of any Event of Default is received by the Trustee at its address specified in <u>Section 12.02</u> hereof and
      such notice references the Securities generally, the Company and this Indenture.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(h)
      The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request
      or direction of any of the Holders pursuant to this Indenture, unless such Holders shall have offered to the Trustee security
      or indemnity reasonably satisfactory to the Trustee against the costs, expenses and liabilities which might be incurred by it
      in compliance with such request or direction.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(i)
      The Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate, statement,
      instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness
      or other paper or document, but the Trustee, in its discretion, may make such further inquiry or investigation into such facts
      or matters as it may see fit, and, if the Trustee shall determine to make such further inquiry or investigation, it shall be entitled
      to examine the books, records and premises of the Company, personally or by agent or attorney at the sole cost of the Company
      and shall incur no liability or additional liability of any kind by reason of such inquiry or investigation.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(j)
      In no event shall the Trustee be responsible or liable for special, indirect, or consequential loss or damage of any kind whatsoever
      (including, but not limited to, loss of profit) irrespective of whether the Trustee has been advised of the likelihood of such
      loss or damage and regardless of the form of action.</font></p>
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(k)
      The rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right to
      be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each agent,
      custodian and other Person employed to act hereunder.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(l)
      The Trustee may request that the Company deliver a certificate setting forth the names of individuals and/or titles of officers
      authorized at such time to take specified actions pursuant to this Indenture.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(m)
      In no event shall the Trustee be responsible or liable for any failure or delay in the performance of its obligations hereunder
      arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages,
      accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural catastrophes or acts of God, and interruptions,
      loss or malfunctions of utilities, communications or computer (software and hardware) services; it being understood that the Trustee
      shall use reasonable efforts which are consistent with accepted practices in the banking industry to resume performance as soon
      as practicable under the circumstances.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Section
        7.03 <u>Individual Rights of Trustee.</u></b></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
      Trustee in its individual or any other capacity may become the owner or pledgee of Securities and may otherwise deal with the
      Company or its affiliates with the same rights it would have if it were not Trustee. Any Agent may do the same with like rights.
      The Trustee, however, must comply with <u>Sections 7.10</u> and <u>7.11</u>.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
      Trustee makes no representation as to the validity or adequacy of this Indenture, the Securities or of any prospectus used to
      sell the Securities of any Series; it shall not be accountable for the Company&#8217;s use of the proceeds from the Securities;
      it shall not be accountable for any money paid to the Company, or upon the Company&#8217;s direction, if made under and in accordance
      with any provision of this Indenture; it shall not be responsible for the use or application of any money received by any Paying
      Agent other than the Trustee; and it shall not be responsible for any statement of the Company in this Indenture or in the Securities
      other than its certificate of authentication.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">If
      a Default on a Series occurs and is continuing and if it is known to the Trustee, the Trustee shall deliver to each Securityholder
      of the Series notice of the Default (which shall specify any uncured Default known to it) within 90 days after the Trustee obtains
      such knowledge. Except in the case of a default in payment of principal of or interest on a Series, the Trustee may withhold the
      notice if and so long as the board of directors of the Trustee, the executive or any trust committee of such directors and/or
      responsible officers of the Trustee in good faith determine(s) that withholding the notice is in the interests of Holders of the
      Series.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Section
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Within
      60 days after each May 15 beginning with the May 15 following the date of this Base Indenture, the Trustee shall mail to each
      Securityholder a brief report dated as of such May 15 that complies with TIA &#167; 313(a) (but if no event described in TIA &#167;
      313(1) through (8) has occurred within the twelve months preceding the reporting date no report in relation thereto need be transmitted).
      The Trustee also shall comply with TIA &#167; 313(b).</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">A
      copy of each report at the time of its mailing to Securityholders shall be delivered to the Company and filed by the Trustee with
      the SEC and each national securities exchange on which the Securities are listed. The Company agrees to notify the Trustee of
      each national securities exchange on which the Securities are listed.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Section
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
      Company shall pay to the Trustee from time to time reasonable compensation for its services subject to any written agreement between
      the Trustee and the Company (which compensation shall not be limited by any provision of law in regard to the compensation of
      a trustee of an express trust). The Company shall reimburse the Trustee upon request for all reasonable out-of-pocket expenses
      incurred by it. Such expenses shall include the reasonable compensation and expenses of the Trustee&#8217;s agents and counsel.
      The Company shall indemnify the Trustee, its officers, directors, employees and agents and hold it harmless against any loss,
      liability or expense incurred or made by or on behalf of it in connection with the administration of this Indenture or the trust
      hereunder and its duties hereunder including the costs and expenses of defending itself against or investigating any claim in
      the premises. The Trustee shall notify the Company promptly of any claim of which it has received written notice and for which
      it may seek indemnity. The Company need not reimburse any expense or indemnify against any loss or liability incurred by the Trustee
      through the Trustee&#8217;s, or its officers&#8217;, directors&#8217;, or employees&#8217; negligence or willful misconduct.</font></p>
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Unless
      otherwise provided in any supplemental indenture or Authorizing Resolution relating to any Series, to ensure the Company&#8217;s
      payment obligations in this Section, the Trustee shall have a claim prior to the Securities of all Series on all money or Property
      held or collected by the Trustee, except that held in trust to pay principal of or interest on particular Securities. When the
      Trustee incurs expenses or renders services in connection with an Event of Default specified in <u>Section 6.01</u> or in connection
      with <u>Article Six</u> hereof, the expenses (including the reasonable fees and expenses of its counsel) and the compensation
      for services in connection therewith are to constitute expenses of administration under any Bankruptcy Law. Section 7.07 shall
      survive the discharge of the Indenture or resignation of Trustee.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
      Trustee may resign with respect to Securities of any or all Series by so notifying the Company. The Holders of a majority in principal
      amount of the outstanding Securities (or of the relevant Series) may remove the Trustee by so notifying the removed Trustee in
      writing and may appoint a successor trustee with the Company&#8217;s consent. Such resignation or removal shall not take effect
      until the appointment by the Securityholders of the relevant Series or the Company as hereinafter provided of a successor trustee
      and the acceptance of such appointment by such successor trustee. The Company may remove the Trustee and any Securityholder may
      petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor trustee for any
      or no reason, including if:</font></p>
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        <td style="vertical-align: top; width: 5%; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">(1)</font></td>
        <td style="vertical-align: top; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">the Trustee fails to comply with <u>Section 7.10</u> after written request by the Company or any bona fide Securityholder
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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
        <td style="width: 4%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="vertical-align: top; width: 5%; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">(2)</font></td>
        <td style="vertical-align: top; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">the Trustee is adjudged a bankrupt or an insolvent; </font></td>
      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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        <td style="vertical-align: top; width: 5%; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">(3)</font></td>
        <td style="vertical-align: top; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">a receiver or other public officer takes charge of the Trustee or its Property; or </font></td>
      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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        <td style="vertical-align: top; width: 5%; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">(4)</font></td>
        <td style="vertical-align: top; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif;">the Trustee becomes incapable of acting. </font></td>
      </tr>

  </table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">If
      the Trustee resigns or is removed or if a vacancy exists in the office of Trustee for any reason, the Company shall promptly appoint
      a successor trustee with respect to the Securities of the relevant Series. If a successor trustee does not take office within
      30 days after the retiring Trustee resigns or is removed, the retiring Trustee at the expense of the Company, the Company or any
      Holder may petition any court of competent jurisdiction for the appointment of a successor trustee.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      successor trustee shall deliver a written acceptance of its appointment to the retiring Trustee and to the Company. Immediately
      after that, the retiring Trustee shall, upon payment of its charges hereunder, transfer all Property held by it as Trustee to
      the successor trustee, the resignation or removal of the retiring Trustee shall become effective, and the successor trustee shall
      have all the rights, powers and duties of the Trustee under this Indenture. A successor trustee shall mail notice of its succession
      to each Securityholder.</font></p>
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      the Trustee consolidates with, merges with or into or converts into, or transfers all or substantially all of its corporate trust
      business to, another corporation, the successor corporation without any further act shall be the successor trustee.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">This
      Indenture shall always have a Trustee who satisfies the requirements of TIA &#167; 310(a)(1). The Trustee shall have a combined
      capital and surplus of at least $10,000,000 as set forth in its most recent published annual report of condition. The Trustee
      shall comply with TIA &#167; 310(b).</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
      Trustee shall comply with TIA &#167; 311(a), excluding any creditor relationship listed in TIA &#167; 311(b). A Trustee who has
      resigned or been removed shall be subject to TIA &#167; 311(a) to the extent indicated therein.</font></p>
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        EIGHT </b></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>DISCHARGE
        OF INDENTURE </b></font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Section
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      The Company may, at its option and at any time, elect to have either <u>paragraph (b)</u> or <u>paragraph (c)</u> below be applied
      to the outstanding Securities of any Series upon compliance with the applicable conditions set forth in <u>paragraph (d)</u>.</font></p>
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      Upon the Company&#8217;s exercise under <u>paragraph (a)</u> of the option applicable to this <u>paragraph (b)</u> with respect
      to any Series, the Company shall be deemed to have been released and discharged from its obligations with respect to the outstanding
      Securities of the Series on the date the applicable conditions set forth below are satisfied (hereinafter, &#8220;<b>Legal Defeasance</b>&#8221;).
      For this purpose, such Legal Defeasance means that the Company shall be deemed to have paid and discharged the entire indebtedness
      represented by the outstanding Securities of a Series, which shall thereafter be deemed to be &#8220;outstanding&#8221; only for
      the purposes of the Sections and matters under this Indenture referred to in (i) and (ii) below, and the Company shall be deemed
      to have satisfied all its other obligations under such Securities and this Indenture insofar as such Securities are concerned,
      except for the following which shall survive until otherwise terminated or discharged hereunder: (i) the rights of Holders of
      outstanding Securities of a Series to receive solely from the trust fund described in <u>paragraph (d)</u> below and as more fully
      set forth in such paragraph, payments in respect of the principal of and interest on such Securities when such payments are due
      and (ii) obligations listed in <u>Section 8.02</u>, subject to compliance with this <u>Section 8.01</u>. The Company may exercise
      its option under this <u>paragraph (b)</u> with respect to a Series notwithstanding the prior exercise of its option under <u>paragraph
        (c)</u> below with respect to the Securities of the Series.</font></p>
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      Upon the Company&#8217;s exercise under <u>paragraph (a)</u> of the option applicable to this <u>paragraph (c)</u> with respect
      to a Series, the Company shall be released and discharged from the obligations under any covenant contained in <u>Article Five</u>,
      <u>Sections 4.03</u> and any other covenant contained in or referenced in the Authorizing Resolution or supplemental indenture
      relating to such Series (to the extent such release and discharge shall not be prohibited thereby), on and after the date the
      conditions set forth below are satisfied (hereinafter, &#8220;<b>Covenant Defeasance</b>&#8221;), and the Securities of such Series
      shall thereafter be deemed to be not &#8220;outstanding&#8221; for the purpose of any direction, waiver, consent or declaration
      or act of Holders (and the consequences of any thereof) in connection with such covenants, but shall continue to be deemed &#8220;outstanding&#8221;
      for all other purposes hereunder. For this purpose, such Covenant Defeasance means that, with respect to the outstanding Securities
      of a Series, the Company may omit to comply with and shall have no liability in respect of any term, condition or limitation set
      forth in the covenants described in the preceding sentence, whether directly or indirectly, by reason of any reference elsewhere
      herein to any such covenant or by reason of any reference in any such covenant to any other provision herein or in any other document
      and such omission to comply shall not constitute a Default or an Event of Default under <u>Section 6.01(3)</u> or otherwise, but,
      except as specified above, the remainder of this Indenture and such Securities shall be unaffected thereby.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(d)
      The following shall be the conditions to application of either <u>paragraph (b)</u> or <u>paragraph (c)</u> above to the outstanding
      Securities of the applicable Series:</font></p>
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      The Company shall have irrevocably deposited in trust with the Trustee (or another qualifying trustee), pursuant to an irrevocable
      trust and security agreement in form and substance reasonably satisfactory to the Trustee, money in the currency in which the
      Securities of such Series are payable or Government Obligations or a combination thereof in such amounts and at such times as
      are sufficient, in the opinion of a nationally recognized firm of independent public accountants, to pay the principal of and
      interest on the outstanding Securities of such Series to maturity or redemption; <i>provided, however,</i> that the Trustee (or
      other qualifying trustee) shall have received an irrevocable written order from the Company instructing the Trustee (or other
      qualifying trustee) to apply such money or the proceeds of such Government Obligations to said payments with respect to the Securities
      of such Series to maturity or redemption;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(2)
      No Default or Event of Default (other than a Default or Event of Default resulting from non-compliance with any covenant from
      which the Company is released upon effectiveness of such Legal Defeasance or Covenant Defeasance pursuant to <u>paragraph (b)
      </u>or <u>(c) </u>hereof, as applicable) shall have occurred and be continuing on the date of such deposit or result therefrom;</font></p>
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      (i) In the event the Company elects <u>paragraph (b)</u> hereof, the Company shall deliver to the Trustee an Opinion of Counsel
      in the United States, in form and substance reasonably satisfactory to the Trustee, to the effect that (A) the Company has received
      from, or there has been published by, the Internal Revenue Service a ruling or (B) since the Issue Date pertaining to such Series,
      there has been a change in the applicable federal income tax law, in either case to the effect that, and based thereon such Opinion
      of Counsel shall state that, or (ii) in the event the Company elects <u>paragraph (c)</u> hereof, the Company shall deliver to
      the Trustee an Opinion of Counsel in the United States, in form and substance reasonably satisfactory to the Trustee, to the effect
      that, in the case of <u>clauses (i)</u> and <u>(ii)</u>, and subject to customary assumptions and exclusions, Holders of the Securities
      of such Series will not recognize income, gain or loss for federal income tax purposes as a result of such deposit and the defeasance
      contemplated hereby and will be subject to federal income tax in the same amounts and in the same manner and at the same times
      as would have been the case if such deposit and defeasance had not occurred;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(4)
      The Company shall have delivered to the Trustee an Officers&#8217; Certificate, stating that the deposit under <u>clause (1)</u>
      was not made by the Company with the intent of preferring the Holders of the Securities of such Series over any other creditors
      of the Company or with the intent of defeating, hindering, delaying or defrauding any other creditors of the Company or others;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(5)
      The Company shall have delivered to the Trustee an Opinion of Counsel (subject to customary assumptions and qualifications) to
      the effect that, assuming no intervening bankruptcy of the Company between the date of deposit and the 91st day following the
      deposit and assuming that no Holder is an &#8220;insider&#8221; of the Company under applicable Bankruptcy Law, after the 91st
      day following the deposit, the trust funds shall not be subject to the effect of Section 547 of the United States Bankruptcy Code
      or any analogous New York State law provision; and</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(6)
      The Company has delivered to the Trustee an Officers&#8217; Certificate and an Opinion of Counsel, each stating that all conditions
      precedent specified herein relating to the defeasance contemplated by this <u>Section 8.01</u> have been complied with.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In
      the event all or any portion of the Securities of a Series are to be redeemed through such irrevocable trust, the Company must
      make arrangements satisfactory to the Trustee, at the time of such deposit, for the giving of the notice of such redemption or
      redemptions by the Trustee in the name and at the expense of the Company.</font></p>
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      In addition to the Company&#8217;s rights above under this <u>Section 8.01</u>, the Company may terminate all of its obligations
      under this Indenture with respect to a Series, when:</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(1)
      All Securities of such Series theretofore authenticated and delivered (other than Securities which have been destroyed, lost or
      stolen and which have been replaced or paid as provided in <u>Section 2.07</u> and Securities for whose payment money has theretofore
      been deposited in trust or segregated and held in trust by the Company and thereafter repaid to the Company or discharged from
      such trust) have been delivered to the Trustee for cancellation or all such Securities not theretofore delivered to the Trustee
      for cancellation (A) have become due and payable, (B) will become due and payable at maturity within one year or (C) are to be
      called for redemption within one year under arrangements satisfactory to the Trustee for the giving of notice of redemption by
      the Trustee in the name, and at the expense, of the Company, and in each such case, the Company has irrevocably deposited or caused
      to be deposited with the Trustee (or another qualifying trustee) as trust funds in trust solely for that purpose an amount of
      money in the currency in which the Securities of such Series are payable or Government Obligations or a combination thereof sufficient,
      in the opinion of a nationally recognized firm of independent public accountants, to pay and discharge the entire indebtedness
      on the Securities of such Series not theretofore delivered to the Trustee for cancellation, for principal of and interest on the
      Securities of such Series, on the date of such deposit or to the maturity or redemption date, as the case may be;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(2)
      The Company has paid or caused to be paid all other sums payable hereunder by the Company;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(3)
      The Company has delivered irrevocable instructions to the Trustee (or such other qualifying trustee), to apply the deposited money
      toward the payment of the Securities of such Series at maturity or redemption, as the case may be; and</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(4)
      The Company has delivered to the Trustee an Officers&#8217; Certificate and an Opinion of Counsel, stating that all conditions
      precedent specified in this <u>Section 8.01(e) </u>relating to the satisfaction and discharge of this Indenture have been complied
      with.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Notwithstanding
      the satisfaction and discharge of this Indenture under <u>Section 8.01</u>, the Company&#8217;s obligations in <u>Paragraph 8
      </u>of the Securities and <u>Sections 2.03</u> through <u>2.07</u>, <u>4.01</u>, <u>7.07</u>, <u>7.08</u>, <u>8.04</u> and <u>8.05</u>,
      however, shall survive until the Securities of an applicable Series are no longer outstanding. Thereafter, the Company&#8217;s
      obligations in <u>Paragraph 8</u> of the Securities of such Series and <u>Sections 7.07</u>, <u>8.04</u> and <u>8.05</u> shall
      survive (as they relate to such Series) such satisfaction and discharge.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Section
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
      Trustee shall hold in trust money or Government Obligations deposited with it pursuant to <u>Section 8.01</u>. It shall apply
      the deposited money and the money from Government Obligations in accordance with this Indenture to the payment of principal of
      and interest on the Securities of the defeased Series.</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
      Trustee and the Paying Agent shall promptly pay to the Company upon request any excess money or securities held by them at any
      time. The Trustee and the Paying Agent shall pay to the Company upon request any money held by them for the payment of principal
      or interest that remains unclaimed for two years, <i>provided, however,</i> that the Trustee or such Paying Agent, before being
      required to make any such repayment, may at the expense of the Company cause to be published once in a newspaper of general circulation
      in the City of New York or mail to each such Holder notice that such money remains unclaimed and that, after a date specified
      therein, which shall not be less than 30 days from the date of such publication or mailing, any unclaimed balance of such money
      then remaining will be repaid to the Company. After payment to the Company, Securityholders entitled to the money must look to
      the Company for payment as general creditors unless applicable abandoned property law designates another person and all liability
      of the Trustee or such Paying Agent with respect to such money shall cease.</font></p>
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      such application, the Company&#8217;s obligations under this Indenture and the Securities relating to the Series shall be revived
      and reinstated as though no deposit had occurred pursuant to <u>Section 8.01</u> until such time as the Trustee is permitted to
      apply all such money or Government Obligations in accordance with <u>Section 8.01</u>; <i>provided</i>, <i>however</i>, that (a)
      if the Company has made any payment of interest on or principal of any Securities of the Series because of the reinstatement of
      its obligations hereunder, the Company shall be subrogated to the rights of the Holders of such Securities to receive such payment
      from the money or Government Obligations held by the Trustee and (b) unless otherwise required by any legal proceeding or any
      order or judgment of any court or governmental authority, the Trustee shall return all such money or Government Obligations to
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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

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      </tr>

  </table>
  <table style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" cellpadding="0" cellspacing="0">

      <tr>
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      </tr>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">After
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      Series without notice to any Securityholder of such Series but with the written consent of the Holders of at least a majority
      in principal amount of the outstanding Securities of such Series (including consents obtained in connection with a purchase of,
      or tender offer or exchange offer for, Securities of such Series). Each such Series shall vote as a separate class. The Holders
      of a majority in principal amount of the outstanding Securities of any Series may waive compliance by the Company with any provision
      of the Securities of such Series or of this Indenture relating to such Series without notice to any Securityholder (including
      any waiver granted in connection with a purchase of, or tender offer or exchange offer for, Securities of such Series). Without
      the consent of each Holder of a Security the terms of which are directly amended, supplemented or waived, however, an amendment,
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      respect to redemption of any Security pursuant to <u>Article Three</u> hereof or with respect to any obligations on the part of
      the Company to offer to purchase or to redeem Securities of a Series pursuant to the Authorizing Resolution or supplemental indenture
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 55.1pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Every
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">A
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      on any Security. Unless otherwise provided in the consent or the consent solicitation statement or other document describing the
      terms of the consent, any Holder or subsequent Holder may revoke the consent as to its Security or portion of a Security. Any
      revocation of a consent by the Holder of a Security or any such subsequent Holder shall be effective only if the Trustee receives
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
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      Series entitled to consent to any amendment, supplement or waiver, which record date shall be at least 10 days prior to the first
      solicitation of such consent. If a record date is fixed, and if Holders otherwise have a right to revoke their consent under the
      consent or the consent solicitation statement or other document describing the terms of the consent, then notwithstanding the
      second to last sentence of the immediately preceding paragraph, those Persons who were Holders at such record date (or their duly
      designated proxies), and only those Persons, shall be entitled to revoke any consent previously given, whether or not such Persons
      continue to be Holders after such record date. No such consent shall be valid or effective for more than 90 days after such record
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">An
      amendment, supplement or waiver with respect to a Series becomes effective upon the (i) receipt by the Company or the Trustee
      of the requisite consents, (ii) satisfaction of any conditions to effectiveness as set forth in this Indenture or any indenture
      supplemental hereto containing such amendment, supplement or waiver and (iii) execution of such amendment, supplement or waiver
      (or the related supplemental indenture) by the Company and the Trustee. After an amendment, supplement or waiver with respect
      to a Series becomes effective, it shall bind every Holder of such Series, unless it makes a change described in any of <u>clauses
        (1)</u> through <u>(9)</u> of <u>Section 10.02</u>, in which case, the amendment, supplement or waiver shall bind a Holder of
      a Security of such Series only if it has consented to such amendment, supplement or waiver and every subsequent Holder of a Security
      or portion of a Security that evidences the same debt as the consenting Holder&#8217;s Security; <i>provided</i> that no such
      waiver shall impair or affect the right of any Holder to receive payment of principal of and interest on a Security, on or after
      the respective due dates expressed in such Security, or to bring suit for the enforcement of any such payment on or after such
      respective dates without the consent of such Holder.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      it to the Trustee, at which time the Trustee shall place an appropriate notation on the Security about the changed terms and return
      it to the Holder. Alternatively, if the Company or the Trustee so determines, the Company in exchange for the Security shall issue
      and the Trustee shall authenticate a new Security that reflects the changed terms.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Subject
      to <u>Section 7.02(b)</u>, the Trustee shall sign any amendment, supplement or waiver authorized pursuant to this Article if the
      amendment, supplement or waiver does not adversely affect the rights, duties, liabilities or immunities of the Trustee. If it
      does, the Trustee may but need not sign it. In signing or refusing to sign such amendment or supplemental indenture, the Trustee
      shall be provided with and shall be fully protected in relying upon, an Officers&#8217; Certificate and an Opinion of Counsel
      as conclusive evidence that such amendment, supplement or waiver is authorized or permitted by this Indenture, and (solely with
      respect to such Opinion of Counsel) that it will be valid and binding upon the Company and enforceable in accordance with its
      terms.</font></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      this Indenture provides for (i) any action by, or the determination of any of the rights of, Holders of Securities of any Series
      in which not all of such Securities are denominated in the same currency, or (ii) any distribution to Holders of Securities, in
      the absence of any provision to the contrary pursuant to this Indenture or the Securities of any particular Series, any amount
      in respect of any Security denominated in a Foreign Currency shall be treated for any such action or distribution as that amount
      of Dollars that could be obtained for such amount on such reasonable basis of exchange and as of the record date with respect
      to Securities of such Series (if any) for such action, determination of rights or distribution (or, if there shall be no applicable
      record date, such other date reasonably proximate to the date of such action, determination of rights or distribution) as the
      Company may specify in a written notice to the Trustee or, in the absence of such written notice, as the Trustee may determine.</font></p>
  <div style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt" class="BRPFPageBreakArea">
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      Indenture by the TIA, the required provision shall control.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">if
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">if
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">[
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      the registration books of the Registrar and shall be sufficiently given to him if so mailed within the time prescribed.</font></p>
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      to mail a notice or communication to a Securityholder or any defect in it shall not affect its sufficiency with respect to other
      Securityholders. If a notice or communication is mailed in the manner provided above, it is duly given, whether or not the addressee
      receives it except that notice to the Trustee shall only be effective upon receipt thereof by the Trustee.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      addition to the foregoing, the Trustee agrees to accept and act upon notice, instructions or directions pursuant to this Indenture
      sent by unsecured e-mail, facsimile transmission or other similar unsecured electronic methods. If the party elects to give the
      Trustee e-mail or facsimile instructions (or instructions by a similar electronic method) and the Trustee in its discretion elects
      to act upon such instructions, the Trustee&#8217;s understanding of such instructions shall be deemed controlling. The Trustee
      shall not be liable for any losses, costs or expenses arising directly or indirectly from the Trustee&#8217;s reliance upon and
      compliance with such instructions notwithstanding such instructions conflict or are inconsistent with a subsequent written instruction.
      The party providing electronic instructions agrees to assume all risks arising out of the use of such electronic methods to submit
      instructions and directions to the Trustee, including without limitation the risk of the Trustee acting on unauthorized instructions,
      and the risk of interception and misuse by third parties.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Securityholders
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      the Securities. The Company, the Trustee, the Registrar and anyone else shall have the protection of TIA &#167; 312(c).</font></p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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      </tr>

  </table>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Any
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      or opinion of, or representations by, internal or external legal counsel. Any Opinion of Counsel may be based, and may state that
      it is so based, insofar as it relates to factual matters, upon a certificate or opinion of, or representations by, an Officer
      or Officers of the Company or any guarantor stating that the information with respect to such factual matters is known to the
      Company or such guarantor, unless such counsel knows that the certificate or opinion or representations with respect to such matters
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        <td style="vertical-align: top; font-size: 11pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">a brief statement as to the nature and scope of the examination or investigation upon which the statements or opinions
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      </tr>

  </table>
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      </tr>

  </table>
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  </table>
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        <td style="vertical-align: top; padding-left: 10pt; font-size: 11pt; text-indent: -10pt; width: 10%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">No.</font></td>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>GYRE
        THERAPEUTICS, INC. </b></font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">[Title
      of Security]</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>GYRE
        THERAPEUTICS</b>, INC., a Delaware corporation (together with its successors and assigns, the &#8220;<b>Company</b>&#8221;), issued
      this Security under an Indenture dated as of (as amended, modified or supplemented from time to time in accordance therewith,
      the &#8220;<b>Base Indenture</b>&#8221;), as supplemented by the Supplemental Indenture dated as of (the &#8220;<b>Supplemental
        Indenture</b>&#8221; and together with the Base Indenture, the &#8220;<b>Indenture</b>&#8221;), by and among the Company and [ ],
      as trustee (in such capacity, the &#8220;<b>Trustee</b>&#8221;), to which reference is hereby made for a statement of the respective
      rights, obligations, duties and immunities thereunder of the Company, the Trustee and the Holders and of the terms upon which
      the Securities are, and are to be, authorized and delivered. All terms used in this Security that are defined in the Indenture
      shall have the meanings assigned to them therein.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>1.
        <u>Interest</u>.</b> The Company promises to pay interest on the principal amount of this Security at the rate per annum shown
      above. The Company will pay interest semiannually on &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; and &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; of each year, commencing &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; , &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;, until the principal is paid
      or made available for payment. Interest on the Securities will accrue from the most recent date to which interest has been paid
      or duly provided for or, if no interest has been paid, from &#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; . Interest will be computed on the basis of a 360-day year of
      twelve 30-day months.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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        <u>Method of Payment</u>.</b> The Company will pay interest on the Securities (except defaulted interest, if any, which will be
      paid on such special payment date to Holders of record on such special record date as may be fixed by the Company) to the persons
      who are registered Holders of Securities at the close of business on the [Insert record dates] immediately preceding the interest
      payment date. Holders must surrender Securities to a Paying Agent to collect principal payments. The Company will pay principal
      and interest in money of [Insert applicable country or currency] that at the time of payment is legal tender for payment of public
      and private debts.</font></p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>3.
        <u>Paying Agent and Registrar</u>.</b> Initially, the Trustee will act as Paying Agent and Registrar. The Company may change or
      appoint any Paying Agent, Registrar or co-Registrar without notice. The Company or any of its Subsidiaries or any of their Affiliates
      may act as Paying Agent, Registrar or co-Registrar.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
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        <u>Optional Redemption</u>.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2</sup></b> The Company may redeem the Securities at any time on or after &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; , in whole or in part, at the following redemption prices (expressed as a percentage of their principal amount) together with
      interest accrued and unpaid to the date fixed for redemption:&#160;</font></p>
  <table style="font: 11pt Times New Roman, Times, Serif; width: 80%; border-collapse: collapse" align="CENTER" cellpadding="0" cellspacing="0">

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        <td style="vertical-align: bottom; width: 13%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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          <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>commencing
                on and ending on in each of</b>&#160;</font></p>
          <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>the
                following years </b>&#160;</font></p>
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        <td style="border-bottom: Black 1pt solid; font-size: 11pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Percentage</b></font></td>
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        <td style="white-space: nowrap; background-color: #CCEEFF; font-size: 11pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
        <td style="background-color: #CCEEFF; font-size: 11pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></td>
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  </table>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&#160;</p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">[Insert
      provisions relating to redemption at option of Holders, if any]</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Notice
      of redemption will be mailed at least 30 days but not more than 60 days before the redemption date to each Holder of Securities
      to be redeemed at its registered address. Securities in denominations larger than&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">3</sup> may be redeemed in part. On
      and after the redemption date interest ceases to accrue on Securities or portions of them called for redemption, <i>provided</i>
      that if the Company shall default in the payment of such Securities at the redemption price together with accrued interest, interest
      shall continue to accrue at the rate borne by the Securities.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>5. <u>Mandatory
          Redemption</u>.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">4</sup></b> The Company shall redeem [&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; ]% of the
      aggregate principal amount of Securities originally issued under the Indenture on each of
      [ &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;], which
      redemptions are calculated to retire [&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; ]% of the Securities originally
      issued prior to maturity. Such redemptions shall be made at a redemption price equal to 100% of the principal amount thereof,
      together with accrued interest to the redemption date. The Company may reduce the principal amount of Securities to be
      redeemed pursuant to this <u>Paragraph 5</u> by the principal amount of any Securities previously redeemed, retired or
      acquired, otherwise than pursuant to this <u>Paragraph 5</u>, that the Company has delivered to the Trustee for
      cancellation and not previously credited to the Company&#8217;s obligations under this <u>Paragraph 5</u>. Each such Security
      shall be received and credited for such purpose by the Trustee at the redemption price and the amount of such mandatory
      redemption payment shall be reduced accordingly.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"></p>
  <!-- Field: Rule-Page -->
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    <div style="font-size: 1pt; border-top: Black 1pt solid; width: 20%">&#160;</div>
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  <!-- Field: /Rule-Page -->
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2
      </sup>If applicable</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">3
      </sup>Insert applicable denominations and multiples.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">4
      </sup>If applicable.&#160;&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"></p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>6.
        <u>Denominations, Transfer, Exchange</u>.</b> The Securities are in registered form only without coupons in denominations of&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">5
      </sup>and integral multiples of&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; in excess thereof.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">6</sup> A Holder may transfer or exchange Securities by presentation
      of such Securities to the Registrar or a co-Registrar with a request to register the transfer or to exchange them for an equal
      principal amount of Securities of other denominations. The Registrar may require a Holder, among other things, to furnish appropriate
      endorsements and transfer documents and to pay any taxes and fees required by law or permitted by the Indenture. The Registrar
      need not transfer or exchange any Security selected for redemption or purchase, except the unredeemed or unpurchased part thereof
      if the Security is redeemed or purchased in part, or transfer or exchange any Securities for a period of 15 days before a selection
      of Securities to be redeemed or purchased.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>7.
        <u>Persons Deemed Owners</u>.</b> The registered Holder of this Security shall be treated as the owner of it for all purposes.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>8.
        <u>Unclaimed Money</u>.</b> Subject to any applicable abandoned property law, the Trustee and the Paying Agent shall pay to the
      Company upon written request any money held by them for the payment of principal or interest that remains unclaimed for two years,
      and thereafter, Holders entitled to the money must look to the Company for payment as general creditors.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>9.
        <u>Amendment, Supplement, Waiver</u>.</b> Subject to certain exceptions, the Indenture or the Securities of a Series may be amended
      or supplemented with the consent of the Holders of at least a majority in principal amount of the outstanding Securities of such
      Series and any past default or compliance with any provision relating to any Series of the Securities may be waived in a particular
      instance with the consent of the Holders of a majority in principal amount of the outstanding Securities of such Series.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">7
      </sup>Without the consent of any Securityholder, the Company and the Trustee may amend or supplement the Indenture or the Securities
      in certain respects as specified in the Indenture.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>10.
        <u>Successor Corporation</u>.</b> When a successor corporation assumes all the obligations of its predecessor under the Securities
      and the Indenture, the predecessor corporation will be released from those obligations.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>11.
        <u>Trustee Dealings With Company</u>.</b> Subject to certain limitations imposed by the TIA, the Trustee under the Indenture,
      in its individual or any other capacity, may make loans to, accept deposits from, and perform services for the Company or its
      affiliates, and may otherwise deal with the Company or its affiliates, as if it were not Trustee, including owning or pledging
      the Securities.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>12.
        <u>No Recourse Against Others</u>.</b> A director, officer, employee or stockholder, as such, of the Company shall not have any
      liability for any obligations of the Company under the Securities or the Indenture or for any claim based on, in respect of or
      by reason of, such obligations or their creation. Each Holder by accepting a Security waives and releases all such liability.
      The waiver and release are part of the consideration for the issue of the Securities. The waiver may not be effective to waive
      liabilities under the federal securities laws.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>13.
        <u>Discharge of Indenture</u>.</b> The Indenture contains certain provisions pertaining to defeasance and discharge, which provisions
      shall for all purposes have the same effect as if set forth herein.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"></p>
  <!-- Field: Rule-Page -->
  <div style="margin-top: 3pt; margin-bottom: 3pt" align="LEFT">
    <div style="font-size: 1pt; border-top: Black 1pt solid; width: 20%">&#160;</div>
  </div>
  <!-- Field: /Rule-Page -->
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">5
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">6
      </sup>Insert applicable denominations and multiples.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">7
      </sup>If different terms apply, insert a brief summary thereof.&#160;</font></p>
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  <div style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt" class="BRPFPageBreakArea">
    <div style="TEXT-ALIGN: center" class="BRPFPageNumberArea"><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: normal; COLOR: #000000; FONT-STYLE: normal" class="BRPFPageNumber">33</font>&#160;</div>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font: 10pt Times New Roman, Times, Serif"></font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>14.
        <u>Authentication</u>.</b> This Security shall not be valid until an authorized signatory of the Trustee signs the certificate
      of authentication on the other side of this Security.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>15.
        <u>Abbreviations</u>.</b> Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (= tenants
      in common), TEN ENT (= tenants by the entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common),
      CUST (= custodian), and U/G/M/A (= Uniform Gift to Minors Act).</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>16.
        <u>GOVERNING LAW</u>.</b> THIS SECURITY SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK.</font></p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>17.
        <u>CUSIP and ISIN Numbers</u>.</b> Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification
      Procedures, the Company has caused CUSIP and ISIN numbers to be printed on the Securities and has directed the Trustee to use
      CUSIP and ISIN numbers in notices of repurchase as a convenience to Holders. No representation is made as to the accuracy of such
      numbers either as printed on the Securities or as contained in any notice of repurchase and reliance may be placed only on the
      other identification numbers placed thereon.</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</font></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>18.
        <u>Copies</u>.</b> The Company will furnish to any Holder upon written request and without charge a copy of the Indenture and
      the applicable Authorizing Resolution or supplemental indenture. Requests may be made to: Gyre Therapeutics, Inc., [&#160; ],
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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>ny20028941x2_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
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<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <div style="text-align: right; font-family: 'Times New Roman',Times,serif;"><font style="font-weight: bold;"> </font>
      <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
    <div style="text-align: right; font-family: 'Times New Roman',Times,serif;"> <font style="font-weight: bold;">Exhibit 5.1</font><br>
    </div>
    <div style="text-align: right; font-family: 'Times New Roman',Times,serif;"><font style="font-weight: bold;"> <br>
      </font></div>
    <div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zdae3fbb009264b2cacbc9fa2f49d5054" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td colspan="1" style="width: 70%; vertical-align: top;">
              <div><img src="ny20028941x2_ex5-1gibson.jpg" height="14" border="0" width="150"> </div>
            </td>
            <td style="width: 30%; vertical-align: top;">
              <div style="font-size: 8pt;">Gibson, Dunn &amp; Crutcher LLP</div>
              <div style="font-size: 8pt;">One Embarcadero Center<br>
                San Francisco, CA&#160; 94111-3715</div>
              <div style="font-size: 8pt;">Tel 415.393.8200</div>
              <div style="font-size: 8pt;">gibsondunn.com</div>
              <div>&#160;</div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <div>May 30, 2024</div>
    <div><br>
    </div>
    <div>Gyre Therapeutics, Inc.</div>
    <div>12770 High Bluff Drive, Suite 150</div>
    <div>San Diego, CA 92130</div>
    <div><br>
    </div>
    <div>Re:&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Gyre Therapeutics, Inc.</div>
    <div>Registration Statement on Form S-3</div>
    <div><br>
    </div>
    <div>Ladies and Gentlemen:</div>
    <div><br>
    </div>
    <div>We have acted as counsel to Gyre Therapeutics, Inc., a Delaware corporation (the &#8220;<u>Company</u>&#8221;), in connection with the preparation and filing with the Securities and Exchange Commission (the &#8220;<u>Commission</u>&#8221;) of a Registration Statement on
      Form S-3 (the &#8220;<u>Registration Statement</u>&#8221;) under the Securities Act of 1933, as amended (the &#8220;<u>Securities Act</u>&#8221;), relating to the registration under the Securities Act and the proposed issuance and sale from time to time pursuant to Rule 415
      under the Securities Act, together or separately and in one or more series (if applicable) of:</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(i) the Company&#8217;s debt securities (the &#8220;<u>Debt Securities</u>&#8221;);</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(ii) shares of the Company&#8217;s common stock, par value $0.001 per share (the &#8220;<u>Common Stock</u>&#8221;);</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(iii) shares of the Company&#8217;s preferred stock, par value $0.001 per share (the &#8220;<u>Preferred Stock</u>&#8221;);</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(iv) warrants for the purchase of Debt Securities, Common Stock, and Preferred Stock (the &#8220;<u>Warrants</u>&#8221;); and</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(v) units of the Company comprised of any combination of Debt Securities, Common Stock, Preferred Stock, and Warrants (the &#8220;<u>Units</u>&#8221;).</div>
    <div><br>
    </div>
    <div>The Debt Securities, Common Stock, Preferred Stock, Warrants, and Units are collectively referred to herein as the &#8220;<u>Securities</u>.&#8221; The Debt Securities are to be issued under an indenture substantially in the form attached to the Registration
      Statement (the &#8220;<u>Base Indenture</u>&#8221;).</div>
    <div><br>
    </div>
    <div>In arriving at the opinions expressed below, we have examined originals, or copies certified or otherwise identified to our satisfaction as being true and complete copies of the originals, of the form of the Base Indenture, form of the Debt
      Securities, specimen Common Stock certificates, and such other documents, corporate records, certificates of officers of the Company and of public officials and other instruments as we have deemed necessary or advisable to enable us to render these
      opinions. In our examination, we have assumed the genuineness of all signatures, the legal capacity and competency of all natural persons, the authenticity of all documents submitted to us as originals and the conformity to original documents of all
      documents submitted to us as copies. As to any facts material to these opinions, we have relied to the extent we deemed appropriate and without independent investigation upon statements and representations of officers and other representatives of the
      Company and others.</div>
    <div><br>
    </div>
    <div>We have assumed without independent investigation that:</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(i) at the time any Securities are sold pursuant to the Registration Statement (the &#8220;<u>Relevant Time</u>&#8221;), the Registration Statement and any supplements and amendments thereto (including post-effective amendments)
      will be effective and will comply with all applicable laws;</div>
    <div><br>
    </div>
    <div>
      <div style="text-align: center; font-size: 8pt;">Abu Dhabi <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Beijing <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Brussels <font style="font-family: 'Wingdings 2', serif;">&#8211;</font>
        Century City <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Dallas <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Denver <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Dubai <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Frankfurt <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Hong Kong <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Houston <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> London <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Los Angeles<br>
        Munich <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> New York <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Orange County <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Palo Alto <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Paris <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Riyadh <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> San Francisco <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Singapore
        <font style="font-family: 'Wingdings 2', serif;">&#8211;</font> Washington, D.C.</div>
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      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td colspan="1" style="width: 70%; vertical-align: top;">
              <div>
                <div><img src="ny20028941x2_ex5-1gibson.jpg" height="14" border="0" width="150"> </div>
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    <div style="text-indent: 55.1pt;"> <br>
    </div>
    <div style="text-indent: 55.1pt;"> <br>
    </div>
    <div style="text-indent: 55.1pt;">(ii) at the Relevant Time, a prospectus supplement will have been prepared and filed with the Commission describing the Securities offered thereby and all related documentation and will comply with all applicable laws;</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(iii) all Securities will be issued and sold in the manner stated in the Registration Statement and the applicable prospectus supplement;</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(iv) at the Relevant Time, all corporate or other action required to be taken by the Company to duly authorize each proposed issuance of Securities and any related documentation (including (i) the due reservation of
      any shares of Common Stock or Preferred Stock for issuance upon exercise, conversion or exchange of any Securities for Common Stock or Preferred Stock (a &#8220;<u>Convertible Security</u>&#8221;), and (ii) the execution (in the case of certificated Securities),
      delivery and performance of the Securities and any related documentation referred to in paragraphs 1 through 5 below) shall have been duly completed and shall remain in full force and effect;</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(v) upon issuance of any Common Stock or Preferred Stock, including upon exercise, conversion or exchange of any Convertible Security, the total number of shares of Common Stock or Preferred Stock issued and
      outstanding will not exceed the total number of shares of Common Stock or Preferred Stock, as applicable, that the Company is then authorized to issue under its certificate of incorporation and other relevant documents;</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(vi) in the case of Debt Securities<font style="font-weight: bold;">,</font> at the Relevant Time, the relevant trustee shall have been qualified under the Trust Indenture Act of 1939, as amended (the &#8220;<u>TIA</u>&#8221;), a
      Statement of Eligibility of the Trustee on Form T-1 shall have been properly filed with the Commission and the relevant Base Indenture shall have been duly executed and delivered by the Company and all other parties thereto and duly qualified under
      the TIA;</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">(vii) at the Relevant Time, a definitive purchase, underwriting or similar agreement and any other necessary agreement with respect to any Securities offered or issued will have been duly authorized by all necessary
      corporate or other action of the Company duly executed and delivered by the Company<font style="font-weight: bold;">&#160;</font>or any relevant trust and the other parties thereto.</div>
    <div><br>
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    <div>Based on the foregoing and in reliance thereon, and subject to the assumptions, exceptions, qualifications and limitations set forth herein, we are of the opinion that:</div>
    <div> <br>
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        <tr>
          <td style="width: 9%; vertical-align: middle;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">
            <div style="color: #000000;">1.</div>
          </td>
          <td style="width: 87%; vertical-align: top;">
            <div style="color: #000000;">With respect to any Debt Securities when:</div>
          </td>
        </tr>

    </table>
    <div><br>
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        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">a.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">the terms and conditions of such Debt Securities have been duly established by supplemental indenture or officers&#8217; certificate in accordance with the terms and conditions of the relevant Base Indenture,</div>
          </td>
        </tr>

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    <div><br>
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    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zd43e42fa6236488995f483f722a2adb6" cellpadding="0" cellspacing="0">

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          <td style="width: 13%; vertical-align: middle;">&#160;</td>
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            <div style="color: #000000;">b.</div>
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            <div style="color: #000000;">any such supplemental indenture has been duly executed and delivered by the Company and the relevant trustee (together with the relevant Base Indenture, the &#8220;<u><font style="font-family: 'Times New Roman',Times,serif; font-style: normal;">Indenture</font></u>&#8221;), and</div>
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    <div><br>
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    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zaffc86ef0fe54e0a881d3020674dbdae" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
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            <div style="color: #000000;">c.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">such Debt Securities have been executed (in the case of certificated Debt Securities), delivered and authenticated in accordance with the terms of the applicable Indenture and issued and sold for the consideration
              set forth in the applicable definitive purchase, underwriting or similar agreement,</div>
          </td>
        </tr>

    </table>
    <div style="text-indent: 24.5pt;"> <br>
    </div>
    <div style="text-indent: 24.5pt;">such Debt Securities will be legal, valid and binding obligations of the Company, enforceable against the Company in accordance with their respective terms.</div>
    <div style="text-indent: 24.5pt;"> <br>
    </div>
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        <tr>
          <td style="width: 9%; vertical-align: middle;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">
            <div style="color: #000000;">2.</div>
          </td>
          <td style="width: 87%; vertical-align: top;">
            <div style="color: #000000;">With respect to any shares of Preferred Stock, when:</div>
          </td>
        </tr>

    </table>
    <div><br>
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        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
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            <div style="color: #000000;">a.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">the certificate of designations relating to such Preferred Stock has been duly executed and filed with the Office of the Secretary of State of the State of Delaware,</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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    <div>
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          <tr>
            <td colspan="1" style="width: 70%; vertical-align: top;">
              <div>
                <div><img src="ny20028941x2_ex5-1gibson.jpg" height="14" border="0" width="150"> </div>
              </div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <div> <br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z80e0773ff9044f588e482ab9146be533" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">b.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">such shares have been issued either (i) in accordance with the applicable definitive purchase, underwriting or similar agreement and for the consideration therefor provided for therein or (ii) upon exercise,
              conversion or exchange of any Convertible Security and for any additional consideration specified in such Convertible Security or the instrument governing such Convertible Security providing for such conversion or exercise, which
              consideration (including any consideration paid for such Convertible Security), on a per-share basis, shall in either event not be less than the par value of the Preferred Stock, and</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 13%; vertical-align: middle;">&#160;</td>
          <td rowspan="1" style="width: 5%; vertical-align: top;">&#160;</td>
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        </tr>
        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">c.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">any such Convertible Security was previously validly issued and is fully paid an non-assessable (in the case of an equity Security) or is a legal, valid and binding obligation of the Company, enforceable against the
              Company in accordance with its terms,</div>
          </td>
        </tr>

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    <div style="text-indent: 24.5pt;"> <br>
    </div>
    <div style="text-indent: 24.5pt;">such shares of Preferred Stock will be validly issued, fully paid and non-assessable.</div>
    <div style="text-indent: 24.5pt;"> <br>
    </div>
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        <tr>
          <td style="width: 9%; vertical-align: middle;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">
            <div style="color: #000000;">3.</div>
          </td>
          <td style="width: 87%; vertical-align: top;">
            <div style="color: #000000;">With respect to shares of Common Stock, when:</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zb311c89dcdc64d03bbdc1cf00a3e9b3e" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">a.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">such shares of Common Stock have been duly executed (in the case of certificated shares) and delivered either (i) in accordance with the applicable definitive purchase, underwriting or similar agreement for the
              consideration provided for therein, or (ii) upon conversion or exercise of any Convertible Security, in accordance with the terms of such Convertible Security or the instrument governing such Convertible Security providing for such conversion
              or exercise, and for any additional consideration specified therein, which consideration (including any consideration paid for such Convertible Security), on a per-share basis, shall in either event not be less than the par value of the
              Common Stock, and</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z7ab30fa4fb5f43ceaef6095d4dbe56f9" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">b.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">any such Convertible Security was previously validly issued and is fully paid and non-assessable (in the case of an equity Security) or is a legal, valid and binding obligation of the Company, enforceable against
              the Company in accordance with its terms,</div>
          </td>
        </tr>

    </table>
    <div style="text-indent: 24.5pt;"> <br>
    </div>
    <div style="text-indent: 24.5pt;">such shares of Common Stock will be validly issued, fully paid and non-assessable.</div>
    <div style="text-indent: 24.5pt;"> <br>
    </div>
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        <tr>
          <td style="width: 9%; vertical-align: middle;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">
            <div style="color: #000000;">4.</div>
          </td>
          <td style="width: 87%; vertical-align: top;">
            <div style="color: #000000;">With respect to any Warrants, when:</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z2c2845cb488642ee907b4c8f56fa938a" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">a.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">the warrant agreement relating to such Warrants (the &#8220;<u><font style="font-family: 'Times New Roman',Times,serif; font-style: normal;">Warrant Agreement</font></u>&#8221;), if any, has been duly executed and delivered by
              the Company and each other party thereto,</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zc02158e9fbbb49318a22e013dbf8858f" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">b.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">the terms of the Warrants have been established in accordance with the Warrant Agreement, if any, and the applicable definitive purchase, underwriting or similar agreement, and</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z8e558b24d95441c7b9f9fa05b0718cbb" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">c.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">the Warrants have been duly executed (in the case of certificated Warrants) and delivered in accordance with the Warrant Agreement, if any, and the applicable definitive purchase, underwriting or similar agreement
              for the consideration provided for therein,</div>
          </td>
        </tr>

    </table>
    <div style="text-indent: 24.5pt;"><br>
      such Warrants will be legal, valid and binding obligations of the Company, enforceable against the Company in accordance with their terms.</div>
    <div style="text-indent: 24.5pt;"> <br>
    </div>
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        <tr>
          <td style="width: 9%; vertical-align: middle;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">
            <div style="color: #000000;">5.</div>
          </td>
          <td style="width: 87%; vertical-align: top;">
            <div style="color: #000000;">With respect to any Units, when:</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z7e653667601e4834ad2e654318b158df" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">a.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">the unit agreement relating to the Units (the &#8220;<u><font style="font-family: 'Times New Roman',Times,serif; font-style: normal;">Unit Agreement</font></u>&#8221;), if any, has been duly executed and delivered by the
              Company and each other party thereto,</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z2ddf5650e22d4e6e9841c0fcd770c457" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">b.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">the terms of the Units have been duly established in accordance with the Unit Agreement, if any, and the applicable definitive purchase, underwriting or similar agreement, and</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z5862d3068c1f41afb8988b2e133f0149" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000;">c.</div>
          </td>
          <td style="width: 82.01%; vertical-align: top;">
            <div style="color: #000000;">the Units have been duly executed (in the case of certificated Units) and delivered in accordance with the Unit Agreement, if any, and the applicable definitive purchase, underwriting or similar agreement for the
              consideration provided for therein,</div>
          </td>
        </tr>

    </table>
    <div style="text-indent: 24.5pt;"> <br>
    </div>
    <div style="text-indent: 24.5pt;">the Units will be legal, valid and binding obligations of the Company, enforceable against the Company in accordance with their terms.</div>
    <div><br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
    </div>
    <div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td colspan="1" style="width: 70%; vertical-align: top;">
              <div>
                <div><img src="ny20028941x2_ex5-1gibson.jpg" height="14" border="0" width="150"> </div>
              </div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <div> <br>
    </div>
    <div>The opinions expressed above are subject to the following exceptions, qualifications, limitations and assumptions:</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">A. We render no opinion herein as to matters involving the laws of any jurisdiction other than the State of New York and the United States of America and, for purposes of paragraphs 2 and 3 above, the Delaware General
      Corporation Law. We are not admitted to practice in the State of Delaware; however, we are generally familiar with the Delaware General Corporation Law as currently in effect and have made such inquiries as we consider necessary to render the
      opinions contained in paragraphs 2 and 3 above. This opinion is limited to the effect of the current state of the laws of the State of New York, the United States of America and, to the limited extent set forth above, the laws of the State of
      Delaware<font style="font-weight: bold;">&#160;</font>and the facts as they currently exist. We assume no obligation to revise or supplement this opinion in the event of future changes in such laws or the interpretations thereof or such facts.</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">B. The opinions above with respect to the Indenture, the Debt Securities, the Warrants, the Warrant Agreement, the Units and the Unit Agreement (collectively, the &#8220;<u>Documents</u>&#8221;) are each subject to (i) the effect
      of any bankruptcy, insolvency, reorganization, moratorium, arrangement or similar laws affecting the rights and remedies of creditors&#8217; generally, including without limitation the effect of statutory or other laws regarding fraudulent transfers or
      preferential transfers, and (ii) general principles of equity, including without limitation concepts of materiality, reasonableness, good faith and fair dealing and the possible unavailability of specific performance, injunctive relief or other
      equitable remedies regardless of whether enforceability is considered in a proceeding in equity or at law.</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">C. We express no opinion regarding the effectiveness of (i) any waiver of stay, extension or usury laws; (ii) provisions relating to indemnification, exculpation or contribution, to the extent such provisions may be
      held unenforceable as contrary to public policy or federal or state securities laws;<font style="font-weight: bold;"> </font>(iii) any provision in any Document waiving the right to object to venue in any court; (iv) any agreement to submit to the
      jurisdiction of any Federal court; or (v) any waiver of the right to jury trial.</div>
    <div><br>
    </div>
    <div style="text-indent: 55.1pt;">D. To the extent relevant to our opinions in paragraphs 4 and 5 and not covered by our opinions in paragraphs 1, 2, and 3, we have assumed that any securities underlying, comprising or issuable upon exchange,
      conversion or exercise of any Warrants or Units are validly issued, fully paid and non-assessable (in the case of an equity security) or a legal, valid and binding obligation of the issuer thereof, enforceable against such issuer in accordance with
      its terms.</div>
    <div><br>
    </div>
    <div>You have informed us that you intend to issue Securities from time to time on a delayed or continuous basis, and we understand that prior to issuing any Securities pursuant to the Registration Statement (i) you will advise us in writing of the
      terms thereof, and (ii) you will afford us an opportunity to (x) review the operative documents pursuant to which such Securities are to be issued or sold (including the applicable offering documents), and (y) file such supplement or amendment to
      this opinion (if any) as we may reasonably consider necessary or appropriate.</div>
    <div><br>
    </div>
    <div>We consent to the filing of this opinion as an exhibit to the Registration Statement, and we further consent to the use of our name under the caption &#8220;Legal Matters&#8221; in the Registration Statement and the prospectus that forms a part thereof. In
      giving these consents, we do not thereby admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission promulgated thereunder.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z955a72068cac483fb5321e096998d56b" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div>Very truly yours,</div>
            <div> <br>
            </div>
            <div>/S/ GIBSON, DUNN &amp; CRUTCHER LLP</div>
            <div> <br>
            </div>
            <div>GIBSON, DUNN &amp; CRUTCHER LLP</div>
          </td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div style="text-indent: -36pt; margin-left: 36pt;"><br>
    </div>
    <div><br>
    </div>
    <div>
      <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>4
<FILENAME>ny20028941x2_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge
         Document created using Broadridge PROfile 24.3.1.5224
         Copyright 1995 - 2024 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">
      <hr style="height: 4px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
    <div style="text-align: right; font-family: 'Times New Roman',Times,serif; font-weight: bold;"> Exhibit 23.1<br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</div>
    <div><br>
    </div>
    <div style="text-align: justify;">We have issued our report dated March 27, 2024, with respect to the consolidated financial statements included in the Annual Report of Gyre Therapeutics, Inc. on Form 10-K for the year ended December 31, 2023, which is
      incorporated by reference in this Registration Statement. We consent to the incorporation by reference of the said report in this Registration Statement, and the use of our name as it appears under the caption &#8220;Experts&#8221;.</div>
    <div><br>
    </div>
    <div style="text-align: justify;">/s/ Grant Thornton Zhitong Certified Public Accountants LLP</div>
    <div><br>
    </div>
    <div style="text-align: justify;">Beijing, China</div>
    <div style="text-align: justify;">May 30, 2024<br>
    </div>
    <div><br>
    </div>
    <div>
      <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
  </div>
</body>
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</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>5
<FILENAME>ny20028941x2_ex23-2.htm
<DESCRIPTION>EXHIBIT 23.2
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge
         Document created using Broadridge PROfile 24.3.1.5224
         Copyright 1995 - 2024 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <div style="text-align: right; font-family: 'Times New Roman',Times,serif; font-weight: bold;">
      <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">Exhibit 23.2<br>
    </div>
    <div style="text-align: justify; font-weight: bold;"> <br>
    </div>
    <div style="text-align: justify; font-weight: bold;">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</div>
    <div><br>
    </div>
    <div style="text-align: justify;">We consent to the incorporation by reference in this Registration Statement of Gyre Therapeutics, Inc. on Form S-3 to be filed on or about May 30, 2024 of our report dated March 30, 2023, on our audits of the financial
      statements of Catalyst Biosciences, Inc. (the &#8220;Company&#8221;) as of December 31, 2022 and 2021 and for each of the years then ended, which report was included in the Annual Report on Form 10-K filed<font style="font-style: italic;">&#160;</font>March 30, 2023.
      Our report includes an explanatory paragraph about the existence of substantial doubt concerning the Company&#8217;s ability to continue as a going concern. We also consent to the reference to our firm under the caption &#8220;Experts&#8221; in this Registration
      Statement.</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify;">EISNERAMPER LLP</div>
    <div style="text-align: justify;">Philadelphia, Pennsylvania</div>
    <div>May 30, 2024</div>
    <div> <br>
    </div>
    <div>
      <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"> </div>
  </div>
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</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>6
<FILENAME>ny20028941x2_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge
         Document created using Broadridge PROfile 24.3.1.5224
         Copyright 1995 - 2024 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <div>
      <div style="text-align: center; font-weight: bold;">
        <div style="text-align: right;">
          <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">Exhibit 99.1<br>
        </div>
        <div><br>
        </div>
        UNAUDITED PRO FORMA CONDENSED FINANCIAL INFORMATION</div>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: justify;">On October 30, 2023, Gyre Therapeutics, Inc. (the &#8220;Company&#8221; or &#8220;Gyre&#8221;, previously known as Catalyst Biosciences, Inc. or &#8220;Catalyst&#8221;) consummated the transactions (the &#8220;Contributions&#8221;) contemplated by the Business
        Combination Agreement as described in the Company&#8217;s Annual Report on Form 10-K for the year ended December 31, 2023 (the &#8220;Annual Report&#8221;), which were accounted for as a reverse asset acquisition and a purchase of noncontrolling interest in
        accordance with United States generally accepted accounting principles (&#8220;GAAP&#8221;). Continent Pharmaceuticals Inc. (&#8220;CPI&#8221;) was treated as the accounting acquirer of the reverse asset acquisition and is presented as the predecessor for post-acquisition
        financial reporting purposes.</div>
      <div><br>
      </div>
      <div style="text-align: justify;">Pursuant to Article 11 of Regulation S-X, the Company prepared the following unaudited pro forma condensed combined financial information and the accompanying notes, reflecting the combined financial results of
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              <div>the historical unaudited condensed financial statements of Catalyst as of and for the nine months ended September 30, 2023, included in Catalyst&#8217;s Quarterly Report on Form 10-Q (the &#8220;10-Q&#8221;) filed with the SEC on October 26, 2023 and
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              <div>the Annual Report filed with the SEC on March 27, 2024 and incorporated by reference.</div>
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      <div><br>
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          <td style="width: 0.72%; vertical-align: middle;">&#160;</td>
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          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
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          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
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              <div>$</div>
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          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
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              <div style="text-align: right;">&#8212;</div>
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          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
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              <div>$</div>
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          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
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          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
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          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
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              <div style="text-align: right;">113,450</div>
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          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
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          <td style="width: 1.6%; vertical-align: middle;">&#160;</td>
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          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom;">&#160;</td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom;">&#160;</td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom;">&#160;</td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
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          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC;">
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              <div style="text-align: right;">4,636</div>
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          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
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              <div style="text-align: right;">4,636</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
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        <tr>
          <td style="width: 40%; vertical-align: middle;">
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            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">61,159</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 11%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 11%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 11%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">61,159</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
            <div>
              <div style="margin-left: 10pt;">Research and development</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div style="text-align: right;">13,780</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">1,321</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">15,101</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle;">
            <div>
              <div style="margin-left: 10pt;">General and administrative</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">14,662</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 11%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">8,603</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 11%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 11%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">23,265</div>
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          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
            <div>
              <div style="margin-left: 10pt;">Acquired in-process research and development</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div style="text-align: right;">83,104</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">83,104</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle;">
            <div>
              <div style="margin-left: 10pt;">Divestiture losses</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">2,711</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 11%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 11%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 11%; vertical-align: bottom;">
            <div>
              <div style="text-align: right;">2,711</div>
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          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
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        <tr>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
            <div>
              <div style="margin-left: 10pt;">GNI cost-sharing reimbursement</div>
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          </td>
          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div style="text-align: right;">&#8212;</div>
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          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
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              <div style="text-align: right;">(1,200</div>
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          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
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          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">&#8212;</div>
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          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
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              <div style="text-align: right;">(1,200</div>
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          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
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          <td style="width: 40%; vertical-align: middle;">
            <div>
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          <td style="width: 1.6%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; border-bottom: #000000 2px solid;">
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              <div style="text-align: right;">628</div>
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          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(4,736</div>
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          <td style="width: 0.72%; vertical-align: bottom;">
            <div>
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          </td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(4,108</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">
            <div>
              <div>)</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
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              <div style="margin-left: 25pt;">Total operating expenses</div>
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          </td>
          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>
              <div style="text-align: right;">180,680</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">3,988</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">184,668</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle;">
            <div>
              <div>Loss from operations</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; border-top: #000000 2px solid;">
            <div>
              <div style="text-align: right;">(67,230</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(3,988</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(71,218</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">
            <div>
              <div>)</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
            <div>
              <div>Interest and other income (expense), net</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div style="text-align: right;">(474</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">216</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252);">
            <div>
              <div style="text-align: right;">(258</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: top;">
            <div>
              <div>Change in fair value of warrant liability</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div>
              <div style="text-align: right;">(9,261</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(9,261</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">
            <div>
              <div>)</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
            <div>
              <div>Loss before income taxes</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC; border-top: #000000 2px solid;">
            <div>
              <div style="text-align: right;">(76,965</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(3,772</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(80,737</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle;">
            <div>
              <div>Provision for income taxes</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div>
              <div style="text-align: right;">(8,515</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(16</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(8,531</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom;">
            <div>
              <div>)</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
            <div>
              <div>Net loss from operations</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC; border-top: #000000 2px solid;">
            <div>
              <div style="text-align: right;">(85,480</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(3,788</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(89,268</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div style="font-weight: bold;">)</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle;">
            <div>
              <div>Net income attributable to noncontrolling interest</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div>
              <div style="text-align: right;">7,453</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">7,453</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
            <div>
              <div>Net loss attributable to common stockholders</div>
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          </td>
          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div>$</div>
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          </td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC; border-top: #000000 2px solid; border-bottom: #000000 4px double;">
            <div>
              <div style="text-align: right;">(92,933</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div>$</div>
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          </td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(3,788</div>
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          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div>$</div>
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          </td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">&#8212;</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div>$</div>
            </div>
          </td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(96,721</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle;">
            <div>
              <div>Net loss per share attributable to common stockholders:</div>
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          </td>
          <td style="width: 1.6%; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-top: 4px double rgb(0, 0, 0);">&#160;</td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-top: 4px double rgb(0, 0, 0);">&#160;</td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-top: 4px double rgb(0, 0, 0);">&#160;</td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-top: 4px double rgb(0, 0, 0);">&#160;</td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
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        <tr>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
            <div>
              <div style="margin-left: 5pt;">Basic and diluted</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-bottom: 4px double rgb(0, 0, 0);">
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              <div>$</div>
            </div>
          </td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC; border-bottom: #000000 4px double;">
            <div>
              <div style="text-align: right;">(1.41</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div>$</div>
            </div>
          </td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">(1.26</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div>)</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle;">
            <div>
              <div>Weighted average shares used in calculating net loss per share attributable to common stockholders:</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-top: 4px double rgb(0, 0, 0);">&#160;</td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom;">&#160;</td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom;">&#160;</td>
          <td style="width: 0.6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-top: 4px double rgb(0, 0, 0);">&#160;</td>
          <td style="width: 0.72%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(207, 240, 252);">
            <div>
              <div style="margin-left: 5pt;">Basic and diluted</div>
            </div>
          </td>
          <td style="width: 1.6%; vertical-align: middle; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
          <td style="width: 10.82%; vertical-align: bottom; background-color: #CFF0FC; border-bottom: #000000 4px double;">
            <div>
              <div style="text-align: right;">65,832</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; background-color: rgb(207, 240, 252);">&#160;</td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">10,752</div>
            </div>
          </td>
          <td style="width: 0.6%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
          <td style="width: 1.64%; vertical-align: bottom; background-color: #CFF0FC;">
            <div>
              <div style="font-weight: bold;">&#160;A</div>
            </div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
          <td style="width: 11%; vertical-align: bottom; background-color: rgb(207, 240, 252); border-bottom: 4px double rgb(0, 0, 0);">
            <div>
              <div style="text-align: right;">76,584</div>
            </div>
          </td>
          <td style="width: 0.72%; vertical-align: bottom; background-color: #CFF0FC;">&#160;</td>
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    </div>
    <div>
      <div><br>
      </div>
    </div>
    <div>
      <div style="text-align: center; font-weight: bold;">NOTES TO UNAUDITED PRO FORMA CONDENSED COMBINED STATEMENT OF OPERATIONS</div>
    </div>
    <div>
      <div><br>
      </div>
    </div>
    <div>
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          <tr>
            <td style="width: 24.45pt;"><br>
            </td>
            <td style="width: 24.5pt; vertical-align: top; font-weight: bold;">1.</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-weight: bold;">Basis of Pro Forma Presentation</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: justify;">The unaudited pro forma condensed combined financial information was prepared in accordance with U.S. GAAP and pursuant to Article 11 of Regulation S-X. The unaudited pro forma condensed combined statement of
        operations for the year ended December 31, 2023, gives effect to the Contributions as if they had been consummated on January 1, 2023, and has aggregated:</div>
      <div><br>
      </div>
    </div>
    <div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="ze9cd40d7f36d44dfa4bb620660a529de" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 24.45pt;"><br>
            </td>
            <td style="width: 24.5pt; vertical-align: top;">a)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>Catalyst&#8217;s operations for the nine months ended September 30, 2023 from the 10-Q, and</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z5cc9a89014844dbca16bd433b9080b39" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 24.45pt;"><br>
            </td>
            <td style="width: 24.5pt; vertical-align: top;">b)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>the Company&#8217;s consolidated operations from the Annual Report, which includes CPI&#8217;s operations for the year ended December 2023, and Gyre&#8217;s operations post-merger from October 30, 2023 to December 31, 2023.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: justify;">The Company determined that there were no significant transactions within Catalyst from October 1 to October 30, 2023. The acquired assets and assumed liabilities upon closing of the Contributions were mainly
        in-process research and development (&#8220;IPR&amp;D&#8221;), in addition to the working capital. Therefore, no pro forma adjustments, other than weighted average shares outstanding and loss per share, were deemed necessary.</div>
      <div><br>
      </div>
    </div>
    <div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb81e248993ca4ca896ee4bd9447b1879" cellpadding="0" cellspacing="0">

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            <td style="width: 24.45pt;"><br>
            </td>
            <td style="width: 24.5pt; vertical-align: top; font-weight: bold;">2.</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-weight: bold;">Proforma Adjustments</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: justify;">(A) The weighted average shares outstanding for the period has been calculated as if the Contributions occurred on January 1, 2023, including:</div>
      <div><br>
      </div>
    </div>
    <div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z87a70d93b816400d89e596b9b27ebf7d" cellpadding="0" cellspacing="0">

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            </td>
            <td style="width: 24.5pt; vertical-align: top;">(1)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>the weighted average shares outstanding for common stock deemed issued to Catalyst upon closing of the Contributions, for the period from October 1 to October 30, 2023, adjusted for the 1-for-15 reverse stock split completed on October
                30, 2023 (the &#8220;Reverse Stock Split&#8221;);</div>
            </td>
          </tr>

      </table>
      <div><br>
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            <td style="width: 24.5pt; vertical-align: top;">(2)</td>
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              <div>the weighted average shares outstanding for common stock issued to certain minority shareholders upon the closing of the Contributions, for the period from October 1 to October 30, 2023, as adjusted for the Reverse Stock Split.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: justify;">The Company&#8217;s Series A Convertible Preferred Stock, stock options and warrants are determined to be anti-dilutive and, therefore, were excluded from the diluted loss per share attributable to common stock calculation
        because including them would have been anti-dilutive.</div>
      <div><br>
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<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>7
<FILENAME>ny20028941x2_ex107.htm
<DESCRIPTION>FILING FEES TABLE
<TEXT>
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      <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
    <div style="text-align: right; font-weight: bold;">Exhibit 107</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Calculation of Filing Fee Tables</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Form S-3</div>
    <div style="text-align: center;">(Form Type)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Gyre Therapeutics, Inc.</div>
    <div style="text-align: center;">(Exact Name of Registrant as Specified in its Charter)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Table 1: Newly Registered and Carry Forward Securities</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z39d62e767e634846895724a7bd3a0cd8" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 9.01%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.68%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7.07%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.57%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.73%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.57%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7.07%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.57%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.27%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.68%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.04%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.57%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.46%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.68%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.96%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.57%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7.3%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.68%; vertical-align: bottom;">&#160;</td>
          <td style="width: 5.13%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.68%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.61%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.57%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7.87%; vertical-align: middle;">&#160;</td>
          <td style="width: 0.68%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.96%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 9.01%;">&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Security</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Type</div>
          </td>
          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 7.3%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Security</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Class</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Title</div>
          </td>
          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Fee</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Calculation</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">or Carry</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Forward</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Rule</div>
          </td>
          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 6.84%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Amount</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Registered</div>
          </td>
          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 6.73%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Proposed</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Maximum</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Offering</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Price Per</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Unit</div>
          </td>
          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 10.03%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Maximum</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Aggregate</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Offering</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Price</div>
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          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Fee</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Rate</div>
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          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 7.87%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Amount of</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Registration</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Fee</div>
          </td>
          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 5.82%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Carry</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Forward</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Form</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Type</div>
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          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 7.3%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Carry</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Forward</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">File</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Number</div>
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            <div style="text-align: center; color: #000000; font-weight: bold;">Carry</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Forward</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Initial</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">effective</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">date</div>
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          <td colspan="2" style="border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid; border-top: 2px solid rgb(0, 0, 0); vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Filing Fee</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Previously</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Paid In</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Connection</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">with Unsold</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Securities to</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">be Carried</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Forward</div>
          </td>
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          <td colspan="25" style="width: 99.89%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: #000000; font-weight: bold;"> Newly Registered Securities</div>
          </td>
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        <tr>
          <td colspan="1" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 9.01%;">&#160;
            <div style="text-align: center; color: #000000;">Fees to Be Paid</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Equity</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Common stock, $0.001</div>
            <div style="text-align: center; color: #000000;">par value per share(1)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Rule 457(o)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.84%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(1)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.73%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(2)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 10.03%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(3)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.87%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 5.82%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 8.55%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-right: 2px solid; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 9.01%;">&#160;
            <div style="text-align: center; color: #000000;">Fees to Be Paid</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Equity</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Preferred stock, $0.001 par value per share(1)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Rule 457(o)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.84%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(1)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.73%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(2)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 10.03%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(3)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.87%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 5.82%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 8.55%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-right: 2px solid; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 9.01%;">&#160;
            <div style="text-align: center; color: #000000;">Fees to Be Paid</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Debt</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Debt Securities</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Rule 457(o)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.84%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(1)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.73%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(2)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 10.03%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(3)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.87%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 5.82%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 8.55%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-right: 2px solid; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 9.01%;">&#160;
            <div style="text-align: center; color: #000000;">Fees to Be Paid</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Other</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Warrants(1)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Rule 457(o)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.84%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(1)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.73%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(2)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 10.03%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(3)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.87%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 5.82%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 8.55%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-right: 2px solid; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 9.01%;">&#160;
            <div style="text-align: center; color: #000000;">Fees to Be Paid</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Other</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Units(1)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Rule 457(o)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.84%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(1)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.73%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(2)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 10.03%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(3)</div>
          </td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.87%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 5.82%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 8.55%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-left: 2px solid #000000; border-right: 2px solid; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 9.01%;">&#160;
            <div style="text-align: center; color: #000000;">Fees to Be Paid</div>
          </td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Unallocated (Universal)</div>
            <div style="text-align: center; color: #000000;">Shelf</div>
          </td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Unallocated (Universal)</div>
            <div style="text-align: center; color: #000000;">Shelf</div>
          </td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">Rule 457(o)</div>
          </td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.84%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(1)</div>
          </td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 6.73%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">(2)</div>
          </td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 10.03%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">$150,000,000</div>
          </td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">0.00014760</div>
          </td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.87%;">&#160;&#160;
            <div style="text-align: center; color: #000000;">$22,140.00</div>
          </td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 5.82%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 7.3%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 8.55%;">&#160;&#160;&#160;</td>
          <td colspan="2" style="border-bottom: 4px double #000000; border-left: 2px solid #000000; border-right: 2px solid; border-top: 2px solid #000000; vertical-align: bottom; width: 7.64%;">&#160;&#160;&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="width: 9.01%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;</td>
          <td colspan="8" style="width: 29.42%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;
            <div style="text-align: center; color: #000000;">Total Offering Amounts</div>
          </td>
          <td colspan="2" style="width: 6.73%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 10.03%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;
            <div style="text-align: center; color: #000000;">$150,000,000</div>
          </td>
          <td colspan="2" style="width: 7.64%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.87%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;
            <div style="text-align: center; color: #000000;">$22,140.00</div>
          </td>
          <td colspan="2" style="width: 5.82%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.3%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 8.55%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.64%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="width: 9.01%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;</td>
          <td colspan="8" style="width: 29.42%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;
            <div style="text-align: center; color: #000000;">Total Fees Previously Paid</div>
          </td>
          <td colspan="2" style="width: 6.73%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 10.03%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.64%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.87%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 5.82%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.3%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 8.55%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.64%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="width: 9.01%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;</td>
          <td colspan="8" style="width: 29.42%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;
            <div style="text-align: center; color: #000000;">Total Fee Offsets</div>
          </td>
          <td colspan="2" style="width: 6.73%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 10.03%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.64%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.87%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;
            <div style="text-align: center; color: #000000;">$16,365.00</div>
          </td>
          <td colspan="2" style="width: 5.82%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.3%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 8.55%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.64%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="width: 9.01%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#160;</td>
          <td colspan="8" style="width: 29.42%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#160;
            <div style="text-align: center; color: #000000;">Net Fee Due</div>
          </td>
          <td colspan="2" style="width: 6.73%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 10.03%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.64%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.87%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#160;
            <div style="text-align: center; color: #000000;">$5,775.00</div>
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          <td colspan="2" style="width: 5.82%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 7.3%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
          <td colspan="2" style="width: 8.55%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;</td>
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    <div style="text-align: center; font-weight: bold;">Table 2: Fee Offset Claims and Sources</div>
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        <tr>
          <td style="width: 11.76%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 7.77%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 3.57%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.77%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 5.77%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 5.77%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.01%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 6.84%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 6.84%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 6.45%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 11.76%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 0.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.29%; vertical-align: middle; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 11.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;</td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Registrant</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">or Filer</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Name</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Form</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">or</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Filing</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Type</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">File</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Number</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Initial</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Filing</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Date</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Filing</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Date</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Fee</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Offset</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Claimed</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Security</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Type</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Associated</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">with Fee</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Offset</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Claimed</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Security</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Title</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Associated</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">with Fee</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Offset</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Claimed</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Unsold</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Securities</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Associated</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">with Fee</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Offset</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Claimed</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Unsold</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Aggregate</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Offering</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Amount</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Associated</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">with Fee</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Offset</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Claimed</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000; font-weight: bold;">Fee</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Paid</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">with</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Fee</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Offset</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Source</div>
          </td>
        </tr>
        <tr>
          <td colspan="23" style="width: 100%; vertical-align: middle; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid;">
            <div style="text-align: center; color: #000000; font-weight: bold;">Rule 457(p)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 11.76%; vertical-align: top; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">Fee Offset Claims</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">Catalyst Biosciences, Inc.</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">S-3</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">333-253874</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">March 4, 2021</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;&#160;</td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">$16,365.00(4)</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">Unallocated (Universal Shelf)</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">Unallocated (Universal Shelf)</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">(4)</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">$150,000,000</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-width: 2px; border-style: solid double solid solid; border-color: rgb(0, 0, 0);">&#160;&#160;</td>
        </tr>
        <tr>
          <td style="width: 11.76%; vertical-align: top; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">Fee Offset Sources</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">Catalyst Biosciences, Inc.</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">S-3</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">333-253874</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;&#160;</td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;
            <div style="text-align: center; color: #000000;">March 4, 2021</div>
          </td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;&#160;</td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;&#160;</td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;&#160;</td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;&#160;</td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;&#160;</td>
          <td colspan="2" rowspan="1" style="width: 0.76%; vertical-align: bottom; border-width: 2px; border-style: solid double solid solid; border-color: rgb(0, 0, 0);">&#160;
            <div style="text-align: center; color: #000000;">$16,365.00(4)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z8238b0b9f47d406b9c16e636f9d657be" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 4%; vertical-align: top;">
            <div style="color: #000000;">(1)</div>
          </td>
          <td style="width: 96%; vertical-align: top;">
            <div style="color: #000000;">The amount to be registered consists of up to $150,000,000 of an indeterminate amount of common stock, preferred stock, debt securities, warrants and/or units. There is also being registered hereunder such currently
              indeterminate number of (i) shares of common stock or other securities of the registrant as may be issued upon conversion of, or in exchange for, convertible or exchangeable debt securities and/or preferred stock registered hereby, or (ii)
              shares of preferred stock, common stock, debt securities or units as may be issued upon exercise of warrants registered hereby, as the case may be. Any securities registered hereunder may be sold separately or as units with the other
              securities registered hereunder.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zb9bb51e3adf840b3b692699120e1c458" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 4%; vertical-align: top;">
            <div style="color: #000000;">(2)</div>
          </td>
          <td style="width: 96%; vertical-align: top;">
            <div style="color: #000000;">The proposed maximum aggregate offering price per unit will be determined from time to time by the registrant in connection with the issuance by the registrant of the securities registered hereunder and is not
              specified as to each class of security pursuant to General Instruction II.D. of Form S-3 under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;).</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z58a3fac5d92d4b2f961f6d844981e3dc" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 4%; vertical-align: top;">
            <div style="color: #000000;">(3)</div>
          </td>
          <td style="width: 96%; vertical-align: top;">
            <div style="color: #000000;">Estimated solely for purposes of computing the registration fee pursuant to Rule 457(o) under the Securities Act. In no event will the aggregate offering price of all securities sold by the registrant from time to
              time pursuant to this registration statement exceed $150,000,000. No separate consideration will be received for (i) common stock or other securities of the registrant that may be issued upon conversion of, or in exchange for, convertible or
              exchangeable debt securities and/or preferred stock registered hereby, or (ii) preferred stock, common stock, debt securities or units that may be issued upon exercise of warrants registered hereby, as the case may be.</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 4%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 96%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4%; vertical-align: top;">
            <div style="color: #000000;">(4)</div>
          </td>
          <td style="width: 96%; vertical-align: top;">
            <div style="color: #000000;">The registrant (formerly known as &#8220;Catalyst Biosciences, Inc.&#8221;) has previously registered the offer and sale of up to $150,000,000 of securities pursuant to a registration statement on Form S-3 (File No.
              333-253874), which was initially filed with the Securities and Exchange Commission on March 4, 2021 and became effective on May 3, 2021 (the &#8220;Prior Registration Statement&#8221;). In connection with the filing of the Prior Registration Statement,
              the registrant made a contemporaneous fee payment in the amount of $16,365.00. Of the $150,000,000 of securities registered under the Prior Registration Statement, $150,000,000 of securities remains unsold (the &#8220;Unsold Securities&#8221;). Pursuant
              to Rule 457(p) under the Securities Act, the registration fee of $16,365.00 that has already been paid and remains unused with respect to the Unsold Securities is hereby offset against the registration fee of $22,140.00 due for this offering.
              The remaining balance of the registration fee, $5,775.00, has been paid in connection with this offering. The offering that includes the Unsold Securities under the Prior Registration Statement is hereby terminated.</div>
          </td>
        </tr>

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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
