<SEC-DOCUMENT>0001140361-24-047980.txt : 20241127
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<ACCEPTANCE-DATETIME>20241127162526
ACCESSION NUMBER:		0001140361-24-047980
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		16
CONFORMED PERIOD OF REPORT:	20241127
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20241127
DATE AS OF CHANGE:		20241127

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GYRE THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001124105
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				562020050
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51173
		FILM NUMBER:		241511555

	BUSINESS ADDRESS:	
		STREET 1:		12770 HIGH BLUFF DRIVE, SUITE 150
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
		BUSINESS PHONE:		(619) 949-3681

	MAIL ADDRESS:	
		STREET 1:		12770 HIGH BLUFF DRIVE, SUITE 150
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CATALYST BIOSCIENCES, INC.
		DATE OF NAME CHANGE:	20150820

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TARGACEPT INC
		DATE OF NAME CHANGE:	20000919
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    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">UNITED STATES</div>

    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>

    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">WASHINGTON, D.C. 20549</div>

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    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;"> <br/>
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    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">CURRENT REPORT</div>

    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934</div>

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    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(Exact name of registrant as specified in its charter)</div>

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    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">N/A</div>

    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(Former name or former address, if changed since last report.)</div>

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    <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the
      following provisions (see General Instruction A.2. below):</div>

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    <td style="width: 97.65%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</div>
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    <td style="width: 97.65%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</div>
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    <td style="width: 97.65%; vertical-align: top;">
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    <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Securities registered pursuant to Section 12(b) of the Act:</div>

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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Title of each class</div>
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    <td style="width: 0.1%; vertical-align: bottom;">&#160;</td>

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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Trading Symbol(s)</div>
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    <td style="width: 0.1%; vertical-align: bottom;">&#160;</td>

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    <td style="width: 0.1%; vertical-align: top;">&#160;</td>

    <td style="width: 23.26%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt;"><ix:nonNumeric name="dei:TradingSymbol" id="Fact_d2393e7be4014c9db655a57d0b398452" contextRef="c20241127to20241127">GYRE</ix:nonNumeric><br/>
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    <td style="width: 0.1%; vertical-align: top;">&#160;</td>

    <td style="width: 54.33%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt;"><span style="-sec-ix-hidden:Fact_d4edf1e1c0684c6ea7be64d7a4393e28">The Nasdaq Capital Market</span><br/>
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    <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (&#167;230.405 of this chapter) or
      Rule 12b-2 of the Securities Exchange Act of 1934 (&#167;240.12b-2 of this chapter).</div>

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    <div><br/>
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    <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or
      revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. <span style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9744;</span></div>

    <div>
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            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Item 1.01</div>
          </td>

    <td style="width: 82.33%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Entry Into a Material Definitive Agreement</div>
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    <div style="text-align: left; text-indent: 24.5pt; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">On November 27, 2024, Gyre Therapeutics, Inc. (the &#8220;Company&#8221;) entered into the <span style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Open Market Sale Agreement</span><sup>S</sup><sup>M</sup>, dated November 27, 2024 (the &#8220;Sale Agreement&#8221;), with Jefferies LLC (the &#8220;Sales Agent&#8221;), pursuant to which the Company may offer and sell from time to time up to
      $50,000,000 of shares of the Company&#8217;s common stock, par value $0.001 (the &#8220;Shares&#8221;), through the Sales Agent. The offering and sale of the Shares has been registered under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), pursuant to
      the Company&#8217;s Registration Statement on Form S-3 (File No. 333-283237) (the &#8220;Registration Statement&#8221;), which was originally filed with the Securities and Exchange Commission (&#8220;SEC&#8221;) on November 14, 2024 and declared effective by the SEC on November
      22, 2024, the base prospectus contained within the Registration Statement, and a prospectus supplement that was filed with the SEC on November 27, 2024.</div>

    <div><br/>
    </div>

    <div style="text-align: left; text-indent: 24.5pt; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Sales of the Shares, if any, pursuant to the Sale Agreement, may be made in sales deemed to be an &#8220;at the market offering&#8221; as defined in
      Rule 415(a)(4) promulgated under the Securities Act, including sales made directly on or through The Nasdaq Capital Market or on any other existing trading market for the Company&#8217;s common stock. The Company has no obligation to sell any of the Shares
      under the Sale Agreement, and may at any time suspend offers under the Sale Agreement or terminate the Sale Agreement. The Sales Agent will act as a sales agent and will use commercially reasonable efforts to sell on the Company&#8217;s behalf all of the
      Shares requested to be sold by the Company, consistent with their normal trading and sales practices, on mutually agreed terms between the Sales Agent and the Company. The Company currently intends to use the proceeds of the offering, if any, for
      research and development, manufacturing and scale-up, as well as for working capital and general corporate purposes. The Company may also use a portion of the proceeds to license, acquire or invest in new programs or for drug development activities
      related to such programs; however, it has no current commitments to do so.</div>

    <div><br/>
    </div>

    <div style="text-align: left; text-indent: 24.5pt; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">The Sale Agreement contains customary representations, warranties and agreements by the Company, as well as indemnification obligations
      of the Company for certain liabilities under the Securities Act. Under the terms of the Sale Agreement, the Company will pay the Sales Agent a commission of up to 3.0% of the gross proceeds of Shares sold pursuant to the Sale Agreement. In addition,
      the Company has agreed to reimburse certain expenses incurred by the Sales Agent in connection with the offering. The Sale Agreement may be terminated by the Sales Agent or the Company at any time upon notice to the other party, as set forth in the
      Sale Agreement, or by the Sales Agent at any time in certain circumstances, including the occurrence of a material and adverse change in the Company&#8217;s business or financial condition that may materially impair the Sales Agent&#8217;s ability to sell the
      Shares.</div>

    <div><br/>
    </div>

    <div style="text-align: left; text-indent: 24.5pt; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">This Current Report on Form 8-K shall not constitute an offer to sell or a solicitation of an offer to buy any securities, nor shall
      there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or other jurisdiction.</div>

    <div><br/>
    </div>

    <div style="text-align: left; text-indent: 24.5pt; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Gibson, Dunn &amp; Crutcher LLP, counsel to the Company, has issued an opinion to the Company, dated November 27, 2024, regarding the
      validity of the Shares. A copy of the opinion is filed herewith as Exhibit 5.1.</div>

    <div><br/>
    </div>

    <div style="text-align: left; text-indent: 24.5pt; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">The description of the material terms of the Sale Agreement is not intended to be complete and is qualified in its entirety by reference
      to the Sale Agreement, which is filed herewith as Exhibit 1.1 and incorporated herein by reference.</div>

    <div style="text-align: left;"><span style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> </span><br/>
    </div>

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    <td style="width: 21.45%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Item 9.01</div>
          </td>

    <td style="width: 78.55%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Financial Statements and Exhibits</div>
          </td>

  </tr>


</table>
    <div> <br/>
    </div>

    <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">(d)<span style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-style: italic;"> Exhibits</span>.</div>

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        <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"/></div>

    </div>

    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;"><span style="text-decoration: underline;">EXHIBIT INDEX</span></div>

    <div><br/>
    </div>

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    <td style="width: 6.77%; vertical-align: bottom; white-space: nowrap;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">No.</div>
          </td>

    <td style="width: 0.06%; vertical-align: bottom;">&#160;</td>

    <td style="width: 93.16%; vertical-align: bottom; white-space: nowrap;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Description</div>
          </td>

  </tr>

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    <td style="width: 6.77%; vertical-align: middle;">&#160;</td>

    <td colspan="2" style="width: 93.23%; vertical-align: middle;">&#160;</td>

  </tr>

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    <td style="width: 6.77%; vertical-align: top; white-space: nowrap;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;"><a href="ny20036484x4_ex1-1.htm">1.1</a></div>
          </td>

    <td style="width: 0.06%; vertical-align: bottom;">&#160;</td>

    <td style="width: 93.16%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;"><span style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Open Market Sale Agreement</span><sup>SM</sup><span style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">, dated November 27, 2024, by and between Gyre Therapeutics, Inc. and Jefferies LLC.</span></div>
          </td>

  </tr>

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    <td style="width: 6.77%; vertical-align: middle;">&#160;</td>

    <td colspan="2" style="width: 93.23%; vertical-align: middle;">&#160;</td>

  </tr>

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    <td style="width: 6.77%; vertical-align: top; white-space: nowrap;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;"><a href="ny20036484x4_ex5-1.htm">5.1</a></div>
          </td>

    <td style="width: 0.06%; vertical-align: bottom;">&#160;</td>

    <td style="width: 93.16%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Opinion of Gibson, Dunn &amp; Crutcher LLP</div>
          </td>

  </tr>

  <tr>

    <td style="width: 6.77%; vertical-align: middle;">&#160;</td>

    <td colspan="2" style="width: 93.23%; vertical-align: middle;">&#160;</td>

  </tr>

  <tr>

    <td style="width: 6.77%; vertical-align: top; white-space: nowrap;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;"><a href="ny20036484x4_ex5-1.htm">23.1</a></div>
          </td>

    <td style="width: 0.06%; vertical-align: bottom;">&#160;</td>

    <td style="width: 93.16%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Consent of Gibson, Dunn &amp; Crutcher LLP (contained in Exhibit 5.1)</div>
          </td>

  </tr>

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    <td style="width: 6.77%; vertical-align: middle;">&#160;</td>

    <td colspan="2" style="width: 93.23%; vertical-align: middle;">&#160;</td>

  </tr>

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    <td style="width: 6.77%; vertical-align: top; white-space: nowrap;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">104</div>
          </td>

    <td style="width: 0.06%; vertical-align: bottom;">&#160;</td>

    <td style="width: 93.16%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Cover Page Interactive Data File (embedded within the Inline XBRL document).</div>
          </td>

  </tr>


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    </div>

    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">SIGNATURES</div>

    <div><br/>
    </div>

    <div style="text-align: justify; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the
      undersigned hereunto duly authorized.</div>

    <div><br/>
    </div>

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    <td colspan="2" style="vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">GYRE THERAPEUTICS, INC.</div>
          </td>

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    <td style="width: 50%; vertical-align: top;">&#160;</td>

    <td colspan="2" style="vertical-align: top;">&#160;</td>

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    <td style="width: 50%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Date: November 27, 2024</div>
          </td>

    <td style="width: 5%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">By:</div>
          </td>

    <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">/s/ Ruoyu Chen</div>
          </td>

  </tr>

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    <td style="width: 50%; vertical-align: top;">&#160;</td>

    <td style="width: 5%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Name:</div>
          </td>

    <td style="width: 45%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Ruoyu Chen</div>
          </td>

  </tr>

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    <td style="width: 50%; vertical-align: top;">&#160;</td>

    <td style="width: 5%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Title:</div>
          </td>

    <td style="width: 45%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">Chief Financial Officer</div>
          </td>

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<TYPE>EX-1.1
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<DESCRIPTION>EXHIBIT 1.1
<TEXT>
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      <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">Exhibit 1.1</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-weight: bold;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);"><u>OPEN MARKET SALE AGREEMENT</u><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">S</sup><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">M</sup></font></div>
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      <div style="text-align: right; color: rgb(0, 0, 0);">November 27, 2024</div>
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      <div style="margin-right: 72pt; color: rgb(0, 0, 0);">JEFFERIES LLC</div>
      <div style="margin-right: 72pt; color: rgb(0, 0, 0);">520 Madison Avenue</div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">New York, New York 10022</div>
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      <div style="text-align: justify; color: rgb(0, 0, 0);">Ladies and Gentlemen:</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; color: rgb(0, 0, 0);">Gyre Therapeutics, Inc., a Delaware corporation
          (the &#8220;</font><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold; color: rgb(0, 0, 0);">Company</font><font style="font-size: 10pt; font-family: 'Times New Roman'; color: rgb(0, 0, 0);">&#8221;), proposes, subject to the
          terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the &#8220;</font><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold; color: rgb(0, 0, 0);">Agent</font><font style="font-size: 10pt; font-family: 'Times New Roman'; color: rgb(0, 0, 0);">&#8221;), shares of the Company&#8217;s common stock, par value $0.001 per share (the &#8220;</font><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold; color: rgb(0, 0, 0);">Common Shares</font><font style="font-size: 10pt; font-family: 'Times New Roman'; color: rgb(0, 0, 0);">&#8221;), having an aggregate offering price of up to $50,000,000 on the terms set forth in this agreement (this &#8220;</font><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold; color: rgb(0, 0, 0);">Agreement</font><font style="font-size: 10pt; font-family: 'Times New Roman'; color: rgb(0, 0, 0);">&#8221;).</font></div>
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      <div style="font-weight: bold; color: rgb(0, 0, 0);">Section 1.&#160; DEFINITIONS</div>
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Agency Period</font>&#8221; means the period commencing on the date of this Agreement and expiring on the earliest to occur of (x)
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Commission</font>&#8221; means the U.S. Securities and Exchange Commission.</div>
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Exchange Act</font>&#8221; means the Securities Exchange Act of 1934, as amended, and the rules and regulations of the Commission
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Floor Price</font>&#8221; means the minimum price set by the Company in an Issuance Notice below which the Agent shall not sell
        Shares during the applicable period set forth in the applicable Issuance Notice, which may be adjusted by the Company at any time during the period set forth in the applicable Issuance Notice by delivering written notice of such change to the Agent
        and which in no event shall be less than $1.00 without the prior written consent of the Agent, which may be withheld in the Agent&#8217;s sole discretion.</div>
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      <div style="color: rgb(0, 0, 0);"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">SM</sup> &#8220;Open Market Sale Agreement&#8221; is a service mark of Jefferies LLC</div>
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Issuance Notice</font>&#8221; means a written notice delivered to the Agent by the Company in accordance with this Agreement in the
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Issuance Notice Date</font>&#8221; means any Trading Day during the Agency Period that an Issuance Notice is delivered pursuant to
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Issuance Price</font>&#8221; means the Sales Price less the Selling Commission.</div>
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Maximum Program Amount</font>&#8221; means Common Shares with an aggregate Sales Price of the lesser of (a) the number or dollar
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Person</font>&#8221; means an individual or a corporation, partnership, limited liability company, trust, incorporated or
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">PRC</font>&#8221; means the People&#8217;s Republic of China, which for purposes hereof excludes Hong Kong, Macao and Taiwan.</div>
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">PRC Entity</font>&#8221; means Beijing Continent Pharmaceuticals Co., Ltd, (d/b/a Gyre Pharmaceuticals), a company formed under the
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Principal Market</font>&#8221; means The Nasdaq Capital Market or such other national securities exchange on which the Common
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Sales Price</font>&#8221; means the actual sale execution price of each Share placed by the Agent pursuant to this Agreement.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Securities Act</font>&#8221; means the Securities Act of 1933, as amended, and the rules and regulations of the Commission
        thereunder.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">2</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Selling Commission</font>&#8221; means three percent (3.0%) of the gross proceeds of Shares sold pursuant to this Agreement, or as
        otherwise agreed between the Company and the Agent with respect to any Shares sold pursuant to this Agreement.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; color: rgb(0, 0, 0);">&#8220;</font><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold; color: rgb(0, 0, 0);">Settlement Date</font><font style="font-size: 10pt; font-family: 'Times New Roman'; color: rgb(0, 0, 0);">&#8221; means the first business day, or such other time period as required by the
          Exchange Act or by the rules promulgated thereunder, following each Trading Day during the period set forth in the applicable Issuance Notice pursuant to which Shares are sold pursuant to this Agreement, when the Company shall deliver to the
          Agent the amount of Shares sold on such Trading Day and the Agent shall deliver to the Company the Issuance Price received on such sales<u style="border-bottom: 1px solid;">.</u></font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Shares</font>&#8221; means the Common Shares issued or issuable pursuant to this Agreement.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">&#8220;<font style="font-weight: bold;">Trading Day</font>&#8221; means any day on which the Principal Market is open for trading.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.&#160; REPRESENTATIONS AND WARRANTIES OF THE COMPANY</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">The Company represents and warrants to, and agrees with, the Agent that, unless such representation, warranty or agreement specifies otherwise, as of (1) the
        date of this Agreement, (2) each Issuance Notice Date, (3) each Settlement Date, (4) each Triggering Event Date (as defined below) with respect to which the Company is required to deliver a certificate pursuant to Section 4(o) and (5) each Time of
        Sale (each of the times referenced above is referred to herein as a &#8220;<font style="font-weight: bold;">Representation Date</font>&#8221;), except as may be disclosed in the Prospectus (including any documents incorporated by reference therein and any
        supplements thereto) on or before a Representation Date:</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)&#160;&#160;&#160;&#160; &#160; &#160; &#160; <u>Registration Statement</u>.&#160; The Company has prepared and filed with the Commission a shelf registration statement on Form S-3
          (File No. 333-283237) that contains a base prospectus.&#160; Such registration statement registers the issuance and sale by the Company of the Shares under the Securities Act.&#160; The Company may file one or more additional registration statements from
          time to time that will contain a base prospectus and related prospectus or prospectus supplement, if applicable, with respect to the Shares, including a Rule 462(b) Registration Statement.&#160; Except where the context otherwise requires, such
          registration statement(s), including any information deemed to be a part thereof pursuant to Rule 430B under the Securities Act, including all financial statements, exhibits and schedules thereto and all documents incorporated or deemed to be
          incorporated therein by reference pursuant to Item 12 of Form S-3 under the Securities Act as from time to time amended or supplemented, is herein referred to as the &#8220;<font style="font-weight: bold;">Registration Statement</font>,&#8221; and the
          prospectus constituting a part of such registration statement(s), together with any prospectus supplement filed with the Commission pursuant to Rule 424(b) under the Securities Act relating to a particular issuance of the Shares, including all
          documents incorporated or deemed to be incorporated therein by reference pursuant to Item 12 of Form S-3 under the Securities Act, in each case, as from time to time amended or supplemented, is referred to herein as the &#8220;<font style="font-weight: bold;">Prospectus</font>,&#8221; except that if any revised prospectus is provided to the Agent by the Company for use in connection with the offering of the Shares that is not required to be filed by the Company pursuant to Rule 424(b) under the
          Securities Act, the term &#8220;<font style="font-weight: bold;">Prospectus</font>&#8221; shall refer to such revised prospectus from and after the time it is first provided to the Agent for such use.&#160; The Registration Statement at the time it originally
          became effective is herein called the &#8220;<font style="font-weight: bold;">Original Registration Statement</font>.&#8221;&#160; As used in this Agreement, the terms &#8220;amendment&#8221; or &#8220;supplement&#8221; when applied to the Registration Statement or the Prospectus shall
          be deemed to include the filing by the Company with the Commission of any document under the Exchange Act after the date hereof that is or is deemed to be incorporated therein by reference.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">3</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">All references in this Agreement to financial statements and schedules and other information which is &#8220;contained,&#8221; &#8220;included&#8221; or &#8220;stated&#8221; in the Registration
        Statement or the Prospectus (and all other references of like import) shall be deemed to mean and include all such financial statements and schedules and other information which is or is deemed to be incorporated by reference in or otherwise deemed
        under the Securities Act to be a part of or included in the Registration Statement or the Prospectus, as the case may be, as of any specified date; and all references in this Agreement to amendments or supplements to the Registration Statement or
        the Prospectus shall be deemed to mean and include, without limitation, the filing of any document under the Exchange Act which is or is deemed to be incorporated by reference in or otherwise deemed under the Securities Act to be a part of or
        included in the Registration Statement or the Prospectus, as the case may be, as of any specified date. The Company&#8217;s obligations under this Agreement to furnish, provide, deliver or make available (and all other similar references) copies of any
        report or statement shall be deemed satisfied if the same is filed in unredacted form with the Commission through its Electronic Data Gathering, Analysis and Retrieval system (&#8220;<font style="font-weight: bold;">EDGAR</font>&#8221;).</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">At the time the Original Registration Statement was or will be declared effective and at the time the Company&#8217;s most recent annual report on Form 10-K was
        filed with the Commission, if later, the Company met the then-applicable requirements for use of Form S-3 under the Securities Act.&#160; During the Agency Period, each time the Company files an annual report on Form 10-K the Company will meet the
        then-applicable requirements for use of Form S-3 under the Securities Act.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(b)&#160;&#160;&#160; &#160; &#160;&#160;&#160; <u>Compliance with Registration Requirements</u>.&#160; The Original Registration Statement and any Rule 462(b) Registration Statement
          have been or will be declared effective by the Commission under the Securities Act.&#160; The Company has complied or will comply to the Commission&#8217;s satisfaction with all requests of the Commission for additional or supplemental information.&#160; No stop
          order suspending the effectiveness of the Original Registration Statement or any Rule 462(b) Registration Statement is in effect and no proceedings for such purpose have been instituted or are pending or, to the knowledge of the Company, are
          contemplated or threatened by the Commission.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">The Prospectus when filed complied or will comply in all material respects with the Securities Act and, if filed with the Commission through EDGAR (except as
        may be permitted by Regulation S&#8209;T under the Securities Act), was identical to the copy thereof delivered to the Agent for use in connection with the issuance and sale of the Shares.&#160; Each of the Registration Statement, any Rule 462(b) Registration
        Statement and any post-effective amendment thereto, at the time it became or becomes effective and at each Representation Date, complied and will comply in all material respects with the Securities Act and did not and will not contain any untrue
        statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading.&#160; As of the date of this Agreement, the Prospectus and any Free Writing Prospectus (as defined
        below) considered together (collectively, the &#8220;<font style="font-weight: bold;">Time of Sale Information</font>&#8221;) did not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements therein, in
        the light of the circumstances under which they were made, not misleading.&#160; The Prospectus, as amended or supplemented, as of its date and as of each Representation Date, did not and will not contain any untrue statement of a material fact or omit
        to state a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading.&#160; The representations and warranties set forth in the three immediately preceding sentences do
        not apply to statements in or omissions from the Registration Statement, any Rule 462(b) Registration Statement, or any post-effective amendment thereto, or the Prospectus, or any amendments or supplements thereto, made in reliance upon and in
        conformity with information relating to the Agent furnished to the Company in writing by the Agent expressly for use therein, it being understood and agreed that the only such information furnished by the Agent to the Company consists of the
        information described in <u>Section 6</u> below.&#160; There are no contracts or other documents required to be described in the Prospectus or to be filed as exhibits to the Registration Statement which have not been described or filed as required.&#160;
        The Registration Statement and the offer and sale of the Shares as contemplated hereby meet the requirements of Rule 415 under the Securities Act and comply in all material respects with said rule.</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);"> <br>
         </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">4</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)&#160;&#160;&#160;&#160; &#160;&#160; &#160; <u>Ineligible Issuer Status</u>.&#160; The Company is not an &#8220;ineligible issuer&#8221; in connection with the offering of the Shares pursuant
          to Rules 164, 405 and 433 under the Securities Act.&#160; Any Free Writing Prospectus that the Company is required to file pursuant to Rule 433(d) under the Securities Act has been, or will be, filed with the Commission in accordance with the
          requirements of the Securities Act.&#160; Each Free Writing Prospectus that the Company has filed, or is required to file, pursuant to Rule 433(d) under the Securities Act or that was prepared by or on behalf of or used or referred to by the Company
          complies or will comply in all material respects with the requirements of Rule 433 under the Securities Act, including timely filing with the Commission or retention where required and legending, and each such Free Writing Prospectus, as of its
          issue date and at each Representation Date through the completion of the issuance and sale of the Shares did not, does not and will not include any information that conflicted, conflicts with or will conflict with the information contained in the
          Registration Statement or the Prospectus, including any document incorporated by reference therein.&#160; Except for the Free Writing Prospectuses, if any, and electronic road shows, if any, furnished to the Agent before first use, the Company has not
          prepared, used or referred to, and will not, without the Agent&#8217;s prior consent, prepare, use or refer to, any Free Writing Prospectus.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(d)&#160;&#160; &#160; &#160;&#160; &#160;&#160; <u>Incorporated Documents</u>.&#160; The documents incorporated or deemed to be incorporated by reference in the Registration Statement
          and the Prospectus, at the time they were filed with the Commission, complied in all material respects with the requirements of the Exchange Act, as applicable, and, when read together with the other information in the Prospectus, do not contain
          an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(e)&#160;&#160;&#160;&#160; &#160;&#160; &#160; <u>Exchange Act Compliance</u>.&#160; The documents incorporated or deemed to be incorporated by reference in the Prospectus, at the
          time they were or hereafter are filed with the Commission, and any Free Writing Prospectus or amendment or supplement thereto complied and will comply in all material respects with the requirements of the Exchange Act, and, when read together
          with the other information in the Prospectus, at the time the Registration Statement and any amendments thereto become effective and at each Time of Sale (as defined below), as the case may be, will not contain an untrue statement of a material
          fact or omit to state a material fact required to be stated therein or necessary to make the fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they were made, not
          misleading.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">5</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(f)&#160;&#160;&#160; &#160; &#160;&#160;&#160; <u>Statistical and Market-Related Data</u>.&#160; All statistical, demographic and market&#8209;related data included in the Registration
          Statement or the Prospectus are based on or derived from sources that the Company reasonably believes to be reliable and accurate.&#160; To the extent required, the Company has obtained the written consent for the use of such data from such sources.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(g)&#160;&#160;&#160; &#160; &#160;&#160; <u>Disclosure Controls and Procedures; Deficiencies in or Changes to Internal Control Over Financial Reporting</u>.&#160; The Company has
          established and maintains disclosure controls and procedures (as defined in Rules 13a-15 and 15d-15 under the Exchange Act), which (i) are designed to ensure that material information relating to the Company, including its consolidated
          subsidiaries, is made known to the Company&#8217;s principal executive officer and its principal financial officer by others within those entities, particularly during the periods in which the periodic reports required under the Exchange Act are being
          prepared; (ii) have been evaluated by management of the Company for effectiveness as of the end of the Company&#8217;s most recent fiscal quarter; and (iii) are effective in all material respects to perform the functions for which they were
          established.&#160; Since the end of the Company&#8217;s most recent audited fiscal year, there have been no significant deficiencies or material weaknesses in the Company&#8217;s internal control over financial reporting (whether or not remediated) and no change
          in the Company&#8217;s internal control over financial reporting that has materially affected, or is reasonably likely to materially affect, the Company&#8217;s internal control over financial reporting.&#160; The Company is not aware of any change in its
          internal control over financial reporting that has occurred during its most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the Company&#8217;s internal control over financial reporting.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(h)&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>This Agreement</u>.&#160; This Agreement has been duly authorized, executed and delivered by the Company.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(i)&#160;&#160; &#160; &#160; &#160;&#160; <u>Authorization of the Shares</u>.&#160; The Shares have been duly authorized for issuance and sale pursuant to this Agreement and,
          when issued and delivered by the Company against payment therefor pursuant to this Agreement, will be validly issued, fully paid and nonassessable, and the issuance and sale of the Shares is not subject to any preemptive rights, rights of first
          refusal or other similar rights to subscribe for or purchase the Shares.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(j)&#160; &#160;&#160;&#160; &#160;&#160;&#160; <u>No Applicable Registration or Other Similar Rights</u>.&#160; There are no persons with registration or other similar rights to have
          any equity or debt securities registered for sale under the Registration Statement or included in the offering contemplated by this Agreement, except for such rights as have been duly waived.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">6</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(k)&#160;&#160; &#160;&#160; &#160;&#160; <u>No Material Adverse Change</u>.&#160; Except as otherwise disclosed in the Registration Statement and the Prospectus, subsequent to
          the respective dates as of which information is given in the Registration Statement and the Prospectus: (i) there has been no material adverse change, or any development that would reasonably be expected to result in a material adverse change, in
          (A) the condition, financial or otherwise, or in the earnings, business, properties, operations, operating results, assets, liabilities or prospects, whether or not arising from transactions in the ordinary course of business, of the Company and
          its subsidiaries, considered as one entity or (B) the ability of the Company to consummate the transactions contemplated by this Agreement or perform its obligations hereunder (any such change being referred to herein as a &#8220;<font style="font-weight: bold;">Material Adverse Change</font>&#8221;); (ii) the Company and its subsidiaries, considered as one entity, have not incurred any material liability or obligation, indirect, direct or contingent, including without limitation
          any losses or interference with their business from fire, explosion, flood, earthquakes, accident or other calamity, whether or not covered by insurance, or from any strike, labor dispute or court or governmental action, order or decree, that are
          material, individually or in the aggregate, to the Company and its subsidiaries, considered as one entity, and have not entered into any transactions not in the ordinary course of business; and (iii) there has not been any material decrease in
          the capital stock of the Company or its subsidiaries or any material increase in any short-term or long-term indebtedness of the Company and its subsidiaries, considered as one entity, and there has been no dividend or distribution of any kind
          declared, paid or made by the Company or, except for dividends paid to the Company or other subsidiaries, by any of the Company&#8217;s subsidiaries on any class of capital stock, or any repurchase or redemption by the Company or any of its
          subsidiaries of any class of capital stock.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(l)&#160;&#160; &#160; &#160; &#160; &#160; <u>Independent Accountants</u>.&#160; Grant Thornton Zhitong Certified Public Accountants LLP, which has expressed its opinion with
          respect to the financial statements (which term as used in this Agreement includes the related notes thereto) filed with the Commission as a part of the Registration Statement and the Prospectus, is (i) an independent registered public accounting
          firm as required by the Securities Act, the Exchange Act and the rules of the Public Company Accounting Oversight Board (&#8220;<font style="font-weight: bold;">PCAOB</font>&#8221;), (ii) in compliance with the applicable requirements relating to the
          qualification of accountants under Rule 2-01 of Regulation S-X under the Securities Act and (iii) a registered public accounting firm as defined by the PCAOB whose registration has not been suspended or revoked and who has not requested such
          registration to be withdrawn.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(m)&#160; &#160; &#160; &#160;&#160; <u>Financial Statements</u>.&#160; The financial statements filed with the Commission as a part of the Registration Statement and the
          Prospectus present fairly, in all material respects, the consolidated financial position of the Company and its subsidiaries as of the dates indicated and the results of their operations, changes in stockholders&#8217; equity and cash flows for the
          periods specified.&#160; Such financial statements have been prepared in conformity with generally accepted accounting principles in the United States (&#8220;<font style="font-weight: bold;">GAAP</font>&#8221;) applied on a consistent basis throughout the
          periods involved, except as may be expressly stated in the related notes thereto and except in the case of unaudited financial statements, which are subject to normal and recurring year-end adjustments and do not contain all footnotes as
          permitted by the applicable rules of the Commission.&#160; The interactive data in eXtensible Business Reporting Language included or incorporated by reference in the Registration Statement fairly presents the information called for in all material
          respects and has been prepared in accordance with the Commission&#8217;s rules and guidelines applicable thereto.&#160; No other financial statements or supporting schedules are required to be included in the Registration Statement or the Prospectus.&#160; The
          financial data set forth in each of the Registration Statement and the Prospectus fairly present, in all material respects, the information set forth therein on a basis consistent with that of the audited financial statements contained in the
          Registration Statement and the Prospectus.&#160; To the Company&#8217;s knowledge, no person who has been suspended or barred from being associated with a registered public accounting firm, or who has failed to comply with any sanction pursuant to Rule 5300
          promulgated by the PCAOB, has participated in or otherwise aided the preparation of, or audited, the financial statements, supporting schedules or other financial data filed with the Commission as a part of the Registration Statement and the
          Prospectus.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">7</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(n)&#160;&#160;&#160;&#160; &#160; &#160;&#160; <u>Company&#8217;s Accounting System</u>.&#160; The Company and each of its subsidiaries make and keep books and records that are accurate in
          all material respects and maintain a system of internal accounting controls sufficient to provide reasonable assurance that:&#160; (i) transactions are executed in accordance with management&#8217;s general or specific authorization; (ii) transactions are
          recorded as necessary to permit preparation of financial statements in conformity with GAAP and to maintain accountability for assets; (iii) access to assets is permitted only in accordance with management&#8217;s general or specific authorization;
          (iv) the recorded accountability for assets is compared with existing assets at reasonable intervals and appropriate action is taken with respect to any differences; and (v) the interactive data in eXtensible Business Reporting Language included
          or incorporated by reference in the Registration Statement and the Prospectus fairly presents the information called for in all material respects and is prepared in accordance with the Commission&#8217;s rules and guidelines applicable thereto.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160; <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(o)&#160;&#160;&#160; &#160; &#160;&#160; <u>Incorporation and Good Standing of the Company</u><font style="font-style: italic;">.</font>&#160; The Company has been duly
          incorporated and is validly existing as a corporation in good standing under the laws of the jurisdiction of its incorporation and has the corporate power and authority to own, lease and operate its properties and to conduct its business as
          described in the Registration Statement and the Prospectus and to enter into and perform its obligations under this Agreement.&#160; The Company is duly qualified as a foreign corporation to transact business and is in good standing in the State of
          California and each other jurisdiction in which such qualification is required, whether by reason of the ownership or leasing of property or the conduct of business, except where the failure to be so qualified or in good standing would not,
          individually or in the aggregate, reasonably be expected to result in a Material Adverse Change.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(p)&#160;&#160;&#160; &#160; &#160;&#160; <u>Subsidiaries.</u>&#160; Each of the Company&#8217;s &#8220;subsidiaries&#8221; (for purposes of this Agreement, as defined in Rule 405 under the
          Securities Act) has been duly incorporated or organized, as the case may be, and is validly existing as a corporation, partnership or limited liability company, as applicable, in good standing (or such equivalent concept to the extent it exists
          under the law of such jurisdiction) under the laws of the jurisdiction of its incorporation or organization and has the power and authority (corporate or other) to own, lease and operate its properties and to conduct its business as described in
          the Registration Statement and the Prospectus.&#160; Each of the Company&#8217;s subsidiaries is duly qualified as a non-U.S. corporation, partnership or limited liability company, as applicable, to transact business and is in good standing (or such
          equivalent concept to the extent it exists under the law of such jurisdiction) in each jurisdiction in which such qualification is required, whether by reason of the ownership or leasing of property or the conduct of business, except where the
          failure to be so qualified or in good standing would not, individually or in the aggregate, reasonably be expected to result in a Material Adverse Change.&#160; All of the issued and outstanding capital stock or other equity or ownership interests of
          each of the Company&#8217;s subsidiaries have been duly authorized and validly issued, are fully paid and nonassessable and are either wholly- or majority-owned by the Company, directly or through subsidiaries, free and clear of any security interest,
          mortgage, pledge, lien, encumbrance or adverse claim.&#160; None of the outstanding capital stock or equity interest in any subsidiary was issued in violation of preemptive or similar rights of any security holder of such subsidiary.&#160; The constitutive
          or organizational documents of each of the subsidiaries comply in all material respects with the requirements of applicable laws of its jurisdiction of incorporation or organization and are in full force and effect.&#160; The Company does not own or
          control, directly or indirectly, any corporation, association or other entity other than the subsidiaries listed in Exhibit 21 to the Company&#8217;s Annual Report on Form 10&#8209;K for the fiscal year ended December 31, 2023.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
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        <div class="BRPFPageBreak" style="page-break-after: always;">
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(q)&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>Capitalization and Other Capital Stock Matters</u>.&#160; The authorized, issued and outstanding capital stock of the Company is as
          set forth in the Registration Statement and the Prospectus under the caption &#8220;Capitalization&#8221; (other than for subsequent issuances, if any, pursuant to employee benefit plans described in the Prospectus or upon the exercise of outstanding options
          or warrants, in each case described in the Registration Statement and the Prospectus).&#160; The Common Shares (including the Shares) conform in all material respects to the description thereof contained in the Prospectus.&#160; All of the issued and
          outstanding Common Shares have been duly authorized and validly issued, are fully paid and nonassessable and have been issued in compliance with all federal and state securities laws.&#160; None of the outstanding Common Shares was issued in violation
          of any preemptive rights, rights of first refusal or other similar rights to subscribe for or purchase securities of the Company.&#160; There are no authorized or outstanding options, warrants, preemptive rights, rights of first refusal or other
          rights to purchase, or equity or debt securities convertible into or exchangeable or exercisable for, any capital stock of the Company or any of its subsidiaries other than those described in the Registration Statement and the Prospectus.&#160; The
          descriptions of the Company&#8217;s stock option, stock bonus and other stock plans or arrangements, and the options or other rights granted thereunder, set forth in the Registration Statement and the Prospectus accurately and fairly presents the
          information required to be shown with respect to such plans, arrangements, options and rights.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(r)&#160;&#160; &#160;&#160; &#160;&#160;&#160;&#160; <u>Stock Exchange Listing</u>.&#160; The Common Shares are registered pursuant to Section 12(b) or 12(g) of the Exchange Act and are
          listed on the Principal Market, and the Company has taken no action designed to, or likely to have the effect of, terminating the registration of the Common Shares under the Exchange Act or delisting the Common Shares from the Principal Market,
          nor has the Company received any notification that the Commission or the Principal Market is contemplating terminating such registration or listing.&#160; To the Company&#8217;s knowledge, it is in compliance with all applicable listing requirements of the
          Principal Market.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">9</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(s)&#160;&#160;&#160; &#160; &#160;&#160;&#160;&#160; <u>Non-Contravention of Existing Instruments; No Further Authorizations or Approvals Required</u>.&#160; Neither the Company nor any of
          its subsidiaries is in violation of its charter or by&#8209;laws, partnership agreement or operating agreement or similar organizational documents, as applicable, or is in default (or, with the giving of notice or lapse of time, would be in default) (&#8220;<font style="font-weight: bold;">Default</font>&#8221;) under any indenture, loan, credit agreement, note, lease, license agreement, contract, franchise or other instrument (including, without limitation, any pledge agreement, security agreement, mortgage
          or other instrument or agreement evidencing, guaranteeing, securing or relating to indebtedness) to which the Company or any of its subsidiaries is a party or by which it or any of them may be bound, or to which any of their respective properties
          or assets are subject (each, an &#8220;<font style="font-weight: bold;">Existing Instrument</font>&#8221;), except for such Defaults as would not reasonably be expected, individually or in the aggregate, to result in a Material Adverse Change.&#160; The Company&#8217;s
          execution, delivery and performance of this Agreement, consummation of the transactions contemplated hereby and by the Registration Statement and the Prospectus and the issuance and sale of the Shares (including the use of proceeds from the sale
          of the Shares as described in the Registration Statement and the Prospectus under the caption &#8220;Use of Proceeds&#8221;) (i) have been duly authorized by all necessary corporate action and will not result in any violation of the provisions of the charter
          or by&#8209;laws, partnership agreement or operating agreement or similar organizational documents, as applicable, of the Company or any subsidiary (ii) will not conflict with or constitute a breach of, or Default or a Debt Repayment Triggering Event
          (as defined below) under, or result in the creation or imposition of any lien, charge or encumbrance upon any property or assets of the Company or any of its subsidiaries pursuant to, or require the consent of any other party to, any Existing
          Instrument and (iii) will not result in any violation of any law, administrative regulation or administrative or court decree applicable to the Company or any of its subsidiaries, except in the cases of clauses (ii) and (iii) as would not
          reasonably be expected, individually or in the aggregate, to result in a Material Adverse Change.&#160; No consent, approval, authorization or other order of, or registration or filing with, any court or other governmental or regulatory authority or
          agency, is required for the Company&#8217;s execution, delivery and performance of this Agreement and consummation of the transactions contemplated hereby and by the Registration Statement and the Prospectus, except such as have been obtained or made
          by the Company and are in full force and effect under the Securities Act and such as may be required under applicable state securities or blue sky laws or FINRA (as defined below).&#160; As used herein, a &#8220;<font style="font-weight: bold;">Debt
            Repayment Triggering Event</font>&#8221; means any event or condition which gives, or with the giving of notice or lapse of time would give, the holder of any note, debenture or other evidence of indebtedness (or any person acting on such holder&#8217;s
          behalf) the right to require the repurchase, redemption or repayment of all or a portion of such indebtedness by the Company or any of its subsidiaries.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(t)&#160;&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>No Material Actions or Proceedings</u>.&#160; Except as otherwise disclosed in the Prospectus, there is no action, suit, proceeding,
          inquiry or investigation brought by or before any legal or governmental entity now pending or, to the knowledge of the Company, threatened, against or affecting the Company or any of its subsidiaries, which would reasonably be expected,
          individually or in the aggregate, to result in a Material Adverse Change.&#160; No material labor dispute with the employees of the Company or any of its subsidiaries, or with the employees of any principal supplier, manufacturer, customer or
          contractor of the Company, exists or, to the knowledge of the Company, is threatened or imminent.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">10</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(u)&#160;&#160;&#160;&#160; &#160;&#160;&#160; <u>Intellectual Property Rights</u>.&#160; Except as otherwise disclosed in the Registration Statement or the Prospectus, the Company and
          its subsidiaries own, or have obtained valid and enforceable licenses for, the inventions, patent applications, patents, trademarks, trade names, service names, copyrights, trade secrets and other intellectual property described in the
          Registration Statement and the Prospectus as being owned or licensed by them and which are necessary for the conduct of their respective businesses as currently conducted or as currently proposed to be conducted (collectively, &#8220;<font style="font-weight: bold;">Intellectual Property</font>&#8221;) and, to the Company&#8217;s knowledge, the conduct of their respective businesses does not and will not infringe, misappropriate or otherwise conflict in any material respect with any such
          rights of others.&#160; The Intellectual Property has not been adjudged by a court of competent jurisdiction to be invalid or unenforceable, in whole or in part, and, except as would not reasonably be expected, individually or in the aggregate, result
          in a Material Adverse Change, the Company is unaware of any facts which would form a reasonable basis for any such adjudication.&#160; To the Company&#8217;s knowledge: (i) there are no third parties who have rights to any Intellectual Property, except for
          customary reversionary rights of third-party licensors with respect to Intellectual Property that is disclosed in the Registration Statement and the Prospectus as licensed to the Company or one or more of its subsidiaries; and (ii) there is no
          infringement by third parties of any Intellectual Property.&#160; Except as otherwise disclosed in the Registration Statement or Prospectus and any related claims, assertions or challenges, there is no pending or, to the Company&#8217;s knowledge,
          threatened action, suit, proceeding or claim by others: (A) challenging the Company&#8217;s rights in or to any Intellectual Property, and the Company is unaware of any facts which would form a reasonable basis for any such action, suit, proceeding or
          claim; (B) challenging the validity, enforceability or scope of any Intellectual Property, and, except as would not reasonably be expected, individually or in the aggregate, result in a Material Adverse Change, the Company is unaware of any facts
          which would form a reasonable basis for any such action, suit, proceeding or claim; or (C) asserting that the Company or any of its subsidiaries infringes or otherwise violates, or would, upon the commercialization of any product or service
          described in the Registration Statement or the Prospectus as under development, infringe or violate, any patent, trademark, trade name, service name, copyright, trade secret or other proprietary rights of others, and, except as would not
          reasonably be expected, individually or in the aggregate, to result in a Material Adverse Change, the Company is unaware of any facts which would form a reasonable basis for any such action, suit, proceeding or claim.&#160; The Company and its
          subsidiaries have complied with the terms of each agreement pursuant to which Intellectual Property has been licensed to the Company or any subsidiary, except for any non-compliance which would not reasonably be expected, individually or in the
          aggregate, to result in a Material Adverse Change, and all such agreements are in full force and effect.&#160; To the Company&#8217;s knowledge, there are no material defects in any of the patents or patent applications included in the Intellectual
          Property.&#160; The Company and its subsidiaries have taken all reasonable steps to protect, maintain and safeguard their Intellectual Property, including the execution of appropriate nondisclosure, confidentiality agreements and invention assignment
          agreements and invention assignments with their employees, and, to the Company&#8217;s knowledge, no employee of the Company is in or has been in violation of any term of any employment contract, patent disclosure agreement, invention assignment
          agreement, non-competition agreement, non-solicitation agreement, nondisclosure agreement, or any restrictive covenant to or with a former employer where the basis of such violation relates to such employee&#8217;s employment with the Company.&#160; The
          duty of candor and good faith as required by the United States Patent and Trademark Office during the prosecution of the United States patents and patent applications included in the Intellectual Property have been complied with and in all
          non-U.S. offices having similar requirements, all such requirements have been complied with.&#160; None of the Company owned Intellectual Property or technology (including information technology and outsourced arrangements) employed by the Company or
          its subsidiaries has been obtained or is being used by the Company or its subsidiary in violation of any contractual obligation binding on the Company or its subsidiaries or any of their respective officers, directors or employees or otherwise in
          violation of the rights of any persons.&#160; The product candidates described in the Registration Statement and the Prospectus as under development by the Company or any subsidiary fall within the scope of the claims of one or more patents owned by,
          or exclusively licensed to, the Company or any subsidiary.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(v)&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>All Necessary Permits, etc</u>.&#160; Except as otherwise disclosed in the Prospectus, the Company and each subsidiary possess such
          valid and current certificates, authorizations or permits required by state, U.S. federal or non-U.S. regulatory agencies or bodies to conduct their respective businesses as currently conducted and as described in the Registration Statement or
          the Prospectus (&#8220;<font style="font-weight: bold;">Permits</font>&#8221;), except where the failure to so possess such Permits would not reasonably be expected, individually or in the aggregate, to result in a Material Adverse Change.&#160; Neither the
          Company nor any of its subsidiaries is in violation of, or in default under, any of the Permits or has received any notice of proceedings relating to the revocation or modification of, or non&#8209;compliance with, any such certificate, authorization
          or permit, except as would not reasonably be expected, individually or in the aggregate, to result in a Material Adverse Change.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">11</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(w)&#160;&#160; &#160; &#160; &#160; <u>Title to Properties</u>.&#160; Except as otherwise disclosed in the Registration Statement or Prospectus, the Company and its
          subsidiaries have good and marketable title to all of the real and personal property and other assets reflected as owned in the financial statements referred to in <u>Section 2(m)</u>&#160; above (or elsewhere in the Registration Statement or the
          Prospectus), in each case free and clear of any security interests, mortgages, liens, encumbrances, equities, adverse claims and other defects, except where the failure to possess such title would not reasonably be expected, individually or in
          the aggregate, to result in a Material Adverse Change.&#160; The real property, improvements, equipment and personal property held under lease by the Company or any of its subsidiaries are held under valid and enforceable leases, with such exceptions
          as are not material and do not materially interfere with the use made or proposed to be made of such real property, improvements, equipment or personal property by the Company or such subsidiary.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(x)&#160;&#160;&#160; &#160;&#160; &#160; <u>No Rights of Immunity</u>. Except as provided by laws or statutes generally applicable to transactions of the type described in
          this Agreement, none of the Company&#8217;s PRC or Hong Kong subsidiaries or any of their respective properties, assets or revenues has any right of immunity under PRC law, Hong Kong law, New York law or United States law, from any legal action, suit
          or proceeding, from the giving of any relief in any such legal action, suit or proceeding, from set-off or counterclaim, from the jurisdiction of any PRC, Hong Kong, New York state or United States federal court, from service of process,
          attachment upon or prior judgment, or attachment in aid of execution of judgment, or from execution of a judgment, or other legal process or proceeding for the giving of any relief or for the enforcement of a judgment, in any such court, with
          respect to its obligations, liabilities or any other matter under or arising out of or in connection with this Agreement. To the extent that the Company or any subsidiaries or any of their respective properties, assets or revenues may have or may
          hereafter become entitled to any such right of immunity in any such court in which proceedings may at any time be commenced, the Company and each of the subsidiaries waives or will waive such right to the extent permitted by law and has consented
          to such relief and enforcement as provided in <u>Section 8(h)</u> of this Agreement.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(y)&#160;&#160; &#160; &#160;&#160; <u>Tax Law Compliance</u>.&#160; The Company and its subsidiaries have filed all necessary U.S. federal, state and non-U.S. income and
          franchise tax returns or have properly requested extensions thereof and have paid all taxes required to be paid by any of them and, if due and payable, any related or similar assessment, fine or penalty levied against any of them except as may be
          being contested in good faith and by appropriate proceedings and except where the failure to file or pay would not reasonably be expected, individually or in the aggregate, to result in a Material Adverse Change.&#160; The Company has made adequate
          charges, accruals and reserves in the applicable financial statements referred to in <u>Section 2(m)</u> above in respect of all U.S. federal, state and non-U.S. income and franchise taxes for all periods as to which the tax liability of the
          Company or any of its subsidiaries has not been finally determined.&#160; All material local and national PRC and Hong Kong governmental tax holidays, exemptions, waivers, financial subsidies, and other local and national PRC and Hong Kong tax relief,
          concessions and preferential treatment enjoyed by the Company, the PRC Entity or its Hong Kong subsidiary as described in the Registration Statement and the Prospectus are valid, binding and enforceable and do not violate any laws, regulations,
          rules, orders, decrees, guidelines, judicial interpretations, notices or other legislation of the PRC or Hong Kong.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">12</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(z)&#160;&#160; &#160; &#160;&#160; &#160; <u>Company Not an &#8220;Investment Company.&#8221;</u>&#160; The Company is not, and will not be, either after receipt of payment for the Shares or
          after the application of the proceeds therefrom as described under &#8220;Use of Proceeds&#8221; in the Registration Statement or the Prospectus, required to register as an &#8220;investment company&#8221; under the Investment Company Act of 1940, as amended (the <font style="font-weight: bold;">&#8220;Investment Company Act&#8221;)</font>.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(aa)&#160; &#160;&#160; &#160;&#160; <u>Insurance</u>.&#160; Except as otherwise disclosed in the Prospectus, each of the Company and its subsidiaries are insured by
          recognized, financially sound and reputable institutions with policies in such amounts and with such deductibles and covering such risks as are generally deemed adequate and customary for their businesses including, but not limited to, policies
          covering material real and personal property owned or leased by the Company and its subsidiaries against theft, damage, destruction, acts of vandalism and earthquakes and policies covering the Company and its subsidiaries for product liability
          claims and clinical trial liability claims.&#160; The Company has no reason to believe that it or any of its subsidiaries will not be able (i) to renew its existing insurance coverage as and when such policies expire or (ii) to obtain comparable
          coverage from similar institutions as may be necessary or appropriate to conduct its business as now conducted and at a cost that would not reasonably be expected to result in a Material Adverse Change.&#160; Neither the Company nor any of its
          subsidiaries has been denied any insurance coverage which it has sought or for which it has applied.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(bb) &#160; &#160; &#160;&#160;&#160; <u>No Price Stabilization or Manipulation; Compliance with Regulation M</u>.&#160; Neither the Company nor any of its subsidiaries has
          taken, directly or indirectly, any action designed to or that, without giving effect to activities by the Agent that were not consented to or directed by the Company, would reasonably be expected to cause or result in stabilization or
          manipulation of the price of the Common Shares or of any &#8220;reference security&#8221; (as defined in Rule 100 of Regulation M under the Exchange Act (<font style="font-weight: bold;">&#8220;Regulation M&#8221;</font>)) with respect to the Common Shares, whether to
          facilitate the sale or resale of the Shares or otherwise, and has taken no action which, without giving effect to activities by the Agent that were not consented to or directed by the Company, would directly or indirectly violate Regulation M.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160; <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(cc)&#160;&#160; &#160;&#160; &#160; <u>Related Party Transactions</u>.&#160; There are no business relationships or related-party transactions involving the Company or any
          of its subsidiaries or any other person required to be described in the Registration Statement or the Prospectus which have not been described as required.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(dd)&#160; &#160;&#160; &#160;&#160; <u>FINRA Matters</u>.&#160; All of the information provided to the Agent or to counsel for the Agent by the Company, its counsel, its
          officers and directors and, to the Company&#8217;s knowledge, the holders of any securities (debt or equity) or options to acquire any securities of the Company in connection with the offering of the Shares is true, complete, correct and compliant in
          all material respects with Financial Industry Regulatory Authority, Inc.&#8217;s (&#8220;<font style="font-weight: bold;">FINRA</font>&#8221;) rules and any letters, filings or other supplemental information provided to FINRA pursuant to FINRA Rules or NASD
          Conduct Rules is true, complete and correct in all material respects.&#160; The Company meets the definition of the term &#8220;experienced issuer&#8221; specified in FINRA Rule 5110(j)(6).</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(ee)&#160;&#160;&#160; &#160;&#160; &#160; <u>No Unlawful Contributions or Other Payments</u>.&#160; Except as otherwise disclosed in the Prospectus, neither the Company nor any
          of its subsidiaries nor, to the Company&#8217;s knowledge, any employee or agent of the Company or any subsidiary, has made any contribution or other payment to any official of, or candidate for, any U.S. federal, state or non-U.S. office in violation
          of any law or of the character required to be disclosed in the Registration Statement and the Prospectus.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">13</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(ff)&#160; &#160; &#160; &#160; <u>Compliance with Environmental Laws</u>.&#160; Except as described in the Prospectus and except as would not reasonably be expected,
          individually or in the aggregate, to result in a Material Adverse Change; (i) neither the Company nor any of its subsidiaries is in violation of any U.S. federal, state, local or non-U.S. statute, law, rule, regulation, ordinance, code, policy or
          rule of common law or any judicial or administrative interpretation thereof, including any judicial or administrative order, consent, decree or judgment, relating to pollution or protection of human health, the environment (including, without
          limitation, ambient air, surface water, groundwater, land surface or subsurface strata) or wildlife, including, without limitation, laws and regulations relating to the release or threatened release of chemicals, pollutants, contaminants, wastes,
          toxic substances, hazardous substances, petroleum or petroleum products (collectively, &#8220;<font style="font-weight: bold;">Hazardous Materials</font>&#8221;) or to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or
          handling of Hazardous Materials (collectively, &#8220;<font style="font-weight: bold;">Environmental Laws</font>&#8221;), (ii) the Company and its subsidiaries have all permits, authorizations and approvals required under any applicable Environmental Laws
          and are each in compliance with their requirements, (iii) there are no pending or, to the Company&#8217;s knowledge, threatened administrative, regulatory or judicial actions, suits, demands, demand letters, claims, liens, notices of non-compliance or
          violation, investigation or proceedings relating to any Environmental Law against the Company or any of its subsidiaries and (iv) there are no events or circumstances that would reasonably be expected to form the basis of an order for clean-up or
          remediation, or an action, suit or proceeding by any private party or governmental body or agency, against or affecting the Company or any of its subsidiaries relating to Hazardous Materials or any Environmental Laws.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(gg)&#160;&#160; &#160;&#160; &#160; <u>Periodic Review of Costs of Environmental Compliance</u>.&#160; In the ordinary course of its business, the Company conducts a
          periodic review of the effect of Environmental Laws on the business, operations and properties of the Company and its subsidiaries, in the course of which it identifies and evaluates associated costs and liabilities (including, without
          limitation, any capital or operating expenditures required for clean-up, closure of properties or compliance with Environmental Laws or any permit, license or approval, any related constraints on operating activities and any potential liabilities
          to third parties).&#160; No facts or circumstances have come to the Company&#8217;s attention that could result in costs or liabilities that could be expected, individually or in the aggregate, to result in a Material Adverse Change.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(hh)&#160;&#160; &#160; &#160; &#160; <u>ERISA Compliance</u>.&#160; Except as otherwise disclosed in the Prospectus, and except as would not reasonably be expected,
          individually or in the aggregate, to result in a Material Adverse Change, the Company and its subsidiaries and any &#8220;employee benefit plan&#8221; (as defined under the Employee Retirement Income Security Act of 1974, as amended, and the regulations and
          published interpretations thereunder (collectively, &#8220;<font style="font-weight: bold;">ERISA</font>&#8221;)) established or maintained by the Company, its subsidiaries or their &#8220;ERISA Affiliates&#8221; (as defined below) are in compliance in all material
          respects with ERISA.&#160; &#8220;<font style="font-weight: bold;">ERISA Affiliate</font>&#8221; means, with respect to the Company or any of its subsidiaries, any member of any group of organizations described in Sections 414(b), (c), (m) or (o) of the Internal
          Revenue Code of 1986, as amended, and the regulations and published interpretations thereunder (the &#8220;<font style="font-weight: bold;">Code</font>&#8221;) of which the Company or such subsidiary is a member.&#160; Except as would not reasonably be expected,
          individually or in the aggregate, to result in a Material Adverse Change, (i) no &#8220;reportable event&#8221; (as defined under ERISA), for which notice has not been waived, has occurred or is reasonably expected to occur with respect to any &#8220;employee
          benefit plan&#8221; established or maintained by the Company, its subsidiaries or any of their ERISA Affiliates, (ii) no &#8220;employee benefit plan&#8221; established or maintained by the Company, its subsidiaries or any of their ERISA Affiliates, if such
          &#8220;employee benefit plan&#8221; were terminated, would have any &#8220;amount of unfunded benefit liabilities&#8221; (as defined under ERISA), and (iii) neither the Company, its subsidiaries nor any of their ERISA Affiliates has incurred or reasonably expects to
          incur any liability under (i) Title IV of ERISA with respect to termination of, or withdrawal from, any &#8220;employee benefit plan&#8221; or (ii) Sections 412, 4971, 4975 or 4980B of the Code.&#160; Each &#8220;employee benefit plan&#8221; established or maintained by the
          Company, its subsidiaries or any of their ERISA Affiliates that is intended to be qualified under Section 401(a) of the Code has received a favorable determination or opinion letter from the Internal Revenue Service or has time remaining to do
          so, and to the knowledge of the Company, whether by action or failure to act, which would cause the loss of such qualification.</font></div>
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        <div class="BRPFPageBreak" style="page-break-after: always;">
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(ii)&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <u>Broker</u><u>s</u>.&#160; Except as otherwise disclosed in the Prospectus, there is no broker, finder or other party that is
          entitled to receive from the Company any brokerage or finder&#8217;s fee or other fee or commission as a result of any transactions contemplated by this Agreement.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(jj)&#160;&#160;&#160;&#160;&#160; &#160; &#160; <u>No Outstanding Loans or Other Extensions of Credit</u>.&#160; The Company does not have any outstanding extension of credit, in the
          form of a personal loan, to or for any director or executive officer (or equivalent thereof) of the Company except for such extensions of credit as are expressly permitted by Section 13(k) of the Exchange Act.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(kk)&#160; &#160;&#160; &#160; <u>Compliance with Laws</u>.&#160; The Company and its subsidiaries have been and are in compliance with all applicable laws, rules and
          regulations, except where failure to be so in compliance would not reasonably be expected, individually or in the aggregate, to result in a Material Adverse Change.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(ll)&#160;&#160;&#160; &#160;&#160; &#160; <u>Dividend Restrictions</u>.&#160; Except as disclosed in the Prospectus, no subsidiary of the Company is prohibited or restricted,
          directly or indirectly, from paying dividends to the Company, or from making any other distribution with respect to such subsidiary&#8217;s equity securities or from repaying to the Company or any other subsidiary of the Company any amounts that may
          from time to time become due under any loans or advances to such subsidiary from the Company or from transferring any property or assets to the Company or to any other subsidiary.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(mm)&#160; &#160; &#160; <u>Anti-Corruption and Anti-Bribery Laws</u><font style="font-weight: normal;">.</font>&#160; Neither the Company nor any of its
          subsidiaries, nor to the knowledge of the Company, any director, officer, employee, agent, affiliate or other person acting on behalf of the Company or any of its subsidiaries has, in the course of its actions for, or on behalf of, the Company or
          any of its subsidiaries (i) used any corporate funds for any unlawful contribution, gift, entertainment or other unlawful expenses relating to political activity; (ii) made or taken any act in furtherance of an offer, promise, or authorization of
          any direct or indirect unlawful payment or benefit to any non-U.S. or domestic government official or employee, including of any government-owned or controlled entity or public international organization, or any political party, party official,
          or candidate for political office; (iii) violated or is in violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977, as amended (the &#8220;<font style="font-weight: bold;">FCPA</font>&#8221;), the UK Bribery Act 2010, or any other
          applicable anti-bribery or anti-corruption law; or (iv) made, offered, authorized, requested, or taken an act in furtherance of any unlawful bribe, rebate, payoff, influence payment, kickback or other unlawful payment or benefit.&#160; The Company and
          its subsidiaries and, to the knowledge of the Company, the Company&#8217;s affiliates have conducted their respective businesses in compliance with the FCPA and have instituted and maintain policies and procedures designed to ensure, and which are
          reasonably expected to continue to ensure, continued compliance therewith.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
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        <div class="BRPFPageBreak" style="page-break-after: always;">
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(nn)&#160;&#160; &#160;&#160; <u>Money Laundering Laws</u>.&#160; The operations of the Company and its subsidiaries are, and have been conducted at all times, in
          compliance with applicable financial recordkeeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the money laundering statutes of all applicable jurisdictions, the rules and regulations
          thereunder and any related or similar applicable rules, regulations or guidelines, issued, administered or enforced by any governmental agency (collectively, the &#8220;<font style="font-weight: bold;">Money Laundering Laws</font>&#8221;) and no action, suit
          or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the Company or any of its subsidiaries with respect to the Money Laundering Laws is pending or, to the Company&#8217;s knowledge, threatened.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(oo)&#160; &#160; &#160;&#160;&#160; <u>Clinical Data and Regulatory Compliance</u><font style="font-weight: bold; font-style: italic;">.</font>&#160; The preclinical tests
          and clinical trials, and other studies (collectively, &#8220;studies&#8221;) that are described in, or the results of which are referred to in, the Registration Statement or the Prospectus were and, if still pending, are being conducted in all material
          respects in accordance with the protocols, procedures and controls designed and approved for such studies and with standard medical and scientific research procedures; each description of the results of such studies is accurate and complete in
          all material respects and fairly presents the data derived from such studies, and the Company and its subsidiaries have no knowledge of any other studies the results of which are inconsistent with, or otherwise call into question, the results
          described or referred to in the Registration Statement or the Prospectus; the Company and its subsidiaries have made all such filings and obtained all such approvals as may be required by the Food and Drug Administration of the U.S. Department of
          Health and Human Services or any committee thereof, the PRC National Medical Products Administration or any committee thereof or from any other U.S. or non-U.S. government or drug or medical device regulatory agency, or health care facility
          Institutional Review Board (collectively, the &#8220;<font style="font-weight: bold;">Regulatory Agencies</font>&#8221;); neither the Company nor any of its subsidiaries has received any notice of, or correspondence from, any Regulatory Agency requiring the
          termination, suspension or modification of any clinical trials that are described or referred to in the Registration Statement or the Prospectus; and the Company and its subsidiaries have each operated and currently are in compliance in all
          material respects with all applicable rules, regulations and policies of the Regulatory Agencies.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">16</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(pp)&#160; &#160;&#160; &#160;&#160; <u>Sanctions.</u>&#160; Neither the Company nor any of its subsidiaries, nor, to the knowledge of the Company, after due inquiry, any
          director, officer, employee, agent, affiliate or other person acting on behalf of the Company or any of its subsidiaries is currently the subject or the target of any U.S. sanctions administered by the Office of Foreign Assets Control of the U.S.
          Department of the Treasury (&#8220;<font style="font-weight: bold;">OFAC</font>&#8221;) or the U.S. Department of State, the United Nations Security Council, the European Union, His Majesty&#8217;s Treasury of the United Kingdom, or other relevant sanctions
          authority (collectively, &#8220;<font style="font-weight: bold;">Sanctions</font>&#8221;); nor is the Company or any of its subsidiaries located, organized or resident in a country or territory that is the subject or the target of Sanctions, including,
          without limitation, the Crimea Region of Ukraine, the so-called Donetsk People&#8217;s Republic, the so-called Luhansk People&#8217;s Republic, the non-government controlled areas of Zaporizhzhia and Kherson regions of Ukraine, Cuba, Iran, North Korea, and
          Syria (each, a &#8220;<font style="font-weight: bold;">Sanctioned Country</font>&#8221;); and the Company will not directly or indirectly use the proceeds of this offering, or lend, contribute or otherwise make available such proceeds to any subsidiary, or
          any joint venture partner or other person or entity, for the purpose of financing the activities of or business with any person, or in any country or territory, that at the time of such financing, is the subject or the target of Sanctions or in
          any other manner that will result in a violation by any person (including any person participating in the transactions contemplated hereby whether as underwriter, advisor, investor or otherwise) of applicable Sanctions.&#160; For the past ten years,
          the Company and its subsidiaries have not knowingly engaged in and are not now knowingly engaged in any dealings or transactions with any person that at the time of the dealing or transaction is or was the subject or the target of Sanctions or
          with any Sanctioned Country.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(qq)&#160;&#160; &#160; &#160;&#160; <u>Sarbanes-Oxley</u>.&#160; The Company is in compliance, in all material respects, with all applicable provisions of the Sarbanes-Oxley
          Act of 2002 and the rules and regulations promulgated thereunder.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(rr)&#160;&#160; &#160;&#160;&#160;&#160; <u>Duties, Transfer Taxes, Etc</u>.&#160; No stamp or other issuance or transfer taxes or duties and no capital gains, income,
          withholding or other taxes are payable by the Agent in the United States, Hong Kong or any political subdivision or taxing authority thereof or therein in connection with the execution, delivery or performance of this Agreement by the Company or
          the sale and delivery by the Company of the Shares.&#160; No transaction, stamp, capital or other issuance, registration, transaction, transfer or withholding taxes or duties are payable in the PRC by or on behalf of the Agent to any PRC taxing
          authority in connection with (i) the execution and delivery of this Agreement or (ii) the consummation of the transactions contemplated hereunder, given that all of the above activities mentioned in clauses (i) and (ii) above shall take place
          outside of the PRC.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(ss)&#160; &#160;&#160; &#160;&#160; <u>Cybersecurity</u>. &#160;The Company and its subsidiaries&#8217; information technology assets and equipment, computers, systems, networks,
          hardware, software, websites, applications, and databases (collectively, &#8220;<font style="font-weight: bold;">IT Systems</font>&#8221;) are adequate for, and operate and perform in all material respects as required in connection with the operation of the
          business of the Company and its subsidiaries as currently conducted, free and clear of all material bugs, errors, defects, Trojan horses, time bombs, malware and other corruptants.&#160; The Company and its subsidiaries have implemented and maintained
          commercially reasonable physical, technical and administrative controls, policies, procedures, and safeguards to maintain and protect their material confidential information and the integrity, continuous operation, redundancy and security of all
          IT Systems and data, including &#8220;Personal Data,&#8221; used in connection with their businesses.&#160; &#8220;<font style="font-weight: bold;">Personal Data</font>&#8221; means (i) a natural person&#8217;s name, street address, telephone number, e-mail address, photograph,
          social security number or tax identification number, driver&#8217;s license number, passport number, credit card number, bank information, or customer or account number; (ii) any information which would qualify as &#8220;personally identifying information&#8221;
          under the Federal Trade Commission Act, as amended; (iii) &#8220;personal data&#8221; as defined by GDPR (as defined below); (iv) any information which would qualify as &#8220;protected health information&#8221; under the Health Insurance Portability and Accountability
          Act of 1996, as amended by the Health Information Technology for Economic and Clinical Health Act (collectively, &#8220;<font style="font-weight: bold;">HIPAA&#8221;</font>); and (v) any other piece of information that allows the identification of such
          natural person, or his or her family, or permits the collection or analysis of any data related to an identified person&#8217;s health or sexual orientation.&#160; To the Company&#8217;s knowledge, there have been no breaches, violations, outages or unauthorized
          uses of or accesses to same, except for those that have been remedied without material cost or liability or the duty to notify any other person, nor any incidents under internal review or investigations relating to the same.&#160; The Company and its
          subsidiaries are presently in material compliance with all applicable laws or statutes and all judgments, orders, rules and regulations of any court or arbitrator or governmental or regulatory authority, internal policies and contractual
          obligations relating to the privacy and security of IT Systems and Personal Data and to the protection of such IT Systems and Personal Data from unauthorized use, access, misappropriation or modification.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">17</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(tt)&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>Compliance with Data Privacy Laws</u>. The Company and its subsidiaries are, and at all prior times were, in material
          compliance with all applicable state and federal data privacy and security laws and regulations, including without limitation HIPAA, and the Company and its subsidiaries have taken commercially reasonable actions to prepare to comply with, and
          since May 25, 2018, have been and currently are in compliance with, the European Union General Data Protection Regulation (&#8220;<font style="font-weight: bold;">GDPR</font>&#8221;) (EU 2016/679) (collectively, the &#8220;<font style="font-weight: bold;">Privacy
            Laws</font>&#8221;).&#160; To ensure compliance with the Privacy Laws, the Company and its subsidiaries have in place, comply with, and take appropriate steps reasonably designed to ensure compliance in all material respects with their policies and
          procedures relating to data privacy and security and the collection, storage, use, disclosure, handling, and analysis of Personal Data (the &#8220;<font style="font-weight: bold;">Policies</font>&#8221;).&#160; The Company and its subsidiaries have at all times
          made all disclosures to users or customers required by applicable laws and regulatory rules or requirements, and none of such disclosures made or contained in any Policy have, to the knowledge of the Company, been inaccurate or in violation of
          any applicable laws and regulatory rules or requirements in any material respect.&#160; The Company further certifies that neither it nor any subsidiary: (i) has received notice of any actual or potential liability under or relating to, or actual or
          potential violation of, any of the Privacy Laws, and has no knowledge of any event or condition that would reasonably be expected to result in any such notice; (ii) is currently conducting or paying for, in whole or in part, any investigation,
          remediation, or other corrective action pursuant to any Privacy Law; or (iii) is a party to any order, decree, or agreement that imposes any obligation or liability under any Privacy Law.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(uu)&#160;&#160; &#160;&#160; &#160; <u>Other Underwriting Agreements</u>.&#160; The Company is not a party to any agreement with an agent or underwriter for any other &#8220;at
          the market&#8221; or continuous equity transaction.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(vv)&#160; &#160;&#160; &#160;&#160; <u>Forward-Looking Statements</u>.&#160; Each financial or operational projection or other &#8220;forward-looking statement&#8221; (as defined by
          Section 27A of the Securities Act or Section 21E of the Exchange Act) contained in the Registration Statement or the Prospectus (i) was so included by the Company in good faith and with reasonable basis after due consideration by the Company of
          the underlying assumptions, estimates and other applicable facts and circumstances and (ii) is accompanied by meaningful cautionary statements identifying those factors that could cause actual results to differ materially from those in such
          forward-looking statement.&#160; No such statement was made with the knowledge of an executive officer or director of the Company that it was false or misleading.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">18</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(ww)&#160;&#160; &#160; &#160; <u>Compliance with Health Care Laws</u>.&#160; The Company and its subsidiaries are, and at all times have been, in compliance in all
          material respects with all applicable Health Care Laws.&#160; For purposes of this Agreement, &#8220;Health Care Laws&#8221; means: (i) the Federal Food, Drug, and Cosmetic Act (21 U.S.C. Section 301 et seq.), the Public Health Service Act (42 U.S.C. Section 201
          et seq.), and the regulations promulgated thereunder; (ii) all applicable U.S. federal, state, local and non-U.S. health care fraud and abuse laws, including, without limitation, the Anti-Kickback Statute (42 U.S.C. Section 1320a-7b(b)), the
          Civil False Claims Act (31 U.S.C. Section 3729 et seq.), the criminal false statements law (42 U.S.C. Section 1320a-7b(a)), 18 U.S.C. Sections 286 and 287, the health care fraud criminal provisions under HIPAA (42 U.S.C. Section 1320d et seq.),
          the Stark Law (42 U.S.C. Section 1395nn), the civil monetary penalties law (42 U.S.C. Section 1320a-7a), the exclusion law (42 U.S.C. Section 1320a-7), the Physician Payments Sunshine Act (42 U.S.C. Section 1320-7h), and applicable laws governing
          government funded or sponsored healthcare programs; (iii) HIPAA, as amended by the Health Information Technology for Economic and Clinical Health Act (42 U.S.C. Section 17921 et seq.); (iv) the Patient Protection and Affordable Care Act of 2010,
          as amended by the Health Care and Education Reconciliation Act of 2010; (v) licensure, quality, safety and accreditation requirements under applicable U.S. federal, state, local or non-U.S. laws or regulatory bodies; (vi) all other local, state,
          U.S. federal, national, supranational and non-U.S. laws, relating to the regulation of the Company or its subsidiaries, and (vii) the directives and regulations promulgated pursuant to such statutes and any state or non-U.S. counterpart thereof.&#160;
          Neither the Company nor any of its subsidiaries has received written notice of any claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from any court or arbitrator or governmental or regulatory
          authority or third party alleging that any product operation or activity is in violation of any Health Care Laws nor, to the Company&#8217;s knowledge, is any such claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or
          other action threatened.&#160; The Company and its subsidiaries have filed, maintained or submitted all material reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments as required by any Health
          Care Laws, and all such reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments were complete and accurate on the date filed in all material respects (or were corrected or supplemented by a
          subsequent submission).&#160; Neither the Company nor any of its subsidiaries is a party to any corporate integrity agreements, monitoring agreements, consent decrees, settlement orders, or similar agreements with or imposed by any governmental or
          regulatory authority.&#160; Additionally, neither the Company, any of its subsidiaries nor any of their respective employees, officers, directors, or agents has been excluded, suspended or debarred from participation in any U.S. federal health care
          program or human clinical research or, to the knowledge of the Company, is subject to a governmental inquiry, investigation, proceeding, or other similar action that could reasonably be expected to result in debarment, suspension, or exclusion.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(xx)&#160; &#160; &#160;&#160; <u>Market Capitalization</u>. At the time the Registration Statement was originally filed, the Company met the then applicable
          requirements for the use of Form S-3 under the Securities Act, including General Instruction I.B.1 of Form S-3. As of the date of this Agreement, the aggregate market value of the outstanding voting and non-voting common equity (as defined in
          Rule 405 under the Securities Act) of the Company held by persons other than affiliates of the Company (pursuant to Rule 144 under the Securities Act, those that, directly or indirectly through one or more intermediaries, control or are
          controlled by, or are under common control with, the Company) (the &#8220;<font style="font-weight: bold;">Non-Affiliate Shares</font>&#8221;), was equal to or greater than $75 million (calculated by multiplying (x) the highest price at which the common
          equity of the Company closed on The Nasdaq Capital Market within 60 days of the date the Registration Statement was declared effective times (y) the number of Non-Affiliate Shares). The Company is not a shell company (as defined in Rule 405 under
          the Securities Act) and has not been a shell company for at least 12 calendar months previously and if it has been a shell company at any time previously, has filed current Form 10 information (as defined in Instruction I.B.6 of Form S-3) with
          the Commission at least 12 calendar months previously reflecting its status as an entity that is not a shell company.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">19</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(yy)&#160;&#160; &#160;&#160; <u>Payments in Foreign Currency</u>. Except as disclosed in the Registration Statement and the Prospectus, under current laws and
          regulations of the United States, Hong Kong and any political subdivision thereof, all dividends and other distributions declared and payable on the Shares may be paid by the Company to the holder thereof in United States dollars that may be
          converted into foreign currency and may be freely transferred out of the United States and Hong Kong and all such payments made to holders thereof or therein who are non-residents of the United States or Hong Kong will not be subject to income,
          withholding or other taxes under laws and regulations of the United States or Hong Kong or any political subdivision or taxing authority thereof or therein and without the necessity of obtaining any governmental authorization in the United States
          and Hong Kong or any political subdivision or taxing authority thereof or therein. Except as disclosed in the Registration Statement and the Prospectus, all dividends and other distributions declared and payable on the share capital of the
          subsidiaries of the Company that are organized in the PRC may, under the current laws and regulations of the PRC and after full payment of withholding tax, as applicable, be freely transferred out of the PRC and may be paid in United States
          dollars, provided that the remittance of such dividends and other distributions outside of the PRC complies with the procedures required under the PRC laws and by the relevant governmental agencies relating to foreign exchange, without other
          consent, approval, authorization or order of, or qualification with, any court or governmental agency or body in such entity&#8217;s jurisdiction of incorporation or tax residence, and all such dividends and other distributions will not be subject to
          other taxes under the laws and regulations of the PRC and are otherwise free and clear of any other tax, withholding or deduction in the PRC, and without the necessity of obtaining any governmental authorization in the PRC.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(zz)&#160;&#160;&#160; &#160; &#160; <u>CSRC Filing</u>.&#160; The Company is aware of and has been advised as to, the content of the Trial Measures for the Administration of
          Overseas Securities Offering and Listing by Domestic Enterprises and any official clarifications, guidance, interpretations or implementation rules in connection with or related thereto (the &#8220;<font style="font-weight: bold;">CSRC Filing Rules</font>&#8221;)

          promulgated by the Chinese Securities Regulatory Commission (the &#8220;<font style="font-weight: bold;">CSRC</font>&#8221;) on February 17, 2023, including the relevant provisions thereof which purport to require that the follow-on offering of shares of an
          issuer in the same overseas market where it has previously issued and listed securities shall be filed with and reported to the CSRC within the prescribed timeframe.&#160; The issuance and sale of the Shares, the listing and trading of the Shares on
          the Principal Market and the consummation of the transactions contemplated by this Agreement do not require the prior filing with or approval of the CSRC, but will require filing with the CSRC within three working days after the completion of the
          initial sale of Shares hereunder and stating in the CSRC filing report the total number of securities to be issued under the Registration Statement (&#8220;<font style="font-weight: bold;">Aggregated Securities</font>&#8221;),&#160; and reporting the overall
          offering information to the CSRC in a consolidated manner after the completion of the sale of the Aggregated Securities.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">20</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(aaa)&#160; &#160;&#160; &#160; <u>Compliance with PRC Regulations on PRC Overseas Investment</u><font style="font-style: italic;">.</font>&#160; The Company has taken
          all reasonable steps to comply with, and has made reasonable efforts to ensure compliance by each of its shareholders, option holders, directors, officers and employees that is, or is directly or indirectly owned or controlled by, a PRC resident
          or citizen with any applicable rules and regulations of the relevant PRC government agencies (including but not limited to the Ministry of Commerce, the National Development and Reform Commission, the CSRC and the State Administration of Foreign
          Exchange) relating to overseas investment by PRC residents and citizens (the &#8220;<font style="font-weight: bold;">PRC Overseas Investment Regulations</font>&#8221;), including requesting each shareholder, option holder, director, officer and employee that
          is, or is directly or indirectly owned or controlled by, a PRC resident or citizen to complete any registration and other procedures required under applicable PRC Overseas Investment Regulations.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(bbb) &#160; &#160; <u>Final Judgments.</u> Any final judgment for a fixed or readily calculable sum of money rendered by a Specified Court having
          jurisdiction under its own domestic laws in respect of any suit, action or proceeding against the Company based upon this Agreement and any instruments or agreements entered into for the consummation of the transactions contemplated herein and
          therein would be recognized and enforced against the Company in the courts of the Hong Kong and the PRC (as the case may be), without re-examination or review of the merits of the cause of action in respect of which the original judgment was
          given or re-litigation of the matters adjudicated upon, by the courts of Hong Kong and the PRC, provided that with respect to courts of the PRC, subject to the uncertainties in respect of PRC courts&#8217; recognition and enforcement of foreign
          judgments disclosed in the Registration Statement and Prospectus, (A) adequate service of process has been effected and the defendant has had a reasonable opportunity to be heard, (B) such judgments or the enforcement thereof are not contrary to
          the law, public policy, security or sovereignty of the PRC, (C) such judgments were not obtained by fraudulent means and do not conflict with any other valid judgment in the same matter between the same parties and (D) an action between the same
          parties in the same matter is not pending in any PRC court at the time the lawsuit is instituted in a foreign court. The Company is not aware of any reason why the enforcement in Hong Kong or the PRC of such a Specified Court judgment would be,
          as of the date hereof, contrary to public policy of Hong Kong or the PRC.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(ccc)&#160; &#160;&#160; &#160; <u>Indemnification and Contribution</u>.&#160; The indemnification and contribution provisions set forth in <u>Section 6</u> hereof do
          not contravene PRC law or public policy.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">Any certificate signed by any officer or representative of the Company or any of its subsidiaries and delivered to the Agent or counsel for the Agent in
        connection with an issuance of Shares shall be deemed a representation and warranty by the Company to the Agent as to the matters covered thereby on the date of such certificate.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">The Company acknowledges that the Agent and, for purposes of the opinions to be delivered pursuant to <u>Section 4(o)</u> hereof, counsel to the Company and
        counsel to the Agent, will rely upon the accuracy and truthfulness of the foregoing representations and hereby consents to such reliance.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="font-weight: bold; color: rgb(0, 0, 0);">Section 3.&#160; ISSUANCE AND SALE OF COMMON SHARES</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)&#160;&#160;&#160; &#160;&#160; &#160; <u>Sale of Securities</u>.&#160; On the basis of the representations, warranties and agreements herein contained, but subject to the
          terms and conditions herein set forth, the Company and the Agent agree that the Company may from time to time seek to sell Shares through the Agent, acting as sales agent, or directly to the Agent, acting as principal, as follows, with an
          aggregate Sales Price of up to the Maximum Program Amount, based on and in accordance with Issuance Notices as the Company may deliver, during the Agency Period.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">21</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(b)&#160;&#160;&#160;&#160;&#160; &#160;&#160; <u>Mechanics of Issuances</u>.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">(i) &#160; &#160; &#160;&#160; &#160; <u>Issuance Notice</u>.&#160; Upon the terms and subject to the conditions set forth herein, on any Trading Day during the Agency Period on which the
        conditions set forth in <u>Section 5(a)</u> and <u>Section 5(b)</u> shall have been satisfied, the Company may exercise its right to request an issuance of Shares by delivering to the Agent an Issuance Notice; <font style="font-style: italic;">provided,

          however</font>, that (A) in no event may the Company deliver an Issuance Notice to the extent that (I) the sum of (x) the aggregate Sales Price of the requested Issuance Amount, plus (y) the aggregate Sales Price of all Shares issued under all
        previous Issuance Notices effected pursuant to this Agreement, would exceed the Maximum Program Amount; and (B) prior to delivery of any Issuance Notice, the period set forth for any previous Issuance Notice shall have expired or been terminated.&#160;
        An Issuance Notice shall be considered delivered on the Trading Day that it is received by e&#8209;mail to the persons set forth in Schedule A hereto and confirmed by the Company by telephone (including a voicemail message to the persons so identified),
        with the understanding that, with adequate prior written notice, the Agent may modify the list of such persons from time to time.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(ii)&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>Agent Efforts</u>.&#160; Upon the terms and subject to the conditions set forth in this Agreement, upon the receipt of an Issuance
          Notice, the Agent will use its commercially reasonable efforts consistent with its normal sales and trading practices to place the Shares with respect to which the Agent has agreed to act as sales agent, subject to, and in accordance with the
          information specified in, the Issuance Notice, unless the sale of the Shares described therein has been suspended, cancelled or otherwise terminated in accordance with the terms of this Agreement.&#160; For the avoidance of doubt, the parties to this
          Agreement may modify an Issuance Notice at any time provided they both agree in writing to any such modification.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(iii)&#160;&#160;&#160; &#160; &#160; <u>Method of Offer and Sale</u>.&#160; The Shares may be offered and sold (A) in privately negotiated transactions with the consent of
          the Company or (B) by any other method permitted by law deemed to be an &#8220;at the market offering&#8221; as defined in Rule 415(a)(4) under the Securities Act, including block transactions, sales made directly on the Principal Market or sales made into
          any other existing trading market of the Common Shares.&#160; Nothing in this Agreement shall be deemed to require either party to agree to the method of offer and sale specified in the preceding sentence, and (except as specified in clause (A) above)
          the method of placement of any Shares by the Agent shall be at the Agent&#8217;s discretion.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(iv)&#160;&#160; &#160;&#160; &#160;&#160; <u>Confirmation to the Company</u>.&#160; If acting as sales agent hereunder, the Agent will provide written confirmation to the Company
          no later than the opening of the Trading Day next following the Trading Day on which it has placed Shares hereunder setting forth the number of shares sold on such Trading Day, the corresponding Sales Price and the Issuance Price payable to the
          Company in respect thereof.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">22</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(v)&#160;&#160;&#160;&#160;&#160; &#160; &#160; <u>Settlement</u>.&#160; Each issuance of Shares will be settled on the applicable Settlement Date for such issuance of Shares and,
          subject to the provisions of <u>Section 5</u>, on or before each Settlement Date, the Company will, or will cause its transfer agent to, electronically transfer the Shares being sold by crediting the Agent or its designee&#8217;s account at The
          Depository Trust Company through its Deposit/Withdrawal At Custodian (DWAC) System, or by such other means of delivery as may be mutually agreed upon by the parties hereto and, upon receipt of such Shares, which in all cases shall be freely
          tradable, transferable, registered shares in good deliverable form, the Agent will deliver, by wire transfer of immediately available funds, the related Issuance Price in same day funds delivered to an account designated by the Company prior to
          the Settlement Date.&#160; The Company may sell Shares to the Agent as principal at a price agreed upon between the Company and the Agent at each relevant time Shares are sold pursuant to this Agreement (each, a &#8220;<font style="font-weight: bold;">Time
            of Sale</font>&#8221;).</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(vi)&#160;&#160; &#160;&#160; &#160; <u>Suspension or Termination of Sales</u>.&#160; Consistent with standard market settlement practices, the Company or the Agent may, upon
          notice to the other party hereto in writing or by telephone (confirmed immediately by verifiable email), suspend any sale of Shares, and the period set forth in an Issuance Notice shall immediately terminate; <font style="font-style: italic;">provided,

            however</font>, that (A) such suspension and termination shall not affect or impair either party&#8217;s obligations with respect to any Shares placed or sold hereunder prior to the receipt of such notice; (B) if the Company suspends or terminates
          any sale of Shares after the Agent confirms such sale to the Company, the Company shall still be obligated to comply with <u>Section 3(b)(v)</u> with respect to such Shares; and (C) if the Company defaults in its obligation to deliver Shares on
          a Settlement Date, the Company agrees that it will hold the Agent harmless against any loss, claim, damage or expense (including, without limitation, penalties, interest and reasonable legal fees and expenses), as incurred, arising out of or in
          connection with such default by the Company.&#160; The parties hereto acknowledge and agree that, in performing its obligations under this Agreement, the Agent may borrow Common Shares from stock lenders in the event that the Company has not delivered
          Shares to settle sales as required by subsection (v) above, and may use the Shares to settle or close out such borrowings.&#160; The Company agrees that no such notice shall be effective against the Agent unless it is made to the persons identified in
          writing by the Agent pursuant to <u>Section 3(b)(i)</u>.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(vii)&#160; &#160;&#160; &#160;&#160; <u>No Guarantee of Placement, Etc.</u>&#160; The Company acknowledges and agrees that (A) there can be no assurance that the Agent will
          be successful in placing Shares; (B) the Agent will incur no liability or obligation to the Company or any other Person if it does not sell Shares; and (C) the Agent shall be under no obligation to purchase Shares on a principal basis pursuant to
          this Agreement, except as otherwise specifically agreed by the Agent and the Company.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(viii)&#160; &#160; &#160;&#160; <u>Material Non-Public Information.</u>&#160; Notwithstanding any other provision of this Agreement, the Company and the Agent agree
          that the Company shall not deliver any Issuance Notice to the Agent, and the Agent shall not be obligated to place any Shares, during any period in which the Company is in possession of material non-public information.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)&#160;&#160; &#160;&#160; &#160; &#160; <u>Fees</u>.&#160; As compensation for services rendered, the Company shall pay to the Agent, on the applicable Settlement Date, the
          Selling Commission for the applicable Issuance Amount (including with respect to any suspended or terminated sale pursuant to <u>Section 3(b)(vi))</u> by the Agent deducting the Selling Commission from the applicable Issuance Amount.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">23</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(d)&#160;&#160;&#160;&#160; &#160; &#160; <u>Expenses</u>.&#160; The Company agrees to pay all costs, fees and expenses incurred in connection with the performance of its
          obligations hereunder and in connection with the transactions contemplated hereby, including without limitation (i) all expenses incident to the issuance and delivery of the Shares (including all printing and engraving costs); (ii) all fees and
          expenses of the registrar and transfer agent of the Shares; (iii) all necessary issue, transfer and other stamp taxes in connection with the issuance and sale of the Shares; (iv) all fees and expenses of the Company&#8217;s counsel, independent public
          or certified public accountants and other advisors; (v) all costs and expenses incurred in connection with the preparation, printing, filing, shipping and distribution of the Registration Statement (including financial statements, exhibits,
          schedules, consents and certificates of experts), the Prospectus, any Free Writing Prospectus prepared by or on behalf of, used by, or referred to by the Company, and all amendments and supplements thereto, and this Agreement; (vi) all filing
          fees, attorneys&#8217; fees and expenses incurred by the Company or the Agent in connection with qualifying or registering (or obtaining exemptions from the qualification or registration of) all or any part of the Shares for offer and sale under the
          state securities or blue sky laws or the provincial securities laws of Canada, and, if requested by the Agent, preparing and printing a &#8220;<font style="font-weight: bold;">Blue Sky Survey</font>&#8221; or memorandum and a &#8220;Canadian wrapper,&#8221; and any
          supplements thereto, advising the Agent of such qualifications, registrations, determinations and exemptions; (vii) the reasonable and documented fees and disbursements of the Agent&#8217;s counsel, including the reasonable and documented fees and
          expenses of counsel for the Agent in connection with, FINRA review, if any, and approval of the Agent&#8217;s participation in the offering and distribution of the Shares; (viii) the filing fees incident to FINRA review, if any; and (ix) the fees and
          expenses associated with listing the Shares on the Principal Market.&#160; The fees and disbursements of Agent&#8217;s counsel pursuant to subsections (vi) and (vii) above shall not exceed (A) $135,000 in connection with the execution of this Agreement (B)
          $25,000 in connection with each Triggering Event Date (as defined below) involving the filing of a Form 10-K on which the Company is required to provide a certificate pursuant to <u>Section 4(o)</u> and (C) $20,000 in connection with each other
          Triggering Event Date (as defined below) on which the Company is required to provide a certificate pursuant to <u>Section 4(o</u>).</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="font-weight: bold; color: rgb(0, 0, 0);">Section 4.&#160; ADDITIONAL COVENANTS</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">The Company covenants and agrees with the Agent as follows, in addition to any other covenants and agreements made elsewhere in this Agreement:</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)&#160;&#160; &#160; &#160; &#160;&#160; <u>Exchange Act Compliance</u>.&#160; During the Agency Period, the Company shall (i) file, on a timely basis, with the Commission all
          reports and documents required to be filed under&#160;Section 13, 14 or 15 of the Exchange Act in the manner and within the time periods required by the Exchange Act; and (ii) either (A) include in its quarterly reports on Form 10-Q and its annual
          reports on Form 10-K, a summary detailing, for the relevant reporting period, (1) the number of Shares sold through the Agent pursuant to this Agreement and (2) the net proceeds received by the Company from such sales or (B) prepare a prospectus
          supplement containing, or include in such other filing permitted by the Securities Act or Exchange Act (each an &#8220;<font style="font-weight: bold;">Interim Prospectus Supplement</font>&#8221;), such summary information and, at least once a quarter and
          subject to this Section 4, file such Interim Prospectus Supplement pursuant to Rule 424(b) under the Securities Act (and within the time periods required by Rule 424(b) and Rule 430B under the Securities Act).</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">24</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(b)&#160;&#160; &#160; &#160; &#160; <u>Securities Act Compliance</u>.&#160; After the date of this Agreement, the Company shall promptly advise the Agent in writing (i) of
          the receipt of any comments of, or requests for additional or supplemental information from, the Commission relating to the Registration Statement or the Prospectus; (ii) of the time and date of any filing of any post-effective amendment to the
          Registration Statement, any Rule 462(b) Registration Statement or any amendment or supplement to the Prospectus or any Free Writing Prospectus; (iii) of the time and date that any post-effective amendment to the Registration Statement or any Rule
          462(b) Registration Statement becomes effective; and (iv) of the issuance by the Commission of any stop order suspending the effectiveness of the Registration Statement or any post-effective amendment thereto, any Rule 462(b) Registration
          Statement or any amendment or supplement to the Prospectus or of any order preventing or suspending the use of any Free Writing Prospectus or the Prospectus, or of any proceedings to remove, suspend or terminate from listing or quotation the
          Common Shares from any securities exchange upon which they are listed for trading or included or designated for quotation, or of the threatening or initiation of any proceedings for any of such purposes.&#160; If the Commission shall enter any such
          stop order at any time, the Company will use its commercially reasonable efforts to obtain the lifting of such order as soon as practicable.&#160; Additionally, the Company agrees that it shall comply with the provisions of Rule 424(b) and Rule 433,
          as applicable, under the Securities Act and will use its commercially reasonable efforts to confirm that any filings made by the Company under such Rule 424(b) or Rule 433 were filed in a timely manner with the Commission.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>Amendments and Supplements to the Prospectus and Other Securities Act Matters</u>.&#160; If any event shall occur or condition exist
          as a result of which it is necessary to amend or supplement the Prospectus so that the Prospectus does not include an untrue statement of a material fact or omit to state a material fact necessary in order to make the statements therein, in the
          light of the circumstances when the Prospectus is delivered to a purchaser, not misleading, or if in the opinion of the Agent or counsel for the Agent it is otherwise necessary to amend or supplement the Prospectus to comply with applicable law,
          including the Securities Act, the Company agrees (subject to <u>Sections 4(d)</u> and <u>4(f)</u>) to promptly prepare, file with the Commission and furnish at its own expense to the Agent, amendments or supplements to the Prospectus (including
          by filing a document incorporated by reference therein) so that the statements in the Prospectus as so amended or supplemented will not include an untrue statement of a material fact or omit to state a material fact necessary in order to make the
          statements therein, in the light of the circumstances when the Prospectus is delivered to a purchaser, not misleading or so that the Prospectus, as amended or supplemented, will comply with applicable law including the Securities Act.&#160; Neither
          the Agent&#8217;s consent to, or delivery of, any such amendment or supplement shall constitute a waiver of any of the Company&#8217;s obligations under <u>Sections 4(d)</u> and <u>4(f)</u>.&#160; Notwithstanding the foregoing, the Company shall not be required
          to file such amendment or supplement if there is no outstanding Issuance Notice and the Company believes based on the advice of its counsel that it is in its best interest not to file such amendment or supplement; however, the Company agrees not
          to provide an Issuance Notice or otherwise sell under this Agreement until such amendment or supplement is filed.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(d)&#160;&#160;&#160; &#160;&#160; <u>Agent&#8217;s Review of Proposed Amendments and Supplements</u>.<font style="font-style: italic;">&#160; </font>Prior to amending or
          supplementing the Registration Statement (including any registration statement filed under Rule 462(b) under the Securities Act, but excluding (i) the filing under the Exchange Act of documents incorporated by reference into the Registration
          Statement that either (A) do not name the Agent and do not relate to the transactions contemplated by this Agreement or (B) include disclosure naming the Agent and regarding the transactions contemplated by this Agreement that is limited to
          disclosure of periodic sales pursuant to this Agreement, and (ii) amendments or supplements that do not name the Agent and do not relate to the transactions contemplated by this Agreement) or the Prospectus (excluding any amendment or supplement
          through incorporation of any report filed under the Exchange Act), the Company shall furnish to the Agent for review, a reasonable amount of time prior to the proposed time of filing or use thereof, a copy of each such proposed amendment or
          supplement, and the Company shall not file or use any such proposed amendment or supplement without the Agent&#8217;s prior consent, which shall not be unreasonably withheld, conditioned or delayed.&#160; The Company shall file with the Commission within
          the applicable period specified in Rule 424(b) under the Securities Act any prospectus required to be filed pursuant to such Rule.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">25</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(e)&#160; &#160;&#160; &#160;&#160;&#160;&#160; <u>Use of Free Writing Prospectus</u>.&#160; Neither the Company nor the Agent has prepared, used, referred to or distributed, or will
          prepare, use, refer to or distribute, without the other party&#8217;s prior written consent, any &#8220;written communication&#8221; that constitutes a &#8220;free writing prospectus&#8221; as such terms are defined in Rule 405 under the Securities Act with respect to
            the offering contemplated by this Agreement (any such free writing prospectus being referred to herein as a &#8220;<font style="font-weight: bold;">Free Writing Prospectus</font>&#8221;).</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(f)&#160;&#160; &#160; &#160; &#160;&#160; <u>Free Writing Prospectuses</u>.&#160; The Company shall furnish to the Agent for review, a reasonable amount of time prior to the
          proposed time of filing or use thereof, a copy of each proposed Free Writing Prospectus or any amendment or supplement thereto to be prepared by or on behalf of, used by, or referred to by the Company and the Company shall not file, use or refer
          to any proposed Free Writing Prospectus or any amendment or supplement thereto without the Agent&#8217;s consent, which shall not be unreasonably withheld, conditioned or delayed.&#160; The Company shall furnish to the Agent, without charge, as many copies
          of any Free Writing Prospectus prepared by or on behalf of, or used by the Company, as the Agent may reasonably request.&#160; If at any time when a prospectus is required by the Securities Act (including, without limitation, pursuant to Rule 173(d))
          to be delivered in connection with sales of the Shares (but in any event if at any time through and including the date of this Agreement) there occurred or occurs an event or development as a result of which any Free Writing Prospectus prepared
          by or on behalf of, used by, or referred to by the Company conflicted or would conflict with the information contained in the Registration Statement or included or would include an untrue statement of a material fact or omitted or would omit to
          state a material fact necessary in order to make the statements therein, in the light of the circumstances prevailing at that subsequent time, not misleading, the Company shall promptly amend or supplement such Free Writing Prospectus to
          eliminate or correct such conflict or so that the statements in such Free Writing Prospectus as so amended or supplemented will not include an untrue statement of a material fact or omit to state a material fact necessary in order to make the
          statements therein, in the light of the circumstances prevailing at such subsequent time, not misleading, as the case may be; <font style="font-style: italic;">provided, however</font>, that prior to amending or supplementing any such Free
          Writing Prospectus, the Company shall furnish to the Agent for review, a reasonable amount of time prior to the proposed time of filing or use thereof, a copy of such proposed amended or supplemented Free Writing Prospectus and the Company shall
          not file, use or refer to any such amended or supplemented Free Writing Prospectus without the Agent&#8217;s consent, which shall not be unreasonably withheld, conditioned or delayed.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(g)&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>Filing of Agent Free Writing Prospectuses</u>.&#160; The Company shall not take any action that would result in the Agent or the
          Company being required to file with the Commission pursuant to Rule 433(d) under the Securities Act a Free Writing Prospectus prepared by or on behalf of the Agent that the Agent otherwise would not have been required to file thereunder.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">26</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(h)&#160;&#160; &#160; &#160; &#160;&#160; <u>Copies of Registration Statement and Prospectus</u>.&#160; After the date of this Agreement through the last time that a prospectus
          is required by the Securities Act (including, without limitation, pursuant to Rule 173(d)) to be delivered in connection with sales of the Shares, the Company agrees to furnish the Agent with copies (which may be electronic copies) of the
          Registration Statement and each amendment thereto, and with copies of the Prospectus and each amendment or supplement thereto in the form in which it is filed with the Commission pursuant to the Securities Act or Rule 424(b) under the Securities
          Act, both in such quantities as the Agent may reasonably request from time to time; and, if the delivery of a prospectus is required under the Securities Act or under the blue sky or securities laws of any jurisdiction at any time on or prior to
          the applicable Settlement Date for any period set forth in an Issuance Notice in connection with the offering or sale of the Shares and if at such time any event has occurred as a result of which the Prospectus as then amended or supplemented
          would include an untrue statement of a material fact or omit to state any material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made when such Prospectus is delivered, not
          misleading, or, if for any other reason it is necessary during such same period to amend or supplement the Prospectus or to file under the Exchange Act any document incorporated by reference in the Prospectus in order to comply with the
          Securities Act or the Exchange Act, to notify the Agent and to request that the Agent suspend offers to sell Shares (and, if so notified, the Agent shall cease such offers as soon as practicable); and if the Company decides to amend or supplement
          the Registration Statement or the Prospectus as then amended or supplemented, to advise the Agent promptly by telephone (with confirmation in writing) and to prepare and cause to be filed promptly with the Commission an amendment or supplement to
          the Registration Statement or the Prospectus as then amended or supplemented that will correct such statement or omission or effect such compliance; provided, however, that if during such same period the Agent is required to deliver a prospectus
          in respect of transactions in the Shares, the Company shall promptly prepare and file with the Commission such an amendment or supplement.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(i)&#160;&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>Blue Sky Compliance</u>.&#160; The Company shall cooperate with the Agent and counsel for the Agent to qualify or register the
          Shares for sale under (or obtain exemptions from the application of) the state securities or blue sky laws or Canadian provincial securities laws of those jurisdictions designated by the Agent, shall comply with such laws and shall continue such
          qualifications, registrations and exemptions in effect so long as required for the distribution of the Shares.&#160; The Company shall not be required to qualify as a foreign corporation or to take any action that would subject it to general service
          of process in any such jurisdiction where it is not presently qualified or where it would be subject to taxation as a foreign corporation.&#160; The Company will advise the Agent promptly of the suspension of the qualification or registration of (or
          any such exemption relating to) the Shares for offering, sale or trading in any jurisdiction or any initiation or threat of any proceeding for any such purpose, and in the event of the issuance of any order suspending such qualification,
          registration or exemption, the Company shall use its reasonable best efforts to obtain the withdrawal thereof as soon as reasonably practicable.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(j)&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <u>Earnings Statement</u>.&#160; As soon as reasonably practicable, the Company will make generally available to its security holders
          and to the Agent an earnings statement (which need not be audited) covering a period of at least twelve months beginning with the first fiscal quarter of the Company occurring after the date of this Agreement which shall satisfy the provisions of
          Section 11(a) of the Securities Act and Rule 158 under the Securities Act.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">27</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(k)&#160; &#160;&#160; &#160;&#160;&#160; <u>Listing; Reservation of Shares</u>.&#160; (i)&#160; The Company will use its reasonable best efforts to maintain the listing of the Shares
          on the Principal Market; and (ii) the Company will reserve and keep available at all times, free of preemptive rights, Shares for the purpose of enabling the Company to satisfy its obligations pursuant to any outstanding Issuance Notice under
          this Agreement.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(l)&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <u>Transfer Agent</u>.&#160; The Company shall engage and maintain, at its expense, a registrar and transfer agent for the Shares.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(m)&#160; &#160; &#160;&#160; <u>Due Diligence</u>.&#160; During the term of this Agreement, the Company will reasonably cooperate with any reasonable due diligence
          review conducted by the Agent in connection with the transactions contemplated hereby, including, without limitation, providing information and making available documents and senior corporate officers, during normal business hours and at the
          Company&#8217;s principal offices or virtually, as the Agent may reasonably request from time to time.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(n)&#160;&#160; &#160; &#160;&#160;&#160; <u>Representations and Warranties</u>.&#160; The Company acknowledges that each delivery of an Issuance Notice and each delivery of
          Shares on a Settlement Date shall be deemed to be (i) an affirmation to the Agent that the representations and warranties of the Company contained in or made pursuant to this Agreement are true and correct as of the date of such Issuance Notice
          or of such Settlement Date, as the case may be, as though made at and as of each such date, except as may be disclosed in the Prospectus (including any documents incorporated by reference therein and any supplements thereto); and (ii) an
          undertaking that the Company will advise the Agent if any of such representations and warranties will not be true and correct as of the Settlement Date for the Shares relating to such Issuance Notice, as though made at and as of each such date
          (except that such representations and warranties shall be deemed to relate to the Registration Statement and the Prospectus as amended and supplemented relating to such Shares).</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(o)&#160; &#160;&#160; &#160;&#160;&#160; <u>Deliverables at Triggering Event Dates; Certificates.</u>&#160; The Company agrees that on or prior to the date of the first Issuance
          Notice and, during the term of this Agreement after the date of the first Issuance Notice, upon:</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(A)&#160;&#160;&#160;&#160;&#160;&#160;&#160; the filing of the Prospectus or the amendment or supplement of any Registration Statement or Prospectus (other than a prospectus
          supplement relating solely to an offering of securities other than the Shares or a prospectus filed pursuant to Section 4(a)(ii)(B)), by means of a post-effective amendment, sticker or supplement, but not by means of incorporation of documents by
          reference into the Registration Statement or Prospectus;</font></div>
      <div style="color: rgb(0, 0, 0);"><br>
         </div>
      <div style="text-align: justify; text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(B)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the filing with the Commission of an annual report on Form 10-K or a quarterly report on Form 10-Q (including any Form 10-K/A or
          Form 10-Q/A containing amended financial information or a material amendment to the previously filed annual report on Form 10-K or quarterly report on Form 10-Q), in each case, of the Company; or</font></div>
      <div style="color: rgb(0, 0, 0);"><br>
         </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">28</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: justify; color: rgb(0, 0, 0); text-indent: 72pt;"> <font style="color: rgb(0, 0, 0);">(C)&#160; &#160; &#160;&#160; the filing with the Commission of a current report on Form 8-K of the Company (i) containing amended financial
          information (other than information &#8220;furnished&#8221; pursuant to Item 2.02 or 7.01 of Form 8-K or to provide disclosure pursuant to Item 8.01 of Form 8-K relating to reclassification of certain properties as discontinued operations in accordance with
          Statement of Financial Accounting Standards No. 144) and/or (ii) disclosing any material transaction requiring the filing of historical or pro forma financial statements under Item 9.01 of Form 8-K and subject to the guidance set forth in Section
          2050.3 of the Financial Reporting Manual of the Commission that is material to the offering of securities of the Company in the Agent&#8217;s reasonable discretion;</font></div>
      <div style="text-align: justify; color: rgb(0, 0, 0);"> <br>
        </div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">(any such event, a &#8220;<font style="font-weight: bold;">Triggering Event Date</font>&#8221;), the Company shall furnish the Agent (but in the case of clause (C) above only if the Agent
        reasonably determines that the information contained in such current report on Form 8-K of the Company is material) with a certificate as of the Triggering Event Date, in the form and substance satisfactory to the Agent and its counsel,
        substantially similar to the form previously provided to the Agent and its counsel, modified, as necessary, to relate to the Registration Statement and the Prospectus as amended or supplemented, (A) confirming that the representations and
        warranties of the Company contained in this Agreement are true and correct, (B) confirming that the Company has performed all of its obligations hereunder to be performed on or prior to the date of such certificate and as to the matters set forth
        in <u>Section 5(a)(iii)</u> hereof, and (C) containing any other certification that the Agent shall reasonably request.&#160; The requirement to provide a certificate under this <u>Section 4(o)</u> shall be waived for any Triggering Event Date
        occurring at a time when no Issuance Notice is pending or a suspension is in effect, which waiver shall continue until the earlier to occur of the date the Company delivers instructions for the sale of Shares hereunder (which for such calendar
        quarter shall be considered a Triggering Event Date) and the next occurring Triggering Event Date. Notwithstanding the foregoing, if the Company subsequently decides to sell Shares following a Triggering Event Date when a suspension was in effect
        and did not provide the Agent with a certificate under this Section 4(o), then before the Company delivers the instructions for the sale of Shares or the Agent sells any Shares pursuant to such instructions, the Company shall provide the Agent with
        a certificate in conformity with this Section 4(o) dated as of the date that the instructions for the sale of Shares are issued.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(p)&#160; &#160; &#160;&#160; &#160;&#160; <u>U.S. Legal Opinions.</u>&#160; On or prior to the date of the first Issuance Notice and on or prior to each Triggering Event Date
          with respect to which the Company is obligated to deliver a certificate pursuant to Section 4(o) for which no waiver is applicable and excluding the date of this Agreement, the Company shall cause to be furnished to the Agent, a negative
          assurances letter and the written legal opinion of Gibson, Dunn &amp; Crutcher LLP, U.S. counsel to the Company and Rimon Law, P.C., intellectual property counsel to the Company, each dated the date of delivery, in form and substance reasonably
          satisfactory to Agent and its counsel, substantially similar to the form previously provided to the Agent and its counsel, modified, as necessary, to relate to the Registration Statement and the Prospectus as then amended or supplemented;
          provided that the Company shall be required to furnish no more than one opinion from each such counsel per each filing of an Annual Report on Form 10-K or Quarterly Report on Form 10-Q filed by the Company.&#160; In lieu of such opinions for
          subsequent periodic filings, in the discretion of the Agent, the Company may furnish a reliance letter from such counsel to the Agent, permitting the Agent to rely on a previously delivered opinion letter, modified as appropriate for any passage
          of time or Triggering Event Date (except that statements in such prior opinion shall be deemed to relate to the Registration Statement and the Prospectus as amended or supplemented as of such Triggering Event Date). The Agent shall also have
          received a negative assurances letter from Wilmer Cutler Pickering Hale and Dorr LLP, U.S. counsel to the Agent, dated as of the date of delivery, in form and substance reasonable satisfactory to Agent, and the Company shall have furnished to
          such counsel such documents as they reasonably request for the purpose of enabling them to give such assurances.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">29</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(q)&#160;&#160;&#160; &#160;&#160; &#160;&#160; <u>PRC Legal Opinions</u>. On or prior to the date of the first Issuance Notice and on or prior to each Triggering Event Date with
          respect to which the Company is obligated to deliver a certificate pursuant to Section 4(o) for which no waiver is applicable and excluding the date of this Agreement, the Agent shall have received the written legal opinion of JunHe, PRC counsel
          to the Company, or such other counsel satisfactory to the Agent, dated the date of delivery, in form and substance reasonably satisfactory to the Agent and its counsel, substantially similar to the form previously provided to the Agent and its
          counsel, modified, as necessary, to relate to the Registration Statement and the Prospectus as then amended or supplemented. In lieu of such opinions for subsequent periodic filings, in the discretion of the Agent, the Company may furnish a
          reliance letter from such counsel to the Agent, permitting the Agent to rely on a previously delivered opinion letter, modified as appropriate for any passage of time or Triggering Event Date (except that statements in such prior opinion shall be
          deemed to relate to the Registration Statement and the Prospectus as amended or supplemented as of such Triggering Event Date).</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(r)&#160; &#160;&#160; &#160;&#160;&#160;&#160; <u>Comfort Letter</u>.&#160; On or prior to the date of the first Issuance Notice and on or prior to each Triggering Event Date with
          respect to which the Company is obligated to deliver a certificate pursuant to Section 4(o) for which no waiver is applicable and excluding the date of this Agreement, the Company shall cause Grant Thornton Zhitong Certified Public Accountants
          LLP, the independent registered public accounting firm who has audited the financial statements included or incorporated by reference in the Registration Statement, to furnish the Agent a comfort letter, dated the date of delivery, in form and
          substance reasonably satisfactory to the Agent and its counsel, substantially similar to the form previously provided to the Agent and its counsel; provided, however, that any such comfort letter will only be required on the Triggering Event Date
          specified to the extent that it contains financial statements filed with the Commission under the Exchange Act and incorporated or deemed to be incorporated by reference into a Prospectus.&#160; At any time when an Issuance Notice is outstanding, if
          requested by the Agent, the Company shall also cause a comfort letter to be furnished to the Agent on the date of occurrence of any material transaction or event requiring the filing of a current report on Form 8-K containing material amended
          financial information of the Company, including the restatement of the Company&#8217;s financial statements.&#160; The Company shall be required to furnish no more than one comfort letter hereunder per each filing of an Annual Report on Form 10-K or a
          Quarterly Report on Form 10-Q.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(r)&#160;&#160;&#160; &#160; &#160;&#160; &#160; <u>Secretary&#8217;s Certificate</u>.&#160; On or prior to the date of the first Issuance Notice and on or prior to each Triggering Event
          Date with respect to which the Company is obligated to deliver a certificate pursuant to <u>Section 4(o)</u> for which no waiver is applicable, the Company shall furnish the Agent a certificate executed by the Secretary of the Company, signing
          in such capacity, dated the date of delivery, (i) certifying that attached thereto are true and complete copies of the resolutions duly adopted by the Board of Directors of the Company authorizing the execution and delivery of this Agreement and
          the consummation of the transactions contemplated hereby (including, without limitation, the issuance of the Shares pursuant to this Agreement), which authorization shall be in full force and effect on and as of the date of such certificate, (ii)
          certifying and attesting to the office, incumbency, due authority and specimen signatures of each Person who executed this Agreement for or on behalf of the Company, and (iii) containing any other certification that the Agent shall
          reasonably request.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">30</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(s)&#160; &#160; &#160;&#160;&#160;&#160; <u>Agent&#8217;s Own Account; Clients&#8217; Account</u>.&#160; The Company consents to the Agent trading, in compliance with applicable law, in the
          Common Shares for the Agent&#8217;s own account and for the account of its clients at the same time as sales of the Shares occur pursuant to this Agreement.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(t) &#160; &#160;&#160;&#160; &#160;&#160; <u>Investment Limitation</u>.&#160; The Company shall not invest, or otherwise use the proceeds received by the Company from its sale of
          the Shares in such a manner as would require the Company or any of its subsidiaries to register as an investment company under the Investment Company Act.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(u)&#160;&#160;&#160; &#160; &#160;&#160;&#160; <u>Market Activities</u>.&#160; The Company will not take, directly or indirectly, any action designed to or that might be reasonably
          expected to cause or result in stabilization or manipulation of the price of the Shares or any other reference security, whether to facilitate the sale or resale of the Shares or otherwise, and the Company will, and shall use commercially
          reasonable efforts to cause each of its affiliates to, comply with all applicable provisions of Regulation M.&#160; If the limitations of Rule 102 of Regulation M (&#8220;<font style="font-weight: bold;">Rule 102</font>&#8221;) do not apply with respect to the
          Shares or any other reference security pursuant to any exception set forth in Section (d) of Rule 102, then promptly upon notice from the Agent (or, if later, at the time stated in the notice), the Company will, and shall use commercially
          reasonable efforts to cause each of its affiliates to, comply with Rule 102 as though such exception were not available but the other provisions of Rule 102 (as interpreted by the Commission) did apply.&#160; The Company shall promptly notify the
          Agent if it no longer meets the requirements set forth in Section (d) of Rule 102. </font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(v)&#160;&#160;&#160; &#160; &#160; <u>Notice of Other Sale</u>.&#160; Without the written consent of the Agent, the Company will not, directly or indirectly, offer to sell,
          sell, contract to sell, grant any option to sell or otherwise dispose of any Common Shares or securities convertible into or exchangeable for Common Shares (other than Shares hereunder), warrants or any rights to purchase or acquire Common
          Shares, during the period beginning on the third Trading Day immediately prior to the date on which any Issuance Notice is delivered to the Agent hereunder and ending on the earlier of (A) the third Trading Day immediately following the
          Settlement Date with respect to Shares sold pursuant to such Issuance Notice and (B) the date such Issuance Notice is cancelled if no Shares have been sold pursuant to such Issuance Notice, other than any reverse stock split approved by the
          stockholders of the Company prior to the date of this Agreement; and will not directly or indirectly enter into any other &#8220;at the market&#8221; or continuous equity transaction to offer to sell, sell, contract to sell, grant any option to sell or
          otherwise dispose of any Common Shares (other than the Shares offered pursuant to this Agreement) or securities convertible into or exchangeable for Common Shares, warrants or any rights to purchase or acquire, Common Shares prior to the
          termination of this Agreement; provided, however, that such restrictions will not be applicable in connection with the Company&#8217;s (i) issuance or sale of Common Shares, options to purchase Common Shares or Common Shares issuable upon the exercise
          of options or other equity awards pursuant to any employee or director share option, incentive or benefit plan, share purchase or ownership plan, long-term incentive plan, dividend reinvestment plan, inducement award under Nasdaq rules or other
          compensation plan of the Company or its subsidiaries, as in effect on the date of this Agreement, (ii) issuance or sale of Common Shares issuable upon exchange, conversion or redemption of preferred stock or other securities or the exercise or
          vesting of warrants, options or other equity awards outstanding at the date of this Agreement, (iii) issuance or sale of Common Shares or securities convertible into or exchangeable for Common Shares as consideration for mergers, acquisitions,
          other business combinations, joint ventures or strategic alliances occurring after the date of this Agreement which are not used for capital raising purposes, provided that the aggregate number of Common Shares issued or sold under this
          subsection (iii) shall not exceed 5% of the number of Common Shares outstanding immediately prior to giving effect to such sale of issuance, and (iv) modification of any options, warrants, preferred stock or any other rights to purchase or
          acquire Common Shares, in each case outstanding as of the date hereof.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">31</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(w)&#160;&#160; &#160;&#160; &#160;&#160; <u>CSRC Filing</u>. The PRC Entity, as the representative of the Company, shall complete the CSRC filing (including submitting a
          CSRC filing report, a copy of the legal opinion of JunHe, the Company&#8217;s PRC counsel with respect to such filing, and other materials requested by the CSRC) within three working days after completion of the initial sales in the offering, and
          report the overall offering information to the CSRC in a consolidated manner after the completion of the sale of the Aggregated Securities, as provided in the CSRC Filing Rules. The Agent shall also&#160; receive a verification report and the written
          &#8220;short form&#8221; legal memorandum of Haiwen &amp; Partners, PRC counsel to the Agent,&#160; in form and substance reasonably satisfactory to Agent, accompanying such report, and the Company shall have furnished to such counsel such documents as they
          reasonably request for the purpose of enabling them to issue such verification report and &#8220;short form&#8221; legal memorandum with respect to such matters.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="font-weight: bold; color: rgb(0, 0, 0);">Section 5.&#160; CONDITIONS TO DELIVERY OF ISSUANCE NOTICES AND TO SETTLEMENT</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)&#160;&#160; &#160; &#160;&#160;&#160;&#160; <u>Conditions Precedent to the Right of the Company to Deliver an Issuance Notice and the Obligation of the Agent to Sell Shares</u>.&#160;
          The right of the Company to deliver an Issuance Notice hereunder is subject to the satisfaction, on the date of delivery of such Issuance Notice, and the obligation of the Agent to use its commercially reasonable efforts to place Shares during
          the applicable period set forth in the Issuance Notice is subject to the satisfaction, on each Trading Day during the applicable period set forth in the Issuance Notice, of each of the following conditions:</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z9cfa58af9ebb424c805bf0a6b5a67d55" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; color: rgb(0, 0, 0);"><br>
               </td>
            <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(i)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman',Times,serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);"><u>Accuracy of the Company&#8217;s Representations and Warranties; Performance by the
                    Company</u>.&#160; The Company shall have delivered the certificate required to be delivered pursuant to <u>Section 4(o)</u> on or before the date on which delivery of such certificate is required pursuant to <u>Section 4(o)</u>.&#160; The
                  Company shall have performed, satisfied and complied with all covenants, agreements and conditions required by this Agreement to be performed, satisfied or complied with by the Company at or prior to such date, including, but not limited
                  to, the covenants contained in <u>Section 4(m)</u>, <u>Section 4(q)</u> and <u>Section 4(r)</u>.</font></div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zc6a827b6abcb4129a8313945f5ee407b" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; color: rgb(0, 0, 0);"><br>
               </td>
            <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(ii)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman',Times,serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);"><u>No Injunction</u>.&#160; No statute, rule, regulation, executive order, decree,
                  ruling or injunction shall have been enacted, entered, promulgated or endorsed by any court or governmental authority of competent jurisdiction or any self-regulatory organization having authority over the matters contemplated hereby that
                  prohibits or directly and materially adversely affects any of the transactions contemplated by this Agreement, and no proceeding shall have been commenced that may have the effect of prohibiting or materially adversely affecting any of
                  the transactions contemplated by this Agreement.</font></div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">32</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <table cellspacing="0" cellpadding="0" id="z5d9e5db073fb45cfba9be4d4c16253b1" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; color: rgb(0, 0, 0);"><br>
               </td>
            <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(iii)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman',Times,serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);"><u>Material Adverse Changes</u>.&#160; Except as disclosed in the Prospectus and the
                  Time of Sale Information, (a) in the judgment of the Agent there shall not have occurred any Material Adverse Change; and (b) there shall not have occurred any downgrading, nor shall any notice have been given of any intended or potential
                  downgrading or of any review for a possible change that does not indicate the direction of the possible change, in the rating accorded any securities of the Company or any of its subsidiaries by any &#8220;nationally recognized statistical
                  rating organization&#8221; as such term is defined for purposes of Section 3(a)(62) of the Exchange Act.</font></div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zde5e68975a9c4c479079a8fcf14046b7" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; color: rgb(0, 0, 0);"><br>
               </td>
            <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(iv)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="font-family: 'Times New Roman',Times,serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);"><u>No Suspension of Trading in or Delisting of Common Shares; Other Events</u>.&#160;
                  The trading of the Common Shares (including without limitation the Shares) shall not have been suspended by the Commission, the Principal Market or FINRA and the Common Shares (including without limitation the Shares) shall have been
                  approved for listing or quotation on and shall not have been delisted from the Nasdaq Stock Market, the New York Stock Exchange or any of their constituent markets.&#160; There shall not have occurred (and be continuing in the case of
                  occurrences under clauses (i) and (ii) below) any of the following:&#160; (i) trading or quotation in any of the Company&#8217;s securities shall have been suspended or limited by the Commission or by the Principal Market or trading in securities
                  generally on the Principal Market shall have been suspended or limited, or minimum or maximum prices shall have been generally established on any of such stock exchanges by the Commission or FINRA; (ii) a general banking moratorium shall
                  have been declared by any federal or New York authorities; or (iii) there shall have occurred any outbreak or escalation of national or international hostilities or any crisis or calamity, or any change in the United States or
                  international financial markets, or any substantial change or development involving a prospective substantial change in United States&#8217; or international political, financial or economic conditions, as in the judgment of the Agent is
                  material and adverse and makes it impracticable to market the Shares in the manner and on the terms described in the Prospectus or to enforce contracts for the sale of securities.</font></div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Documents Required to be Delivered on each Issuance Notice Date</u>.&#160; The Agent&#8217;s obligation to use its commercially reasonable
          efforts to place Shares hereunder shall additionally be conditioned upon the delivery to the Agent on or before the Issuance Notice Date of a certificate in form and substance reasonably satisfactory to the Agent, executed by the Chief Executive
          Officer, President or Chief Financial Officer of the Company, to the effect that all conditions to the delivery of such Issuance Notice shall have been satisfied as at the date of such certificate (which certificate shall not be
          required if the foregoing representations shall be set forth in the Issuance Notice).</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">33</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>No Misstatement or Material Omission</u>.&#160; The Agent shall not have advised the Company that the Registration Statement, the
          Prospectus or the Time of Sale Information, or any amendment or supplement thereto, contains an untrue statement of fact that in the Agent&#8217;s reasonable opinion is material, or omits to state a fact that in the Agent&#8217;s reasonable opinion is
          material and is required to be stated therein or is necessary to make the statements therein not misleading.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.&#160; INDEMNIFICATION AND CONTRIBUTION</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)&#160;&#160;&#160;&#160;&#160; &#160;&#160;&#160; <u>Indemnification of the Agent</u>.&#160; The Company agrees to indemnify and hold harmless the Agent, its officers and employees, and
          each person, if any, who controls the Agent within the meaning of the Securities Act or the Exchange Act against any loss, claim, damage, liability or expense, as incurred, to which the Agent or such officer, employee or controlling person may
          become subject, under the Securities Act, the Exchange Act, other federal or state statutory law or regulation, or the laws or regulations of foreign jurisdictions where Shares have been offered or sold or at common law or otherwise (including in
          settlement of any litigation), insofar as such loss, claim, damage, liability or expense (or actions in respect thereof as contemplated below) arises out of or is based upon (i) any untrue statement or alleged untrue statement of a material fact
          contained in the Registration Statement, or any amendment thereto, including any information deemed to be a part thereof pursuant to Rule 430B under the Securities Act, or the omission or alleged omission therefrom of a material fact required to
          be stated therein or necessary to make the statements therein not misleading; (ii) any untrue statement or alleged untrue statement of a material fact contained in any Free Writing Prospectus that the Company has used, referred to or filed, or is
          required to file, pursuant to Rule 433(d) of the Securities Act or the Prospectus (or any amendment or supplement thereto), or the omission or alleged omission therefrom of a material fact necessary in order to make the statements therein, in the
          light of the circumstances under which they were made, not misleading; or (iii) any of the CSRC filings relating to or in connection with this offering or any amendments or supplements thereto containing any untrue, incorrect or inaccurate or
          alleged untrue, incorrect or inaccurate statement of a material fact, or omitting or being alleged to have omitted a material fact necessary to make any statement therein, in the light of the circumstances under which it was made, not misleading,
          or not containing, or being alleged not to contain, all material information in the context of this offering or otherwise required to be contained thereto, and to reimburse the Agent and each such officer, employee and controlling person for any
          and all reasonable and documented expenses (including the reasonable and documented fees and disbursements of counsel chosen by the Agent) as such expenses are reasonably incurred by the Agent or such officer, employee or controlling person in
          connection with investigating, defending, settling, compromising or paying any such loss, claim, damage, liability, expense or action; provided, however, that the foregoing indemnity agreement shall not apply to any loss, claim, damage, liability
          or expense to the extent, but only to the extent, arising out of or based upon any untrue statement or alleged untrue statement or omission or alleged omission made in reliance upon and in conformity with written information furnished to the
          Company by the Agent expressly for use in the Registration Statement, any such Free Writing Prospectus or the Prospectus (or any amendment or supplement thereto), it being understood and agreed that the only such information furnished by the
          Agent to the Company consists of the information described in subsection (b) below.&#160; The indemnity agreement set forth in this <u>Section 6(a)</u>&#160; shall be in addition to any liabilities that the Company may otherwise have.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">34</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(b)&#160;&#160;&#160;&#160;&#160; &#160; &#160; <u>Indemnification of the Company, its Directors and Officers</u>.&#160; The Agent agrees to indemnify and hold harmless the Company,
          each of its directors, each of its officers who signed the Registration Statement and each person, if any, who controls the Company within the meaning of the Securities Act or the Exchange Act against any loss, claim, damage, liability or
          expense, as incurred, to which the Company or any such director, officer or controlling person may become subject, under the Securities Act, the Exchange Act, or other U.S. federal or state statutory law or regulation, or the laws or regulations
          of non-U.S. jurisdictions where Shares have been offered or sold or at common law or otherwise (including in settlement of any litigation), insofar as such loss, claim, damage, liability or expense arises out of or is based upon (i) any untrue
          statement or alleged untrue statement of a material fact contained in the Registration Statement, or any amendment thereto, including any information deemed to be a part thereof pursuant to Rule 430B under the Securities Act, or the omission or
          alleged omission therefrom of a material fact required to be stated therein or necessary to make the statements therein not misleading; or (ii) any untrue statement or alleged untrue statement of a material fact contained in any Free Writing
          Prospectus that the Company has used, referred to or filed, or is required to file, pursuant to Rule 433(d) of the Securities Act or the Prospectus (or any amendment or supplement thereto), or the omission or alleged omission therefrom of a
          material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading; but, for each of (i) and (ii) above, only to the extent arising out of or based upon any untrue
          statement or alleged untrue statement or omission or alleged omission made in reliance upon and in conformity with written information furnished to the Company by the Agent expressly for use in the Registration Statement, any such Free Writing
          Prospectus or the Prospectus (or any amendment or supplement thereto), it being understood and agreed that the only such information furnished by the Agent to the Company consists of the information set forth in the first sentence of the ninth
          paragraph under the caption &#8220;Plan of Distribution&#8221; in the Prospectus, and to reimburse the Company and each such director, officer and controlling person for any and all expenses (including the fees and disbursements of one counsel chosen by the
          Company) as such expenses are reasonably incurred by the Company or such officer, director or controlling person in connection with investigating, defending, settling, compromising or paying any such loss, claim, damage, liability, expense or
          action.&#160; The indemnity agreement set forth in this <u>Section 6(b)</u> shall be in addition to any liabilities that the Agent or the Company may otherwise have.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">35</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)&#160;&#160; &#160;&#160; &#160;&#160;&#160; <u>Notifications and Other Indemnification Procedures</u>.&#160; Promptly after receipt by an indemnified party under this <u>Section 6</u>
          of notice of the commencement of any action, such indemnified party will, if a claim in respect thereof is to be made against an indemnifying party under this <u>Section 6</u>, notify the indemnifying party in writing of the commencement
          thereof, but the omission so to notify the indemnifying party will not relieve it from any liability which it may have to any indemnified party for contribution or otherwise than under the indemnity agreement contained in this <u>Section 6</u>
          or to the extent it is not prejudiced as a proximate result of such failure.&#160; In case any such action is brought against any indemnified party and such indemnified party seeks or intends to seek indemnity from an indemnifying party, the
          indemnifying party will be entitled to participate in, and, to the extent that it shall elect, jointly with all other indemnifying parties similarly notified, by written notice delivered to the indemnified party promptly after receiving the
          aforesaid notice from such indemnified party, to assume the defense thereof with counsel reasonably satisfactory to such indemnified party; provided, however, if the defendants in any such action include both the indemnified party and the
          indemnifying party and the indemnified party shall have reasonably concluded based on advice of counsel that a conflict may arise between the positions of the indemnifying party and the indemnified party in conducting the defense of any such
          action or that there may be legal defenses available to it and/or other indemnified parties which are different from or additional to those available to the indemnifying party, the indemnified party or parties shall have the right to select
          separate counsel to assume such legal defenses and to otherwise participate in the defense of such action on behalf of such indemnified party or parties.&#160; Upon receipt of notice from the indemnifying party to such indemnified party of such
          indemnifying party&#8217;s election so to assume the defense of such action and approval by the indemnified party of counsel, the indemnifying party will not be liable to such indemnified party under this <u>Section 6</u> for any reasonable and
          documented legal or other expenses subsequently incurred by such indemnified party in connection with the defense thereof unless (i) the indemnified party shall have employed separate counsel in accordance with the proviso to the preceding
          sentence (it being understood, however, that the indemnifying party shall not be liable for the fees and expenses of more than one separate counsel (together with local counsel), representing the indemnified parties who are parties to such
          action), which counsel (together with any local counsel) for the indemnified parties shall be selected by the indemnified party (in the case of counsel for the indemnified parties referred to in <u>Section 6(a)</u> and <u>Section 6(b)</u>
          above), (ii) the indemnifying party shall not have employed counsel reasonably satisfactory to the indemnified party to represent the indemnified party within a reasonable time after notice of commencement of the action or (iii) the indemnifying
          party has authorized in writing the employment of counsel for the indemnified party at the expense of the indemnifying party, in each of which cases the fees and expenses of counsel shall be at the expense of the indemnifying party and shall be
          paid as they are incurred.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(d)&#160;&#160; &#160;&#160; &#160; &#160; <u>Settlements</u>.&#160; The indemnifying party under this <u>Section 6</u> shall not be liable for any settlement of any proceeding
          effected without its written consent, but if settled with such consent or if there be a final judgment for the plaintiff, the indemnifying party agrees to indemnify the indemnified party against any loss, claim, damage, liability or expense by
          reason of such settlement or judgment.&#160; Notwithstanding the foregoing sentence, if at any time an indemnified party shall have requested an indemnifying party to reimburse the indemnified party for fees and expenses of counsel as contemplated by
          Section<u> 6(c)</u> hereof, the indemnifying party agrees that it shall be liable for any settlement of any proceeding effected without its written consent if (i) such settlement is entered into more than thirty (30) calendar days after receipt
          by such indemnifying party of the aforesaid request; and (ii) such indemnifying party shall not have reimbursed the indemnified party in accordance with such request prior to the date of such settlement.&#160; No indemnifying party shall, without the
          prior written consent of the indemnified party, effect any settlement, compromise or consent to the entry of judgment in any pending or threatened action, suit or proceeding in respect of which any indemnified party is or could have been a party
          and indemnity was or could have been sought hereunder by such indemnified party, unless such settlement, compromise or consent includes an unconditional release of such indemnified party from all liability on claims that are the subject matter of
          such action, suit or proceeding.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">36</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Contribution</u>.&#160; If the indemnification provided for in this <u>Section 6</u> is for any reason held to be unavailable to or
          otherwise insufficient to hold harmless an indemnified party in respect of any losses, claims, damages, liabilities or expenses referred to therein, then each indemnifying party shall contribute to the aggregate amount paid or payable by such
          indemnified party, as incurred, as a result of any losses, claims, damages, liabilities or expenses referred to therein (i) in such proportion as is appropriate to reflect the relative benefits received by the Company, on the one hand, and the
          Agent, on the other hand, from the offering of the Shares pursuant to this Agreement; or (ii) if the allocation provided by clause (i) above is not permitted by applicable law, in such proportion as is appropriate to reflect not only the relative
          benefits referred to in clause (i) above but also the relative fault of the Company, on the one hand, and the Agent, on the other hand, in connection with the statements or omissions which resulted in such losses, claims, damages, liabilities or
          expenses, as well as any other relevant equitable considerations.&#160; The relative benefits received by the Company, on the one hand, and the Agent, on the other hand, in connection with the offering of the Shares pursuant to this Agreement shall be
          deemed to be in the same respective proportions as the total gross proceeds from the offering of the Shares (before deducting expenses) received by the Company bear to the total Selling Commission received by the Agent.&#160; The relative fault of the
          Company, on the one hand, and the Agent, on the other hand, shall be determined by reference to, among other things, whether any such untrue or alleged untrue statement of a material fact or omission or alleged omission to state a material fact
          relates to information supplied by the Company, on the one hand, or the Agent, on the other hand, and the parties&#8217; relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">The amount paid or payable by a party as a result of the losses, claims, damages, liabilities and expenses referred to above shall be deemed to include,
        subject to the limitations set forth in <u>Section</u> 6(c), any reasonable and documented legal or other fees or expenses incurred by such party in connection with investigating or defending any action or claim.&#160; The provisions set forth in
        Section<u> 6(c)</u> with respect to notice of commencement of any action shall apply if a claim for contribution is to be made under this <u>Section 6(e)</u>; <font style="font-style: italic;">provided, however,</font> that no additional notice
        shall be required with respect to any action for which notice has been given under <u>Section</u> 6(c) for purposes of indemnification.</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">The Company and the Agent agree that it would not be just and
          equitable if contribution pursuant to this <u>Section</u> 6(e) were determined by pro rata allocation or by any other method of allocation which does not take account of the equitable considerations referred to in this <u>Section 6(e)</u>.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">Notwithstanding the provisions of this <u>Section</u>
          6(e), the Agent shall not be required to contribute any amount in excess of the Selling Commission received by the Agent in connection with the offering contemplated hereby.&#160; No person guilty of fraudulent misrepresentation (within the meaning of
          Section 11(f) of the Securities Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation.&#160; For purposes of this <u>Section</u> 6(e), each officer and employee of the Agent and each person, if
          any, who controls the Agent within the meaning of the Securities Act or the Exchange Act shall have the same rights to contribution as the Agent, and each director of the Company, each officer of the Company who signed the Registration Statement,
          and each person, if any, who controls the Company within the meaning of the Securities Act and the Exchange Act shall have the same rights to contribution as the Company.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.&#160; TERMINATION &amp; SURVIVAL</div>
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Term</u>.&#160; Subject to the provisions of this <u>Section 7</u>, the term of this Agreement shall continue from the date of this
          Agreement until the end of the Agency Period, unless earlier terminated by the parties to this Agreement pursuant to this <u>Section 7</u>.</font></div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
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      <div style="color: rgb(0, 0, 0);">&#160;</div>
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              <div>Either party may terminate this Agreement prior to the end of the Agency Period, by giving written notice as required by this Agreement, upon ten (10) Trading Days&#8217; notice to the other party; provided that, (A)
                if the Company terminates this Agreement after the Agent confirms to the Company any sale of Shares, the Company shall remain obligated to comply with <u>Section 3(b)(v)</u> with respect to such Shares and (B) <u>Section 2</u>, Section<u>
                  3(d)</u>, <u>Section 6</u>, <u>Section 7</u> and <u>Section 8</u> shall survive termination of this Agreement.&#160; If termination shall occur prior to the Settlement Date for any sale of Shares, such sale shall nevertheless settle in
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      <div style="color: rgb(0, 0, 0);">&#160;</div>
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                <div style="text-align: justify; color: rgb(0, 0, 0);">In addition to the survival provision of <u>Section 7(b)(i)</u>, the respective indemnities, agreements, representations, warranties and other statements of the
                  Company, of its officers and of the Agent set forth in or made pursuant to this Agreement will remain in full force and effect, regardless of any investigation made by or on behalf of the Agent or the Company or any of its or their
                  partners, officers or directors or any controlling person, as the case may be, and, anything herein to the contrary notwithstanding, will survive delivery of and payment for the Shares sold hereunder and any termination of this Agreement;
                  <u>provided that</u>, for the avoidance of doubt, upon termination of this Agreement, the Company shall not have any liability to the Agent for any discount, commission or other compensation with respect to any Shares not sold by the
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              </td>
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          describing the material terms of the transactions contemplated hereby, and the Company shall consult with the Agent prior to making such disclosures, and the parties hereto shall use all commercially reasonable efforts, acting in good faith, to
          agree upon a text for such disclosures that is reasonably satisfactory to all parties hereto.&#160; No party hereto shall issue thereafter any press release or like public statement (including, without limitation, any disclosure required in reports
          filed with the Commission pursuant to the Exchange Act) related to this Agreement or any of the transactions contemplated hereby without the prior written approval of the other party hereto, except as may be necessary or appropriate in the
          reasonable opinion of the party seeking to make disclosure to comply with the requirements of applicable law or stock exchange rules.&#160; If any such press release or like public statement is so required, the party making such disclosure shall
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      <div style="color: rgb(0, 0, 0);">&#160;</div>
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          acting solely as a principal and is not the agent or fiduciary of the Company, or its stockholders, creditors, employees or any other party, (iii) the Agent has not assumed nor will assume an advisory or fiduciary responsibility in favor of the
          Company with respect to the transactions contemplated hereby or the process leading thereto (irrespective of whether the Agent has advised or is currently advising the Company on other matters) and the Agent does not have any obligation to the
          Company with respect to the transactions contemplated hereby except the obligations expressly set forth in this Agreement, (iv) the Agent and its Affiliates may be engaged in a broad range of transactions that involve interests that differ from
          those of the Company, and (v) the Agent has not provided any legal, accounting, regulatory or tax advice with respect to the transactions contemplated hereby and the Company has consulted its own legal, accounting, regulatory and tax advisors to
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Research Analyst Independence</u>.&#160; The Company acknowledges that the Agent&#8217;s research analysts and research departments are
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          recommendations and/or publish research reports with respect to the Company or the offering that differ from the views of their respective investment banking divisions.&#160; The Company understands that the Agent is a full service securities firm and
          as such from time to time, subject to applicable securities laws, may effect transactions for its own account or the account of its customers and hold long or short positions in debt or equity securities of the companies that may be the subject
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      <div style="color: rgb(0, 0, 0);">&#160;</div>
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            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Jefferies LLC</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>520 Madison Avenue</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>New York, NY 10022</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Attention:&#160; General Counsel</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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          <tr>
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              <div>with a copy (which shall not constitute notice) to:</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>Wilmer Cutler Pickering Hale and Dorr LLP</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>7 World Trade Center</div>
            </td>
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          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>250 Greenwich Street</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>New York, NY 10007</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Attention: Lisa Firenze</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Gyre Therapeutics, Inc.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>12770 High Bluff Drive</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>Suite 150</div>
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              <div>San Diego, CA 92130</div>
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            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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          <tr>
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            <td style="width: 6%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">39</font></div>
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              <div>with a copy (which shall not constitute notice) to:</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 7%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 90%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 7%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>Gibson, Dunn &amp; Crutcher LLP</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 7%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>One Embarcadero Center</div>
            </td>
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          <tr>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 7%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>Suite 2600</div>
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            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 7%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>San Francisco, CA 94111</div>
            </td>
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          <tr>
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            <td style="width: 7%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 90%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Attention: Ryan A. Murr; Branden C. Berns</div>
            </td>
          </tr>

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      <div style="text-align: justify; color: rgb(0, 0, 0);">Any party hereto may change the address for receipt of communications by giving written notice to the others in accordance with this <u>Section 8(d)</u>.</div>
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(h)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Governing Law Provisions</u>.&#160; This Agreement shall be governed by and construed in accordance with the internal laws of the
          State of New York applicable to agreements made and to be performed in such state.&#160; Any legal suit, action or proceeding arising out of or based upon this Agreement or the transactions contemplated hereby may be instituted in the federal courts
          of the United States of America located in the Borough of Manhattan in the City of New York or the courts of the State of New York in each case located in the Borough of Manhattan in the City of New York (collectively, the &#8220;<font style="font-weight: bold;">Specified Courts</font>&#8221;), and each party irrevocably submits to the exclusive jurisdiction (except for proceedings instituted in regard to the enforcement of a judgment of any such court, as to which such
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          or other proceeding brought in any such court.&#160; The parties irrevocably and unconditionally waive any objection to the laying of venue of any suit, action or other proceeding in the Specified Courts and irrevocably and unconditionally waive and
          agree not to plead or claim in any such court that any such suit, action or other proceeding brought in any such court has been brought in an inconvenient forum.</font></div>
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      <div style="text-align: justify; text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(i)&#160;&#160;&#160; &#160; &#160; &#160;&#160; <u>Judgment Currency&#894; Payments</u>. The obligation of the Company in respect of any sum due to the Agent under this Agreement
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          greater than the sum originally due to the Agent hereunder, the Agent agrees to pay to the Company an amount equal to the excess of the U.S. dollars so purchased over the sum originally due to the Agent hereunder. All payments made or deemed to
          be made by the Company under this Agreement, if any, to the Agent, their respective affiliates, and their affiliates&#8217; respective partners, members, directors, officers, employees and agents or to any person controlling the Agent within the
          meaning of the Securities Act or the Exchange Act or that is controlled by or is under common control with the Agent, will be made without withholding or deduction for or on account of any present or future taxes, duties, assessments or
          governmental charges of whatever nature (other than taxes on net income or similar taxes) imposed or levied by or on behalf of the PRC, Hong Kong or any political subdivision or any taxing authority thereof or therein unless the Company is or
          becomes required by law to withhold or deduct such taxes, duties, assessments or other governmental charges. In such event, the Company will pay such additional amounts as will result, after such withholding or deduction, in the receipt by the
          Agent, their respective affiliates, and their affiliates&#8217; respective partners, members, directors, officers, employees and agents or to any person controlling the Agent within the meaning of the Securities Act or the Exchange Act or that is
          controlled by or is under common control with the Agent, as the case may be, of the amounts that would otherwise have been receivable in respect thereof.</font></div>
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          prior written or oral and all contemporaneous oral agreements, understandings and negotiations with respect to the subject matter hereof.&#160; This Agreement may be executed in two or more counterparts, each one of which shall be an original, with
          the same effect as if the signatures thereto and hereto were upon the same instrument, and may be delivered by facsimile transmission or by electronic delivery of a portable document format (PDF) file (including any electronic signature covered
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          parties hereto, and no condition herein (express or implied) may be waived unless waived in writing by each party whom the condition is meant to benefit.&#160; The Article and Section headings herein are for the convenience of the parties only and
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      <div style="text-align: center; font-style: italic; color: rgb(0, 0, 0);">[Signature Page Immediately Follows]</div>
      <div style="text-align: center; font-style: italic; color: rgb(0, 0, 0);"> <br>
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">If the foregoing is in accordance with your understanding of our agreement, kindly sign and return to the Company the enclosed copies hereof, whereupon this
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      <div style="color: rgb(0, 0, 0);">&#160;</div>
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              <div>Very truly yours,</div>
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          <tr>
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            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 5%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div style="font-weight: bold;">GYRE THERAPEUTICS, INC.</div>
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              <div style="color: rgb(0, 0, 0);">/s/ Ruoyu Chen</div>
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            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>Chief Financial Officer</div>
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      <div style="text-indent: 36pt; color: rgb(0, 0, 0);">The foregoing Agreement is hereby confirmed and accepted by the Agent in New York, New York as of the date first above written.</div>
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              <div style="font-weight: bold;">JEFFERIES LLC</div>
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            <td style="width: 42%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>By:</div>
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              <div>/s/ Donald Lynaugh</div>
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              <div>Title:</div>
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              <div>Managing Director</div>
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      <div style="text-align: center; font-weight: bold; color: rgb(0, 0, 0);">EXHIBIT A</div>
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      <div style="text-align: center; color: rgb(0, 0, 0);">ISSUANCE NOTICE</div>
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      <div style="color: rgb(0, 0, 0);">[Date]</div>
      <div style="color: rgb(0, 0, 0);">&#160;</div>
      <div style="color: rgb(0, 0, 0);">Jefferies LLC</div>
      <div style="color: rgb(0, 0, 0);">520 Madison Avenue</div>
      <div style="color: rgb(0, 0, 0);">New York, New York 10022</div>
      <div style="color: rgb(0, 0, 0);"><br>
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      <div style="color: rgb(0, 0, 0);">Attn: [__________]</div>
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      <div style="text-align: justify; color: rgb(0, 0, 0);">Reference is made to the Open Market Sale Agreement between Gyre Therapeutics, Inc. (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;) and Jefferies LLC (the &#8220;<font style="font-weight: bold;">Agent</font>&#8221;) dated as of November 27, 2024.&#160; The Company confirms that all conditions to the delivery of this Issuance Notice are satisfied as of the date hereof.</div>
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      <div style="color: rgb(0, 0, 0);"> </div>
      <div style="color: rgb(0, 0, 0);"> Date of Delivery of Issuance Notice (determined pursuant to <u>Section 3(b)(i)</u>):</div>
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      <div style="color: rgb(0, 0, 0);">Issuance Amount (equal to the total Sales Price for such Shares):</div>
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              <div>$</div>
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            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0); padding-bottom: 2px;">&#160;</td>
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              <div>Number of days in selling period:</div>
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            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0); padding-bottom: 2px;">&#160;</td>
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            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0); padding-bottom: 2px;">&#160;</td>
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            <td style="width: 30%; vertical-align: top; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
            <td style="width: 20%; vertical-align: top; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
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      <div style="color: rgb(0, 0, 0);">Settlement Date(s) if other than standard T+1 settlement:</div>
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            <td style="width: 30%; vertical-align: top; color: rgb(0, 0, 0); padding-bottom: 2px;">&#160;</td>
            <td style="width: 20%; vertical-align: top; color: rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0); padding-bottom: 2px;">&#160;</td>
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      <div style="text-align: justify; color: rgb(0, 0, 0);"> <br>
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      <div style="text-align: justify; color: rgb(0, 0, 0);">Floor Price Limitation (in no event less than $1.00 without the prior written consent of the Agent, which consent may be withheld in the Agent&#8217;s sole discretion): $ ____ per
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              <div>Comments:</div>
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      <div style="color: rgb(0, 0, 0);"><br>
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              <div>GYRE THERAPEUTICS, INC.</div>
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            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 5%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 42%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>By:</div>
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            <td style="vertical-align: top; color: rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">&#160;</td>
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            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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              <div>Name:</div>
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            <td style="width: 42%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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          <tr>
            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 5%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Title:</div>
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            <td style="width: 42%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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      <div style="color: rgb(0, 0, 0);"><br>
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        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">A-1</font></div>
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      <div style="text-align: center; font-weight: bold; color: rgb(0, 0, 0);">Schedule A</div>
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  <div style="text-align: right;"><font style="font-weight: bold; font-family: 'Times New Roman';">Exhibit 5.1</font><font style="font-family: 'Times New Roman';"><br>
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            <div>Gibson, Dunn &amp; Crutcher LLP</div>
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            <div>One Embarcadero Center</div>
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            <div>San Francisco, CA 94111-3715</div>
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            <div>gibsondunn.com</div>
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            <div>Client: 21582.00005</div>
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    <div style="font-family: 'Times New Roman';">November 27, 2024</div>
    <div style="font-family: 'Times New Roman';">&#160;</div>
    <div style="font-family: 'Times New Roman';">Gyre Therapeutics, Inc.</div>
    <div style="font-family: 'Times New Roman';">12770 High Bluff Drive, Suite 150</div>
    <div style="font-family: 'Times New Roman';">San Diego, CA 92130</div>
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              <div style="text-align: left;">Re:</div>
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              <div><font style="font-style: italic;">Gyre Therapeutics, Inc.</font></div>
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    <div style="font-family: 'Times New Roman'; font-style: italic;">Registration Statement on Form S-3</div>
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    <div style="font-family: 'Times New Roman';">Ladies and Gentlemen</div>
    <div style="font-family: 'Times New Roman';">&#160;</div>
    <div style="font-family: 'Times New Roman';">We have examined the Registration Statement on Form S-3 (the &#8220;Registration Statement&#8221;) of Gyre Therapeutics, Inc., a Delaware corporation (the &#8220;Company&#8221;), filed with the Securities and Exchange Commission
      (the &#8220;Commission&#8221;) pursuant to the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), and the prospectus supplement thereto dated November 27, 2024 (the &#8220;Prospectus Supplement&#8221;), in connection with the offering by the Company of up to
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    <div style="font-family: 'Times New Roman';">&#160;</div>
    <div style="font-family: 'Times New Roman';">In arriving at the opinion expressed below, we have examined originals, or copies certified or otherwise identified to our satisfaction as being true and complete copies of the originals, of specimen common
      stock certificates and such other documents, corporate records, certificates of officers of the Company and of public officials and other instruments as we have deemed necessary or advisable to enable us to render the opinions set forth below. In our
      examination, we have assumed without independent investigation the genuineness of all signatures, the legal capacity and competency of all natural persons, the authenticity of all documents submitted to us as originals and the conformity to original
      documents of all documents submitted to us as copies. We have further assumed that all offers and sales of the Shares will comply with the minimum offering price and pricing formula set forth in the authorization of the offering and sale of the
      Shares by the Company&#8217;s Board of Directors.</div>
    <div style="font-family: 'Times New Roman';">&#160;</div>
    <div style="font-family: 'Times New Roman';">Based upon the foregoing, and subject to the assumptions, exceptions, qualifications and limitations set forth herein, we are of the opinion that the Shares, when issued against payment therefor as set forth
      in the Registration Statement and the Prospectus Supplement thereto, will be validly issued, fully paid and non-assessable.</div>
    <div style="font-family: 'Times New Roman';">&#160;</div>
    <div style="font-family: 'Times New Roman';">We consent to the filing of this opinion as an exhibit to the Registration Statement, and we further consent to the use of our name under the caption &#8220;Legal Matters&#8221; in the Registration Statement and the
      Prospectus Supplement. In giving these consents, we do not thereby admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the Rules and Regulations of the Commission.</div>
    <div style="font-family: 'Times New Roman';">&#160;</div>
    <div style="font-family: 'Times New Roman';">Very truly yours,</div>
    <div style="font-family: 'Times New Roman';"><br>
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    <div style="font-family: 'Times New Roman';">/s/ Gibson, Dunn &amp; Crutcher LLP</div>
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        <div style="font-family: 'Times New Roman'; font-size: 10pt;"><font style="font-weight: bold;">Gibson, Dunn &amp; Crutcher LLP</font> </div>
        <div style="font-family: 'Times New Roman'; font-size: 10pt;">One Embarcadero Center Suite 2600 | San Francisco, CA 94111-3715 | T: 415.393.8200 | F: 415.393.8306 | gibsondunn.com</div>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentPeriodEndDate" xlink:label="DocumentPeriodEndDate" xlink:title="DocumentPeriodEndDate" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentPeriodEndDate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentPeriodEndDate" xml:lang="en-US" id="dei_DocumentPeriodEndDate">Document Period End Date</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentPeriodEndDate" xlink:to="dei_DocumentPeriodEndDate" xlink:title="label: DocumentPeriodEndDate to dei_DocumentPeriodEndDate" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityRegistrantName" xlink:label="EntityRegistrantName" xlink:title="EntityRegistrantName" />
    <link:label xlink:type="resource" xlink:label="dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityRegistrantName" xml:lang="en-US" id="dei_EntityRegistrantName">Entity Registrant Name</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityRegistrantName" xlink:to="dei_EntityRegistrantName" xlink:title="label: EntityRegistrantName to dei_EntityRegistrantName" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCentralIndexKey" xlink:label="EntityCentralIndexKey" xlink:title="EntityCentralIndexKey" />
    <link:label xlink:type="resource" xlink:label="dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityCentralIndexKey" xml:lang="en-US" id="dei_EntityCentralIndexKey">Entity Central Index Key</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityCentralIndexKey" xlink:to="dei_EntityCentralIndexKey" xlink:title="label: EntityCentralIndexKey to dei_EntityCentralIndexKey" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityFileNumber" xlink:label="EntityFileNumber" xlink:title="EntityFileNumber" />
    <link:label xlink:type="resource" xlink:label="dei_EntityFileNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityFileNumber" xml:lang="en-US" id="dei_EntityFileNumber">Entity File Number</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityFileNumber" xlink:to="dei_EntityFileNumber" xlink:title="label: EntityFileNumber to dei_EntityFileNumber" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityTaxIdentificationNumber" xlink:label="EntityTaxIdentificationNumber" xlink:title="EntityTaxIdentificationNumber" />
    <link:label xlink:type="resource" xlink:label="dei_EntityTaxIdentificationNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityTaxIdentificationNumber" xml:lang="en-US" id="dei_EntityTaxIdentificationNumber">Entity Tax Identification Number</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityTaxIdentificationNumber" xlink:to="dei_EntityTaxIdentificationNumber" xlink:title="label: EntityTaxIdentificationNumber to dei_EntityTaxIdentificationNumber" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="EntityIncorporationStateCountryCode" xlink:title="EntityIncorporationStateCountryCode" />
    <link:label xlink:type="resource" xlink:label="dei_EntityIncorporationStateCountryCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityIncorporationStateCountryCode" xml:lang="en-US" id="dei_EntityIncorporationStateCountryCode">Entity Incorporation, State or Country Code</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityIncorporationStateCountryCode" xlink:to="dei_EntityIncorporationStateCountryCode" xlink:title="label: EntityIncorporationStateCountryCode to dei_EntityIncorporationStateCountryCode" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityEmergingGrowthCompany" xlink:label="EntityEmergingGrowthCompany" xlink:title="EntityEmergingGrowthCompany" />
    <link:label xlink:type="resource" xlink:label="dei_EntityEmergingGrowthCompany" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityEmergingGrowthCompany" xml:lang="en-US" id="dei_EntityEmergingGrowthCompany">Entity Emerging Growth Company</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityEmergingGrowthCompany" xlink:to="dei_EntityEmergingGrowthCompany" xlink:title="label: EntityEmergingGrowthCompany to dei_EntityEmergingGrowthCompany" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine1" xlink:label="EntityAddressAddressLine1" xlink:title="EntityAddressAddressLine1" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressAddressLine1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressAddressLine1" xml:lang="en-US" id="dei_EntityAddressAddressLine1">Entity Address, Address Line One</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressAddressLine1" xlink:to="dei_EntityAddressAddressLine1" xlink:title="label: EntityAddressAddressLine1 to dei_EntityAddressAddressLine1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine2" xlink:label="EntityAddressAddressLine2" xlink:title="EntityAddressAddressLine2" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressAddressLine2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressAddressLine2" xml:lang="en-US" id="dei_EntityAddressAddressLine2">Entity Address, Address Line Two</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressAddressLine2" xlink:to="dei_EntityAddressAddressLine2" xlink:title="label: EntityAddressAddressLine2 to dei_EntityAddressAddressLine2" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine3" xlink:label="EntityAddressAddressLine3" xlink:title="EntityAddressAddressLine3" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressAddressLine3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressAddressLine3" xml:lang="en-US" id="dei_EntityAddressAddressLine3">Entity Address, Address Line Three</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressAddressLine3" xlink:to="dei_EntityAddressAddressLine3" xlink:title="label: EntityAddressAddressLine3 to dei_EntityAddressAddressLine3" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCityOrTown" xlink:label="EntityAddressCityOrTown" xlink:title="EntityAddressCityOrTown" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressCityOrTown" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressCityOrTown" xml:lang="en-US" id="dei_EntityAddressCityOrTown">Entity Address, City or Town</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressStateOrProvince" xlink:label="EntityAddressStateOrProvince" xlink:title="EntityAddressStateOrProvince" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressStateOrProvince" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressStateOrProvince" xml:lang="en-US" id="dei_EntityAddressStateOrProvince">Entity Address, State or Province</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressStateOrProvince" xlink:to="dei_EntityAddressStateOrProvince" xlink:title="label: EntityAddressStateOrProvince to dei_EntityAddressStateOrProvince" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCountry" xlink:label="EntityAddressCountry" xlink:title="EntityAddressCountry" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressCountry" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressCountry" xml:lang="en-US" id="dei_EntityAddressCountry">Entity Address, Country</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressCountry" xlink:to="dei_EntityAddressCountry" xlink:title="label: EntityAddressCountry to dei_EntityAddressCountry" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressPostalZipCode" xlink:label="EntityAddressPostalZipCode" xlink:title="EntityAddressPostalZipCode" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressPostalZipCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressPostalZipCode" xml:lang="en-US" id="dei_EntityAddressPostalZipCode">Entity Address, Postal Zip Code</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CityAreaCode" xlink:label="CityAreaCode" xlink:title="CityAreaCode" />
    <link:label xlink:type="resource" xlink:label="dei_CityAreaCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_CityAreaCode" xml:lang="en-US" id="dei_CityAreaCode">City Area Code</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_LocalPhoneNumber" xlink:label="LocalPhoneNumber" xlink:title="LocalPhoneNumber" />
    <link:label xlink:type="resource" xlink:label="dei_LocalPhoneNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_LocalPhoneNumber" xml:lang="en-US" id="dei_LocalPhoneNumber">Local Phone Number</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="LocalPhoneNumber" xlink:to="dei_LocalPhoneNumber" xlink:title="label: LocalPhoneNumber to dei_LocalPhoneNumber" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_Security12bTitle" xlink:label="Security12bTitle" xlink:title="Security12bTitle" />
    <link:label xlink:type="resource" xlink:label="dei_Security12bTitle" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_Security12bTitle" xml:lang="en-US" id="dei_Security12bTitle">Title of 12(b) Security</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_NoTradingSymbolFlag" xlink:label="NoTradingSymbolFlag" xlink:title="NoTradingSymbolFlag" />
    <link:label xlink:type="resource" xlink:label="dei_NoTradingSymbolFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_NoTradingSymbolFlag" xml:lang="en-US" id="dei_NoTradingSymbolFlag">No Trading Symbol Flag</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="NoTradingSymbolFlag" xlink:to="dei_NoTradingSymbolFlag" xlink:title="label: NoTradingSymbolFlag to dei_NoTradingSymbolFlag" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_TradingSymbol" xlink:label="TradingSymbol" xlink:title="TradingSymbol" />
    <link:label xlink:type="resource" xlink:label="dei_TradingSymbol" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_TradingSymbol" xml:lang="en-US" id="dei_TradingSymbol">Trading Symbol</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="TradingSymbol" xlink:to="dei_TradingSymbol" xlink:title="label: TradingSymbol to dei_TradingSymbol" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SecurityExchangeName" xlink:label="SecurityExchangeName" xlink:title="SecurityExchangeName" />
    <link:label xlink:type="resource" xlink:label="dei_SecurityExchangeName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_SecurityExchangeName" xml:lang="en-US" id="dei_SecurityExchangeName">Security Exchange Name</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="SecurityExchangeName" xlink:to="dei_SecurityExchangeName" xlink:title="label: SecurityExchangeName to dei_SecurityExchangeName" />
  </link:labelLink>
</link:linkbase>
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</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>6
<FILENAME>gyre-20241127_pre.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii"?>
<!--Generated by Broadridge PROfile 24.11.1.5268 Broadridge-->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance">
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    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="AmendmentFlag" xlink:title="presentation: CoverAbstract to AmendmentFlag" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
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    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="DocumentFiscalPeriodFocus" xlink:title="presentation: CoverAbstract to DocumentFiscalPeriodFocus" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityRegistrantName" xlink:label="EntityRegistrantName" xlink:title="EntityRegistrantName" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityRegistrantName" xlink:title="presentation: CoverAbstract to EntityRegistrantName" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityTaxIdentificationNumber" xlink:label="EntityTaxIdentificationNumber" xlink:title="EntityTaxIdentificationNumber" />
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine1" xlink:label="EntityAddressAddressLine1" xlink:title="EntityAddressAddressLine1" />
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<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="include/report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
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<span style="display: none;">v3.24.3</span><table class="report" border="0" cellspacing="2" id="idm46080580290256">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Document and Entity Information<br></strong></div></th>
<th class="th"><div>Nov. 27, 2024</div></th>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CoverAbstract', window );"><strong>Cover [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentType', window );">Document Type</a></td>
<td class="text">8-K<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AmendmentFlag', window );">Amendment Flag</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Nov. 27,  2024<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityFileNumber', window );">Entity File Number</a></td>
<td class="text">000-51173<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">GYRE THERAPEUTICS, INC.<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0001124105<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityIncorporationStateCountryCode', window );">Entity Incorporation, State or Country Code</a></td>
<td class="text">DE<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityTaxIdentificationNumber', window );">Entity Tax Identification Number</a></td>
<td class="text">56-2020050<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine1', window );">Entity Address, Address Line One</a></td>
<td class="text">12770 High Bluff Drive<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine2', window );">Entity Address, Address Line Two</a></td>
<td class="text">Suite 150<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressCityOrTown', window );">Entity Address, City or Town</a></td>
<td class="text">San Diego<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressStateOrProvince', window );">Entity Address, State or Province</a></td>
<td class="text">CA<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressPostalZipCode', window );">Entity Address, Postal Zip Code</a></td>
<td class="text">92130<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CityAreaCode', window );">City Area Code</a></td>
<td class="text">858<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_LocalPhoneNumber', window );">Local Phone Number</a></td>
<td class="text">567-7770<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Title of 12(b) Security</a></td>
<td class="text">Common Stock<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">GYRE<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NASDAQ<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_WrittenCommunications', window );">Written Communications</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SolicitingMaterial', window );">Soliciting Material</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementTenderOffer', window );">Pre-commencement Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementIssuerTenderOffer', window );">Pre-commencement Issuer Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
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<div style="display: none;">
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CityAreaCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Area code of city</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CityAreaCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
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<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CoverAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Cover page.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CoverAbstract</td>
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<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period. The format of the date is YYYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentType">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 1 such as Attn, Building Name, Street Name</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine2">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 2 such as Street or Suite number</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine2</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressCityOrTown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the City or Town</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressCityOrTown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressPostalZipCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Code for the postal or zip code</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressPostalZipCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressStateOrProvince">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the state or province.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressStateOrProvince</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:stateOrProvinceItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:centralIndexKeyItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityEmergingGrowthCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFileNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFileNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fileNumberItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityIncorporationStateCountryCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Two-character EDGAR code representing the state or country of incorporation.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityIncorporationStateCountryCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarStateCountryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityRegistrantName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityTaxIdentificationNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityTaxIdentificationNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:employerIdItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_LocalPhoneNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Local phone number for entity.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_LocalPhoneNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementIssuerTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 13e<br> -Subsection 4c<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementIssuerTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14d<br> -Subsection 2b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_Security12bTitle">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Title of a 12(b) registered security.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_Security12bTitle</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:securityTitleItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SecurityExchangeName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the Exchange on which a security is registered.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection d1-1<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SecurityExchangeName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarExchangeCodeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SolicitingMaterial">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14a<br> -Subsection 12<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SolicitingMaterial</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_TradingSymbol">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Trading symbol of an instrument as listed on an exchange.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_TradingSymbol</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:tradingSymbolItemType</td>
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<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_WrittenCommunications">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Securities Act<br> -Number 230<br> -Section 425<br></p></div>
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